LOCUS NM_024090 6570 bp mRNA linear PRI 06-AUG-2024
DEFINITION Homo sapiens ELOVL fatty acid elongase 6 (ELOVL6), transcript
variant 1, mRNA.
ACCESSION NM_024090
VERSION NM_024090.3
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6570)
AUTHORS Wang,R., Liu,X., Li,X., Qian,M., Yang,X., Jiang,Q., Wang,Y.,
Liu,H., Chen,J., Wang,X. and Gong,L.
TITLE ELOVL6 promotes the progression of head and neck squamous cell
carcinoma via activating WNT/beta-catenin pathway
JOURNAL Mol Carcinog 63 (6), 1079-1091 (2024)
PUBMED 38426809
REMARK GeneRIF: ELOVL6 promotes the progression of head and neck squamous
cell carcinoma via activating WNT/beta-catenin pathway.
REFERENCE 2 (bases 1 to 6570)
AUTHORS Chen,B., Shen,K., Zhang,T. and Gao,W.C.
TITLE ELOVL6 is associated with immunosuppression in lung adenocarcinoma
through bioinformatics analysis
JOURNAL Medicine (Baltimore) 102 (36), e35013 (2023)
PUBMED 37682172
REMARK GeneRIF: ELOVL6 is associated with immunosuppression in lung
adenocarcinoma through bioinformatics analysis.
REFERENCE 3 (bases 1 to 6570)
AUTHORS Fan,X., Zhu,W., Qiu,L., Zhang,G., Zhang,Y. and Miao,Y.
TITLE Elongase of very long chain fatty acids 6 (ELOVL6) promotes lipid
synthesis in buffalo mammary epithelial cells
JOURNAL J Anim Physiol Anim Nutr (Berl) 106 (1), 1-11 (2022)
PUBMED 33742447
REFERENCE 4 (bases 1 to 6570)
AUTHORS Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
TITLE A reference map of the human binary protein interactome
JOURNAL Nature 580 (7803), 402-408 (2020)
PUBMED 32296183
REFERENCE 5 (bases 1 to 6570)
AUTHORS Motoi,Y., Ito,Z., Suzuki,S., Takami,S., Matsuo,K., Sato,M., Ota,Y.,
Tsuruta,M., Kojima,M., Noguchi,M., Uchiyama,K. and Kubota,T.
TITLE FADS2 and ELOVL6 mutation frequencies in Japanese Crohn's disease
patients
JOURNAL Drug Discov Ther 13 (6), 354-359 (2019)
PUBMED 31956234
REMARK GeneRIF: 33 ELOVL6 mutations were found with a new variant in the
promoter region, though no mutation in the coding region was found.
However no mutations were found that largely deviated in allele
frequency as compared with healthy Japanese individuals.
REFERENCE 6 (bases 1 to 6570)
AUTHORS Kalsi,G., Kuo,P.H., Aliev,F., Alexander,J., McMichael,O.,
Patterson,D.G., Walsh,D., Zhao,Z., Schuckit,M., Nurnberger,J. Jr.,
Edenberg,H., Kramer,J., Hesselbrock,V., Tischfield,J.A.,
Vladimirov,V., Prescott,C.A., Dick,D.M., Kendler,K.S. and
Riley,B.P.
TITLE A systematic gene-based screen of chr4q22-q32 identifies
association of a novel susceptibility gene, DKK2, with the
quantitative trait of alcohol dependence symptom counts
JOURNAL Hum Mol Genet 19 (12), 2497-2506 (2010)
PUBMED 20332099
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
Erratum:[Hum Mol Genet. 2010 Oct 15;19(20):4121. Hesselbrock,
Victor [added]; Tischfield, Jay A [added]]
REFERENCE 7 (bases 1 to 6570)
AUTHORS Matsuzaka,T. and Shimano,H.
TITLE Elovl6: a new player in fatty acid metabolism and insulin
sensitivity
JOURNAL J Mol Med (Berl) 87 (4), 379-384 (2009)
PUBMED 19259639
REMARK GeneRIF: Studies suggest that inhibition of ELOVL6 could be a new
therapeutic approach for the treatment of insulin resistance,
diabetes, cardiovascular disease, and other metabolic diseases.
