LOCUS NM_015490 4634 bp mRNA linear PRI 04-APR-2024
DEFINITION Homo sapiens SEC31 homolog B, COPII coat complex component
(SEC31B), mRNA.
ACCESSION NM_015490
VERSION NM_015490.4
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4634)
AUTHORS Del-Aguila,J.L., Beitelshees,A.L., Cooper-Dehoff,R.M.,
Chapman,A.B., Gums,J.G., Bailey,K., Gong,Y., Turner,S.T.,
Johnson,J.A. and Boerwinkle,E.
TITLE Genome-wide association analyses suggest NELL1 influences adverse
metabolic response to HCTZ in African Americans
JOURNAL Pharmacogenomics J 14 (1), 35-40 (2014)
PUBMED 23400010
REFERENCE 2 (bases 1 to 4634)
AUTHORS Wu,J.H., Lemaitre,R.N., Manichaikul,A., Guan,W., Tanaka,T., Foy,M.,
Kabagambe,E.K., Djousse,L., Siscovick,D., Fretts,A.M., Johnson,C.,
King,I.B., Psaty,B.M., McKnight,B., Rich,S.S., Chen,Y.D.,
Nettleton,J.A., Tang,W., Bandinelli,S., Jacobs,D.R. Jr.,
Browning,B.L., Laurie,C.C., Gu,X., Tsai,M.Y., Steffen,L.M.,
Ferrucci,L., Fornage,M. and Mozaffarian,D.
TITLE Genome-wide association study identifies novel loci associated with
concentrations of four plasma phospholipid fatty acids in the de
novo lipogenesis pathway: results from the Cohorts for Heart and
Aging Research in Genomic Epidemiology (CHARGE) consortium
JOURNAL Circ Cardiovasc Genet 6 (2), 171-183 (2013)
PUBMED 23362303
REFERENCE 3 (bases 1 to 4634)
AUTHORS Fusco,C., Micale,L., Egorov,M., Monti,M., D'Addetta,E.V.,
Augello,B., Cozzolino,F., Calcagni,A., Fontana,A., Polishchuk,R.S.,
Didelot,G., Reymond,A., Pucci,P. and Merla,G.
TITLE The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and
promotes the sequestration and clearance of ubiquitinated proteins
into the aggresome
JOURNAL PLoS One 7 (7), e40440 (2012)
PUBMED 22792322
REFERENCE 4 (bases 1 to 4634)
AUTHORS Stankewich,M.C., Stabach,P.R. and Morrow,J.S.
TITLE Human Sec31B: a family of new mammalian orthologues of yeast Sec31p
that associate with the COPII coat
JOURNAL J Cell Sci 119 (Pt 5), 958-969 (2006)
PUBMED 16495487
REMARK GeneRIF: The SEC31B protein is an orthologue of Saccharomyces
cerevisiae Sec31p, a component of the COPII vesicle coat that
mediates vesicular traffic from the endoplasmic reticulum.
REFERENCE 5 (bases 1 to 4634)
AUTHORS Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
TITLE A scan of chromosome 10 identifies a novel locus showing strong
association with late-onset Alzheimer disease
JOURNAL Am J Hum Genet 78 (1), 78-88 (2006)
PUBMED 16385451
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 6 (bases 1 to 4634)
AUTHORS Tang,B.L., Zhang,T., Low,D.Y., Wong,E.T., Horstmann,H. and Hong,W.
TITLE Mammalian homologues of yeast sec31p. An ubiquitously expressed
form is localized to endoplasmic reticulum (ER) exit sites and is
essential for ER-Golgi transport
JOURNAL J Biol Chem 275 (18), 13597-13604 (2000)
PUBMED 10788476
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AL133352.12, BC034946.1,
AF274863.1 and BM719543.1.
On Nov 23, 2018 this sequence version replaced NM_015490.3.
Summary: This gene encodes a protein of unknown function. The
protein has moderate similarity to rat VAP1 protein which is an
endosomal membrane-associated protein, containing a putative
Ca2+/calmodulin-dependent kinase II phosphorylation site. [provided
by RefSeq, Jul 2008].
