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Mus musculus tropomodulin 1 (Tmod1), transcript variant 1, mRNA

NCBI Reference Sequence: NM_021883.3

FASTA Graphics 

LOCUS       NM_021883               2863 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus tropomodulin 1 (Tmod1), transcript variant 1, mRNA.
ACCESSION   NM_021883
VERSION     NM_021883.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2863)
  AUTHORS   Geng,X., Xia,X., Liang,Z., Li,S., Yue,Z., Zhang,H., Guo,L., Ma,S.,
            Jiang,S., Lian,X., Zhou,J., Sung,L.A., Wang,X. and Yao,W.
  TITLE     Tropomodulin1 exacerbates inflammatory response in macrophages by
            negatively regulating LPS-induced TLR4 endocytosis
  JOURNAL   Cell Mol Life Sci 81 (1), 402 (2024)
   PUBMED   39276234
  REMARK    GeneRIF: Tropomodulin1 exacerbates inflammatory response in
            macrophages by negatively regulating LPS-induced TLR4 endocytosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2863)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2863)
  AUTHORS   Patel,T., Hammelman,J., Aziz,S., Jang,S., Closser,M.,
            Michaels,T.L., Blum,J.A., Gifford,D.K. and Wichterle,H.
  TITLE     Transcriptional dynamics of murine motor neuron maturation in vivo
            and in vitro
  JOURNAL   Nat Commun 13 (1), 5427 (2022)
   PUBMED   36109497
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2863)
  AUTHORS   Liu,X., Xia,X., Wang,X., Zhou,J., Sung,L.A., Long,J., Geng,X.,
            Zeng,Z. and Yao,W.
  TITLE     Tropomodulin1 Expression Increases Upon Maturation in Dendritic
            Cells and Promotes Their Maturation and Immune Functions
  JOURNAL   Front Immunol 11, 587441 (2021)
   PUBMED   33552047
  REMARK    GeneRIF: Tropomodulin1 Expression Increases Upon Maturation in
            Dendritic Cells and Promotes Their Maturation and Immune Functions.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2863)
  AUTHORS   Gao,R., Liang,X., Cheedipudi,S., Cordero,J., Jiang,X., Zhang,Q.,
            Caputo,L., Gunther,S., Kuenne,C., Ren,Y., Bhattacharya,S., Yuan,X.,
            Barreto,G., Chen,Y., Braun,T., Evans,S.M., Sun,Y. and Dobreva,G.
  TITLE     Pioneering function of Isl1 in the epigenetic control of
            cardiomyocyte cell fate
  JOURNAL   Cell Res 29 (6), 486-501 (2019)
   PUBMED   31024170
REFERENCE   6  (bases 1 to 2863)
  AUTHORS   Watakabe,A., Kobayashi,R. and Helfman,D.M.
  TITLE     N-tropomodulin: a novel isoform of tropomodulin identified as the
            major binding protein to brain tropomyosin
  JOURNAL   J Cell Sci 109 (Pt 9), 2299-2310 (1996)
   PUBMED   8886980
REFERENCE   7  (bases 1 to 2863)
  AUTHORS   Schiaffino,S. and Reggiani,C.
  TITLE     Molecular diversity of myofibrillar proteins: gene regulation and
            functional significance
  JOURNAL   Physiol Rev 76 (2), 371-423 (1996)
   PUBMED   8618961
  REMARK    Review article
REFERENCE   8  (bases 1 to 2863)
  AUTHORS   White,R.A., Dowler,L.L., Woo,M., Adkison,L.R., Pal,S., Gershon,D.
            and Fowler,V.M.
  TITLE     The tropomodulin (Tmod) gene maps to chromosome 4, closely linked
            to Mup1
  JOURNAL   Mamm Genome 6 (5), 332-333 (1995)
   PUBMED   7626883
REFERENCE   9  (bases 1 to 2863)
  AUTHORS   Pilz,A., Woodward,K., Povey,S. and Abbott,C.
  TITLE     Comparative mapping of 50 human chromosome 9 loci in the laboratory
            mouse
  JOURNAL   Genomics 25 (1), 139-149 (1995)
   PUBMED   7774911
REFERENCE   10 (bases 1 to 2863)
  AUTHORS   Ito,M., Swanson,B., Sussman,M.A., Kedes,L. and Lyons,G.