Review article
REFERENCE 8 (bases 1 to 6570)
AUTHORS Lu,Y., Dolle,M.E., Imholz,S., van 't Slot,R., Verschuren,W.M.,
Wijmenga,C., Feskens,E.J. and Boer,J.M.
TITLE Multiple genetic variants along candidate pathways influence plasma
high-density lipoprotein cholesterol concentrations
JOURNAL J Lipid Res 49 (12), 2582-2589 (2008)
PUBMED 18660489
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 9 (bases 1 to 6570)
AUTHORS Moon,Y.A., Shah,N.A., Mohapatra,S., Warrington,J.A. and Horton,J.D.
TITLE Identification of a mammalian long chain fatty acyl elongase
regulated by sterol regulatory element-binding proteins
JOURNAL J Biol Chem 276 (48), 45358-45366 (2001)
PUBMED 11567032
REFERENCE 10 (bases 1 to 6570)
AUTHORS Lehner,R. and Kuksis,A.
TITLE Biosynthesis of triacylglycerols
JOURNAL Prog Lipid Res 35 (2), 169-201 (1996)
PUBMED 8944226
REMARK Review article
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AK027031.1, BC001305.1, BE539688.1, DB368351.1, H65618.1 and
AC004050.1.
On Jun 2, 2019 this sequence version replaced NM_024090.2.
Summary: Fatty acid elongases (EC 6.2.1.3), such as ELOVL6, use
malonyl-CoA as a 2-carbon donor in the first and rate-limiting step
of fatty acid elongation (Moon et al., 2001 [PubMed
11567032]).[supplied by OMIM, Mar 2008].
Transcript Variant: This variant (1) represents the longer
transcript.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK027031.1, SRR1660807.148193.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1966682
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000302274.8/ ENSP00000304736.3
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1420 AK027031.1 1-1420
1421-2889 BC001305.1 1254-2722
2890-3023 BE539688.1 286-419
3024-3322 DB368351.1 1-299 c
3323-3343 H65618.1 1-21 c
3344-6570 AC004050.1 66244-69470
FEATURES Location/Qualifiers
source 1..6570
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="4"
/map="4q25"
gene 1..6570
/gene="ELOVL6"
/gene_synonym="FACE; FAE; hELO2; LCE"
/note="ELOVL fatty acid elongase 6"
/db_xref="GeneID:79071"
/db_xref="HGNC:HGNC:15829"
/db_xref="MIM:611546"
exon 1..369
/gene="ELOVL6"
/gene_synonym="FACE; FAE; hELO2; LCE"
/inference="alignment:Splign:2.1.0"
misc_feature 257..259
/gene="ELOVL6"
/gene_synonym="FACE; FAE; hELO2; LCE"
/note="upstream in-frame stop codon"
CDS 281..1078
/gene="ELOVL6"
/gene_synonym="FACE; FAE; hELO2; LCE"
/EC_number="2.3.1.199"
/note="long-chain fatty-acyl elongase; ELOVL family member
6, elongation of long chain fatty acids (FEN1/Elo2,
SUR4/Elo3-like, yeast); elongation of very long chain
fatty acids protein 6; fatty acid elongase 2; fatty
acyl-CoA elongase; 3-keto acyl-CoA synthase ELOVL6; ELOVL
FA elongase 6; very long chain 3-oxoacyl-CoA synthase 6;
