LOCUS NM_026830 8877 bp mRNA linear ROD 13-DEC-2024
DEFINITION Mus musculus ras responsive element binding protein 1 (Rreb1),
transcript variant 3, mRNA.
ACCESSION NM_026830
VERSION NM_026830.3
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 8877)
AUTHORS Han,G., Cui,M., Lu,P., Zhang,T., Yin,R., Hu,J., Chai,J., Wang,J.,
Gao,K., Liu,W., Yao,S., Cao,Z., Zheng,Y., Tian,W., Guo,R., Shen,M.,
Liu,Z., Li,W., Zhao,S., Lin,X., Zhang,Y., Song,K., Sun,Y., Zhou,F.
and Zhang,H.
TITLE Selective translation of nuclear mitochondrial respiratory proteins
reprograms succinate metabolism in AML development and
chemoresistance
JOURNAL Cell Stem Cell 31 (12), 1777-1793 (2024)
PUBMED 39357516
REFERENCE 2 (bases 1 to 8877)
AUTHORS Wu,Z., Chen,X., Yan,T., Yu,L., Zhang,L., Zheng,M. and Zhu,H.
TITLE Rreb1 is a key transcription factor in Sertoli cell maturation and
function and spermatogenesis in mouse
JOURNAL Zygote 32 (2), 130-138 (2024)
PUBMED 38248872
REMARK GeneRIF: Rreb1 is a key transcription factor in Sertoli cell
maturation and function and spermatogenesis in mouse.
REFERENCE 3 (bases 1 to 8877)
AUTHORS Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
Jackson,S.P. and Balmus,G.
CONSRTM Sanger Mouse Genetics Project
TITLE Genetic determinants of micronucleus formation in vivo
JOURNAL Nature 627 (8002), 130-136 (2024)
PUBMED 38355793
REFERENCE 4 (bases 1 to 8877)
AUTHORS Griffin,E.N., Jucius,T., Sim,S.E., Harris,B.S., Heinz,S. and
Ackerman,S.L.
TITLE RREB1 regulates neuronal proteostasis and the microtubule network
JOURNAL Sci Adv 10 (2), eadh3929 (2024)
PUBMED 38198538
REMARK GeneRIF: RREB1 regulates neuronal proteostasis and the microtubule
network.
REFERENCE 5 (bases 1 to 8877)
AUTHORS Cazzaro,S., Woo,J.A., Wang,X., Liu,T., Rego,S., Kee,T.R., Koh,Y.,
Vazquez-Rosa,E., Pieper,A.A. and Kang,D.E.
TITLE Slingshot homolog-1-mediated Nrf2 sequestration tips the balance
from neuroprotection to neurodegeneration in Alzheimer's disease
JOURNAL Proc Natl Acad Sci U S A 120 (30), e2217128120 (2023)
PUBMED 37463212
REFERENCE 6 (bases 1 to 8877)
AUTHORS Yamane,T., Suzui,S., Kitaura,H., Takahashi-Niki,K.,
Iguchi-Ariga,S.M. and Ariga,H.
TITLE Transcriptional activation of the cholecystokinin gene by DJ-1
through interaction of DJ-1 with RREB1 and the effect of DJ-1 on
the cholecystokinin level in mice
JOURNAL PLoS One 8 (11), e78374 (2013)
PUBMED 24348900
REMARK Publication Status: Online-Only
REFERENCE 7 (bases 1 to 8877)
AUTHORS Kent,O.A., Chivukula,R.R., Mullendore,M., Wentzel,E.A.,
Feldmann,G., Lee,K.H., Liu,S., Leach,S.D., Maitra,A. and
Mendell,J.T.
TITLE Repression of the miR-143/145 cluster by oncogenic Ras initiates a
tumor-promoting feed-forward pathway
JOURNAL Genes Dev 24 (24), 2754-2759 (2010)
PUBMED 21159816
REFERENCE 8 (bases 1 to 8877)
AUTHORS Chen,R.L., Chou,Y.C., Lan,Y.J., Huang,T.S. and Shen,C.K.