  TITLE     Cloning of tropomodulin cDNA and localization of gene transcripts
            during mouse embryogenesis
  JOURNAL   Dev Biol 167 (1), 317-328 (1995)
   PUBMED   7851652
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732615.15.
            
            On Oct 16, 2023 this sequence version replaced NM_021883.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784648.879786.1,
                                           SRR9219381.84729.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AL732615.15        71685-71764
            81-249              AL732615.15        93421-93589
            250-406             AL732615.15        110769-110925
            407-526             AL732615.15        115999-116118
            527-616             AL732615.15        123301-123390
            617-747             AL732615.15        124594-124724
            748-855             AL732615.15        126364-126471
            856-999             AL732615.15        129390-129533
            1000-1144           AL732615.15        139325-139469
            1145-2863           AL732615.15        146769-148487
FEATURES             Location/Qualifiers
     source          1..2863
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 24.49 cM"
     gene            1..2863
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /note="tropomodulin 1"
                     /db_xref="GeneID:21916"
                     /db_xref="MGI:MGI:98775"
     exon            1..80
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            81..249
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1209
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /note="isoform 1 is encoded by transcript variant 1;
                     erythrocyte tropomodulin"
                     /codon_start=1
                     /product="tropomodulin-1 isoform 1"
                     /protein_id="NP_068683.1"
                     /db_xref="CCDS:CCDS18143.1"
                     /db_xref="GeneID:21916"
                     /db_xref="MGI:MGI:98775"
                     /translation="MSYRRELEKYRDLDEDEILGALTEEELRTLENELDELDPDNALL
                     PAGLRQKDQTTKAPTGPFKREELLDHLEKQAKEFKDREDLVPYTGEKRGKVWVPKQKP
                     MDPVLESVTLEPELEEALANASDAELCDIAAILGMHTLMSNQQYYQALGSSSIVNKEG
                     LNSVIKPTQYKPVPDEEPNSTDVEETLERIKNNDPELEEVNLNNIRNIPIPTLKAYAE
                     ALKENSYVKKFSIVGTRSNDPVAFALAEMLKVNKVLKTLNVESNFISGAGILRLVEAL
                     PHNTSLVELKIDNQSQPLGNKVEMEIVNMLEKNTTLLKFGYHFTQQGPRLRASNAMMS
                     NNDLVRKRRLADLTGPIIPKCRSGV"
     misc_feature    235..312
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /note="propagated from UniProtKB/Swiss-Prot (P49813.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    244..543
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /note="propagated from UniProtKB/Swiss-Prot (P49813.2);
                     Region: Tropomyosin-binding. /evidence=ECO:0000255"
     exon            250..406
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            407..526
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            527..616
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            617..747
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            748..855
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            856..999
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1144
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..2863
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2845..2850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /note="hexamer: ATTAAA"
     polyA_site      2863
                     /gene="Tmod1"
                     /gene_synonym="E-Tmod; Tmod"
