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Homo sapiens HIC ZBTB transcriptional repressor 2 (HIC2), mRNA

NCBI Reference Sequence: NM_015094.2

FASTA Graphics 

LOCUS       NM_015094               6812 bp    mRNA    linear   PRI 20-OCT-2018
DEFINITION  Homo sapiens HIC ZBTB transcriptional repressor 2 (HIC2), mRNA.
ACCESSION   NM_015094
VERSION     NM_015094.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6812)
  AUTHORS   Dykes IM, van Bueren KL, Ashmore RJ, Floss T, Wurst W, Szumska D,
            Bhattacharya S and Scambler PJ.
  TITLE     HIC2 is a novel dosage-dependent regulator of cardiac development
            located within the distal 22q11 deletion syndrome region
  JOURNAL   Circ. Res. 115 (1), 23-31 (2014)
   PUBMED   24748541
  REMARK    GeneRIF: data suggest that HIC2 haploinsufficiency likely
            contributes to the cardiac defects seen in distal 22q11 deletion
            syndrome
REFERENCE   2  (bases 1 to 6812)
  AUTHORS   Kamatani Y, Matsuda K, Okada Y, Kubo M, Hosono N, Daigo Y, Nakamura
            Y and Kamatani N.
  TITLE     Genome-wide association study of hematological and biochemical
            traits in a Japanese population
  JOURNAL   Nat. Genet. 42 (3), 210-215 (2010)
   PUBMED   20139978
REFERENCE   3  (bases 1 to 6812)
  AUTHORS   Han,J.W., Zheng,H.F., Cui,Y., Sun,L.D., Ye,D.Q., Hu,Z., Xu,J.H.,
            Cai,Z.M., Huang,W., Zhao,G.P., Xie,H.F., Fang,H., Lu,Q.J., Xu,J.H.,
            Li,X.P., Pan,Y.F., Deng,D.Q., Zeng,F.Q., Ye,Z.Z., Zhang,X.Y.,
            Wang,Q.W., Hao,F., Ma,L., Zuo,X.B., Zhou,F.S., Du,W.H., Cheng,Y.L.,
            Yang,J.Q., Shen,S.K., Li,J., Sheng,Y.J., Zuo,X.X., Zhu,W.F.,
            Gao,F., Zhang,P.L., Guo,Q., Li,B., Gao,M., Xiao,F.L., Quan,C.,
            Zhang,C., Zhang,Z., Zhu,K.J., Li,Y., Hu,D.Y., Lu,W.S., Huang,J.L.,
            Liu,S.X., Li,H., Ren,Y.Q., Wang,Z.X., Yang,C.J., Wang,P.G.,
            Zhou,W.M., Lv,Y.M., Zhang,A.P., Zhang,S.Q., Lin,D., Li,Y.,
            Low,H.Q., Shen,M., Zhai,Z.F., Wang,Y., Zhang,F.Y., Yang,S.,
            Liu,J.J. and Zhang,X.J.
  TITLE     Genome-wide association study in a Chinese Han population
            identifies nine new susceptibility loci for systemic lupus
            erythematosus
  JOURNAL   Nat. Genet. 41 (11), 1234-1237 (2009)
   PUBMED   19838193
REFERENCE   4  (bases 1 to 6812)
  AUTHORS   Vaquerizas JM, Kummerfeld SK, Teichmann SA and Luscombe NM.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat. Rev. Genet. 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   5  (bases 1 to 6812)
  AUTHORS   Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG,
            Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM and
            Dunham I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol. 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   6  (bases 1 to 6812)
  AUTHORS   Deltour S, Pinte S, Guerardel C, Wasylyk B and Leprince D.
  TITLE     The human candidate tumor suppressor gene HIC1 recruits CtBP
            through a degenerate GLDLSKK motif
  JOURNAL   Mol. Cell. Biol. 22 (13), 4890-4901 (2002)
   PUBMED   12052894
REFERENCE   7  (bases 1 to 6812)
  AUTHORS   Deltour S, Pinte S, Guerardel C and Leprince D.
  TITLE     Characterization of HRG22, a human homologue of the putative tumor
            suppressor gene HIC1
  JOURNAL   Biochem. Biophys. Res. Commun. 287 (2), 427-434 (2001)
   PUBMED   11554746
  REMARK    GeneRIF: HIC1 and HRG22 define a subgroup of BTB/POZ domains unable
            to recruit repressing complexes containing a histone deacetylase
            activity.
