LOCUS NM_021078 3115 bp mRNA linear PRI 15-JUL-2024
DEFINITION Homo sapiens lysine acetyltransferase 2A (KAT2A), transcript
variant 1, mRNA.
ACCESSION NM_021078
VERSION NM_021078.3
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3115)
AUTHORS Han,Y., Zhao,H., Li,G., Jia,J., Guo,H., Tan,J., Sun,X., Li,S.,
Ran,Q., Bai,C., Gu,Y., Li,Z., Guan,H., Gao,S. and Zhou,P.K.
TITLE GCN5 mediates DNA-PKcs crotonylation for DNA double-strand break
repair and determining cancer radiosensitivity
JOURNAL Br J Cancer 130 (10), 1621-1634 (2024)
PUBMED 38575732
REMARK GeneRIF: GCN5 mediates DNA-PKcs crotonylation for DNA double-strand
break repair and determining cancer radiosensitivity.
REFERENCE 2 (bases 1 to 3115)
AUTHORS Xu,Z., Wang,X., Yu,P., Zhang,Y., Huang,L., Mao,E. and Han,Y.
TITLE Lysine acetyltransferase KAT2A modulates ferroptosis during
colorectal cancer development
JOURNAL Scand J Gastroenterol 59 (4), 437-444 (2024)
PUBMED 38258976
REMARK GeneRIF: Lysine acetyltransferase KAT2A modulates ferroptosis
during colorectal cancer development.
REFERENCE 3 (bases 1 to 3115)
AUTHORS Chen,Y., Wu,J., Zhai,L., Zhang,T., Yin,H., Gao,H., Zhao,F.,
Wang,Z., Yang,X., Jin,M., Huang,B., Ding,X., Li,R., Yang,J., He,Y.,
Wang,Q., Wang,W., Kloeber,J.A., Li,Y., Hao,B., Zhang,Y., Wang,J.,
Tan,M., Li,K., Wang,P., Lou,Z. and Yuan,J.
TITLE Metabolic regulation of homologous recombination repair by MRE11
lactylation
JOURNAL Cell 187 (2), 294-311 (2024)
PUBMED 38128537
REFERENCE 4 (bases 1 to 3115)
AUTHORS Militi,S., Nibhani,R., Jalali,M. and Pauklin,S.
TITLE RBL2-E2F-GCN5 guide cell fate decisions during tissue specification
by regulating cell-cycle-dependent fluctuations of
non-cell-autonomous signaling
JOURNAL Cell Rep 42 (9), 113146 (2023)
PUBMED 37725511
REMARK GeneRIF: RBL2-E2F-GCN5 guide cell fate decisions during tissue
specification by regulating cell-cycle-dependent fluctuations of
non-cell-autonomous signaling.
REFERENCE 5 (bases 1 to 3115)
AUTHORS Li,H., Li,C., Yang,L.Z. and Liu,J.
TITLE Integrative analysis of histone acetyltransferase KAT2A in human
cancer
JOURNAL Cancer Biomark 38 (4), 443-463 (2023)
PUBMED 38007639
REMARK GeneRIF: Integrative analysis of histone acetyltransferase KAT2A in
human cancer.
REFERENCE 6 (bases 1 to 3115)
AUTHORS Carter,K.C., Wang,L., Shell,B.K., Zamir,I., Berger,S.L. and
Moore,P.A.
TITLE The human transcriptional adaptor genes TADA2L and GCN5L2
colocalize to chromosome 17q12-q21 and display a similar tissue
expression pattern
JOURNAL Genomics 40 (3), 497-500 (1997)
PUBMED 9073520
REFERENCE 7 (bases 1 to 3115)
AUTHORS Wang,L., Mizzen,C., Ying,C., Candau,R., Barlev,N., Brownell,J.,
Allis,C.D. and Berger,S.L.
TITLE Histone acetyltransferase activity is conserved between yeast and
human GCN5 and is required for complementation of growth and
transcriptional activation
JOURNAL Mol Cell Biol 17 (1), 519-527 (1997)
PUBMED 8972232
REFERENCE 8 (bases 1 to 3115)
AUTHORS Yang,X.J., Ogryzko,V.V., Nishikawa,J., Howard,B.H. and Nakatani,Y.
TITLE A p300/CBP-associated factor that competes with the adenoviral
oncoprotein E1A
JOURNAL Nature 382 (6589), 319-324 (1996)
PUBMED 8684459
REFERENCE 9 (bases 1 to 3115)
AUTHORS Candau,R., Moore,P.A., Wang,L., Barlev,N., Ying,C.Y., Rosen,C.A.
and Berger,S.L.