very long chain 3-ketoacyl-CoA synthase 6"
/codon_start=1
/product="very long chain fatty acid elongase 6"
/protein_id="NP_076995.1"
/db_xref="CCDS:CCDS3690.1"
/db_xref="GeneID:79071"
/db_xref="HGNC:HGNC:15829"
/db_xref="MIM:611546"
/translation="MNMSVLTLQEYEFEKQFNENEAIQWMQENWKKSFLFSALYAAFI
FGGRHLMNKRAKFELRKPLVLWSLTLAVFSIFGALRTGAYMVYILMTKGLKQSVCDQG
FYNGPVSKFWAYAFVLSKAPELGDTIFIILRKQKLIFLHWYHHITVLLYSWYSYKDMV
AGGGWFMTMNYGVHAVMYSYYALRAAGFRVSRKFAMFITLSQITQMLMGCVVNYLVFC
WMQHDQCHSHFQNIFWSSLMYLSYLVLFCHFFFEAYIGKMRKTTKAE"
misc_feature 284..286
/gene="ELOVL6"
/gene_synonym="FACE; FAE; hELO2; LCE"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255|HAMAP-Rule:MF_03206; propagated from
UniProtKB/Swiss-Prot (Q9H5J4.1); glycosylation site"
misc_feature 380..433
/gene="ELOVL6"
/gene_synonym="FACE; FAE; hELO2; LCE"
/note="propagated from UniProtKB/Swiss-Prot (Q9H5J4.1);
transmembrane region"
misc_feature 488..550
/gene="ELOVL6"
/gene_synonym="FACE; FAE; hELO2; LCE"
/note="propagated from UniProtKB/Swiss-Prot (Q9H5J4.1);
transmembrane region"
misc_feature 611..673
/gene="ELOVL6"
/gene_synonym="FACE; FAE; hELO2; LCE"
/note="propagated from UniProtKB/Swiss-Prot (Q9H5J4.1);
transmembrane region"
misc_feature 686..748
/gene="ELOVL6"
/gene_synonym="FACE; FAE; hELO2; LCE"
/note="propagated from UniProtKB/Swiss-Prot (Q9H5J4.1);
transmembrane region"
misc_feature 755..817
/gene="ELOVL6"
/gene_synonym="FACE; FAE; hELO2; LCE"
/note="propagated from UniProtKB/Swiss-Prot (Q9H5J4.1);
transmembrane region"
misc_feature 869..931
/gene="ELOVL6"
/gene_synonym="FACE; FAE; hELO2; LCE"
/note="propagated from UniProtKB/Swiss-Prot (Q9H5J4.1);
transmembrane region"
misc_feature 974..1036
/gene="ELOVL6"
/gene_synonym="FACE; FAE; hELO2; LCE"
/note="propagated from UniProtKB/Swiss-Prot (Q9H5J4.1);
transmembrane region"
exon 370..501
/gene="ELOVL6"
/gene_synonym="FACE; FAE; hELO2; LCE"
/inference="alignment:Splign:2.1.0"
exon 502..653
/gene="ELOVL6"
/gene_synonym="FACE; FAE; hELO2; LCE"
/inference="alignment:Splign:2.1.0"
exon 654..6570
/gene="ELOVL6"
/gene_synonym="FACE; FAE; hELO2; LCE"
/inference="alignment:Splign:2.1.0"
regulatory 3008..3013
/regulatory_class="polyA_signal_sequence"
/gene="ELOVL6"
/gene_synonym="FACE; FAE; hELO2; LCE"
/note="hexamer: AATAAA"
polyA_site 3035
/gene="ELOVL6"
/gene_synonym="FACE; FAE; hELO2; LCE"
/note="major polyA site"
regulatory 3360..3365
/regulatory_class="polyA_signal_sequence"
/gene="ELOVL6"
/gene_synonym="FACE; FAE; hELO2; LCE"
/note="hexamer: ATTAAA"
polyA_site 3380
/gene="ELOVL6"
/gene_synonym="FACE; FAE; hELO2; LCE"
regulatory 5343..5348
/regulatory_class="polyA_signal_sequence"
/gene="ELOVL6"
/gene_synonym="FACE; FAE; hELO2; LCE"