##Evidence-Data-START##
Transcript exon combination :: AF274863.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000370345.8/ ENSP00000359370.3
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-23 AL133352.12 56769-56791 c
24-80 BC034946.1 6-62
81-4602 AF274863.1 54-4575
4603-4634 BM719543.1 388-419
FEATURES Location/Qualifiers
source 1..4634
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q24.31"
gene 1..4634
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/note="SEC31 homolog B, COPII coat complex component"
/db_xref="GeneID:25956"
/db_xref="HGNC:HGNC:23197"
/db_xref="MIM:610258"
exon 1..80
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/inference="alignment:Splign:2.1.0"
exon 81..204
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/inference="alignment:Splign:2.1.0"
misc_feature 120..122
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/note="upstream in-frame stop codon"
CDS 126..3665
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/note="secretory pathway component Sec31B-1; SEC31-related
protein B; SEC31-like protein 2; SEC31-like 2; SEC31
homolog B, COPII coating complex component"
/codon_start=1
/product="protein transport protein Sec31B"
/protein_id="NP_056305.1"
/db_xref="CCDS:CCDS7495.1"
/db_xref="GeneID:25956"
/db_xref="HGNC:HGNC:23197"
/db_xref="MIM:610258"
/translation="MKLKELERPAVQAWSPASQYPLYLATGTSAQQLDSSFSTNGTLE
IFEVDFRDPSLDLKHRGVLSALSRFHKLVWGSFGSGLLESSGVIVGGGDNGMLILYNV
THILSSGKEPVIAQKQKHTGAVRALDLNPFQGNLLASGASDSEIFIWDLNNLNVPMTL
GSKSQQPPEDIKALSWNRQAQHILSSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHCSG
LAWHPDIATQLVLCSEDDRLPVIQLWDLRFASSPLKVLESHSRGILSVSWSQADAELL
LTSAKDSQILCRNLGSSEVVYKLPTQSSWCFDVQWCPRDPSVFSAASFNGWISLYSVM
GRSWEVQHMRQADKISSSFSKGQPLPPLQVPEQVAQAPLIPPLKKPPKWIRRPTGVSF
AFGGKLVTFGLPSTPAHLVPQPCPRLVFISQVTTESEFLMRSAELQEALGSGNLLNYC
QNKSQQALLQSEKMLWQFLKVTLEQDSRMKFLKLLGYSKDELQKKVATWLKSDVGLGE
SPQPKGNDLNSDRQQAFCSQASKHTTKEASASSAFFDELVPQNMTPWEIPITKDIDGL
LSQALLLGELGPAVELCLKEERFADAIILAQAGGTDLLKQTQERYLAKKKTKISSLLA
CVVQKNWKDVVCTCSLKNWREALALLLTYSGTEKFPELCDMLGTRMEQEGSRALTSEA
RLCYVCSGSVERLVECWAKCHQALSPMALQDLMEKVMVLNRSLEQLRGPHGVSPGPAT
TYRVTQYANLLAAQGSLATAMSFLPRDCAQPPVQQLRDRLFHAQGSAVLGQQSPPFPF
PRIVVGATLHSKETSSYRLGSQPSHQVPTPSPRPRVFTPQSSPAMPLAPSHPSPYQGP
RTQNISDYRAPGPQAIQPLPLSPGVRPASSQPQLLGGQRVQVPNPVGFPGTWPLPGSP
LPMACPGIMRPGSTSLPETPRLFPLLPLRPLGPGRMVSHTPAPPASFPVPYLPGDPGA
PCSSVLPTTGILTPHPGPQDSWKEAPAPRGNLQRNKLPETFMPPAPITAPVMSLTPEL
QGILPSQPPVSSVSHAPPGVPGELSLQLQHLPPEKMERKELPPEHQSLKSSFEALLQR
CSLSATDLKTKRKLEEAAQRLEYLYEKLCEGTLSPHVVAGLHEVARCVDAGSFEQGLA
VHAQVAGCSSFSEVSSFMPILKAVLIIAHKLLV"
misc_feature 174..293
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/note="propagated from UniProtKB/Swiss-Prot (Q9NQW1.1);
Region: WD 1"
misc_feature 324..455
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/note="propagated from UniProtKB/Swiss-Prot (Q9NQW1.1);
Region: WD 2"
misc_feature 480..602
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/note="propagated from UniProtKB/Swiss-Prot (Q9NQW1.1);
Region: WD 3"
misc_feature 621..743
