LOCUS NM_032062 8980 bp mRNA linear ROD 03-APR-2024
DEFINITION Rattus norvegicus kalirin, RhoGEF kinase (Kalrn), mRNA.
ACCESSION NM_032062
VERSION NM_032062.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 8980)
AUTHORS Huang,H., Chen,L., Yuan,J., Zhang,H., Yang,J., Xu,Z. and Chen,Y.
TITLE Role and mechanism of EphB3 in epileptic seizures and
epileptogenesis through Kalirin
JOURNAL Mol Cell Neurosci 128, 103915 (2024)
PUBMED 38143048
REMARK GeneRIF: Role and mechanism of EphB3 in epileptic seizures and
epileptogenesis through Kalirin.
REFERENCE 2 (bases 1 to 8980)
AUTHORS Wang,X., Weng,M., Ke,Y., Sapp,E., DiFiglia,M. and Li,X.
TITLE Kalirin Interacts with TRAPP and Regulates Rab11 and Endosomal
Recycling
JOURNAL Cells 9 (5), 1132 (2020)
PUBMED 32375403
REMARK GeneRIF: Kalirin Interacts with TRAPP and Regulates Rab11 and
Endosomal Recycling.
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 8980)
AUTHORS Paskus,J.D., Tian,C., Fingleton,E., Shen,C., Chen,X., Li,Y.,
Myers,S.A., Badger,J.D. 2nd, Bemben,M.A., Herring,B.E. and
Roche,K.W.
TITLE Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF
Protein-Dependent Neuroligin-1 Mechanism of Action
JOURNAL Cell Rep 29 (10), 2944-2952 (2019)
PUBMED 31801062
REFERENCE 4 (bases 1 to 8980)
AUTHORS Li,M.X., Qiao,H., Zhang,M. and Ma,X.M.
TITLE Role of Cdk5 in Kalirin7-Mediated Formation of Dendritic Spines
JOURNAL Neurochem Res 44 (5), 1243-1251 (2019)
PUBMED 30875016
REMARK GeneRIF: that Cdk5 affects the function of Kal-7 on spine
morphology and function via GluN2B and GluA1 receptors during
dendritic spine formation
REFERENCE 5 (bases 1 to 8980)
AUTHORS Xie,Z., Shapiro,L.P., Cahill,M.E., Russell,T.A., Lacor,P.N.,
Klein,W.L. and Penzes,P.
TITLE Kalirin-7 prevents dendritic spine dysgenesis induced by amyloid
beta-derived oligomers
JOURNAL Eur J Neurosci 49 (9), 1091-1101 (2019)
PUBMED 30565792
REMARK GeneRIF: our results suggest that kalirin-7 may play a role in the
early events leading to synapse degeneration
REFERENCE 6 (bases 1 to 8980)
AUTHORS Penzes,P., Johnson,R.C., Alam,M.R., Kambampati,V., Mains,R.E. and
Eipper,B.A.
TITLE An isoform of kalirin, a brain-specific GDP/GTP exchange factor, is
enriched in the postsynaptic density fraction
JOURNAL J Biol Chem 275 (9), 6395-6403 (2000)
PUBMED 10692441
REFERENCE 7 (bases 1 to 8980)
AUTHORS Mains,R.E., Alam,M.R., Johnson,R.C., Darlington,D.N., Back,N.,
Hand,T.A. and Eipper,B.A.
TITLE Kalirin, a multifunctional PAM COOH-terminal domain interactor
protein, affects cytoskeletal organization and ACTH secretion from
AtT-20 cells
JOURNAL J Biol Chem 274 (5), 2929-2937 (1999)
PUBMED 9915831
REFERENCE 8 (bases 1 to 8980)
AUTHORS Colomer,V., Engelender,S., Sharp,A.H., Duan,K., Cooper,J.K.,
Lanahan,A., Lyford,G., Worley,P. and Ross,C.A.
TITLE Huntingtin-associated protein 1 (HAP1) binds to a Trio-like
polypeptide, with a rac1 guanine nucleotide exchange factor domain
JOURNAL Hum Mol Genet 6 (9), 1519-1525 (1997)
PUBMED 9285789
REFERENCE 9 (bases 1 to 8980)
AUTHORS Alam,M.R., Johnson,R.C., Darlington,D.N., Hand,T.A., Mains,R.E. and
Eipper,B.A.