REFERENCE   8  (bases 1 to 6812)
  AUTHORS   Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE,
            Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida
            JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O,
            Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD,
            O'Brien KP et al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000556.2, CN373403.1, AP000557.2, BC094787.1 and BM675330.1.
            
            [WARNING] On Nov 23, 2018 this sequence was replaced by
            NM_015094.3.
            
            On Apr 3, 2007 this sequence version replaced NM_015094.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB028943.2 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AP000556.2         67448-67452
            6-203               CN373403.1         1-198
            204-212             AP000557.2         13024-13032
            213-1087            BC094787.1         146-1020
            1088-6246           AP000557.2         15972-21130
            6247-6812           BM675330.1         1-566               c
FEATURES             Location/Qualifiers
     source          1..6812
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..6812
                     /gene="HIC2"
                     /gene_synonym="HRG22; ZBTB30; ZNF907"
                     /note="HIC ZBTB transcriptional repressor 2"
                     /db_xref="GeneID:23119"
                     /db_xref="HGNC:HGNC:18595"
                     /db_xref="MIM:607712"
     exon            1..157
                     /gene="HIC2"
                     /gene_synonym="HRG22; ZBTB30; ZNF907"
                     /inference="alignment:Splign:2.1.0"
     exon            158..256
                     /gene="HIC2"
                     /gene_synonym="HRG22; ZBTB30; ZNF907"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    159..161
                     /gene="HIC2"
                     /gene_synonym="HRG22; ZBTB30; ZNF907"
                     /note="upstream in-frame stop codon"
     CDS             231..2078
                     /gene="HIC2"
                     /gene_synonym="HRG22; ZBTB30; ZNF907"
                     /note="hic-2; hic-3; HIC1-related gene on chromosome 22
                     protein; zinc finger and BTB domain-containing protein 30"
                     /codon_start=1
                     /product="hypermethylated in cancer 2 protein"
                     /protein_id="NP_055909.2"
                     /db_xref="CCDS:CCDS13789.1"
                     /db_xref="GeneID:23119"
                     /db_xref="HGNC:HGNC:18595"
                     /db_xref="MIM:607712"
                     /translation="MVSGPLALRWCAWAGRGDMGPDMELPSHSKQLLLQLNQQRTKGF
                     LCDVIIMVENSIFRAHKNVLAASSIYFKSLVLHDNLINLDTDMVSSTVFQQILDFIYT
                     GKLLPSDQPAEPNFSTLLTAASYLQLPELAALCRRKLKRAGKPFGSGRAGSTGMGRPP
                     RSQRLSTASVIQARYQGLVDGRKGAHAPQELPQAKGSDDELFLGGSNQDSVQGLGRAV
                     CPAGGEAGLGGCSSSTNGSSGGCEQELGLDLSKKSPPLPPATPGPHLTPDDAAQLSDS
                     QHGSPPAASAPPVANSASYSELGGTPDEPMDLEGAEDNHLSLLEAPGGQPRKSLRHST
                     RKKEWGKKEPVAGSPFERREAGPKGPCPGEEGEGVGDRVPNGILASGAGPSGPYGEPP
                     YPCKEEEENGKDASEDSAQSGSEGGSGHASAHYMYRQEGYETVSYGDNLYVCIPCAKG
                     FPSSEQLNAHVETHTEEELFIKEEGAYETGSGGAEEEAEDLSAPSAAYTAEPRPFKCS
                     VCEKTYKDPATLRQHEKTHWLTRPFPCNICGKMFTQRGTMTRHMRSHLGLKPFACDEC
                     GMRFTRQYRLTEHMRVHSGEKPYECQLCGGKFTQQRNLISHLRMHTSPS"