/note="hexamer: AATAAA"
polyA_site 5366
/gene="ELOVL6"
/gene_synonym="FACE; FAE; hELO2; LCE"
regulatory 6539..6544
/regulatory_class="polyA_signal_sequence"
/gene="ELOVL6"
/gene_synonym="FACE; FAE; hELO2; LCE"
/note="hexamer: AATAAA"
polyA_site 6570
/gene="ELOVL6"
/gene_synonym="FACE; FAE; hELO2; LCE"
ORIGIN
1 actaagaccg caaggcattc atttcctcct acggtggatg cggacgccgg gaggaggaga
61 gccccagaga gaggagctgg gagcggaggc gcaggcaatg ctcagccctg gatgtagctg
121 agaggctggg agaagagacg accgctggag accgagcggc gtggggaaga cctagggggg
181 tgggtggggg aagcagacag gagaacactc gaaatcaagc gctttacaga ttattttatt
241 ttgtatagag aacacgtagc gactccgaag atcagcccca atgaacatgt cagtgttgac
301 tttacaagaa tatgaattcg aaaagcagtt caacgagaat gaagccatcc aatggatgca
361 ggaaaactgg aagaaatctt tcctgttttc tgctctgtat gctgccttta tattcggtgg
421 tcggcaccta atgaataaac gagcaaagtt tgaactgagg aagccattag tgctctggtc
481 tctgaccctt gcagtcttca gtatattcgg tgctcttcga actggtgctt atatggtgta
541 cattttgatg accaaaggcc tgaagcagtc agtttgtgac cagggttttt acaatggacc
601 tgtcagcaaa ttctgggctt atgcatttgt gctaagcaaa gcacccgaac taggagatac
661 aatattcatt attctgagga agcagaagct gatcttcctg cactggtatc accacatcac
721 tgtgctcctg tactcttggt actcctacaa agacatggtt gccgggggag gttggttcat
781 gactatgaac tatggcgtgc acgccgtgat gtactcttac tatgccttgc gggcggcagg
841 tttccgagtc tcccggaagt ttgccatgtt catcaccttg tcccagatca ctcagatgct
901 gatgggctgt gtggttaact acctggtctt ctgctggatg cagcatgacc agtgtcactc
961 tcactttcag aacatcttct ggtcctcact catgtacctc agctaccttg tgctcttctg
1021 ccatttcttc tttgaggcct acatcggcaa aatgaggaaa acaacgaaag ctgaatagtg
1081 ttggaactga ggaggaagcc atagctcagg gtcatcaaga aaaataatag acaaaagaaa
1141 atggcacaag gaatcacacg tggtgcagct aaaacaaaac aaaacatgag caaacacaaa
1201 acccaaggca gcttagggat aattaggttg atttaaccca gtaagtttat gatcctttta
1261 gggtgaggac tcactgagtg cacctccatc tccaagcact gctgctggaa gaccccattc
1321 cctctttatc tatcaactct aggacaaggg agaacaaaag caagccagaa gcagaggaga
1381 ctaatcaaag gcaaacaaag gctattaaca cataggaaaa aatgtattta ctaagtgtca
1441 catttctcta agatgaaaga tttttactct agaaactgtg cgagcacaac acacacaatc
1501 ctttctaact ttatggacac taaactggag ccaatagaaa agacaaaaat gaaagagaca
1561 cagggtgtat atctagaacg ataatgcttt tgcagaaact aaagcctttt taagaaatgc
1621 cagctgctgt agaccccatg agaaaagatg tcttaatcat ccttatgaaa acagatgtaa
1681 acaactatat ttcaactaac ttcatcttca ctgcatagcc tcaggctagt gagtttgcca
1741 aaaccaaagg gggtgaatac ttccccaaga ttcttcctgg gaggatggaa acagtgcagc
1801 ccaggtccca tgggggcagc tccatcccag agcatttctg atagttgaac tgtaatttct
1861 actcttaagt gagatatgaa gcattatcct tttgttcagt tgccccgggc ttttgaacag
1921 aagagtaaat acagaattga aaaagataaa cactcaacca aacaatgtga aaacgggttc
1981 tgtagtattt gtaaaaaggc ccggcccagg accactgtga gctggaaaag ggagaaaggc