TITLE Developmental silencing of human zeta-globin gene expression is
mediated by the transcriptional repressor RREB1
JOURNAL J Biol Chem 285 (14), 10189-10197 (2010)
PUBMED 20133935
REFERENCE 9 (bases 1 to 8877)
AUTHORS Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
TITLE Identification of transcripts with enriched expression in the
developing and adult pancreas
JOURNAL Genome Biol 9 (6), R99 (2008)
PUBMED 18554416
REFERENCE 10 (bases 1 to 8877)
AUTHORS Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
Takeda,J., Ohara,O. and Seino,S.
TITLE Construction of a multi-functional cDNA library specific for mouse
pancreatic islets and its application to microarray
JOURNAL DNA Res 11 (5), 315-323 (2004)
PUBMED 15747579
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC022682.16 and CT010477.16.
On Apr 14, 2022 this sequence version replaced NM_026830.2.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC080680.1, AK154980.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849374, SAMN00849375
[ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-318 AC022682.16 31727-32044 c
319-420 CT010477.16 151318-151419 c
421-527 CT010477.16 147632-147738 c
528-740 CT010477.16 146306-146518 c
741-830 CT010477.16 141789-141878 c
831-994 CT010477.16 140503-140666 c
995-1133 CT010477.16 124130-124268 c
1134-1270 CT010477.16 123695-123831 c
1271-1460 CT010477.16 111978-112167 c
1461-8877 CT010477.16 103316-110732 c
FEATURES Location/Qualifiers
source 1..8877
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="13"
/map="13"
gene 1..8877
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/note="ras responsive element binding protein 1"
/db_xref="GeneID:68750"
/db_xref="MGI:MGI:2443664"
exon 1..318
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/inference="alignment:Splign:2.1.0"
exon 319..420
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/inference="alignment:Splign:2.1.0"
exon 421..527
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/inference="alignment:Splign:2.1.0"
exon 528..740
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/inference="alignment:Splign:2.1.0"
misc_feature 555..557
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/note="upstream in-frame stop codon"
CDS 570..4445
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/note="isoform 1 is encoded by transcript variant 3;
RAS-responsive zinc finger transcription factor RREB"
/codon_start=1
/product="ras-responsive element-binding protein 1 isoform
1"
/protein_id="NP_081106.1"
/db_xref="CCDS:CCDS36634.1"
/db_xref="GeneID:68750"
/db_xref="MGI:MGI:2443664"
/translation="MTSNSPIGLEGSDLSSINTMMSAVMSVASVTENGGSPQGIKSPM
KPPGPNRIGRRNQETKEEKSSYNCPLCEKICTTQHQLTMHIRQHNTDTGGADHACSIC
GKSLSSASSLDRHMLVHSGERPYKCTVCGQSFTTNGNMHRHMKIHEKDTNSTTAAAPP
SPLKRRRLSSKRKLSHDAESEDPGPAKKMVEDGQSGDLDKMSDEIFHCPVCFKEFVCK
YELETHMETHSDNPLRCDICCVTFRTHRGLLRHNALVHKQLPRDAMGRPFIQNNPSIP
AGFHDLGFTDFSCRKFPRISQAWCETNLRRCISEQHRFVCDTCDKAFPMLSSLILHRQ
SHIPADQGREKLQTKTLAAESLEQKAFLALLGLQHTKDVKPAPAEELLPDDNQAIQLQ
TLKYQLPQEPGCPTVLSVSPLDAASLGGSLTVLPATKENMKHLSLQPFQKGFIIQPDS
SIVVKPISGESAIELADIQQILKMAASAPPQISLPPLSKAPATPLQAIFKHMPPLKPK