     misc_feature    726..728
                     /gene="HIC2"
                     /gene_synonym="HRG22; ZBTB30; ZNF907"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q96JB3.2); other
                     site"
     misc_feature    735..737
                     /gene="HIC2"
                     /gene_synonym="HRG22; ZBTB30; ZNF907"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q96JB3.2); other
                     site"
     misc_feature    819..821
                     /gene="HIC2"
                     /gene_synonym="HRG22; ZBTB30; ZNF907"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q96JB3.2); other
                     site"
     misc_feature    966..980
                     /gene="HIC2"
                     /gene_synonym="HRG22; ZBTB30; ZNF907"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96JB3.2);
                     Region: Binding to CtBP"
     misc_feature    1272..1274
                     /gene="HIC2"
                     /gene_synonym="HRG22; ZBTB30; ZNF907"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q96JB3.2); other
                     site"
     misc_feature    1464..1466
                     /gene="HIC2"
                     /gene_synonym="HRG22; ZBTB30; ZNF907"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q96JB3.2); other
                     site"
     exon            257..6798
                     /gene="HIC2"
                     /gene_synonym="HRG22; ZBTB30; ZNF907"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6779..6784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HIC2"
                     /gene_synonym="HRG22; ZBTB30; ZNF907"
     polyA_site      6798
                     /gene="HIC2"
                     /gene_synonym="HRG22; ZBTB30; ZNF907"
ORIGIN      
        1 gtgagcggcg ctcggggcgc gctaggcggg gagccgagcc gggctggcgg caggcggacg
       61 gggcgggcgc gtgcggcgcg agccgggcgc tgaggacaag ggccgctggt agggccggcc
      121 ggccggcggg cggagcgccg ccgccgacgc acacgaggtg accaggcatt gatgcacccc
      181 caggaaggcc acgcgctcag gagccccccc cgccgctggc tgctgctcac atggtgtctg
      241 ggcccttggc actccggtgg tgcgcgtggg cagggcgcgg ggacatgggg cccgacatgg
      301 agctgcccag ccactcgaag cagctcctgc tgcagctgaa ccagcagagg accaagggct
      361 tcctgtgtga cgtcatcatc atggtggaga actccatctt ccgggcccac aagaacgtcc
      421 tagccgccag cagcatctat ttcaagtccc tggtcctgca cgacaacctc atcaacctgg
      481 acacagacat ggtcagctcc acagtgttcc agcagatctt ggacttcatc tacacaggca
      541 agctgctgcc cagcgaccag ccagccgagc ccaacttcag caccctcctc actgccgcca
      601 gctacctcca gctgcccgag ttggcagccc tctgccgccg caaactcaag cgagccggca
      661 agccctttgg ctctgggagg gcggggtcca ctggcatggg gcggcccccc cgcagccagc
      721 ggctgtccac ggcctctgtc atccaagctc ggtatcaggg gctcgtggat gggcgcaagg
      781 gggcccacgc cccccaggag ctcccccaag ccaaaggctc agacgatgaa ctctttcttg
      841 gtggctctaa ccaggatagc gtgcaaggtc tgggccgggc tgtctgccca gctggcgggg
      901 aggcgggtct ggggggctgc agcagcagca ccaacgggag cagcgggggc tgcgagcagg
      961 agctgggctt ggacctgtcc aagaaaagcc cacccttgcc ccctgccacc ccaggtcccc
     1021 acctcactcc cgatgacgca gcccagctga gcgacagcca acatggctcg ccccctgcgg
     1081 cctctgctcc tcccgttgcc aacagtgcct cttattctga gctggggggc acccctgatg
     1141 agcccatgga tctggagggg gccgaggaca accacctgag cctgctggag gcgcctggtg
     1201 ggcagcctcg gaagagcctc cggcactcca ctcggaagaa ggagtggggc aagaaggagc
     1261 ctgtggctgg ctcccccttt gagcggagag aagcagggcc caagggtccc tgcccgggag
