LOCUS NM_019069 4217 bp mRNA linear PRI 06-AUG-2024
DEFINITION Homo sapiens WD repeat domain 5B (WDR5B), mRNA.
ACCESSION NM_019069
VERSION NM_019069.4
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4217)
AUTHORS Bailey,J.K., Ma,D. and Clegg,D.O.
TITLE Initial Characterization of WDR5B Reveals a Role in the
Proliferation of Retinal Pigment Epithelial Cells
JOURNAL Cells 13 (14), 1189 (2024)
PUBMED 39056772
REMARK GeneRIF: Initial Characterization of WDR5B Reveals a Role in the
Proliferation of Retinal Pigment Epithelial Cells.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 4217)
AUTHORS O'Seaghdha,C.M., Yang,Q., Glazer,N.L., Leak,T.S., Dehghan,A.,
Smith,A.V., Kao,W.H., Lohman,K., Hwang,S.J., Johnson,A.D.,
Hofman,A., Uitterlinden,A.G., Chen,Y.D., Brown,E.M.,
Siscovick,D.S., Harris,T.B., Psaty,B.M., Coresh,J., Gudnason,V.,
Witteman,J.C., Liu,Y.M., Kestenbaum,B.R., Fox,C.S. and Kottgen,A.
CONSRTM GEFOS Consortium
TITLE Common variants in the calcium-sensing receptor gene are associated
with total serum calcium levels
JOURNAL Hum Mol Genet 19 (21), 4296-4303 (2010)
PUBMED 20705733
REFERENCE 3 (bases 1 to 4217)
AUTHORS Gilley,J. and Fried,M.
TITLE Extensive gene order differences within regions of conserved
synteny between the Fugu and human genomes: implications for
chromosomal evolution and the cloning of disease genes
JOURNAL Hum Mol Genet 8 (7), 1313-1320 (1999)
PUBMED 10369878
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC083798.14, BC025762.1,
BC043494.1, AA310178.1, AA587370.1 and BU678251.1.
On May 17, 2019 this sequence version replaced NM_019069.3.
Summary: This intronless gene encodes a protein containing several
WD40 repeats. WD repeats are approximately 30- to 40-amino acid
domains containing several conserved residues, including a trp-asp
at the C-terminal end. The encoded protein may mediate
protein-protein interactions. [provided by RefSeq, Jul 2008].
##Evidence-Data-START##
Transcript is intronless :: SRR1803612.13213.1, SRR1803616.36101.1
[ECO:0000345]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000330689.6/ ENSP00000330381.4
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-27 AC083798.14 130855-130881 c
28-984 BC025762.1 1-957
985-1944 BC043494.1 547-1506
1945-2036 BC025762.1 1917-2008
2037-3132 BC043494.1 1599-2694
3133-3171 AA310178.1 19-57
3172-3731 BC043494.1 2734-3293
3732-4149 AA587370.1 75-492 c
4150-4210 BU678251.1 436-496
4211-4217 AC083798.14 126665-126671 c
FEATURES Location/Qualifiers
source 1..4217
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3q21.1"
gene 1..4217
/gene="WDR5B"
/note="WD repeat domain 5B"
/db_xref="GeneID:54554"
/db_xref="HGNC:HGNC:17826"
exon 1..4217
/gene="WDR5B"
/inference="alignment:Splign:2.1.0"
misc_feature 382..384
/gene="WDR5B"
/note="upstream in-frame stop codon"
CDS 535..1527
/gene="WDR5B"
/codon_start=1
/product="WD repeat-containing protein 5B"
/protein_id="NP_061942.2"
/db_xref="CCDS:CCDS3012.1"
/db_xref="GeneID:54554"
/db_xref="HGNC:HGNC:17826"
/translation="MATKESRDAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAV
SSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSAS
DDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCL
KTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKF
SPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED
NLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLWMSNH"
misc_feature 535..612
/gene="WDR5B"
/note="propagated from UniProtKB/Swiss-Prot (Q86VZ2.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 649..768
/gene="WDR5B"
/note="propagated from UniProtKB/Swiss-Prot (Q86VZ2.1);
Region: WD 1"
misc_feature 775..900
/gene="WDR5B"
/note="propagated from UniProtKB/Swiss-Prot (Q86VZ2.1);
Region: WD 2"
misc_feature 904..1026
/gene="WDR5B"
/note="propagated from UniProtKB/Swiss-Prot (Q86VZ2.1);
Region: WD 3"
misc_feature 1027..1146
/gene="WDR5B"
/note="propagated from UniProtKB/Swiss-Prot (Q86VZ2.1);
Region: WD 4"
misc_feature 1096..1110
/gene="WDR5B"
/note="propagated from UniProtKB/Swiss-Prot (Q86VZ2.1);
Region: DDB1-binding motif"
misc_feature 1156..1281
/gene="WDR5B"
/note="propagated from UniProtKB/Swiss-Prot (Q86VZ2.1);
Region: WD 5"
misc_feature 1288..1410
/gene="WDR5B"
/note="propagated from UniProtKB/Swiss-Prot (Q86VZ2.1);
Region: WD 6"
misc_feature 1417..1524
/gene="WDR5B"
/note="propagated from UniProtKB/Swiss-Prot (Q86VZ2.1);
Region: WD 7"
polyA_site 2036
/gene="WDR5B"
/note="major polyA site"
regulatory 3682..3687
/regulatory_class="polyA_signal_sequence"
/gene="WDR5B"
/note="hexamer: AATAAA"
polyA_site 3699
/gene="WDR5B"
regulatory 3714..3719
/regulatory_class="polyA_signal_sequence"
/gene="WDR5B"
/note="hexamer: AATAAA"
polyA_site 3736
/gene="WDR5B"
regulatory 3754..3759
/regulatory_class="polyA_signal_sequence"
/gene="WDR5B"
/note="hexamer: AACAAA"
polyA_site 3790
/gene="WDR5B"
regulatory 4196..4201
/regulatory_class="polyA_signal_sequence"
/gene="WDR5B"
/note="hexamer: AATAAA"
polyA_site 4217
/gene="WDR5B"
ORIGIN
1 agtgcacacc tgctggtacg agcaaaagta gccgacaggc cagagtttcc agtttcggtg
61 gcttcgtagg cttttagctt ctgaaatccg ctaaaagcgg cggttcattc atcttcaagt
121 acctagcctg actggtaggg ctgctcagca ttccgaaaca tttcgacctg gggagggggg
181 cggcggtgaa agaatacttt ctgtagagag tgcccctcgc gtcgcccctg ctttgaaggc
241 tttatgtatt aacggaatgc cgaacatttg tgtcctactt gctgacagcg cacaggatcc
301 ttctaacagt atttctcaag tacttaacaa aaagatgaaa acttgaagtc caagccgtgc
361 tgctgattcc gtctcacagt ttaaagactg tccagaaact ttaagctttc aaaactgtac
421 attttaaaat cctgtgcgtt tatcttcatt ttgctgggca gaaagccaaa gtactggact
481 gcctggttca gggctgaacg cctagtacac ctgctaactt ggagcttcag agccatggca
541 accaaggagt caagagacgc caaagcacag ttggccctct cctcatcggc caatcagagc
601 aaggaagtgc ctgaaaaccc aaactatgct ctcaaatgta ctcttgtggg acacacggaa
661 gcagtgtcat cagttaagtt tagtcctaat ggagaatggc tagcaagttc ttctgctgat
721 aggctaatca taatttgggg agcatatgat ggaaaatatg agaaaacact ctatggtcat
781 aatttggaaa tatcggatgt tgcctggtca tcagattcca gtcgtcttgt ttctgcctca
841 gatgataaaa ctctaaaatt atgggatgtg agatctggaa aatgtttgaa aacactgaag
901 gggcacagta attatgtctt ttgttgtaac ttcaatccgc catccaacct tataatctcg
961 ggatcttttg atgagactgt aaaaatatgg gaggtgaaaa caggaaagtg tctcaagact
1021 ttgtctgctc attctgaccc agtttctgct gttcatttta attgtagtgg gtccttgata
1081 gtgtcaggta gctatgatgg cctctgtaga atctgggatg ctgcatcagg tcagtgttta
1141 aaaacgctcg ttgatgacga taaccctcct gtctcttttg taaaattttc tccaaatggt
1201 aaatacattc tcactgcaac tttggacaac actcttaaac tatgggatta tagcagaggc
1261 aggtgcctga aaacatacac tggtcataag aatgagaaat attgcatatt tgccaatttt
1321 tcagttactg gtggaaagtg gattgtgtct ggttccgagg ataacctggt ttacatttgg
1381 aaccttcaga ctaaagagat tgtgcagaaa ttacaaggcc atacagatgt tgtgatctca
