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Mus musculus endothelin converting enzyme-like 1 (Ecel1), transcript variant 2, mRNA

NCBI Reference Sequence: NM_021306.4

FASTA Graphics 

LOCUS       NM_021306               3070 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Mus musculus endothelin converting enzyme-like 1 (Ecel1),
            transcript variant 2, mRNA.
ACCESSION   NM_021306 XM_017314898
VERSION     NM_021306.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3070)
  AUTHORS   Huang,Y., Mai,Y., Ye,W., Lv,S., Zhou,Y., Wu,P., Zhou,L., Li,Y. and
            Zhong,K.
  TITLE     Brachial Plexus Root Avulsion Injury-Induced Endothelin-Converting
            Enzyme-Like 1 Overexpression Is Associated with Injured Motor
            Neurons Survival
  JOURNAL   Mol Neurobiol 61 (8), 5194-5205 (2024)
   PUBMED   38170441
  REMARK    GeneRIF: Brachial Plexus Root Avulsion Injury-Induced
            Endothelin-Converting Enzyme-Like 1 Overexpression Is Associated
            with Injured Motor Neurons Survival.
REFERENCE   2  (bases 1 to 3070)
  AUTHORS   Yao,S.Q., Wang,M., Liang,J.J., Ng,T.K. and Cen,L.P.
  TITLE     Retinal transcriptome of neonatal mice after optic nerve injury
  JOURNAL   PLoS One 18 (5), e0286344 (2023)
   PUBMED   37252932
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3070)
  AUTHORS   Kiral,F.R., Cakir,B., Tanaka,Y., Kim,J., Yang,W.S., Wehbe,F.,
            Kang,Y.J., Zhong,M., Sancer,G., Lee,S.H., Xiang,Y. and Park,I.H.
  TITLE     Generation of ventralized human thalamic organoids with thalamic
            reticular nucleus
  JOURNAL   Cell Stem Cell 30 (5), 677-688 (2023)
   PUBMED   37019105
REFERENCE   4  (bases 1 to 3070)
  AUTHORS   Puelles,L., Diaz,C., Stuhmer,T., Ferran,J.L., Martinez-de la
            Torre,M. and Rubenstein,J.L.R.
  TITLE     LacZ-reporter mapping of Dlx5/6 expression and genoarchitectural
            analysis of the postnatal mouse prethalamus
  JOURNAL   J Comp Neurol 529 (2), 367-420 (2021)
   PUBMED   32420617
REFERENCE   5  (bases 1 to 3070)
  AUTHORS   Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
            Anton,E.S. and Zylka,M.J.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3070)
  AUTHORS   Harrow,J.L., Steward,C.A., Frankish,A., Gilbert,J.G.,
            Gonzalez,J.M., Loveland,J.E., Mudge,J., Sheppard,D., Thomas,M.,
            Trevanion,S. and Wilming,L.G.
  TITLE     The Vertebrate Genome Annotation browser 10 years on
  JOURNAL   Nucleic Acids Res 42 (Database issue), D771-D779 (2014)
   PUBMED   24316575
REFERENCE   7  (bases 1 to 3070)
  AUTHORS   Nagata,K., Kiryu-Seo,S., Maeda,M., Yoshida,K., Morita,T. and
            Kiyama,H.
  TITLE     Damage-induced neuronal endopeptidase is critical for presynaptic
            formation of neuromuscular junctions
  JOURNAL   J Neurosci 30 (20), 6954-6962 (2010)
   PUBMED   20484637
  REMARK    GeneRIF: The data of this study suggested that DINE is a crucial
            molecule in distal axonal arborization into muscle to establish
            neuromuscular junctions.
REFERENCE   8  (bases 1 to 3070)
  AUTHORS   Kiryu-Seo,S., Kato,R., Ogawa,T., Nakagomi,S., Nagata,K. and
            Kiyama,H.
