LOCUS NM_021306 3070 bp mRNA linear ROD 23-JUL-2024
DEFINITION Mus musculus endothelin converting enzyme-like 1 (Ecel1),
transcript variant 2, mRNA.
ACCESSION NM_021306 XM_017314898
VERSION NM_021306.4
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 3070)
AUTHORS Huang,Y., Mai,Y., Ye,W., Lv,S., Zhou,Y., Wu,P., Zhou,L., Li,Y. and
Zhong,K.
TITLE Brachial Plexus Root Avulsion Injury-Induced Endothelin-Converting
Enzyme-Like 1 Overexpression Is Associated with Injured Motor
Neurons Survival
JOURNAL Mol Neurobiol 61 (8), 5194-5205 (2024)
PUBMED 38170441
REMARK GeneRIF: Brachial Plexus Root Avulsion Injury-Induced
Endothelin-Converting Enzyme-Like 1 Overexpression Is Associated
with Injured Motor Neurons Survival.
REFERENCE 2 (bases 1 to 3070)
AUTHORS Yao,S.Q., Wang,M., Liang,J.J., Ng,T.K. and Cen,L.P.
TITLE Retinal transcriptome of neonatal mice after optic nerve injury
JOURNAL PLoS One 18 (5), e0286344 (2023)
PUBMED 37252932
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 3070)
AUTHORS Kiral,F.R., Cakir,B., Tanaka,Y., Kim,J., Yang,W.S., Wehbe,F.,
Kang,Y.J., Zhong,M., Sancer,G., Lee,S.H., Xiang,Y. and Park,I.H.
TITLE Generation of ventralized human thalamic organoids with thalamic
reticular nucleus
JOURNAL Cell Stem Cell 30 (5), 677-688 (2023)
PUBMED 37019105
REFERENCE 4 (bases 1 to 3070)
AUTHORS Puelles,L., Diaz,C., Stuhmer,T., Ferran,J.L., Martinez-de la
Torre,M. and Rubenstein,J.L.R.
TITLE LacZ-reporter mapping of Dlx5/6 expression and genoarchitectural
analysis of the postnatal mouse prethalamus
JOURNAL J Comp Neurol 529 (2), 367-420 (2021)
PUBMED 32420617
REFERENCE 5 (bases 1 to 3070)
AUTHORS Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
Anton,E.S. and Zylka,M.J.
TITLE Single-cell transcriptomic analysis of mouse neocortical
development
JOURNAL Nat Commun 10 (1), 134 (2019)
PUBMED 30635555
REMARK Publication Status: Online-Only
REFERENCE 6 (bases 1 to 3070)
AUTHORS Harrow,J.L., Steward,C.A., Frankish,A., Gilbert,J.G.,
Gonzalez,J.M., Loveland,J.E., Mudge,J., Sheppard,D., Thomas,M.,
Trevanion,S. and Wilming,L.G.
TITLE The Vertebrate Genome Annotation browser 10 years on
JOURNAL Nucleic Acids Res 42 (Database issue), D771-D779 (2014)
PUBMED 24316575
REFERENCE 7 (bases 1 to 3070)
AUTHORS Nagata,K., Kiryu-Seo,S., Maeda,M., Yoshida,K., Morita,T. and
Kiyama,H.
TITLE Damage-induced neuronal endopeptidase is critical for presynaptic
formation of neuromuscular junctions
JOURNAL J Neurosci 30 (20), 6954-6962 (2010)
PUBMED 20484637
REMARK GeneRIF: The data of this study suggested that DINE is a crucial
molecule in distal axonal arborization into muscle to establish
neuromuscular junctions.
REFERENCE 8 (bases 1 to 3070)
AUTHORS Kiryu-Seo,S., Kato,R., Ogawa,T., Nakagomi,S., Nagata,K. and
Kiyama,H.
TITLE Neuronal injury-inducible gene is synergistically regulated by
ATF3, c-Jun, and STAT3 through the interaction with Sp1 in damaged
neurons
JOURNAL J Biol Chem 283 (11), 6988-6996 (2008)
PUBMED 18192274
REMARK GeneRIF: Sp1 recruits ATF3, c-Jun, and STAT3 to obtain the
requisite synergistic effect in neuronal injury through DINE
neuronal injury-inducible gene
REFERENCE 9 (bases 1 to 3070)
AUTHORS Kiryu-Seo,S., Sasaki,M., Yokohama,H., Nakagomi,S., Hirayama,T.,
Aoki,S., Wada,K. and Kiyama,H.
