LOCUS NM_021883 2863 bp mRNA linear ROD 24-SEP-2024
DEFINITION Mus musculus tropomodulin 1 (Tmod1), transcript variant 1, mRNA.
ACCESSION NM_021883
VERSION NM_021883.3
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 2863)
AUTHORS Geng,X., Xia,X., Liang,Z., Li,S., Yue,Z., Zhang,H., Guo,L., Ma,S.,
Jiang,S., Lian,X., Zhou,J., Sung,L.A., Wang,X. and Yao,W.
TITLE Tropomodulin1 exacerbates inflammatory response in macrophages by
negatively regulating LPS-induced TLR4 endocytosis
JOURNAL Cell Mol Life Sci 81 (1), 402 (2024)
PUBMED 39276234
REMARK GeneRIF: Tropomodulin1 exacerbates inflammatory response in
macrophages by negatively regulating LPS-induced TLR4 endocytosis.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 2863)
AUTHORS Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
Jackson,S.P. and Balmus,G.
CONSRTM Sanger Mouse Genetics Project
TITLE Genetic determinants of micronucleus formation in vivo
JOURNAL Nature 627 (8002), 130-136 (2024)
PUBMED 38355793
REFERENCE 3 (bases 1 to 2863)
AUTHORS Patel,T., Hammelman,J., Aziz,S., Jang,S., Closser,M.,
Michaels,T.L., Blum,J.A., Gifford,D.K. and Wichterle,H.
TITLE Transcriptional dynamics of murine motor neuron maturation in vivo
and in vitro
JOURNAL Nat Commun 13 (1), 5427 (2022)
PUBMED 36109497
REMARK Publication Status: Online-Only
REFERENCE 4 (bases 1 to 2863)
AUTHORS Liu,X., Xia,X., Wang,X., Zhou,J., Sung,L.A., Long,J., Geng,X.,
Zeng,Z. and Yao,W.
TITLE Tropomodulin1 Expression Increases Upon Maturation in Dendritic
Cells and Promotes Their Maturation and Immune Functions
JOURNAL Front Immunol 11, 587441 (2021)
PUBMED 33552047
REMARK GeneRIF: Tropomodulin1 Expression Increases Upon Maturation in
Dendritic Cells and Promotes Their Maturation and Immune Functions.
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 2863)
AUTHORS Gao,R., Liang,X., Cheedipudi,S., Cordero,J., Jiang,X., Zhang,Q.,
Caputo,L., Gunther,S., Kuenne,C., Ren,Y., Bhattacharya,S., Yuan,X.,
Barreto,G., Chen,Y., Braun,T., Evans,S.M., Sun,Y. and Dobreva,G.
TITLE Pioneering function of Isl1 in the epigenetic control of
cardiomyocyte cell fate
JOURNAL Cell Res 29 (6), 486-501 (2019)
PUBMED 31024170
REFERENCE 6 (bases 1 to 2863)
AUTHORS Watakabe,A., Kobayashi,R. and Helfman,D.M.
TITLE N-tropomodulin: a novel isoform of tropomodulin identified as the
major binding protein to brain tropomyosin
JOURNAL J Cell Sci 109 (Pt 9), 2299-2310 (1996)
PUBMED 8886980
REFERENCE 7 (bases 1 to 2863)
AUTHORS Schiaffino,S. and Reggiani,C.
TITLE Molecular diversity of myofibrillar proteins: gene regulation and
functional significance
JOURNAL Physiol Rev 76 (2), 371-423 (1996)
PUBMED 8618961
REMARK Review article
REFERENCE 8 (bases 1 to 2863)
AUTHORS White,R.A., Dowler,L.L., Woo,M., Adkison,L.R., Pal,S., Gershon,D.
and Fowler,V.M.
TITLE The tropomodulin (Tmod) gene maps to chromosome 4, closely linked
to Mup1
JOURNAL Mamm Genome 6 (5), 332-333 (1995)
PUBMED 7626883
REFERENCE 9 (bases 1 to 2863)
AUTHORS Pilz,A., Woodward,K., Povey,S. and Abbott,C.
TITLE Comparative mapping of 50 human chromosome 9 loci in the laboratory
mouse
JOURNAL Genomics 25 (1), 139-149 (1995)
PUBMED 7774911
REFERENCE 10 (bases 1 to 2863)
AUTHORS Ito,M., Swanson,B., Sussman,M.A., Kedes,L. and Lyons,G.
TITLE Cloning of tropomodulin cDNA and localization of gene transcripts
during mouse embryogenesis
JOURNAL Dev Biol 167 (1), 317-328 (1995)
PUBMED 7851652
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AL732615.15.