TITLE Kalirin, a cytosolic protein with spectrin-like and GDP/GTP
exchange factor-like domains that interacts with peptidylglycine
alpha-amidating monooxygenase, an integral membrane
peptide-processing enzyme
JOURNAL J Biol Chem 272 (19), 12667-12675 (1997)
PUBMED 9139723
REFERENCE 10 (bases 1 to 8980)
AUTHORS Alam,M.R., Caldwell,B.D., Johnson,R.C., Darlington,D.N., Mains,R.E.
and Eipper,B.A.
TITLE Novel proteins that interact with the COOH-terminal cytosolic
routing determinants of an integral membrane peptide-processing
enzyme
JOURNAL J Biol Chem 271 (45), 28636-28640 (1996)
PUBMED 8910496
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AF230644.1 and AF232669.1.
On Apr 23, 2010 this sequence version replaced NM_032062.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
RNAseq introns :: single sample supports all introns SAMEA5760393,
SAMEA5760396 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on computational evidence
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-399 AF230644.1 1-399
400-8980 AF232669.1 370-8950
FEATURES Location/Qualifiers
source 1..8980
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="Sprague-Dawley"
/db_xref="taxon:10116"
/chromosome="11"
/map="11q22"
gene 1..8980
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/note="kalirin, RhoGEF kinase"
/db_xref="GeneID:84009"
/db_xref="RGD:621865"
CDS 1..8934
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/EC_number="2.7.11.1"
/note="P-CIP10; protein Duo; PAM COOH-terminal interactor
protein 10; huntingtin-associated protein-interacting
protein; serine/threonine kinase with Dbl- and pleckstrin
homology domain; serine/threonine-protein kinase with Dbl-
and pleckstrin homology domain; huntingtin-associated
protein interacting protein (duo); cyclin B1"
/codon_start=1
/product="kalirin"
/protein_id="NP_114451.2"
/db_xref="GeneID:84009"
/db_xref="RGD:621865"
/translation="MTDRFWDQWYLWYLRLLRLLDRGSFRNDGLKASDVLPILKEKVA
FVSGGRDKRGGPILTFPARTNHDRIRQEDLRKLVTNLASVPSEDVCKRGFTVIIDMRG
SKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMVSVEGLT
KLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPV
DVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQS
LVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFL
QSHTEIGVSYQHALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQI
STQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDL
ELAIHHHQSLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVL
DVVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGV
GKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEV
RIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEVLEDVCADSVDAVQELIKQ
FQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPTEARDSAVSNNKTPHSSSISHI
ESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMND
FNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYIMEVQASGIELICEKDVD
LAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLN
ASLVNASSLSEAEQLQREHEQFQLAIEKTHQSALQVQQKAEALLQAGHYDADAIRECA
EKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKL
GPAAEMDHVIPLLSKHLEQKEAFLKACTLARRNAEVFLKYIHRNNVSMPSVASHTRGP
EQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEYYLS
THTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWV
TTVDKHYRDFSLRMGKYRYTLEKALGVNTEDNKDLELDIIPASLSDREVKLRDANHEV
NEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHII
FGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLIL
EHAGTFFDEIQQRHGLANSISSYLIKPVQRVTKYQLLLKELLTCCEEGKGELKDGLEV
MLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFLFEI
SLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLK
ASNIETKQEWIKNIREVIQERIIHLKGALKEPIQLPKTPAKLRNNSKRDGVEDGDSQG
DGSSQPDTISIASRTSQNTVESDKLSGGCELTVVLQDFSAAHSSELSIQVGQTVELLE
RPSERPGWCLVRTTERSPPQEGLVPSSTLCISHSRSSVEMDCFFPLVKDSYSHSSGEN
GGKSESVANLQSQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRLNSGKADGNIKKQKKV
RDGRKSFDLGSPKPGDETTPQGDSADEKSKKGWGEDEPDEESHTPLPPPMKIFDNDPT
QDEMSSLLAARQAPTDVPTAADLVSAIEKLVKSKLTLEGGSYRGSLKDPTVCLNEGMA
PPTPPRNLEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDM
RGKEKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKP
RSEYIVAEYDAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLEC
SDIEKAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRT
KERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEEDVDDDPCKFALMNRET
SERVILQAANSDIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERSTAVIRSQPPRV
PQASPRPYSSVPVGSEKPPKGSSYNPPLPPLKISTSNGSPGFDYHQPGDKFDASKQND
LGGCNGTSTMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEG
WVPGSILAPLTKATAPAESSDESIKKSCSWHTLRMRKRADVENTGKNEATGPRKPKDI
LGNKASVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVL
LQCKACGRPKPTITWKGPDQNILDTDNSSATYTISSCDSGESTLKICNLMPQDSGIYT
CIATNDHGTASTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPASTGNCTISGYTV
EYREEGSQVWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVHLP
EYDAAADGATISWKENFDSAYTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKK
KEQAAHEAALLQHLQHPQYVTLHDTYESPTSYILILELMDDGRLLDYLMNHDELMEEK
VAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHI
HHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRV
DFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWLQPHNGSYSKIPLDTS
RLACFIERRKHQNDVRPIPNVKSYIVNRVNQGT"
exon 1..67
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 68..142
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 143..257
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 258..450
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 451..963
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 964..1086
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 1087..1278
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 1279..1410
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 1411..1641
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 1642..1764
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 1765..1956
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 1957..2165
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 2166..2340
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 2341..2536
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 2537..2703
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 2704..2823
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 2824..3015
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 3016..3165
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 3166..3280
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 3281..3396
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 3397..3519
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 3520..3702
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 3703..3821
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 3822..3888
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 3889..3998
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 3999..4068
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 4069..4158
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 4159..4251
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 4252..4363
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 4364..4554
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 4555..4656
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 4657..4799
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 4800..4902
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 4903..5149
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 5150..5433
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 5434..5538
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 5539..5631
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 5632..5762