2041 agtgggaaaa gaggtgagcc gaagatcaat tcgacagaca gatggtgtgt atgcccctcc
2101 ctgtttgact tcacacacac tcataacttt ccaaatgaaa ccccacagta tagcgcatat
2161 tttcgatatt tttgtgaatt ccaaaaggaa atcacagggc tgttcgaaat attgggggaa
2221 cactgtgttt ctgcatcatc tgcatttgct ccccaagcaa tgtagaggtg tttaaagggc
2281 cctctgctgg ctgagtggca atactacaac aaacttcaag gcaagtttgg ctgaaaacag
2341 ttgacaacaa agggccccca tacacttatc cctcaaattt taagtgatat gaaatacttg
2401 tcatgtcttt ggccaaatca gaagatattc atcctgcttc aagtcagctt cagaaatgtt
2461 ttaaaaggga ctttagctct ggaactcaaa atcaatttat taagagccat attctttaaa
2521 aaaaaaaagc tggataatat tctctgtaat atttcagtcc tttacaagcc aaatacatgt
2581 gtcaatgttt ctagtatttc aaagaagcaa ttatgtaaag ttgttcaatg tgacataata
2641 gtattataat tggttaagta gcttaatgat taggcaaact agatgaaaag attaggggct
2701 tccacactgc atagattaca cgcacatagc cacgcataca cacacagaca cacagatgtg
2761 gggtacactg aacttcaaag cccaaatgaa tagaaacaca ttttctggct agcagaaaaa
2821 aacaaaacaa aactgttgtt tctctttctt gctttgagag tgtacagtaa aagggatttt
2881 ttcgaattat ttttatatta ttttagcttt aattgtgctg tcgttcatga aacagagctg
2941 ctctgctttt ctgtcagaga tggcaagggc tttttcagca tctcgtttat gtgtggaatt
3001 taaaaagaat aaagttttat tccattctgt gtgaatggtt tgagcagtga acaaagaatc
3061 catgcaaacc aagtcatgac tggaagaaat ggggagtggg ggacagtgca ggggaggaaa
3121 gctgttacat ctatgttaaa tgattgtgag cagtctataa tgtcttgatg ttggttcata
3181 ggtgagacac aactgatgga ggaatgtatt ataaattatg caaaatctga catgagctga
3241 aaagacaggt ccttttataa gagctaatag atgcttagga tgcaaatgtt attttgagct
3301 tcgcaaatac atgataccgt gcaataagcc ttttttcctt ataacagaaa atgagaataa
3361 ttaaaatgag gagaaggcca cataacagtt gacttgaatt taattgaagg acccattgga
3421 ggctcatctg gttgatttaa ttatttaatt gagtgattta ttgcagatct cttaatgcag
3481 gttagaaacg gaagtgagca taaaccttaa aaagactcta aatgatgctt ccaaagcact
3541 ttcattttgg tattaggttc atgtttgttt gtctttactt gtaaaataat ttggaatttt
3601 tgtttacagg gtgaatgtct taatagtttt aaaattagct aaatatatct aaaggcattt
3661 ccaatgttta tcatgggagg aaaaaagcca catttttttt aaaacaaaac aaaacaaaac
3721 aaaattttgg taatataggt tcaatacact gtttttaaca tctcagctta gccgctttaa
3781 tcatatcaag atatgaggct ggatcactgg cccatgacaa atctgaaacc taccagagaa
3841 ttgactgctg catagataat cctgctgcca gttaacattc cagaaaaact tgggcaggca
3901 agtttttata gctgccccac tatgctgcaa tagagtatct ttctattgaa gattttccac
3961 tgcatcccga tcctactatg gtgaaagcat tgttcttggg ctaaaaaaaa atcctttatt
4021 tcatacacac atgatttcat acactaggtc tgagcatcaa gccaagtcca tgagtttgca
4081 atgaagttct agtgagaaat gctctattca taaagcaggg ggtttacgtg gaccttctag
4141 tgttgcttat gggaaaagag taactaccat attacatcta acgcaaggcc aaagtaccaa
4201 attaaaacca tggattgagg tggttattcg aagtcactta ctcccatcct tctaattatg
4261 ctccactaca aaagtaaggg gagaagaggg aatactttac atgtacattg ctagagggaa