PLVTPRTVVAASTPPPLINAQQASPGCISPSLPPQSLKFLKGSVEAVSNVHLLQSKSG
IQPSTTTQLFLQQAGVELPGQPEMKTQLEQESIIEALLPLNMEAKIKQEITEGDLKAI
MTGPSGKKTPAMRKVLYPCRFCNQVFAFSGVLRAHVRSHLGISPYQCNICDYIAADKA
ALIRHIRTHSGERPYICKICHYPFTVKANCERHLRKKHLKATRKDIEKNIEYVSSPTA
ELVDAFCAPETVCRLCGEDLKHYRALRIHMRTHCSRGLGGCHKGRKPFECKECNAPFV
AKRNCIHHILKQHLHVPEKDIESYVLATNSGLGPADTPTDAASRGEEGSCVTFAECKP
LATFLEPQNGFLHSSPTQPLPSHISVKLEPASSFAMDFNEPLDFSQKGLALVQVKQEN
VSSLLTSSSSSALYDCSMEPIDLSIPKSVKKGDKDTVVPSDAKKPEPEAGQAEPLSPR
PPPCPTLSVTVEPKGSLETPTGTVVAVTTAAKLEPHTQPLQGSVQLAVPIYSPALVSN
TPLLGNSAALLNNPALLRPLRPKPPLLLPKPSMTEELPPLASIAQIISSVSSAPTLLK
TKVADPGPSITSSNTVATDSPGSSIPKAAATPTDTTSSKESSEPPPAASSPEEALPTE
QGPAATSSSRKRGRKRGLRNRPLPNSSAVDLDSSGEFASIEKMLATTDTNKFSPFLQT
AEDDTQEEVAGAPADQHGPADEEQGSPAEDRLLRAKRNSYANCLQKINCPHCPRVFPW
ASSLQRHMLTHTGKKALTAHQAVSLERKE"
misc_feature 660..758
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/note="propagated from UniProtKB/Swiss-Prot (Q3UH06.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 675..677
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q92766; propagated from
UniProtKB/Swiss-Prot (Q3UH06.2); phosphorylation site"
misc_feature 693..695
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q92766; propagated from
UniProtKB/Swiss-Prot (Q3UH06.2); phosphorylation site"
misc_feature 1005..1154
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/note="propagated from UniProtKB/Swiss-Prot (Q3UH06.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 1050..1052
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:21183079; propagated from
UniProtKB/Swiss-Prot (Q3UH06.2); phosphorylation site"
misc_feature 1092..1094
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q92766; propagated from
UniProtKB/Swiss-Prot (Q3UH06.2); phosphorylation site"
misc_feature 1107..1109
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q92766; propagated from
UniProtKB/Swiss-Prot (Q3UH06.2); phosphorylation site"
misc_feature 1254..1256
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q92766; propagated from
UniProtKB/Swiss-Prot (Q3UH06.2); phosphorylation site"
misc_feature 3384..3542
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/note="propagated from UniProtKB/Swiss-Prot (Q3UH06.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 3477..3479
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:21183079; propagated from
UniProtKB/Swiss-Prot (Q3UH06.2); phosphorylation site"
misc_feature 3843..4100
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/note="propagated from UniProtKB/Swiss-Prot (Q3UH06.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 3942..3944
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q92766; propagated from
UniProtKB/Swiss-Prot (Q3UH06.2); phosphorylation site"
misc_feature 3978..3980
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:17242355,
ECO:0007744|PubMed:21183079; propagated from
UniProtKB/Swiss-Prot (Q3UH06.2); phosphorylation site"
misc_feature 3981..3983
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:17242355,
ECO:0007744|PubMed:21183079; propagated from
UniProtKB/Swiss-Prot (Q3UH06.2); phosphorylation site"