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 5763..5829
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 5830..5933
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 5934..6003
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 6004..6090
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 6091..6183
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 6184..6234
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 6235..6312
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 6313..6498
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 6499..6670
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 6671..6909
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 6910..7166
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 7167..7290
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 7291..7350
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 7351..7378
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 7379..7550
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 7551..7672
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 7673..7804
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 7805..7969
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 7970..8048
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 8049..8249
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 8250..8388
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
exon 8389..8980
/gene="Kalrn"
/gene_synonym="Duo; Hapip; Kalirin"
/inference="alignment:Splign:2.1.0"
ORIGIN
1 atgacggacc gcttctggga ccagtggtat ctttggtatc tccgcttgct tcggcttctg
61 gatcgaggat cttttcggaa tgatggtttg aaagcttctg atgtccttcc tatcctaaag
121 gagaaagtgg cctttgtgtc tgggggtcgt gataagcgag gtggacccat cctgaccttc
181 cctgcccgaa ccaatcatga cagaataaga caggaagacc tacggaaact cgtgacgaat
241 ttggccagcg tgccaagcga ggacgtttgc aaacgtggct tcaccgtcat catcgacatg
301 cggggctcca agtgggacct catcaagccc ctcctcaaga cgctgcagga agcctttccc
361 gccgagatcc atgtggccct catcatcaag cctgacaact tctggcagaa gcagaagacc
421 aactttggca gctccaaatt catctttgag acgagcatgg tgtctgtgga gggcctcacg
481 aagctggtgg acccctccca gctgacagaa gagtttgacg gttccctgga ttacaaccac
541 gaggagtgga ttgagttgcg cctctccctg gaggagttct tcaacagtgc ggtccacctg
601 ctctcacgcc tcgaggacct gcaggagatg ctggcccgga aggagttccc tgtggatgtg
661 gagggctctc ggaggcttat cgacgagcac acacaactta agaaaaaggt gctgaaggcc
721 cccgtggaag agctggaccg ggaggggcag cggctactgc agtgtatccg ctgcagtgat
781 ggcttctcag ggcgcaactg catcccagga agtgccgact tccagagcct tgtacccaag
841 atcaccagcc tcctggacaa gctgcattcc acccgacaac acctgcacca gatgtggcac
901 gtccgaaagc tcaagctgga tcagtgcttc cagctgcggc tcttcgagca ggatgccgag
961 aagatgttcg actggataag ccacaacaag gagttatttc ttcagagcca cacagagatc
1021 ggagtcagct accagcatgc actagacctc cagacacagc acaatcactt tgccatgaac
1081 tccatgaatg cctatgtcaa catcaaccgc atcatgtctg tcgcatcccg cctctcagag
1141 gctggccatt atgcctccca gcaaatcaag cagatctcca cgcagctaga ccaggagtgg
1201 aagagctttg ctgctgccct ggatgaacgc agtacaatcc tggccatgtc tgctgtgttc
1261 caccagaagg cagagcagtt cctgtcagga gtggatgcct ggtgtaagat gtgcagtgaa
1321 ggcggccttc cttctgagat gcaggacctg gagctggcaa tccaccatca ccagtccttg
1381 tatgagcagg tgacccaggc ctacacagag gtcagccagg atgggaaagc actcctggat
1441 gtcctgcagc gtcccctgag ccctgggaac tccgagtccc tcacagccac agccaactac
1501 tccaaggcgg tacaccaggt gctggatgtg gtacatgagg tgctgcacca ccagcggcgg
1561 ctcgagagca tctggcagca ccgtaaagtg cggcttcacc agcggctgca gctgtgcgtc
1621 ttccagcagg atgtgcagca ggtgctggac tggattgaaa accacggtga ggcctttctc
1681 agcaaacaca ctggggtcgg caagtccctg catcgggcac gggcattgca gaagaggcat
1741 gatgactttg aagaggtggc tcagaataca tacaccaatg cggacaagct cctagaggca
1801 gcagagcagc tggctcagac tggggaatgt gacccggaag agatctacaa ggctgcccga
1861 cacctggagg tgcgcatcca agacttcgtg cgcagagtgg agcagcggaa gcttcttctg