TITLE Identification of human proteins functionally conserved with the
yeast putative adaptors ADA2 and GCN5
JOURNAL Mol Cell Biol 16 (2), 593-602 (1996)
PUBMED 8552087
REFERENCE 10 (bases 1 to 3115)
AUTHORS Berry,R., Stevens,T.J., Walter,N.A., Wilcox,A.S., Rubano,T.,
Hopkins,J.A., Weber,J., Goold,R., Soares,M.B. and Sikela,J.M.
TITLE Gene-based sequence-tagged-sites (STSs) as the basis for a human
gene map
JOURNAL Nat Genet 10 (4), 415-423 (1995)
PUBMED 7670491
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC105024.8, DB497139.1 and BC105977.1.
On Nov 22, 2018 this sequence version replaced NM_021078.2.
Summary: KAT2A, or GCN5, is a histone acetyltransferase (HAT) that
functions primarily as a transcriptional activator. It also
functions as a repressor of NF-kappa-B (see MIM 164011) by
promoting ubiquitination of the NF-kappa-B subunit RELA (MIM
164014) in a HAT-independent manner (Mao et al., 2009 [PubMed
19339690]).[supplied by OMIM, Sep 2009].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC105977.1, SRR11853567.13044.1
[ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000225916.10/ ENSP00000225916.5
RefSeq Select criteria :: based on conservation, expression
##RefSeq-Attributes-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-3 AC105024.8 143134-143136 c
4-34 DB497139.1 1-31
35-3115 BC105977.1 1-3081
FEATURES Location/Qualifiers
source 1..3115
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q21.2"
gene 1..3115
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/note="lysine acetyltransferase 2A"
/db_xref="GeneID:2648"
/db_xref="HGNC:HGNC:4201"
/db_xref="MIM:602301"
exon 1..402
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/inference="alignment:Splign:2.1.0"
CDS 64..2577
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/EC_number="2.3.1.48"
/note="isoform 1 is encoded by transcript variant 1;
General control of amino acid synthesis, yeast,
homolog-like 2; GCN5 (general control of amino-acid
synthesis, yeast, homolog)-like 2; histone
acetyltransferase KAT2A; K(lysine) acetyltransferase 2A;
STAF97; hsGCN5; histone acetyltransferase GCN5; general
control of amino acid synthesis protein 5-like 2; histone
succinyltransferase KAT2A; histone glutaryltransferase
KAT2A"
/codon_start=1
/product="histone acetyltransferase KAT2A isoform 1"
/protein_id="NP_066564.2"
/db_xref="CCDS:CCDS11417.1"
/db_xref="GeneID:2648"
/db_xref="HGNC:HGNC:4201"
/db_xref="MIM:602301"
/translation="MAEPSQAPTPAPAAQPRPLQSPAPAPTPTPAPSPASAPIPTPTP
APAPAPAAAPAGSTGTGGPGVGSGGAGSGGDPARPGLSQQQRASQRKAQVRGLPRAKK
LEKLGVFSACKANETCKCNGWKNPKPPTAPRMDLQQPAANLSELCRSCEHPLADHVSH
LENVSEDEINRLLGMVVDVENLFMSVHKEEDTDTKQVYFYLFKLLRKCILQMTRPVVE
GSLGSPPFEKPNIEQGVLNFVQYKFSHLAPRERQTMFELSKMFLLCLNYWKLETPAQF
RQRSQAEDVATYKVNYTRWLCYCHVPQSCDSLPRYETTHVFGRSLLRSIFTVTRRQLL
EKFRVEKDKLVPEKRTLILTHFPKFLSMLEEEIYGANSPIWESGFTMPPSEGTQLVPR
PASVSAAVVPSTPIFSPSMGGGSNSSLSLDSAGAEPMPGEKRTLPENLTLEDAKRLRV
MGDIPMELVNEVMLTITDPAAMLGPETSLLSANAARDETARLEERRGIIEFHVIGNSL
TPKANRRVLLWLVGLQNVFSHQLPRMPKEYIARLVFDPKHKTLALIKDGRVIGGICFR
MFPTQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHNILYFLTYADEYAIGYFKK
QGFSKDIKVPKSRYLGYIKDYEGATLMECELNPRIPYTELSHIIKKQKEIIKKLIERK
QAQIRKVYPGLSCFKEGVRQIPVESVPGIRETGWKPLGKEKGKELKDPDQLYTTLKNL
LAQIKSHPSAWPFMEPVKKSEAPDYYEVIRFPIDLKTMTERLRSRYYVTRKLFVADLQ
RVIANCREYNPPDSEYCRCASALEKFFYFKLKEGGLIDK"
misc_feature 64..360
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/note="propagated from UniProtKB/Swiss-Prot (Q92830.3);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 67..69
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/note="N-acetylalanine.