misc_feature 4083..4085
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q92766; propagated from
UniProtKB/Swiss-Prot (Q3UH06.2); phosphorylation site"
misc_feature 4104..4106
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:17242355; propagated from
UniProtKB/Swiss-Prot (Q3UH06.2); phosphorylation site"
misc_feature 4107..4109
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:17242355; propagated from
UniProtKB/Swiss-Prot (Q3UH06.2); phosphorylation site"
misc_feature 4152..4274
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/note="propagated from UniProtKB/Swiss-Prot (Q3UH06.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 4257..4259
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q92766; propagated from
UniProtKB/Swiss-Prot (Q3UH06.2); phosphorylation site"
exon 741..830
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/inference="alignment:Splign:2.1.0"
exon 831..994
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/inference="alignment:Splign:2.1.0"
exon 995..1133
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/inference="alignment:Splign:2.1.0"
exon 1134..1270
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/inference="alignment:Splign:2.1.0"
exon 1271..1460
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/inference="alignment:Splign:2.1.0"
exon 1461..8877
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/inference="alignment:Splign:2.1.0"
regulatory 4577..4582
/regulatory_class="polyA_signal_sequence"
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/note="hexamer: AATAAA"
polyA_site 4596
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/note="major polyA site"
regulatory 8854..8859
/regulatory_class="polyA_signal_sequence"
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
/note="hexamer: AATAAA"
polyA_site 8877
/gene="Rreb1"
/gene_synonym="1110037N09Rik; B930013M22Rik; sao"
ORIGIN
1 aacacgtgat gtgtctactt atcagggtga gagggggaga gcgagtctcc gagtgtgcgg
61 gtgaggaagc ggggcggggg gccgaggcgg gggccgggaa gacggctagg gcaacggggt
121 cgccagctcc tcgcccacct ccctccctat gggagaagag gaggagggga agtgactgcg
181 gagttgatga actttgcaca tccagaaacg ccattttgat tccttttccg gaacaagttt
241 gcatctctcc tcgttctctc cccgaagccc accggtcctc accgcatcat gcctgggagc
301 ccagcaccct gccgggccgt tgttgcaatc ctgtgctcca gaagtggtgg ctttgaggtg
361 tgaccctgcc cacatttggg cccagtcctc accagctcct cggcagaacg aagaaaacag
421 cataaaggag tgatatccag agaataaaag ggctccccag agtcatttcc tactccatgt
481 ggatgacagc aggagcaagg gactatcatt tggggcagaa aatggagttc tatagcagag
541 acttcttaga agcataaaac cctgtcccga tgacgtcgaa ttcgcccatt ggtttagaag
601 gctcagacct gtcttccatc aacaccatga tgtcagcagt aatgagcgta gcgagtgtca
661 cagagaatgg tgggagcccc cagggcatca agtcccccat gaaacctcca ggaccaaatc
721 ggattggcag aaggaaccag gaaacgaaag aggagaagtc ttcctacaac tgtcccctat
781 gtgaaaagat ttgcaccacc cagcaccagc tgaccatgca catccgtcag cacaacacag
841 acacgggagg agctgaccac gcatgcagta tctgtgggaa gtcgctgagc tcggccagct
901 ccctggatcg tcacatgctg gtgcactctg gcgagaggcc ttacaagtgt acagtgtgtg
961 gccagtcttt caccaccaat gggaacatgc acagacatat gaagattcat gagaaggata