On Oct 16, 2023 this sequence version replaced NM_021883.2.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR17784648.879786.1,
SRR9219381.84729.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849374, SAMN00849375
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-80 AL732615.15 71685-71764
81-249 AL732615.15 93421-93589
250-406 AL732615.15 110769-110925
407-526 AL732615.15 115999-116118
527-616 AL732615.15 123301-123390
617-747 AL732615.15 124594-124724
748-855 AL732615.15 126364-126471
856-999 AL732615.15 129390-129533
1000-1144 AL732615.15 139325-139469
1145-2863 AL732615.15 146769-148487
FEATURES Location/Qualifiers
source 1..2863
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="4"
/map="4 24.49 cM"
gene 1..2863
/gene="Tmod1"
/gene_synonym="E-Tmod; Tmod"
/note="tropomodulin 1"
/db_xref="GeneID:21916"
/db_xref="MGI:MGI:98775"
exon 1..80
/gene="Tmod1"
/gene_synonym="E-Tmod; Tmod"
/inference="alignment:Splign:2.1.0"
exon 81..249
/gene="Tmod1"
/gene_synonym="E-Tmod; Tmod"
/inference="alignment:Splign:2.1.0"
CDS 130..1209
/gene="Tmod1"
/gene_synonym="E-Tmod; Tmod"
/note="isoform 1 is encoded by transcript variant 1;
erythrocyte tropomodulin"
/codon_start=1
/product="tropomodulin-1 isoform 1"
/protein_id="NP_068683.1"
/db_xref="CCDS:CCDS18143.1"
/db_xref="GeneID:21916"
/db_xref="MGI:MGI:98775"
/translation="MSYRRELEKYRDLDEDEILGALTEEELRTLENELDELDPDNALL
PAGLRQKDQTTKAPTGPFKREELLDHLEKQAKEFKDREDLVPYTGEKRGKVWVPKQKP
MDPVLESVTLEPELEEALANASDAELCDIAAILGMHTLMSNQQYYQALGSSSIVNKEG
LNSVIKPTQYKPVPDEEPNSTDVEETLERIKNNDPELEEVNLNNIRNIPIPTLKAYAE
ALKENSYVKKFSIVGTRSNDPVAFALAEMLKVNKVLKTLNVESNFISGAGILRLVEAL
PHNTSLVELKIDNQSQPLGNKVEMEIVNMLEKNTTLLKFGYHFTQQGPRLRASNAMMS
NNDLVRKRRLADLTGPIIPKCRSGV"
misc_feature 235..312
/gene="Tmod1"
/gene_synonym="E-Tmod; Tmod"
/note="propagated from UniProtKB/Swiss-Prot (P49813.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 244..543
/gene="Tmod1"
/gene_synonym="E-Tmod; Tmod"
/note="propagated from UniProtKB/Swiss-Prot (P49813.2);
Region: Tropomyosin-binding. /evidence=ECO:0000255"
exon 250..406
/gene="Tmod1"
/gene_synonym="E-Tmod; Tmod"
/inference="alignment:Splign:2.1.0"
exon 407..526
/gene="Tmod1"
/gene_synonym="E-Tmod; Tmod"
/inference="alignment:Splign:2.1.0"
exon 527..616
/gene="Tmod1"
/gene_synonym="E-Tmod; Tmod"
/inference="alignment:Splign:2.1.0"
exon 617..747
/gene="Tmod1"
/gene_synonym="E-Tmod; Tmod"
/inference="alignment:Splign:2.1.0"
exon 748..855
/gene="Tmod1"
/gene_synonym="E-Tmod; Tmod"
/inference="alignment:Splign:2.1.0"
exon 856..999
/gene="Tmod1"
/gene_synonym="E-Tmod; Tmod"
/inference="alignment:Splign:2.1.0"
exon 1000..1144
/gene="Tmod1"
/gene_synonym="E-Tmod; Tmod"
/inference="alignment:Splign:2.1.0"
exon 1145..2863
/gene="Tmod1"
/gene_synonym="E-Tmod; Tmod"
/inference="alignment:Splign:2.1.0"
regulatory 2845..2850
/regulatory_class="polyA_signal_sequence"
/gene="Tmod1"
/gene_synonym="E-Tmod; Tmod"
/note="hexamer: ATTAAA"
polyA_site 2863
/gene="Tmod1"
/gene_synonym="E-Tmod; Tmod"
/note="major polyA site"
ORIGIN
1 acccgcggcc gccagggaac tcgccaagcc ccgcgttccg ctcattgccg ccgcccgcgc
61 tcgcgccacc ccgcatcccg gtcagcagcc agcacagaag ttcaggagac aaagacacag
121 cctcacacaa tgtcctacag acgagagctg gagaaatatc gagacctgga tgaggatgaa