  TITLE     Neuronal injury-inducible gene is synergistically regulated by
            ATF3, c-Jun, and STAT3 through the interaction with Sp1 in damaged
            neurons
  JOURNAL   J Biol Chem 283 (11), 6988-6996 (2008)
   PUBMED   18192274
  REMARK    GeneRIF: Sp1 recruits ATF3, c-Jun, and STAT3 to obtain the
            requisite synergistic effect in neuronal injury through DINE
            neuronal injury-inducible gene
REFERENCE   9  (bases 1 to 3070)
  AUTHORS   Kiryu-Seo,S., Sasaki,M., Yokohama,H., Nakagomi,S., Hirayama,T.,
            Aoki,S., Wada,K. and Kiyama,H.
  TITLE     Damage-induced neuronal endopeptidase (DINE) is a unique
            metallopeptidase expressed in response to neuronal damage and
            activates superoxide scavengers
  JOURNAL   Proc Natl Acad Sci U S A 97 (8), 4345-4350 (2000)
   PUBMED   10759559
REFERENCE   10 (bases 1 to 3070)
  AUTHORS   Schweizer,A., Valdenaire,O., Koster,A., Lang,Y., Schmitt,G.,
            Lenz,B., Bluethmann,H. and Rohrer,J.
  TITLE     Neonatal lethality in mice deficient in XCE, a novel member of the
            endothelin-converting enzyme and neutral endopeptidase family
  JOURNAL   J Biol Chem 274 (29), 20450-20456 (1999)
   PUBMED   10400672
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102611.10.
            
            On or before Apr 26, 2023 this sequence version replaced
            XM_017314898.1, NM_021306.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AK039467.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMN00849374,
                                    SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AC102611.10        115263-115412       c
            151-311             AC102611.10        114515-114675       c
            312-1196            AC102611.10        112471-113355       c
            1197-1265           AC102611.10        111785-111853       c
            1266-1376           AC102611.10        111568-111678       c
            1377-1469           AC102611.10        111387-111479       c
            1470-1594           AC102611.10        111086-111210       c
            1595-1817           AC102611.10        110250-110472       c
            1818-1916           AC102611.10        109716-109814       c
            1917-1991           AC102611.10        109402-109476       c
            1992-2095           AC102611.10        109167-109270       c
            2096-2154           AC102611.10        108873-108931       c
            2155-2206           AC102611.10        108744-108795       c
            2207-2274           AC102611.10        108051-108118       c
            2275-2399           AC102611.10        107763-107887       c
            2400-2465           AC102611.10        107401-107466       c
            2466-2561           AC102611.10        106892-106987       c
            2562-2638           AC102611.10        106493-106569       c
            2639-3070           AC102611.10        105922-106353       c
FEATURES             Location/Qualifiers
     source          1..3070
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 44.06 cM"
     gene            1..3070
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /note="endothelin converting enzyme-like 1"
                     /db_xref="GeneID:13599"
                     /db_xref="MGI:MGI:1343461"
     exon            1..150
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            151..311
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            312..1196
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    369..371
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /note="upstream in-frame stop codon"
     CDS             411..2738