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/note="propagated from UniProtKB/Swiss-Prot (Q9NQW1.1);
Region: WD 4"
misc_feature 750..887
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/note="propagated from UniProtKB/Swiss-Prot (Q9NQW1.1);
Region: WD 5"
misc_feature 897..1019
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/note="propagated from UniProtKB/Swiss-Prot (Q9NQW1.1);
Region: WD 6"
misc_feature 1026..1148
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/note="propagated from UniProtKB/Swiss-Prot (Q9NQW1.1);
Region: WD 7"
misc_feature 1296..1391
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/note="propagated from UniProtKB/Swiss-Prot (Q9NQW1.1);
Region: WD 8, interaction with SEC13.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00221"
misc_feature 2559..2693
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/note="propagated from UniProtKB/Swiss-Prot (Q9NQW1.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
exon 205..328
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/inference="alignment:Splign:2.1.0"
exon 329..524
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/inference="alignment:Splign:2.1.0"
exon 525..620
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/inference="alignment:Splign:2.1.0"
exon 621..764
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/inference="alignment:Splign:2.1.0"
exon 765..907
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/inference="alignment:Splign:2.1.0"
exon 908..1007
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/inference="alignment:Splign:2.1.0"
exon 1008..1169
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/inference="alignment:Splign:2.1.0"
exon 1170..1304
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/inference="alignment:Splign:2.1.0"
exon 1305..1535
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/inference="alignment:Splign:2.1.0"
exon 1536..1610
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/inference="alignment:Splign:2.1.0"
exon 1611..1709
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/inference="alignment:Splign:2.1.0"
exon 1710..1809
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/inference="alignment:Splign:2.1.0"
exon 1810..1988
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/inference="alignment:Splign:2.1.0"
exon 1989..2115
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/inference="alignment:Splign:2.1.0"
exon 2116..2261
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/inference="alignment:Splign:2.1.0"
exon 2262..2435
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/inference="alignment:Splign:2.1.0"
exon 2436..2597
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/inference="alignment:Splign:2.1.0"
exon 2598..2775
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/inference="alignment:Splign:2.1.0"
exon 2776..3090
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/inference="alignment:Splign:2.1.0"
exon 3091..3149
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/inference="alignment:Splign:2.1.0"
exon 3150..3296