1021 ccaacagtac tacagctgca gcccctccat cccctctgaa gcgcaggcgg ttgtcctcca
1081 aaaggaagct gagtcacgat gccgagtcag aagacccagg accagctaaa aagatggtag
1141 aagacgggca gtcaggcgat ttggacaaga tgagcgatga aatctttcac tgcccagtgt
1201 gtttcaagga gtttgtttgc aagtatgaac tggagaccca catggagacc cactcagata
1261 acccactaag atgtgacatt tgctgcgtca ccttccgcac acatcgagga ctgctgcgcc
1321 acaatgcact tgtccacaag cagcttccca gagatgccat gggaagacct tttatccaga
1381 acaacccttc gattcctgct ggcttccatg atttagggtt tactgacttc tcctgtagga
1441 agtttcctcg aatctctcag gcctggtgtg agacaaacct acggcggtgc atcagcgagc
1501 agcaccggtt tgtgtgtgac acctgcgaca aggcgttccc catgctgtcg tcactcatcc
1561 tgcacaggca gagccacatc cctgccgatc agggacggga gaagctccag accaagaccc
1621 tggctgccga gtccttggaa cagaaggcct tcctggcctt gctgggcctg cagcacacca
1681 aagacgtcaa gcctgccccg gcggaggagc tcctgccgga cgacaaccaa gcaatacagc
1741 tccagacact taagtaccag ctacctcagg agcctggctg ccccaccgtg ctgagtgtgt
1801 ctcctcttga cgctgcttct ttaggtggct ctctgacagt cctcccagct accaaggaga
1861 atatgaagca tctgtccctg cagcccttcc agaagggctt catcatccag ccagacagta
1921 gcattgtggt taagcctatt tcaggagagt cggccattga gctggcagat atccaacaga
1981 ttctaaagat ggcagcttcc gctcctccgc agatcagtct tccgccactt tccaaggccc
2041 ctgccacccc gctgcaggcg attttcaagc acatgcctcc tttgaagcca aagcccttgg
2101 tcacaccccg gacagtggta gccgcctcca cgcccccacc tctcatcaac gcccagcagg
2161 catctcccgg ttgtatcagc cccagccttc ctccacagtc cctgaagttc ctcaaggggt
2221 cggtggaggc agtgtccaat gttcatctgc ttcagtccaa gtctgggatc cagccaagca
2281 ccaccacaca gctcttcctg cagcaagctg gagtggagtt gccgggccag cccgagatga
2341 agacacagct ggaacaagag agtatcattg aggccctgct gcccctcaac atggaggcga
2401 agatcaagca ggagataaca gaaggtgacc tcaaggccat catgacaggc cccagtggca
2461 agaagacccc cgccatgcgc aaggtgctct acccctgccg cttttgcaac caggtgtttg
2521 ctttctctgg agtcctgcga gcccacgttc gctcccacct gggcatctca ccctaccaat
2581 gcaacatctg tgactatatt gctgcagaca aagccgccct gatccgtcac atccgcacac
2641 acagcgggga acggccttac atctgcaaga tctgccacta cccattcacg gtcaaagcca
2701 actgtgagcg gcacctgcgc aagaagcacc tcaaggccac caggaaggac attgagaaga
2761 acatagagta cgtgagcagc cccaccgcag agctggtgga cgccttctgc gccccagaga
2821 ccgtgtgcag actgtgcggg gaggatctga agcactaccg agctctacgc atccacatgc
2881 gcacacactg cagccggggc ctgggcggct gccacaaagg ccggaaaccc ttcgagtgca
2941 aggaatgcaa cgctcccttc gtggccaagc gcaactgcat ccatcacatc ctcaagcagc
3001 acctgcacgt gcccgagaag gacatcgaga gctacgtgct tgccaccaac agtggcctcg
3061 gccccgcgga cacgcccacg gatgccgctt ccagaggaga agagggcagc tgtgtcactt
3121 tcgcggagtg caagcccctc gccactttcc tggagcccca aaatggcttt cttcactcga
3181 gccccaccca gcccctgcct tcccacatct ctgtcaagct ggagccagcc agcagctttg
3241 ccatggactt caacgaaccc cttgactttt cgcagaaagg cctggcactg gtccaagtga
3301 agcaggaaaa tgtttcctcc ttgctgacgt cttcctcctc ctctgccctc tatgactgct
3361 ccatggagcc cattgacctg tccatcccca agagcgtcaa gaaaggagac aaggacacag
3421 ttgttcccag tgacgccaag aaaccggaac cggaagctgg gcaagccgag ccgctctcac
3481 cccgcccacc accctgccct accttgtcag tgactgtgga gcccaagggg agcctggaaa
3541 cccccacagg cacggtggtg gccgtcacca cagctgccaa gctagagccc cacactcagc
3601 ccctccaggg ctccgtgcag ctggctgtcc ccatctactc ccccgcgctc gtcagcaata