     1321 aggagggtga gggggtcggg gacagggttc ccaatggcat cctggctagt ggggctggcc
     1381 ctagcgggcc ctatggggag cccccctacc cctgcaagga ggaggaggag aacggcaagg
     1441 atgcaagtga agacagtgcg cagagcggga gcgagggggg cagcggccat gccagcgccc
     1501 actacatgta ccggcaggag ggctacgaga cggtgtccta cggggacaac ttgtatgtgt
     1561 gcattccctg cgccaagggc ttccccagct ctgagcagct caatgcgcac gtggagactc
     1621 acacggagga agagctgttc atcaaggaag agggggccta cgagacaggc agtgggggtg
     1681 ccgaggagga ggccgaggac ctgtcagcac ccagtgcggc ctacacggct gagccccggc
     1741 ccttcaagtg ttcggtctgc gagaagacct acaaggaccc agccacgctg cggcagcacg
     1801 agaagacgca ctggctgaca cggcccttcc cctgcaacat ctgtggcaaa atgttcacgc
     1861 agcgcggcac catgacgcgt cacatgcgga gccacctggg cctgaagccc ttcgcctgcg
     1921 atgagtgtgg catgcgcttc acccgtcagt accgcctcac ggagcacatg cgtgtgcact
     1981 cgggcgagaa accttacgag tgccagctgt gcgggggcaa gttcacccag cagcgcaacc
     2041 tcatcagcca cctgcgcatg cacacctccc cctcctagaa gccaaagacc cgcgggcgcc
     2101 ctctgccacc ttgctccccg ggaacccatg gaaggagaag cgaggtgatg cagcagcagg
     2161 ggcaagaccc tgggtccagt ggaggctccg ggtggcccct ctggccccca ctgcccacac
     2221 ccagagcttt aatggacagt ccgtaccaag cagagccgag aggagggaag ccaggggtcc
     2281 cagcccgtct acctccccat cccacccagg cccccagctc cccgcggggg ccaccgcagg
     2341 gcctgtgggc tgggtcacgt gggtctcgct gggacctggt ccctttgttg caggcggctt
     2401 ggagaaaggg cagtgggacg ctggccacgg ccagggtggt gtcgggagca ggcctcaccc
     2461 cgctggccgt gtctgtgtgt gtgcacgtgt gcttgtgtct gtgcgggcgc gtgcagccct
     2521 ggttctgcag ggaacaggtg ctgggggtgc agatccctcc ctccttgagc cagggtggca
     2581 ctgttcactg gcgctgggac agtcagggtg accccaccgc ctacctctct acatctaaag
     2641 agccctctgg gcctgtgttg ctgttattcc tactgatctg ttcctctgtt tttctttttg
     2701 atttttgttt tttaaaccaa aacagacaat agcttatttt ctttccgccc cctccggggc
     2761 tgagcctggg tctgaagact gaatgtaaca ggggccgctg gcactcctgc gcgtcccccg
     2821 gctctggcgc tgcaggggtg tcggcgcgcc acctctccag gccccagaag cccttcttgc
     2881 ccaaaggctt ccctggtccc tgagccctgc ctcggctgcc tcaggggaga gtgcttttcc
     2941 tgtagtttcc aaggaatatt ctttgtttag aggtacttgt tttttattaa gagaaaaacc
     3001 agtgtaacgt ttatgtgact gtttgaactg gaaggtctgg ggttccgggg ggtgggggga
     3061 ggctagactc aatgccgggg ccgtcggtac tcttgttttc atttgtgtgt gcgtgcgtgt
     3121 gtgtgtgtgt atgtgcgtat gtgtgtgtct atgtgtggtg tgtgccgtat gcatgggcag
     3181 atgtttcgct ttccctcctt cctcgctgaa caaggtggag acttctgacc ttttgctacc
     3241 tcttgaattc atgacaacga tatgttggtg actggcagtg gaagcccttg acactcttgt
     3301 tttccttcgc ttagcaccta ggaagtcgtg tgcaggagcc agcagggcgc caagtggccc
     3361 agtgcctgca gctcacctgt gggttttccc tttgagcctt tggccacatc cacctcgagg
     3421 ggaccctggc accccgggca cacaaacctc tgtggtatag gtgaggggtg tgaggcccca
     3481 gcctggagcc aggcactggg tgctgacagg ggaaccatga ggagggtggc aggtctttgc
     3541 agctcccggc cagggtgagg cggaagtgag ccctcatcct gccactccta tcctccattc
     3601 ctgcaagagt tttaagcttg agagagctga ccacagggcc ccccggggaa cagggatggc
     3661 acttccctga gcagtcctgg cccccggcca ctgtctcggg gcccacctct cgcccctcat
     3721 cttggtaatt agccagcctc agatacttct gtgggccctg aagtgggctc tcaaggtcag
     3781 accaaggttg ctgatctcag tcccactgtc ttcagccagc tgaagctgtg gggctgggct
     3841 ggcagccttt attgtcatct tgcttcacca tttttttttc tctctctttt cattctattt
     3901 taagtttaga ccaaaaaaat acagagtcat cccctacccc cacccctcta gagaccctcc
     3961 agctaaaaac agagcctgag ttcagggacc caagtggtga gcggcgtctt ttgggggtga
     4021 gggagcttgg gtagatgagg ctcctggctg agccctccct gtggtgatcc cagcctaaga