                     /note="major polyA site"
ORIGIN      
        1 acccgcggcc gccagggaac tcgccaagcc ccgcgttccg ctcattgccg ccgcccgcgc
       61 tcgcgccacc ccgcatcccg gtcagcagcc agcacagaag ttcaggagac aaagacacag
      121 cctcacacaa tgtcctacag acgagagctg gagaaatatc gagacctgga tgaggatgaa
      181 atcctggggg ccctcacaga ggaggagctg aggacgctgg aaaatgagct agatgaacta
      241 gaccctgata atgcactgct ccctgcaggc ctgaggcaga aggatcagac caccaaggca
      301 cccacaggcc cctttaaaag agaggagctt ttggaccact tggaaaagca agcgaaggaa
      361 tttaaggacc gagaagatct ggttccctac acaggggaga aacgaggaaa ggtctgggtc
      421 cccaagcaga agccaatgga tcccgtgctg gagagtgtga cactggagcc agaactggag
      481 gaggccctag caaatgcctc ggatgcagaa ctgtgtgaca tcgcagctat cctgggcatg
      541 cacacactca tgagcaacca gcagtactac caagccttgg gcagcagctc catcgtgaac
      601 aaggaggggc tcaacagtgt gatcaaaccc acacaataca agcctgtgcc tgatgaagaa
      661 ccaaattcaa cagacgtaga ggaaacgctg gagcgaataa agaacaatga cccagaacta
      721 gaagaggtta atcttaacaa catccggaat attcccatac ccaccctcaa ggcatatgca
      781 gaagccctga aagagaactc ctatgtgaag aagttcagca tcgtggggac ccgcagcaat
      841 gaccctgtgg cgtttgccct tgctgaaatg ctgaaagtga acaaggtgct gaagaccctg
      901 aacgtggagt ccaacttcat ctctggagct gggatcctgc gcctggtgga agctctcccc
      961 cacaacactt ctctggtcga gctgaaaatc gataaccaga gccaaccttt gggcaacaaa
     1021 gtggaaatgg agatcgtgaa catgttggag aaaaacacaa cgctcctcaa atttggctac
     1081 cactttaccc agcaggggcc ccggctgcgg gcatccaacg ccatgatgag caacaacgac
     1141 cttgtgagga agaggaggct cgcagacctg acggggccta ttatccccaa gtgccgcagc
     1201 ggtgtctagc atgcgaaggg aagcccacgc ctaggaactg gacgtgttct accgatgatg
     1261 cgtgtgcccc agtggagccc aggacgaatg ctggcgtgga gctcttgtgg ctcagttctt
     1321 tgtgcactga ggtttaggtt aactagactg tagtcggacc ttttataaaa catggctaat
     1381 gtgaagtttt tctttaggca cagaagttca gtctggtaat tatttaaaca tgcagaagcc
     1441 ctcaagctag cgggccttgc tgcagacagt gtgacactgg cagagacggc ccaggagccc
     1501 cctggcggcc ctgctttggg gcctaggtgc acttacaaca tgggacgcac cagcacagag
     1561 cactcttccc acctagtttg gaagcgtggt gaaacaatct tttatttcca atttgatcgt
     1621 agcaactcag taaaaagaac acataatcat gatctgtcaa cccccacttg aaactttgac
     1681 atcaagatta aagctgccaa attgattcca ggatcaaacc cccaccccta agaatgaaag
     1741 acaagccaca gaattttcta agagtcagaa agacacagga ttccttttgc caggtaagat
     1801 aaagagggag aaaaaggcaa tggtgaattt tcaagtttca aaacccacca caccaggcaa
     1861 cagacatcct tctgagtgct gtgggaacac ctgcggggta ctcatctgca gtcagaaatc
     1921 atttcttctt tattgaattc caacttcatg atggatgaaa acttacagcc gctgggcagt
     1981 ggtggcacac gcctttaatc ccagcacttg ggaggcagag gcaggcggat ttctgagttc
     2041 gaggccagcc tggtctacag agtgagttcc aggacagcca gggctataca gagaaaccct
     2101 gtctcgaaaa accaaaaaaa aaaaaaaaag gaaaaaaaaa gaaaacttac agccacataa
     2161 aaacatcttc ctataccaca gtgggcaatg gcttatgtga gatcaacacc attgggtgaa
     2221 tttccagtcc accatgcctg tggtatttag catggccctg cttacagaca ccaagtgcct
     2281 gcctggtcat ttatgagaca aatcaaatca cacagagctc ttgcctacaa acaaagcctc
     2341 tagaggacag cagagtacag catcttaatg gtaaggaatt aggagatcct ggccaaacaa
     2401 cacacgggat tactctgaaa cctaatcttg gtgttcctac tggatttcct tttttaacac
     2461 catgggagcc agtaaaaatg ttcaaataca ctgttcttgt gccttttaat agaccacagt
     2521 gccagttaaa ctagtatttt tgttgttttg gggagttatt ttccttaggg attcagccaa
     2581 tattatagta atgataaggc tcaaaagctg ttgagcatag ccagggggct tctgacttaa
     2641 gagaaagcct gcacaccgaa ctgtaacagt atggacagta cagggtaact agaggtggca
     2701 tcggggcctc agcactgagt gtccactgag gctgcacacg ggcccaggag tggcaccaag
     2761 ctgcagggac agccagcccc actcagcttc tccttgaaac acaactgcag ctgcattctg
     2821 catcactgga aactgcaaaa taatattaaa gccatttggt cta
//
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