1921 gacatgtccg tctctttcca cacgcacacc aaagagctgt ggacatggat ggaagacctt
1981 cagaaggagg tgctggagga tgtctgtgca gactctgtgg atgcggtcca ggaactgatc
2041 aagcagttcc agcagcagca gaccgctacc ctggacgcca ctctcaacgt catcaaggaa
2101 ggcgaagacc ttatccagca gctcaggtca gcgcctccct ccctggggga gcccaccgag
2161 gccagggact cagctgtatc caacaacaag acgccccaca gtagttccat cagccatatc
2221 gagtctgtcc tccagcagct ggacgatgct caggtacaga tggaggagct gtttcacgag
2281 cggaagatca agctggacat cttcctgcag ctgcgcatct tcgaacagta caccattgag
2341 gtcaccgcag agctggatgc ctggaatgag gacttgctcc ggcagatgaa tgacttcaac
2401 acagaggacc tgaccctggc agagcagcgg ctacagcgcc acacagaacg gaagcttgcc
2461 atgaacaaca tgacattcga ggtcatccag cagggccagg acctgcacca atatatcatg
2521 gaagtccaag cctcaggaat cgagttaatc tgtgagaagg acgttgacct ggcagctcag
2581 gtgcaagagc tactggaatt tctccatgag aagcagcacg aactggagct caatgcggag
2641 cagacgcaca agcggctaga gcagtgtctc cagctgcggc acctccaggc tgaggtcaaa
2701 caggttctgg gatggatccg caatggagag tccatgctca acgccagcct ggtcaatgcc
2761 agctctttgt ctgaggcaga gcagctacag cgggagcacg aacagttcca gctagccatc
2821 gagaagacgc accagagcgc cctgcaggta cagcagaagg cagaggcact gctccaggcc
2881 ggccactatg acgccgatgc tatccgggaa tgtgcggaga aggtggccct ccactggcaa
2941 cagctcatgc taaagatgga ggaccggctg aaactcgtca atgcctctgt ggccttttac
3001 aagacctctg agcaggtgtg cagcgttctg gagagcttag agcaggagta ccggagagac
3061 gaagactggt gcggcgggag agacaagctg gggccggcgg cagagatgga ccacgtcatt
3121 ccactcctca gcaagcatct ggagcagaag gaggccttcc tgaaggcctg cactctggca
3181 cggcggaatg ccgaggtgtt cctcaagtac atccacagga acaatgtgag catgcccagt
3241 gttgccagcc acaccagggg acccgaacag caagtaaaag ccatcttgag tgagctcttg
3301 cagagagaga atcgcgtcct gcacttctgg accttgaaga agcggcggtt agaccagtgt
3361 cagcaatatg tggtgtttga acgcagtgct aaacaggcac tagactggat ccaagaaaca
3421 ggagaatatt acctctcaac ccatacctcc actggagaga ccacagagga gactcaggag
3481 ctgctgaaag agtatggaga attcagggtg cctgccaagc aaacaaaaga gaaggtgaag
3541 cttctgatcc agctagcaga cagctttgtg gaaaagggcc acatccatgc cacagagata
3601 cggaaatggg tgaccacggt ggacaagcac taccgggatt tctccctgag gatggggaag
3661 taccggtaca ccctggagaa agccctggga gtcaacacgg aggataacaa ggacctagag
3721 ctggacatta tcccagcaag cctttcagac cgggaggtca agctccggga tgctaaccac
3781 gaggtcaatg aagagaaacg gaagtcagct cgaaagaaag aattcattat ggctgaactg
3841 ctccagaccg agaaggctta tgtaagagac ctacacgagt gcttggagac ctacctgtgg
3901 gaaatgacca gtggtgtgga agagatacca cctgggatcc tcaataagga gcacatcatc
3961 ttcggcaaca tccaggagat ctatgacttc cacaacaaca tcttcctcaa agagctggag
4021 aagtacgagc agctgcctga ggatgtggga cactgctttg ttacctgggc agacaaattt
4081 cagatgtatg tcacctactg taaaaacaag cctgattcca accagctgat cctggagcac
4141 gcaggcacct tctttgatga gatccagcag cggcacgggc tggccaactc catctcttcc
4201 tacttaatta agcctgtcca gagagttacg aagtaccagc tgctcctgaa ggaactttta
4261 acttgctgtg aagaagggaa aggggagctc aaggatggcc tggaggtgat gctcagtgtc
4321 cccaagaaag ccaatgatgc catgcatgtc agcatgcttg aagggttcga tgagaacttg
4381 gatgtacagg gggagttgat tctccaggat gcctttcaag tgtgggaccc aaagtcgctg
4441 atccggaagg ggcgggaacg gcatctgttc ctctttgaga tctccttggt gtttagcaaa
4501 gagatcaaag actcttcagg acacacgaaa tatgtttaca agaacaagct actgacctca
4561 gagctgggtg tgaccgagca cgtagaaggt gacccctgca aattcgcctt gtggtctggg
4621 cgcaccccat cctcagacaa taaaacagtg ctcaaagctt ccaacatcga aaccaagcag
4681 gaatggatca agaacattcg ggaagtgatt caggaaagga tcattcatct taaaggagct
4741 ttaaaggagc caatccagct ccccaaaaca ccagccaaac tgaggaacaa tagtaagagg
4801 gatggggtag aggatggtga cagccagggg gacgggagca gccagcccga taccatatcc
4861 attgcctcca ggacctctca gaacacagtg gagagtgaca agctctcagg tggatgtgag
4921 ctgaccgtgg tcctccagga cttcagcgcg gcccacagca gtgagctgag catccaggtg
4981 gggcagactg tggagctgtt ggaacgaccc agtgagagac ccggctggtg tctggtccgc
5041 accacagagc ggagcccccc acaggaaggc ctggtcccca gcagcacctt gtgcatctca