TITLE Damage-induced neuronal endopeptidase (DINE) is a unique
metallopeptidase expressed in response to neuronal damage and
activates superoxide scavengers
JOURNAL Proc Natl Acad Sci U S A 97 (8), 4345-4350 (2000)
PUBMED 10759559
REFERENCE 10 (bases 1 to 3070)
AUTHORS Schweizer,A., Valdenaire,O., Koster,A., Lang,Y., Schmitt,G.,
Lenz,B., Bluethmann,H. and Rohrer,J.
TITLE Neonatal lethality in mice deficient in XCE, a novel member of the
endothelin-converting enzyme and neutral endopeptidase family
JOURNAL J Biol Chem 274 (29), 20450-20456 (1999)
PUBMED 10400672
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC102611.10.
On or before Apr 26, 2023 this sequence version replaced
XM_017314898.1, NM_021306.3.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
CDS exon combination :: AK039467.1 [ECO:0000331]
RNAseq introns :: mixed sample support SAMN00849374,
SAMN00849375 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
inferred exon combination :: based on alignments, homology
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-150 AC102611.10 115263-115412 c
151-311 AC102611.10 114515-114675 c
312-1196 AC102611.10 112471-113355 c
1197-1265 AC102611.10 111785-111853 c
1266-1376 AC102611.10 111568-111678 c
1377-1469 AC102611.10 111387-111479 c
1470-1594 AC102611.10 111086-111210 c
1595-1817 AC102611.10 110250-110472 c
1818-1916 AC102611.10 109716-109814 c
1917-1991 AC102611.10 109402-109476 c
1992-2095 AC102611.10 109167-109270 c
2096-2154 AC102611.10 108873-108931 c
2155-2206 AC102611.10 108744-108795 c
2207-2274 AC102611.10 108051-108118 c
2275-2399 AC102611.10 107763-107887 c
2400-2465 AC102611.10 107401-107466 c
2466-2561 AC102611.10 106892-106987 c
2562-2638 AC102611.10 106493-106569 c
2639-3070 AC102611.10 105922-106353 c
FEATURES Location/Qualifiers
source 1..3070
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="1"
/map="1 44.06 cM"
gene 1..3070
/gene="Ecel1"
/gene_synonym="DINE; xce"
/note="endothelin converting enzyme-like 1"
/db_xref="GeneID:13599"
/db_xref="MGI:MGI:1343461"
exon 1..150
/gene="Ecel1"
/gene_synonym="DINE; xce"
/inference="alignment:Splign:2.1.0"
exon 151..311
/gene="Ecel1"
/gene_synonym="DINE; xce"
/inference="alignment:Splign:2.1.0"
exon 312..1196
/gene="Ecel1"
/gene_synonym="DINE; xce"
/inference="alignment:Splign:2.1.0"
misc_feature 369..371
/gene="Ecel1"
/gene_synonym="DINE; xce"
/note="upstream in-frame stop codon"
CDS 411..2738
/gene="Ecel1"
/gene_synonym="DINE; xce"
/EC_number="3.4.24.11"
/note="damage-induced neuronal endopeptidase"
/codon_start=1
/product="endothelin-converting enzyme-like 1"
/protein_id="NP_067281.2"
/db_xref="CCDS:CCDS15128.1"
/db_xref="GeneID:13599"
/db_xref="MGI:MGI:1343461"
/translation="MEAPYSMTAHYDEFQEVKYVSRCGTGGARGTSLPPGFPRGSGRS
ASGSRSGLPRWNRREVCLLSGLVFAAGLCAILAAMLALKYLGPGAAGGGGACPEGCPE
RKAFARAARFLSANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAAIGEQNEE
RLRRLLARPTGGPGGAAQRKVRAFFRSCLDMREIERLGPRPMLEVIEDCGGWDLGGAA
DRPGAARWDLNRLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLY
LAQDEESEKILAAYRVFMQRLLRLLGADAVEQKAQEILQLEQRLANISVSEYDDLRRD
VSSAYNKVTLGQLQKIIPHLQWKWLLDQIFQEDFSEEEEVVLLATDYMQQVSQLIRST
PRRILHNYLVWRVVVVLSEHLSSPFREALHELAKEMEGNDKPQELARVCLGQANRHFG