1441 gcagcttgtc atcctacaga aaacctcatc gcatcagcag cattagaaaa tgacaaaaca
1501 attaaactgt ggatgagtaa ccactaatcc ctttgaaaat caagtagtag agccaagttg
1561 gccaaaaaac ttggatattt aaaaagacgg tttcttttaa ttttggcagt ttggtatttt
1621 aaaaattgtc tattgttaaa ttttgagatt catacactac atttacaaaa tgagatagtt
1681 gaaaaagcac atctagaatt cagcttctga ctaccaatct tttttgagca actttttgta
1741 atttttatgg atttatgtca cttttattac agggatatat tgcatagtgg tgaaatctgg
1801 gcttagtata ccctcaccca aatagtatac attgtaccta gtaaatactt tcccatctct
1861 caccccactc ccacctttga aggctctagt gtctatgatt ctgctctcca cgtccaggtg
1921 tacacattgt ttatctccca cttacgagaa catgtggttt ttgactttct gtatcattac
1981 ttcacttaat ggcctccagg tccatccatg ttgttgcaaa agataagatt tcattatttt
2041 tttttggctg agtagtattc tgtggtgtgt atgtgtgtgt gtgtatgcat atatgtgtat
2101 gtgtatgtat ataagtatat acaccacatt atccagtcat ctggatatgt atataagtat
2161 atacaccaca ttttctttat ccagtcatct cttgatggac ccttaggttg gttccataac
2221 tttgctatta cgaatagtgc tgcgataaac agcactatta tgaatagtgc tgcgataaac
2281 agtgcaggtg attttaaaat ataatttcct ttgggtagat acctactagt gggattgctg
2341 gatcgaatgg tagtttttag ttggaaaatc tccatactgt tttccagagg ttgtaaaatg
2401 tacattcctc cccacagtgt ataagctgtg cctttactct gcatctttgc catgattctt
2461 tttgagacag agtctctggt gcccaggctg gagtgcagtg gcacaatctt ggctcactgc
2521 aacctctgcc tcccgggttc aagcagttct catgtctcaa catcccaggt agctaggatt
2581 acaggcgtgc caccatgcct ggctaatgtt tctattttta gtagagacag ggtttcacca
2641 tgttcgaggc tggtcttgaa ctcctggcct caagtgatcc acctgcctcg gcctcccaaa
2701 gtgctgggat tacaggcatg agccactgta cccagccatt ttttgacttt ttaataatag
2761 ccattctaac tggtttaaga gagtatctca ttgtggttat attttgtatt cctctgatga
2821 ttagtgatgt tgagcatttt tttgtgtgtg tttgttggcc acttgtatgt cttctttgaa
2881 aactgacttc taatcttgag gcctattaat aatttcattt gtctgtcact ggacaatttc
2941 tcattcctct cagtgactat cctagaggat cagtgtattt gagaaatatt tagaagtaaa
3001 gttgacagga caggatgatt gattaaaaga ggggagcaag ggaatttgaa ataattccag
3061 ggtttctggt ttgggagatc agatgaacaa gtgcataagc ctgggatgct ggtggaggac
3121 tggagagaca tggcagatgc tacctgcaca cttttggtaa tattctgtgt gatgggatat
3181 gaaatggtcc atagaaaaaa accggaaaaa tacgccaagg ttaggttcat tctaagagtc
3241 taaaaatttc aaaaaccaaa acaacattat aaatggtgtt tctcaaggac ctttcactac
3301 ctttttagat tgtgcttgtg attttcaggc aagctaaatg tctgatgaag actgctcttc
3361 ttttgttctg tgtctgacct actaattcct gcccatgctt caaactcagt tcagaaatca
3421 ctgaaggaac catccactgc cggcctgcct gcaaccacag ctgacagctg agttagttag
3481 gttttcctgt ccctattatt taccagtttg tactgaaatg ctttcatggg ctgtgcttcc
3541 agattatgag ttctgtggaa tcaggaagta tgtctctgta ttcttgtatt ctttggcttt
3601 tttgtgtagt aaagggactc aagtaatgtt tgacagtgaa ggatacaact tcattccttg
3661 cctgctttga taaattttag taataaattc ccaaaactat catgttgatt aaaaataaaa
3721 agtaaccgta acctcacaca ttaactttat tcaaacaaac agcacttaca ggaaatgtaa
3781 agtagaaaaa gatttctgcc cactttacct acggagacat gataaacacg caaaaaaaac
3841 ctagaaatta agcaaaaaat agcacaataa tttaactgaa agcaacaagg gcaaaactgt
3901 ctccttttgt agtttgtggt accttatagt agtgctcatt cagtttcgtt tgcttgataa
3961 atctgaggac tatgagatat cagagttact agtagggtag gagtgctgta agggtactgg
4021 gagaagtagg attagttagg ggcagatctt gaattctggc caagaaactg atatttaacc
4081 cataaagaga tagtcactat atgttatcaa ataggagaat aacacaaatg agaaatgact
4141 gttaattcct gatgcataat aacagttgtg agctttagtt taatgtaata tttgtaataa
4201 aaacgtttgg ccaggca
//