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /EC_number="3.4.24.11"
                     /note="damage-induced neuronal endopeptidase"
                     /codon_start=1
                     /product="endothelin-converting enzyme-like 1"
                     /protein_id="NP_067281.2"
                     /db_xref="CCDS:CCDS15128.1"
                     /db_xref="GeneID:13599"
                     /db_xref="MGI:MGI:1343461"
                     /translation="MEAPYSMTAHYDEFQEVKYVSRCGTGGARGTSLPPGFPRGSGRS
                     ASGSRSGLPRWNRREVCLLSGLVFAAGLCAILAAMLALKYLGPGAAGGGGACPEGCPE
                     RKAFARAARFLSANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAAIGEQNEE
                     RLRRLLARPTGGPGGAAQRKVRAFFRSCLDMREIERLGPRPMLEVIEDCGGWDLGGAA
                     DRPGAARWDLNRLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLY
                     LAQDEESEKILAAYRVFMQRLLRLLGADAVEQKAQEILQLEQRLANISVSEYDDLRRD
                     VSSAYNKVTLGQLQKIIPHLQWKWLLDQIFQEDFSEEEEVVLLATDYMQQVSQLIRST
                     PRRILHNYLVWRVVVVLSEHLSSPFREALHELAKEMEGNDKPQELARVCLGQANRHFG
                     MALGALFVHEHFSAASKAKVQQLVEDIKYILGQRLEELDWMDAQTKAAARAKLQYMMV
                     MVGYPDFLLKPEAVDKEYEFEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKSSWLLP
                     PQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQ
                     YDRSGNLLHWWTETSYSHFLRKAECIVRLYDNFTVYNQRVNGKHTLGENIADMGGLKL
                     AYYAYQKWVREHGPEHPLHRLKYTHNQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPE
                     HYRVLGSVSQFEEFGRAFHCPKDSPMNPVHKCSVW"
     misc_feature    498..566
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JMI0.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    594..656
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JMI0.2);
                     transmembrane region"
     misc_feature    1173..1175
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JMI0.2); glycosylation site"
     misc_feature    1374..1376
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JMI0.2); glycosylation site"
     misc_feature    2376..2378
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JMI0.2); glycosylation site"
     exon            1197..1265
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1376
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1469
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1594
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1817
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1916
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..1991
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2095
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2154
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2206
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2274
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2399
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..2465
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2561
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2638
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..3070
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3047..3052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /note="hexamer: AATAAA"
     polyA_site      3070
                     /gene="Ecel1"
                     /gene_synonym="DINE; xce"
                     /note="major polyA site"
ORIGIN      
        1 ctctccgcag tcccacctca acatgggttc tatcacatcg gtcttcacca atgtctgaaa
       61 cattgcttag gccagggctg caggctggag ccacaaggtt gggattgctg gggctgtgtg
      121 gtcctttgct ggggatacca gaagagatgg actggtaggt ggctccaagt ggctcatcag