MALGALFVHEHFSAASKAKVQQLVEDIKYILGQRLEELDWMDAQTKAAARAKLQYMMV
MVGYPDFLLKPEAVDKEYEFEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKSSWLLP
PQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQ
YDRSGNLLHWWTETSYSHFLRKAECIVRLYDNFTVYNQRVNGKHTLGENIADMGGLKL
AYYAYQKWVREHGPEHPLHRLKYTHNQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPE
HYRVLGSVSQFEEFGRAFHCPKDSPMNPVHKCSVW"
misc_feature 498..566
/gene="Ecel1"
/gene_synonym="DINE; xce"
/note="propagated from UniProtKB/Swiss-Prot (Q9JMI0.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 594..656
/gene="Ecel1"
/gene_synonym="DINE; xce"
/note="propagated from UniProtKB/Swiss-Prot (Q9JMI0.2);
transmembrane region"
misc_feature 1173..1175
/gene="Ecel1"
/gene_synonym="DINE; xce"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9JMI0.2); glycosylation site"
misc_feature 1374..1376
/gene="Ecel1"
/gene_synonym="DINE; xce"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9JMI0.2); glycosylation site"
misc_feature 2376..2378
/gene="Ecel1"
/gene_synonym="DINE; xce"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9JMI0.2); glycosylation site"
exon 1197..1265
/gene="Ecel1"
/gene_synonym="DINE; xce"
/inference="alignment:Splign:2.1.0"
exon 1266..1376
/gene="Ecel1"
/gene_synonym="DINE; xce"
/inference="alignment:Splign:2.1.0"
exon 1377..1469
/gene="Ecel1"
/gene_synonym="DINE; xce"
/inference="alignment:Splign:2.1.0"
exon 1470..1594
/gene="Ecel1"
/gene_synonym="DINE; xce"
/inference="alignment:Splign:2.1.0"
exon 1595..1817
/gene="Ecel1"
/gene_synonym="DINE; xce"
/inference="alignment:Splign:2.1.0"
exon 1818..1916
/gene="Ecel1"
/gene_synonym="DINE; xce"
/inference="alignment:Splign:2.1.0"
exon 1917..1991
/gene="Ecel1"
/gene_synonym="DINE; xce"
/inference="alignment:Splign:2.1.0"
exon 1992..2095
/gene="Ecel1"
/gene_synonym="DINE; xce"
/inference="alignment:Splign:2.1.0"
exon 2096..2154
/gene="Ecel1"
/gene_synonym="DINE; xce"
/inference="alignment:Splign:2.1.0"
exon 2155..2206
/gene="Ecel1"
/gene_synonym="DINE; xce"
/inference="alignment:Splign:2.1.0"
exon 2207..2274
/gene="Ecel1"
/gene_synonym="DINE; xce"
/inference="alignment:Splign:2.1.0"
exon 2275..2399
/gene="Ecel1"
/gene_synonym="DINE; xce"
/inference="alignment:Splign:2.1.0"
exon 2400..2465
/gene="Ecel1"
/gene_synonym="DINE; xce"
/inference="alignment:Splign:2.1.0"
exon 2466..2561
/gene="Ecel1"
/gene_synonym="DINE; xce"
/inference="alignment:Splign:2.1.0"
exon 2562..2638
/gene="Ecel1"
/gene_synonym="DINE; xce"
/inference="alignment:Splign:2.1.0"
exon 2639..3070
/gene="Ecel1"
/gene_synonym="DINE; xce"
/inference="alignment:Splign:2.1.0"
regulatory 3047..3052
/regulatory_class="polyA_signal_sequence"
/gene="Ecel1"
/gene_synonym="DINE; xce"
/note="hexamer: AATAAA"
polyA_site 3070
/gene="Ecel1"
/gene_synonym="DINE; xce"
/note="major polyA site"
ORIGIN
1 ctctccgcag tcccacctca acatgggttc tatcacatcg gtcttcacca atgtctgaaa
61 cattgcttag gccagggctg caggctggag ccacaaggtt gggattgctg gggctgtgtg
121 gtcctttgct ggggatacca gaagagatgg actggtaggt ggctccaagt ggctcatcag
181 aagggaccgt gcttcctcct cccgggacag atctggactc cggagtcctg gagccagaag
241 ctggtgcatc actctcagga gcgttatctc cgcggtcgcc atccccacct ccgcactgct
301 ggagctgaca gctgcgaccg agggccatgt gggctccgac cagaaagccc gcagacagaa