181 atcctggggg ccctcacaga ggaggagctg aggacgctgg aaaatgagct agatgaacta
241 gaccctgata atgcactgct ccctgcaggc ctgaggcaga aggatcagac caccaaggca
301 cccacaggcc cctttaaaag agaggagctt ttggaccact tggaaaagca agcgaaggaa
361 tttaaggacc gagaagatct ggttccctac acaggggaga aacgaggaaa ggtctgggtc
421 cccaagcaga agccaatgga tcccgtgctg gagagtgtga cactggagcc agaactggag
481 gaggccctag caaatgcctc ggatgcagaa ctgtgtgaca tcgcagctat cctgggcatg
541 cacacactca tgagcaacca gcagtactac caagccttgg gcagcagctc catcgtgaac
601 aaggaggggc tcaacagtgt gatcaaaccc acacaataca agcctgtgcc tgatgaagaa
661 ccaaattcaa cagacgtaga ggaaacgctg gagcgaataa agaacaatga cccagaacta
721 gaagaggtta atcttaacaa catccggaat attcccatac ccaccctcaa ggcatatgca
781 gaagccctga aagagaactc ctatgtgaag aagttcagca tcgtggggac ccgcagcaat
841 gaccctgtgg cgtttgccct tgctgaaatg ctgaaagtga acaaggtgct gaagaccctg
901 aacgtggagt ccaacttcat ctctggagct gggatcctgc gcctggtgga agctctcccc
961 cacaacactt ctctggtcga gctgaaaatc gataaccaga gccaaccttt gggcaacaaa
1021 gtggaaatgg agatcgtgaa catgttggag aaaaacacaa cgctcctcaa atttggctac
1081 cactttaccc agcaggggcc ccggctgcgg gcatccaacg ccatgatgag caacaacgac
1141 cttgtgagga agaggaggct cgcagacctg acggggccta ttatccccaa gtgccgcagc
1201 ggtgtctagc atgcgaaggg aagcccacgc ctaggaactg gacgtgttct accgatgatg
1261 cgtgtgcccc agtggagccc aggacgaatg ctggcgtgga gctcttgtgg ctcagttctt
1321 tgtgcactga ggtttaggtt aactagactg tagtcggacc ttttataaaa catggctaat
1381 gtgaagtttt tctttaggca cagaagttca gtctggtaat tatttaaaca tgcagaagcc
1441 ctcaagctag cgggccttgc tgcagacagt gtgacactgg cagagacggc ccaggagccc
1501 cctggcggcc ctgctttggg gcctaggtgc acttacaaca tgggacgcac cagcacagag
1561 cactcttccc acctagtttg gaagcgtggt gaaacaatct tttatttcca atttgatcgt
1621 agcaactcag taaaaagaac acataatcat gatctgtcaa cccccacttg aaactttgac
1681 atcaagatta aagctgccaa attgattcca ggatcaaacc cccaccccta agaatgaaag
1741 acaagccaca gaattttcta agagtcagaa agacacagga ttccttttgc caggtaagat
1801 aaagagggag aaaaaggcaa tggtgaattt tcaagtttca aaacccacca caccaggcaa
1861 cagacatcct tctgagtgct gtgggaacac ctgcggggta ctcatctgca gtcagaaatc
1921 atttcttctt tattgaattc caacttcatg atggatgaaa acttacagcc gctgggcagt
1981 ggtggcacac gcctttaatc ccagcacttg ggaggcagag gcaggcggat ttctgagttc
2041 gaggccagcc tggtctacag agtgagttcc aggacagcca gggctataca gagaaaccct
2101 gtctcgaaaa accaaaaaaa aaaaaaaaag gaaaaaaaaa gaaaacttac agccacataa
2161 aaacatcttc ctataccaca gtgggcaatg gcttatgtga gatcaacacc attgggtgaa
2221 tttccagtcc accatgcctg tggtatttag catggccctg cttacagaca ccaagtgcct
2281 gcctggtcat ttatgagaca aatcaaatca cacagagctc ttgcctacaa acaaagcctc
2341 tagaggacag cagagtacag catcttaatg gtaaggaatt aggagatcct ggccaaacaa
2401 cacacgggat tactctgaaa cctaatcttg gtgttcctac tggatttcct tttttaacac
2461 catgggagcc agtaaaaatg ttcaaataca ctgttcttgt gccttttaat agaccacagt
2521 gccagttaaa ctagtatttt tgttgttttg gggagttatt ttccttaggg attcagccaa
2581 tattatagta atgataaggc tcaaaagctg ttgagcatag ccagggggct tctgacttaa
2641 gagaaagcct gcacaccgaa ctgtaacagt atggacagta cagggtaact agaggtggca
2701 tcggggcctc agcactgagt gtccactgag gctgcacacg ggcccaggag tggcaccaag
2761 ctgcagggac agccagcccc actcagcttc tccttgaaac acaactgcag ctgcattctg
2821 catcactgga aactgcaaaa taatattaaa gccatttggt cta
//