3661 ctcccctctt gggcaattct gctgccctct tgaacaaccc agccttgctt cggcccttac
3721 ggccaaagcc ccccctcctc ttgccaaagc cctcgatgac agaggagctg ccgccactgg
3781 cctccatcgc ccagatcatt tcttccgtgt cctcggcccc tactctgctg aaaacgaagg
3841 tagctgaccc tggaccatcg atcaccagca gtaacactgt ggccacagac agcccaggaa
3901 gctccatccc caaagctgcc gccaccccca ctgacaccac aagctctaaa gaatccagtg
3961 agccaccccc tgcagccagc agccctgagg aagccttgcc tactgaacaa gggccggctg
4021 ccacttcctc gtcgaggaag aggggcagga aaaggggact gagaaaccgg cccctcccca
4081 acagcagtgc tgtggacctg gactccagtg gggagtttgc tagcatcgag aagatgctgg
4141 ccaccacaga taccaacaag ttcagtccct ttctgcagac tgcagaggat gacactcagg
4201 aagaggtggc tggagcccct gccgaccagc atgggcccgc tgatgaggag caaggtagcc
4261 ccgcagaaga caggctgctg agagcaaagc ggaactccta tgccaactgc ctgcaaaaga
4321 tcaactgtcc ccactgtccc cgggtcttcc cttgggccag ctccctgcag cggcacatgc
4381 ttacacacac tggtaagaag gccctcacgg ctcaccaggc ggtgagtctt gaaaggaaag
4441 agtaatgggt agggatagga gtaggcctaa agtttggggc ctttgtctca tgctccattc
4501 tttgtctcag aagtcacagg ctgttacttt ccatataatc tgtgcctgtg gtctgagcca
4561 ccaaggctta tctgtaaata aatgtatcag acacagtgac agtggtcata ggctccttca
4621 cttccctccc cataaccttt gcctgacaag ttccaagagt ttctaagtat ggaggccatt
4681 ccggagaagt gggactttgc attaaggtaa cagtgatgta atgagcttgg tgctttgaca
4741 tgataatctt cagtgccgtc tttttttttt ttttttgaac attctatgga gttctttagc
4801 taccacacat gtaatacaga aaagtgggat tggatatttt ttccccttca ctgaggtagc
4861 tccagcgtcc cttacttatt ttgacttttt ttcctatttg gaatacttag atgattgata
4921 gtagtaattt ttctaaagtt ctatttatcc taaaattgtc aactgttgag gaaaacattc
4981 tgcgtatcat ttgaatgttt taattaacaa agctagatta ccaaaacaac atcccggaaa
5041 tagttttcag atgtcagttt ctagaagttg aagtgtagaa cagagactta tctattaaat
5101 tactttatgc ctagtgcttc taatatttca atagccatct agaaaggtat aattataatt
5161 ttctgaatag tatcacagga tttgtatcat cgatcgattg ggcgattgtt gtacattcag
5221 tgaagtcctt acccttttgg agtttacagt ttaaaatatg gatcactggc aagatttgac
5281 ttttcagacc aacaagtatt ttgtagtatt tgggacagac ggaaacatta cttattgatc
5341 agaatgatgc tcaaatttta ctgcagatct ttttgcagta gatcttgcta gaaacactcc
5401 aggaaggaat gctgtgattt ccacccaccc acccccgccc actgaagatt tgtgtagata
5461 ggccatctct cagcaaactg acaggcttcc tgggagccaa agtgtccatt tcttttccat
5521 ttgtgatggc atctgcagat accagagacg tgtcccctct ttccctgggg tttgatcact
5581 gttggtgtag gagcatctga acctgttcgg tccccagggc ccacagagta gaaaaaagag
5641 ccaactccta caagttgttc tcttgcttct acacgcaagc catggcacaa gtgtgcttac
5701 gtgtgcacgc acacacaaac agagagagag agagagagag agagagagag agagagagag
5761 agagagagag cgcagccaac agcattgagc aaaacccaat ttcaactgta gttaagcaaa
5821 ctgcctccat catgagagag ggtctctttc catcctctca gctactttgt tgaattatcc
5881 cagcatctgt acttggtctc aacccatttc tccattctac ccactcccta ccacggaaca
5941 aagaggtcag ctgctgaatg tccaactagg ggtccacctg ctggctgcca gcacaaacat
6001 ggctttagct ctttaccctg cttagttagg ttccaagaat gtactctgag gaggaagctg
6061 tcatctttca tgtcctcttg ggcagtttct acacactcga tttcctccct cctccagctc
6121 tccaacctgt ggctcactgc gctccctctg gacatgttgt acctcgtgag acaacaatgc
6181 actgtctctg ccagttcccc tcacagcatc tcggcctgtg tctttaggcc acaggaggac