361 gcagcctata atcgaccaaa caaggggtct gcagccaaag cctcggcaca atggaggccc
421 cgtattccat gacagcgcac tacgacgagt tccaggaagt caagtatgtg agccggtgtg
481 gcaccggggg cgctcgaggg acctcactgc ctccaggctt cccgaggggc tcagggcgca
541 gtgctagcgg gtccaggtct gggctgcccc gctggaatcg acgcgaggtg tgcctgctgt
601 cggggttggt gtttgctgcc ggcctctgcg ccatcctggc ggccatgctg gcgctcaaat
661 acctgggccc gggagcggcg ggcggtggcg gagcctgtcc cgagggctgc cccgagcgca
721 aggcctttgc acgcgccgcc cgctttctgt ctgccaacct ggacgccagc atcgacccgt
781 gccaggactt ctactcgttc gcgtgcggag gctggctgcg gcgccacgct atccccgacg
841 acaagctcac ctacggcacg atcgcggcca tcggagagca gaacgaggag cgtctgcggc
901 gcctgctggc gagacccacc ggaggccccg gcggcgctgc gcagcgcaag gtgcgcgcct
961 tcttccgctc gtgcctcgac atgcgcgaga tcgagaggct cgggccgcgg cccatgctcg
1021 aggtcatcga ggactgcggc ggctgggacc tgggcggcgc ggccgatcgc cccggggcgg
1081 ctcgctggga cctcaaccga ctgctgtaca aggcacaggg tgtgtacagc gcggccgcgc
1141 tcttctcgct tacagtcagc ctggacgaca ggaactcctc gcgctacgtc atccgcattg
1201 accaggatgg gctcaccctg ccagagagaa ccctgtacct agctcaagac gaggagagtg
1261 agaagatctt ggctgcatac agggtgttca tgcagcgtct actcagacta ctgggagcgg
1321 acgctgtgga gcagaaggcg caggaaatcc ttcagctgga acagaggctg gccaatatct
1381 ctgtgtcaga atatgatgat ctccgtcgtg atgtcagctc cgcgtacaac aaagtgactc
1441 tggggcagct gcagaagatc atcccccatt tgcagtggaa gtggctgctg gatcagatct
1501 tccaggaaga cttctcggag gaggaggagg tggtgctgct ggccacagac tacatgcagc
1561 aggtgtccca gctcatccgc tccacacctc gaaggatcct gcacaactac ctagtgtggc
1621 gtgtggtggt ggttctgagt gagcacctgt cctcaccatt ccgagaggca ctgcatgagc
1681 tggccaaaga gatggagggc aatgacaagc cccaggagtt ggcccgagtc tgcctgggcc
1741 aggccaaccg ccacttcggc atggctcttg gtgccctctt tgtacatgaa cacttctcag
1801 ctgccagtaa agccaaggtg cagcagctag tggaagatat caagtacatc ttgggccagc
1861 gcctggagga gctggactgg atggatgccc agaccaaggc agctgctcgg gccaagctcc
1921 agtacatgat ggtcatggtt ggctatccag acttcctgct gaaacctgag gctgtagaca
1981 aagaatatga gttcgaggtc cacgagaaga cctacttcaa gaacattttg aacagcatcc
2041 gattcagtat ccagttgtcc gtcaaaaaga ttcgacagga ggtggacaaa tcctcgtggc
2101 tcctcccacc acaggcgctc aatgcctact atctgcccaa caagaatcaa atggtcttcc
2161 cagctggcat cctgcagccc accctgtatg acccagactt cccacagtct ctgaactacg
2221 ggggtattgg caccatcatt gggcacgaac tgacccatgg ctatgacgac tgggggggac
2281 agtatgaccg ctcaggaaac ctgttgcact ggtggactga gacctcctac agccactttc
2341 tgcgcaaggc cgagtgcatc gttcgcctct atgacaactt caccgtctac aaccagcgcg
2401 tgaatgggaa acacacactt ggcgagaaca tcgcagacat gggaggcctc aagctggcct
2461 actatgccta tcagaagtgg gtccgggagc atggcccgga gcacccgctg caccggctca
2521 agtacacaca caaccagctt ttcttcattg cctttgcaca gaactggtgc atcaagcgac
2581 ggtcacagtc catctacctg caggtgctga cagacaagca tgcacctgag cactaccggg
2641 tcctgggcag cgtatcccag tttgaggaat tcggccgggc cttccactgt cccaaggact
2701 ctcccatgaa ccccgtccat aagtgctctg tgtggtgagc ctggccgtct gcctgtctac
2761 ctgcacgtcc ccactgccct gcacggatca cctctaccag ctgtggggca acatgagccc
2821 catgcttcct gctccgggtc tatcttcctt cccaaccttt atgtgattgt cttcccgccc
2881 cctgcagtcc ttcacttaag cgagggcctg gagcaggggt aaggctaggt tctgggggac
2941 actcgagggg gaattatgag gtcctcacac ccggctctag gcagctggac ccccctaccg
3001 gggctggata ggtcccactg atgtgttctt gctgattagt ctggtcaata aagctgctgt
3061 actatatata
//