/evidence=ECO:0007744|PubMed:22814378; propagated from
UniProtKB/Swiss-Prot (Q92830.3); acetylation site"
misc_feature 982..984
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/note="Phosphoserine.
/evidence=ECO:0000269|PubMed:23142079; propagated from
UniProtKB/Swiss-Prot (Q92830.3); phosphorylation site"
misc_feature 1282..1365
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/note="propagated from UniProtKB/Swiss-Prot (Q92830.3);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 1708..1710
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/note="N6-acetyllysine.
/evidence=ECO:0000269|PubMed:23142079; propagated from
UniProtKB/Swiss-Prot (Q92830.3); acetylation site"
misc_feature 1978..2007
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/note="propagated from UniProtKB/Swiss-Prot (Q92830.3);
Region: Loop 3. /evidence=ECO:0000269|PubMed:29211711"
misc_feature 2266..2268
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/note="Phosphothreonine.
/evidence=ECO:0000269|PubMed:23142079; propagated from
UniProtKB/Swiss-Prot (Q92830.3); phosphorylation site"
exon 403..526
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/inference="alignment:Splign:2.1.0"
exon 527..672
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/inference="alignment:Splign:2.1.0"
exon 673..762
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/inference="alignment:Splign:2.1.0"
exon 763..944
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/inference="alignment:Splign:2.1.0"
exon 945..1136
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/inference="alignment:Splign:2.1.0"
exon 1137..1243
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/inference="alignment:Splign:2.1.0"
exon 1244..1354
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/inference="alignment:Splign:2.1.0"
exon 1355..1491
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/inference="alignment:Splign:2.1.0"
exon 1492..1700
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/inference="alignment:Splign:2.1.0"
exon 1701..1827
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/inference="alignment:Splign:2.1.0"
exon 1828..1938
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/inference="alignment:Splign:2.1.0"
exon 1939..2082
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/inference="alignment:Splign:2.1.0"
exon 2083..2197
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/inference="alignment:Splign:2.1.0"
exon 2198..2234
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/inference="alignment:Splign:2.1.0"
exon 2235..2298
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/inference="alignment:Splign:2.1.0"
exon 2299..2383
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/inference="alignment:Splign:2.1.0"
exon 2384..3115
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/inference="alignment:Splign:2.1.0"
regulatory 3092..3097
/regulatory_class="polyA_signal_sequence"
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/note="hexamer: AATAAA"
polyA_site 3115
/gene="KAT2A"
/gene_synonym="GCN5; GCN5L2; hGCN5; PCAF-b"
/note="major polyA site"
ORIGIN
1 gctggttgcc catgcggccc tagggctggg agcgcggcgc cgctctccgc tgcgggggag
61 gccatggcgg aaccttccca ggccccgacc ccggccccgg ctgcgcagcc ccggcccctt
121 cagtccccag cccctgcccc aactccgact cctgcaccca gcccggcttc agccccgatt
181 ccgactccca ccccggcacc agcccctgcc ccagctgcag ccccagccgg cagcacaggg