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/inference="alignment:Splign:2.1.0"
exon 3297..3413
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/inference="alignment:Splign:2.1.0"
exon 3414..3485
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/inference="alignment:Splign:2.1.0"
exon 3486..4634
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/inference="alignment:Splign:2.1.0"
regulatory 4614..4619
/regulatory_class="polyA_signal_sequence"
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/note="hexamer: AATAAA"
polyA_site 4634
/gene="SEC31B"
/gene_synonym="SEC31B-1; SEC31L2"
/note="major polyA site"
ORIGIN
1 gcccggctcc gcgcgagagc cctgccagag gagcggctcc ggccgccgcg cctgaccctt
61 gtccggggtc ttccgcacag tgggctgagg gccatgtcag ttttctgcca cctacaggat
121 agaccatgaa gctgaaggaa cttgagcggc cagctgtcca ggcatggagc ccagccagcc
181 aatacccttt gtatctggcc acaggaacat ctgcccaaca gctagattcc tccttcagca
241 caaatggcac attggaaata tttgaggttg atttcaggga cccttctctg gacttgaaac
301 acagaggagt cctttctgcc ttgagcaggt ttcacaagct ggtctggggg agctttggca
361 gtgggcttct ggaaagctcc ggggttattg ttggcggcgg ggacaatggc atgcttattc
421 tatacaatgt gacccacatc ctgtcttcgg ggaaggagcc tgtgattgct cagaaacaga
481 agcacacggg ggctgtcaga gccctcgact tgaatccttt ccagggcaac ctcctggctt
541 caggggccag cgattctgaa atcttcattt gggatctgaa taacttgaat gtgccaatga
601 ccctgggatc caagtcacag cagcctccag aggacatcaa ggcactgtct tggaaccggc
661 aagcccaaca cattctgtct tctgctcacc ccagtggcaa ggcagttgtg tgggatctca
721 ggaagaatga acctatcatc aaagtcagtg atcacagcaa caggatgcac tgctcaggcc
781 tggcctggca tcctgacata gccacccagt tagtgctgtg ctcagaggat gatcgacttc
841 ccgtgattca gctgtgggac ttgcgctttg cctcctcgcc cttgaaggtg ctggagagcc
901 acagcagggg gatcttgtca gtgtcatgga gccaggctga tgctgagctg ctgctcacta
961 gtgctaagga cagccagatc ttgtgccgga acctggggag cagtgaggtg gtatataagc
1021 taccaacaca gagcagctgg tgctttgatg tgcagtggtg ccctcgggac ccttcagtgt
1081 tctctgctgc ctccttcaac ggctggatca gtttgtactc tgtgatgggt aggagctggg
1141 aagtccagca tatgagacag gctgacaaga tctcctcttc cttcagcaaa ggccagcctc
1201 tcccaccact gcaggtgcca gagcaagtgg cacaagcacc actgatacct cccctgaaaa
1261 aaccccccaa atggattaga agaccaacag gtgtttcatt tgcttttgga gggaagctgg
1321 ttacttttgg cctccccagc acccctgccc atctggtgcc acagccttgc ccccgcctag
1381 tcttcatcag tcaagtcacc acagaatctg aattcctgat gcgatcagct gagctgcagg
1441 aggccttggg atcaggaaat ctactgaatt actgtcagaa caagagccag caagctttac
1501 tgcaaagtga aaagatgctg tggcagttcc tgaaggtgac cttagagcaa gactccagaa
1561 tgaaattcct aaagctttta ggatacagta aagatgagct tcagaagaag gtggccacat
1621 ggttgaagag tgacgtgggg ctaggtgaga gtcctcagcc caagggaaat gacctcaaca
1681 gtgacagaca acaggccttc tgcagccagg cctccaaaca caccacaaag gaagcctctg
1741 cttcctcagc cttctttgat gagctggtcc ctcagaacat gactccttgg gagatcccca
1801 tcacaaaaga tattgatgga ctcctaagcc aggctctcct gcttggggaa ctgggtccgg
1861 ccgtggagct gtgtctgaag gaggagcgct ttgctgatgc cattatcctg gcccaggctg
1921 ggggtacaga tctgctgaag caaacacagg agcgctactt ggccaagaag aaaaccaaaa
1981 tctcctcgct tctagcctgt gttgtgcaaa agaattggaa ggatgtggtg tgtacctgta