     4081 tggcccctct tccctcctgg tgggagacag aggactggac cctgggtctc aggttccagc
     4141 aagtcaggct agggacctgg ggggaggaga cccatggact tcacccatac tcagtgaggg
     4201 ggctcctgcc gtcctgacgc caccccgccc catcagcact taagccacat gacacaaagt
     4261 ctgtaccgca cgggaaatgt tcacgcgcct ggccgtgtgc atggcctccc gggctgtggg
     4321 cagccgcatc tgtgaggtga ctcgtgaaag taggtgattc ctttgcagaa cttcagggac
     4381 tgggagcaga ggcccctcac tcaacgacgt ttgtgcgaca tagtattgta tccaccttag
     4441 tattgtatcg agccttttct gtgttttaat gagaaagcag aacactagtt tcctatttaa
     4501 gactttaagg gtttgtgggg cggggcggga ttaacacaac atttggcttt gttttctttt
     4561 tcctttgatt tccacatcag gtgtgtgcga gtgtgtgtgt gtggagatgt taagagcctc
     4621 acaaggaaac tgggttattg gaggccaagg cggcttacag ttctctgcgt tcgtcactta
     4681 attcctgaat gtttcagaga aacaggaatc agaaaatagc agatatcatg taggaaagag
     4741 aggataaaca aagaaaaaag aaaaaaaaat aagctcatac ccaaattcac aaagcctatt
     4801 ttttaaacca aagcacattt tgaatgagta tggaacctcc atgggctcag aaaaaagatg
     4861 ctaatatatt tatctcattg tttacataag cttttacagt ttcagacctc agcagctgta
     4921 aggccagtcc agggaaccct cccctgctgc tggaaaccct tctgagttgg ccctggagtg
     4981 gctcacgggc agagaagggt agccctgggg ctgggggagg gattggaagc ctccctggag
     5041 tcacctgagc cctcgtcccc attcccaggg cccctccaag cccagctggc accaaagagc
     5101 ttgggcccgt gctgaccagc ccccaaggcc ctctggccgg accatgctgg tcctgaccag
     5161 ctagcctacg cggggatggc cgtcagttct ggccacagga cccgagtctg ggcttgggtc
     5221 cccctgctgc tctgcccgtg acccttgggg atgggttgat gcgagggtcc cactcaagcc
     5281 aaaaagccgg gacctttgcg cagctctgtc gactctggtg ggtccccact cctggggccc
     5341 cctaacccca ccccaggcag cggaaggggc tgactgggtc tggtccttac caacatagac
     5401 ggtgcaaaca ctcttaacag tgttgttttt gtatcaatat gtttgtgcag tgatgaatgt
     5461 atttatttct cagacttggg gcgagtgagc gggtggcagg ccgggctccg ccactgcatg
     5521 ctcccgccgg accgagcccc agcaagggct cctccaggat tgcaaaaaaa aaaggaagag
     5581 aaaagatgaa cctttaagca aataagaatc tcagagactc gcagcatagc catacacctc
     5641 agcctgtgaa atgaacgatc cggaccctca ccaactttcc ccacctcagg cagccctgtg
     5701 tgtttaccgt tcatcaccac tcgggggcac cgggccgccc acccactccc aaaatccgtc
     5761 agtattcact ggacctcagg ccctgtgcag gagtgcgatc cgggctgggc cgctgggcag
     5821 gctgaccccc tgccctcctg cggccatcct gagttggggt gaggcctggg cagccggagg
     5881 gcagggctca gggagcagga ggctgcatcc gtccaccccc aggcgtgggg gacaaaagcc
     5941 aaaggtgcca ggccttagag cagacaaggg ctctcagccc tggcatgccc cctaaaggga
     6001 ccaaggtcct cctatttccc agaaccccgt tggggcagat gttactgaac ctgtgaatca
     6061 gacgccagga gtgagggctg gggagggacc taactggagc ctcagtctga cattccacgc
     6121 cggggtgggg gtgggcatga gcggtgggaa ctgaggctgc ccaggacccc cttcctagga
     6181 tgccccggct tcagtcaccc cactttaact ttctaccagg accccctccc cctacctcac
     6241 cttgctattt attgctgtaa tttattgacc tcaaaaatgc tgcataacag acctcactgg
     6301 ggcagggagg atccccaggg ctcccaccct ccacttggcg ggccccgtgg ggccaggtgc
     6361 tgaggggagc ctctctaccc cacccatcac tagcttccct ctgccctctc ccaccccggg
     6421 ggggacccag gttgggcact ggctcatttc tcgcaaatac ctcgaagggg aggggggagg
     6481 gatggggtta tagctgtttt gtttaattgg aactggaaga gggatcatgt tttgttttat
     6541 gcccttccca gaagggggga gggacaccgg gatcgcactc ctgtactggc caccgccgct
     6601 gtcacttgtc acattgagtt catgtccctt gagagtttgt ataaattcag gtcagagctg
     6661 cagctacaca gctgcccagt gtcatagaaa agcaattcac caacgactga tctctccatt
     6721 cagaagtgtg cagtcttaaa tgtacagcga taagaaactg ttattttatg atcttttcat
     6781 taaaagcttg attgaaaaaa aaaaaaaaaa aa
//
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