      181 aagggaccgt gcttcctcct cccgggacag atctggactc cggagtcctg gagccagaag
      241 ctggtgcatc actctcagga gcgttatctc cgcggtcgcc atccccacct ccgcactgct
      301 ggagctgaca gctgcgaccg agggccatgt gggctccgac cagaaagccc gcagacagaa
      361 gcagcctata atcgaccaaa caaggggtct gcagccaaag cctcggcaca atggaggccc
      421 cgtattccat gacagcgcac tacgacgagt tccaggaagt caagtatgtg agccggtgtg
      481 gcaccggggg cgctcgaggg acctcactgc ctccaggctt cccgaggggc tcagggcgca
      541 gtgctagcgg gtccaggtct gggctgcccc gctggaatcg acgcgaggtg tgcctgctgt
      601 cggggttggt gtttgctgcc ggcctctgcg ccatcctggc ggccatgctg gcgctcaaat
      661 acctgggccc gggagcggcg ggcggtggcg gagcctgtcc cgagggctgc cccgagcgca
      721 aggcctttgc acgcgccgcc cgctttctgt ctgccaacct ggacgccagc atcgacccgt
      781 gccaggactt ctactcgttc gcgtgcggag gctggctgcg gcgccacgct atccccgacg
      841 acaagctcac ctacggcacg atcgcggcca tcggagagca gaacgaggag cgtctgcggc
      901 gcctgctggc gagacccacc ggaggccccg gcggcgctgc gcagcgcaag gtgcgcgcct
      961 tcttccgctc gtgcctcgac atgcgcgaga tcgagaggct cgggccgcgg cccatgctcg
     1021 aggtcatcga ggactgcggc ggctgggacc tgggcggcgc ggccgatcgc cccggggcgg
     1081 ctcgctggga cctcaaccga ctgctgtaca aggcacaggg tgtgtacagc gcggccgcgc
     1141 tcttctcgct tacagtcagc ctggacgaca ggaactcctc gcgctacgtc atccgcattg
     1201 accaggatgg gctcaccctg ccagagagaa ccctgtacct agctcaagac gaggagagtg
     1261 agaagatctt ggctgcatac agggtgttca tgcagcgtct actcagacta ctgggagcgg
     1321 acgctgtgga gcagaaggcg caggaaatcc ttcagctgga acagaggctg gccaatatct
     1381 ctgtgtcaga atatgatgat ctccgtcgtg atgtcagctc cgcgtacaac aaagtgactc
     1441 tggggcagct gcagaagatc atcccccatt tgcagtggaa gtggctgctg gatcagatct
     1501 tccaggaaga cttctcggag gaggaggagg tggtgctgct ggccacagac tacatgcagc
     1561 aggtgtccca gctcatccgc tccacacctc gaaggatcct gcacaactac ctagtgtggc
     1621 gtgtggtggt ggttctgagt gagcacctgt cctcaccatt ccgagaggca ctgcatgagc
     1681 tggccaaaga gatggagggc aatgacaagc cccaggagtt ggcccgagtc tgcctgggcc
     1741 aggccaaccg ccacttcggc atggctcttg gtgccctctt tgtacatgaa cacttctcag
     1801 ctgccagtaa agccaaggtg cagcagctag tggaagatat caagtacatc ttgggccagc
     1861 gcctggagga gctggactgg atggatgccc agaccaaggc agctgctcgg gccaagctcc
     1921 agtacatgat ggtcatggtt ggctatccag acttcctgct gaaacctgag gctgtagaca
     1981 aagaatatga gttcgaggtc cacgagaaga cctacttcaa gaacattttg aacagcatcc
     2041 gattcagtat ccagttgtcc gtcaaaaaga ttcgacagga ggtggacaaa tcctcgtggc
     2101 tcctcccacc acaggcgctc aatgcctact atctgcccaa caagaatcaa atggtcttcc
     2161 cagctggcat cctgcagccc accctgtatg acccagactt cccacagtct ctgaactacg
     2221 ggggtattgg caccatcatt gggcacgaac tgacccatgg ctatgacgac tgggggggac
     2281 agtatgaccg ctcaggaaac ctgttgcact ggtggactga gacctcctac agccactttc
     2341 tgcgcaaggc cgagtgcatc gttcgcctct atgacaactt caccgtctac aaccagcgcg
     2401 tgaatgggaa acacacactt ggcgagaaca tcgcagacat gggaggcctc aagctggcct
     2461 actatgccta tcagaagtgg gtccgggagc atggcccgga gcacccgctg caccggctca
     2521 agtacacaca caaccagctt ttcttcattg cctttgcaca gaactggtgc atcaagcgac
     2581 ggtcacagtc catctacctg caggtgctga cagacaagca tgcacctgag cactaccggg
     2641 tcctgggcag cgtatcccag tttgaggaat tcggccgggc cttccactgt cccaaggact
     2701 ctcccatgaa ccccgtccat aagtgctctg tgtggtgagc ctggccgtct gcctgtctac
     2761 ctgcacgtcc ccactgccct gcacggatca cctctaccag ctgtggggca acatgagccc
     2821 catgcttcct gctccgggtc tatcttcctt cccaaccttt atgtgattgt cttcccgccc
     2881 cctgcagtcc ttcacttaag cgagggcctg gagcaggggt aaggctaggt tctgggggac
     2941 actcgagggg gaattatgag gtcctcacac ccggctctag gcagctggac ccccctaccg
     3001 gggctggata ggtcccactg atgtgttctt gctgattagt ctggtcaata aagctgctgt
     3061 actatatata
//
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