2041 gcctgaagaa ctggagagag gcactggctt tgctactgac atactcaggc acagagaaat
2101 ttcccgagct ctgtgacatg ctgggaactc gcatggaaca ggagggcagc agggcactaa
2161 cctccgaagc cagactctgt tatgtgtgct cagggagtgt ggagcggctg gtggagtgct
2221 gggcaaaatg ccaccaggct ttgtccccca tggctctgca ggacctgatg gagaaggtga
2281 tggttcttaa caggagcttg gagcaactgc ggggtcctca tggggtgagc ccaggccctg
2341 ccacaaccta cagggtcact cagtatgcca acctcctggc agcccagggc agcctggcca
2401 ctgccatgag ctttctaccc agggactgtg ctcagccacc agttcagcag ctaagagatc
2461 ggctttttca tgctcaaggt tctgctgtct tgggccaaca gtctccccct ttccccttcc
2521 cccggattgt tgtgggagct accctccact ctaaagagac atcatcttac agattgggat
2581 cccagccttc tcaccaggtc ccaactccat ctccaaggcc aagggttttc acccctcagt
2641 catcaccagc gatgcccttg gcaccttccc atcctagccc ttatcagggt cccaggacac
2701 agaatataag tgactacagg gcacctgggc cccaggccat ccagcctttg cctttgagcc
2761 ctggggtaag gcctgcttca tctcagccac agctattagg agggcaaagg gtgcaagttc
2821 ctaacccggt gggattccct gggacatggc ctcttcctgg ttcccctcta cccatggcat
2881 gcccaggcat catgcgacct ggctctacct ccctgcctga gactcctaga ctgttccctc
2941 tgcttcctct gagaccacta ggtcccggcc gcatggtctc ccacacccca gcccctcctg
3001 caagcttccc tgtgccatac cttccagggg acccaggtgc cccatgctct agtgtcctcc
3061 caaccactgg catcttgact cctcacccag gacctcaaga ttcctggaaa gaagccccag
3121 cccccagggg aaacctccag aggaacaagc tgccagagac atttatgccc ccagcaccaa
3181 ttactgctcc agttatgagc ctcacccctg agctacaagg gattcttccc tcacagcccc
3241 ctgtctccag tgtgagtcat gctcccccag gagttccagg agaactcagc ctgcagcttc
3301 agcacctgcc acctgagaag atggaaagga aggagctgcc cccagagcat cagtccttga
3361 agagcagctt tgaggcgctt ctccaacgct gctccctgtc tgcaactgac ttaaagacaa
3421 aaaggaagct ggaagaggca gcccagcgtc tggagtatct atatgagaag ctctgtgagg
3481 ggacactctc acctcatgtc gtggctgggc tccatgaggt tgcccgatgt gtggatgcag
3541 gaagctttga gcagggcctt gcagtgcatg cccaggtggc gggctgtagc agcttcagcg
3601 aggtgtccag cttcatgcct atcctgaagg ctgtcctcat catcgctcat aagctgctgg
3661 tctaaaccag gcagcctctc ttgctaggag gccacttctg ctgttacata actcctccct
3721 gcagaagagg ggacttctgc aacagattct gtttcttttt cccgactctt ttccttgctg
3781 ccaggtatgt gatgctgtag gcttggctcc aaaccagctg agtgcctgct ttttactcct
3841 ttatgtctgg ccttctagga tctgtccaag acactctcag gcctggaggc agggcataga
3901 atcagttctt cactctccct aatactacac tctgtaagga cctggggcag gatatcttct
3961 cccccaggga tcttctattt aagtggcttc tgagagggtg aacaggattg ttacttttaa
4021 gcctacctct gctgtgaccc atcatgtggg tcttttgttt ctcccttctg tggtttatga
4081 gcctgccctt accttttccc tgcctctgac ttggtatttc caggtccgta tttctctgta
4141 gcccagggtc tggggtagag ctgactgctg ttcacccttt gaacaactca tggacgtgag
4201 ggatgggtgc tgagcagaac caagagagga aactttggcg ctgttaaaat ggaatttctc
4261 atctgccggc attattaagg gtgggctagg ttggatggaa ggtgaaaggg atgaactgcc
4321 ttttgctgga agctgtctta ggctgtgaga caggagcagg ggaaccacag cctatgggga
4381 actgcccttg actccaccta tgttggagcc ttagcccaag gccattcctt ctgtgatgat
4441 aaagcccagt tctggaattg gagccatatt aaggaatgat tctcttccag cgctgctcct
4501 caagggttgg gggtccttct ccctcgcagc caccacatgt ctcagggcta ccttctccga
4561 ttggatttgc atttgtggca ctgtctttga tgcagtgatg tacttaatgg tgcaataaag
4621 ctgcttcgat ttgg
//