241 actggggggc ccggggtagg aagtgggggg gccgggagcg ggggggatcc ggctcgacct
301 ggcctgagcc agcagcagcg cgccagtcag aggaaggcgc aagtccgggg gctgccgcgc
361 gccaagaagc ttgagaagct aggggtcttc tcggcttgca aggccaatga aacctgtaag
421 tgtaatggct ggaaaaaccc caagcccccc actgcacccc gcatggatct gcagcagcca
481 gctgccaacc tgagtgagct gtgccgcagt tgtgagcacc ccttggctga ccacgtatcc
541 cacttggaga atgtgtcaga ggatgagata aaccgactgc tggggatggt ggtggatgtg
601 gagaatctct tcatgtctgt tcacaaggaa gaggacacag acaccaagca ggtctatttc
661 tacctcttca agctactgcg gaaatgcatc ctgcagatga cccggcctgt ggtggagggg
721 tccctgggca gccctccatt tgagaaacct aatattgagc agggtgtgct gaactttgtg
781 cagtacaagt ttagtcacct ggctccccgg gagcggcaga cgatgttcga gctctcaaag
841 atgttcttgc tctgccttaa ctactggaag cttgagacac ctgcccagtt tcggcagagg
901 tctcaggctg aggacgtggc tacctacaag gtcaattaca ccagatggct ctgttactgc
961 cacgtgcccc agagctgtga tagcctcccc cgctacgaaa ccactcatgt ctttgggcga
1021 agccttctcc ggtccatttt caccgttacc cgccggcagc tgctggaaaa gttccgagtg
1081 gagaaggaca aattggtgcc cgagaagagg accctcatcc tcactcactt ccccaaattc
1141 ctgtccatgc tggaggagga gatctatggg gcaaactctc caatctggga gtcaggcttc
1201 accatgccac cctcagaggg gacacagctg gttccccggc cagcttcagt cagtgcagcg
1261 gttgttccca gcacccccat cttcagcccc agcatgggtg ggggcagcaa cagctccctg
1321 agtctggatt ctgcaggggc cgagcctatg ccaggcgaga agaggacgct cccagagaac
1381 ctgaccctgg aggatgccaa gcggctccgt gtgatgggtg acatccccat ggagctggtc
1441 aatgaggtca tgctgaccat cactgaccct gctgccatgc tggggcctga gacgagcctg
1501 ctttcggcca atgcggcccg ggatgagaca gcccgcctgg aggagcgccg cggcatcatc
1561 gagttccatg tcatcggcaa ctcactgacg cccaaggcca accggcgggt gttgctgtgg
1621 ctcgtggggc tgcagaatgt cttttcccac cagctgccgc gcatgcctaa ggagtatatc
1681 gcccgcctcg tctttgaccc gaagcacaag actctggcct tgatcaagga tgggcgggtc
1741 atcggtggca tctgcttccg catgtttccc acccagggct tcacggagat tgtcttctgt
1801 gctgtcacct cgaatgagca ggtcaagggt tatgggaccc acctgatgaa ccacctgaag
1861 gagtatcaca tcaagcacaa cattctctac ttcctcacct acgccgacga gtacgccatc
1921 ggctacttca aaaagcaggg tttctccaag gacatcaagg tgcccaagag ccgctacctg
1981 ggctacatca aggactacga gggagcgacg ctgatggagt gtgagctgaa tccccgcatc
2041 ccctacacgg agctgtccca catcatcaag aagcagaaag agatcatcaa gaagctgatt
2101 gagcgcaaac aggcccagat ccgcaaggtc tacccggggc tcagctgctt caaggagggc
2161 gtgaggcaga tccctgtgga gagcgttcct ggcattcgag agacaggctg gaagccattg
2221 gggaaggaga aggggaagga gctgaaggac cccgaccagc tctacacaac cctcaaaaac
2281 ctgctggccc aaatcaagtc tcaccccagt gcctggccct tcatggagcc tgtgaagaag
2341 tcggaggccc ctgactacta cgaggtcatc cgcttcccca ttgacctgaa gaccatgact
2401 gagcggctgc gaagccgcta ctacgtgacc cggaagctct ttgtggccga cctgcagcgg
2461 gtcatcgcca actgtcgcga gtacaacccc ccggacagcg agtactgccg ctgtgccagc
2521 gccctggaga agttcttcta cttcaagctc aaggagggag gcctcattga caagtaggcc
2581 catctttggg ccgcagccct gacctggaat gtctccacct cggattctga tctgatcctt
2641 agggggtgcc ctggccccac ggacccgact cagcttgaga cactccagcc aagggtcctc
2701 cggacccgat cctgcagctc tttctggacc ttcaggcacc cccaagcgtg cagctctgtc
2761 ccagccttca ctgtgtgtga gaggtctcct gggttggggc ccagcccctc tagagtagct
2821 ggtggccagg gatgaacctt gcccagccgt ggtggccccc aggcctggtc cccaagagct
2881 ttggaggctt ggattcctgg gcctggccca ggtggctgtt tccctgagga ccagaactgc
2941 tcattttagc ttgagtgatg gcttcagggg ttggaagttc agcccaaact gaagggggcc
3001 atgccttgtc cagcactgtt ctgtcagtct cccccagggg tggggggtat ggggaccatt
3061 cattccctgg cattaatccc ttagagggaa taataaagct ttttatttct ctgtg
//