4321 aagaaaggct tgattatatc ccctcgcttc tccacctctc tgctcatgta aagaaactga
4381 tgagaaaaga gactaatatg tctagactga gttagaaact tcatatgagt gggttttgta
4441 gaattgatgg gaaagacagt gggaacctag aagaacagaa agagacccac agaatgtctt
4501 tctttttttt tttttttttt tttttgaggt ggattcttgc tgttgttgcc caggctggag
4561 tgcagtggcg cgatctagac tcactgcaac ctccgcctcc caggttccag caattctcct
4621 gcctcagcct cccaaatagc tgaggttaca ggcgcccgcc accacaccca gctaattttt
4681 gtatttttag tagagacagg gtttcaccat gttggccagg ctggtctcga gctcctgacc
4741 tcaggggatc cacccgcctt ggtctcccaa agtgctggga ttataggcgt gagccaccgt
4801 gcctggccca gaatgttttt ttaaatcaga tgtagcatct tcataaggta aagcctgtca
4861 catcagagta acaaagctcc tggagtacag tgatgctaga gtagaatgtt ccagaagtct
4921 ggccatagcc ccagcttctg aattacctgg gagagacaag atgctcaggt tactattttt
4981 tctttattct gatagtacag cctctactca gagaccacgg tgtgtgtcac acaaccgagg
5041 cagctagggc atattctgag ggcttttttt tttttttggt ttccttaatg attctttaac
5101 agagtaactg gattggccaa ggtctgattc aagaggctgt gaggagagta gagaacaaat
5161 agactttgcc tctcagagtt cagagcttta agttgtataa gcatggtcca tgtccacctc
5221 ttgtagacac ttattcctta aaagtttcca tcatgaaaaa taatatcatg tcaaaatttt
5281 ataagcaccc agaatgtccc agtagtcaaa tgtagtgtct ttctccagtc tctgttttcg
5341 ataataaata ccttgctctc aatttaggat gatcgtaaag cctatgttca tgctgtgagt
5401 cattgtctcc cacagctttt gaaacatcgt tctttgtctt ttctatacaa cacctgattc
5461 tttgtgcctc agactcattg ctatcaggaa gagactttgc caagatccac caccacattt
5521 ggccagtagt gtatacacat taaagtgaga gctgatgaaa tcacaatgct ctattttgtt
5581 ccgacaatca gtatgaaggg gtaggtccca gtttgccaat gagcaacagc ctctgtatgc
5641 tggtgtccaa gacttacaca aaacaagtgt cagtgcagtc acagcatttt cttgaatgct
5701 gttgtgacag actccagtta taaacatctg cgagccatat ggcacaactc atagctaaag
5761 aggccggtac agggcacatg cacagagctt tgaagaacat acacaaacct gttgaatcaa
5821 gttactttcc tcatcctcag agactttgac aattcagagc tcacagatgg cagggggaat
5881 tctcaggctt cccttcctcc tgattgacac tttttaaagg aagtgatgtg gaagttgttc
5941 tagaagttag atggacagtg ggagcacatt cgtgagtggg gcttgggaga gctcaaaagt
6001 ggcactttga ttttaggctg ggcaggcaga agtctcacag taaaatatat ttcactagac
6061 gtccaaacca acactgcatt gtagtaacct cttctgaagt aactggttaa attaataact
6121 ggtcccataa gtcagggtca agccacattt ataacccatt cgggccggcc atgaagggtt
6181 ctgactcgac attggtattt aaatgctgtt actttcccaa tgcttagtag cacttgagac
6241 tttatttcca tcgacaaaaa ctaagaaggc cacagaagta gcctaacagt cctccctggt
6301 catactcgtt tcaaacaggt ctgcctgtct agacatattc aggcaggagg ttgcttgctg
6361 ctatcttgaa aaccactgga agattcagct tcttggggac ctcagagccc atattcatat
6421 ggaagcccac ccatataagc ctcacagagc aaatcacagc aatgttgaag ttgttatttt
6481 caagtgctta tttcacgaca ttaaaaaaaa tattttttcc tggtgtatta aaattaaaaa
6541 taaaatcata acttttgatt taaaatcaaa
//