6241 aaagtgccag caaacacaac cagtcccttt cagcagtatc tgtcctcacc ttttcctcct
6301 tccctttgct ctggttcctt gttcacagtg ctgggtcagg atggtgcaat ctctgagaac
6361 ccctccagct gtggcatctg ggatccccta gctccctctc attctcatgg gtgcttggag
6421 ctcctttgcc agctcctggg ctcttccatc tcaccttctg ccccactgct aatgggtaac
6481 aagcactgac gtttaaattt gggagatgtc ctcacagtat agaaagcaac ttgagctact
6541 tgtacctagc tgccttttac taaggtttaa tccatgtttt tgtatgtggg tttgtgtctg
6601 cacatacgtg tgcaggtaac tgcccaggct agaagaaaga gttggatccc ctggagccaa
6661 ggttacaggt gcttgtgagc taccagatgt aggtgctgag aaccaaaggg tcttcaagag
6721 cagcactttc tttaccactg agccatctct ccagcccaag tactttatta agtggtagct
6781 ttgactgcaa aagaagaaaa gtaccaagaa accctgggcc ccgagggtaa agtatgtggg
6841 aagtccaaag atgcttagct cctacagtct tgtcagcaca aaaactccat gtgtgtccca
6901 ggctagttct aaccttgatt ctcttcagag aacatttgca gctcgtccat ttaggacttg
6961 acaaacaagg tcccgttgtc ctcagcaaac tcttgttcct tctgcctggc tttgttccca
7021 gtgcccttca gataatgcct ctcttccttt tctgactgct ctgcatgaat gaatttggat
7081 gactggtggc tttaatgttc acattggggt gggagacata caggccccgg atacaaaagt
7141 atggtcacag ctgctcttac acacacatat acactcgcgc acgcgcgcac acacacagtc
7201 taccagattg gtaaagtgca ctagtgactt tcagacatac actaaacagg ctcaccattt
7261 ttacatccct gcaaggcaaa aagcatatta ctattttaaa agtaattttc tgctttgtat
7321 aagctttaaa tgattgtgtt acttgtcagt ttgaggtcct tcagtggcac taatgtgact
7381 gttcatggaa tacagcaaaa gcatgtgaaa attaaaaagt aaattatttc ataccaaaaa
7441 aaaaaaaacc aaccctacca ttttcttaaa atctggaatc ccagcctagt ggagtcggga
7501 agatggctgg attaaataca gagttcagtt gcccgcatcc atgtgtaagt tgtacatctt
7561 acaaatgctt gtaactccat ctcgaagaga ttccacaccc tctcttgcct cccacacatg
7621 gtgtacatgt attcatgcac acagaggcac caataaaaaa taattaatta aaggaatccc
7681 agtatagtag cctttggccc ttaagtcttt tttttttaac cccttttggt gctggtactt
7741 gaaccagtgc ttcagcattc tccatagctc cctgccagct ccttgtttct ccgttctctt
7801 cctccctatc tgaccagacc tgaagaagct gccatctttc ttttagacaa aggaaattta
7861 agatattctg ttgttattaa tgaaaagcaa aagagccact tgaaaaatac atggggaaat
7921 gttttatacc cggtcacttc aagatttaaa aaaaaatgag ggtgttgggg ctggagagat
7981 tgctcagagg ttaagagcac tgactgctct tccagaggcc ctgagttcaa ttcccagcaa
8041 ccacattaca ggtggctcac aaccatctgt aatggggatc tgatgccctc ttctggtgtg
8101 tctgaaataa ataaataaat cttaaaaaaa aataattgag ggtgttttca gtgcttcaag
8161 catttggtag gtcctctact agtgtgcaag ggtccttgtc tatacacata gtgggatttt
8221 tatgaggcct ttccaaggtc tctaagtatg cttggattga tgcaaatatt cctgtctgtt
8281 tggtcacccc atccttatac atctcttgta tgcctttcta ctccattgct cattgctggg
8341 gttggggtcg ttggttggtt tcatgggtgg tggttgttgc tgctgctgct tttttcagtg
8401 ctgtagtttg ttgtgggtgg ctctgggctg cttgctttcc tggaagaggc tgtctggaat
8461 gagtaatgag tcacacacac aagtggattc ctgtgaacca atcgcctaat gaataaagga
8521 gccaatcact aggcgagtag acagggcttc caggttggag agaggagagc aagcagcaca
8581 gagccattca caacatttcc ccctttctgt tctaataaaa aaacaaaacc tttctcacag
8641 tatagagtac aacaagatta gacctaacac ccagtccatc atctatccta aattaaaagg
8701 ctggagagat ggctcagcag ttaagagcac tgactgcact tccagaggtc ctgagttcaa
8761 ttcccagcaa ctacatggtg gctcacaacc atctgtaatg ggatctgatg ccttcttctg
8821 gtggtctgaa gacagcgaca gtatactcat ataaataaaa aaaataataa atctgaa
//