5101 cactcgagaa gcagcgtgga aatggactgc ttcttccccc tggtgaaaga ttcatactct
5161 cattcctccg gtgagaatgg aggcaagtct gagtccgtgg ccaacctgca gtctcagccc
5221 tccctgaact ccatccacag ttcccctggt cccaagcgct ccaccaacac ccttaagaag
5281 tggctgacga gccctgtgcg tcggctcaac agcgggaaag cagacggaaa catcaaaaag
5341 cagaagaaag tacgggatgg gcggaagagc ttcgacctgg gctcacccaa gccaggggac
5401 gagacaaccc ctcagggaga cagcgctgat gagaagagca agaaaggttg gggagaagat
5461 gagccagatg aagagtcaca cacacctctc cccccgccca tgaagatctt tgacaacgac
5521 cccacccagg atgagatgtc ctctttgcta gcagcccggc aggctcccac tgacgtgcct
5581 actgctgcag accttgtcag tgcaatagaa aagttggtca aaagtaagct gactctggaa
5641 ggaggctctt accgggggag cttgaaggac cctacagtct gcctgaatga ggggatggcc
5701 cctcccacac ctcctagaaa cctggaagaa gaacagaaag ccaaggctct aagaggcagg
5761 atgtttgtcc tgaatgagtt ggtgcagaca gagaaggact acgtcaagga cctggggatt
5821 gtggtggagg gcttcatgaa aagaatagaa gagaaggggg tccccgagga catgcgaggg
5881 aaggaaaaga tcgtgtttgg aaacatccac cagatttacg actggcataa agattttttc
5941 ctggctgaac tggaaaaatg catccaagag caagacagat tggcccagct cttcattaaa
6001 catgagcgga agctgcacat ctatgtgtgg tactgccaga acaaaccacg ttccgaatac
6061 atcgtggctg aatatgatgc ctactttgag gaggttaaac aagagatcaa tcaaaggctg
6121 acccttagtg acttcctcat caagcccatt cagagaataa caaagtacca gctgctactc
6181 aaggacttcc tgcggtacag cgagaaggct ggtttggagt gttctgatat tgagaaagca
6241 gtggagttaa tgtgccttgt ccccaagcgc tgtaatgaca tgatgaatct gggacgcctg
6301 cagggctttg agggcaccct gaccgcccag ggcaagcttc tacagcagga cacgttctat
6361 gtgattgagc tggatgctgg catgcagtcc cggaccaagg agaggcgtgt gtttctcttt
6421 gagcagattg tcatctttag tgaactgctc cgaaagggat ccctcacccc aggctacatg
6481 ttcaagagga gcatcaagat gaattacttg gttctggaag aagatgtgga tgatgacccc
6541 tgcaaatttg cacttatgaa cagggagact tcagaaaggg tcattctgca ggccgccaac
6601 tcagacatcc agcaggcctg ggtgcaggac atcaaccaag tcctagaaac acagagggac
6661 ttcttaaatg ctctgcagtc acccatcgag tatcagcgga aggagaggag cacagctgtg
6721 atccggtccc agccccctag ggttcctcaa gccagcccca ggccctattc gtctgtccca
6781 gtgggctcag agaaaccccc caagggctcc agctacaacc cgcccctgcc acccctgaaa
6841 atatctacct cgaatggcag tccagggttc gactaccacc agcctgggga caagtttgac
6901 gctagcaagc agaacgacct gggaggctgc aatgggacct caaccatggc cgtaattaaa
6961 gattactatg cactgaagga gaacgaaatc tgtgtgagcc aaggtgaggt ggtccaggtc
7021 ctcgccgtca accagcagaa catgtgtctg gtgtaccagc ctgccagcga ccattcccca
7081 gcagcggagg gctgggtccc aggcagcatc ctggcacccc tcaccaaagc cacagcgccg
7141 gccgagagta gtgatgagag catcaagaag tcatgctcat ggcacactct acgcatgaga
7201 aagcgggcag acgtggagaa cacgggtaaa aatgaagcca cagggcctcg taaacccaag
7261 gatattctgg gcaacaaagc ctctgttaaa gagacgaaca gttccgagga gtcagagtgt
7321 gatgatcttg accctaatac tagtatggag atcttgaatc cgaatttcat ccaggaagtg
7381 gctccggaat tccttgtgcc cttggtagat gtgacctgct tgctcggaga cacagtactg
7441 ctacagtgca aagcctgtgg gcggccaaag cctaccatca cctggaaggg tccagatcag
7501 aacatcctag acaccgacaa cagttcagcc acatacacca tctcctcctg tgattctggg
7561 gaaagcaccc tcaagatctg caacctgatg ccccaagaca gcgggattta tacctgcata
7621 gcaacaaatg accacggaac cgcatccacg tctgctacag ttaaggtgca aggtgtaccc
7681 gcagccccca atcgcccaat cgcacaggag aggagctgca cctccgtcat cctccgctgg
7741 ctgcccccag ccagcaccgg aaactgcact atttcggggt acacagtgga gtaccgcgag
7801 gaaggttcgc aggtctggca gcagtcggta gcttcaacct tggacactta cctagtcatt
7861 gaagatctta gtccagggtg cccttatcag ttcagggtca gcgccagcaa cccctgggga
7921 atcagccttc ccagtgagcc ctcggagttt gtgcaccttc cagagtacga tgcagctgct
7981 gatggtgcca ccatttcttg gaaggaaaat tttgattctg cttacaccga actgaacgag
8041 attggcagag gccgtttctc tattgtaaag aaatgcattc acaaagctac ccgcaaagac
8101 gttgctgtga aatttgtgag caagaaaatg aaaaagaagg aacaggctgc gcacgaggcc
8161 gccctgctcc agcacctgca gcacccccag tacgtcaccc tccacgacac ctacgagtcc
8221 cccacatcct acatcctgat tttggaactg atggatgacg gccgactctt ggactaccta
8281 atgaatcacg atgagctgat ggaagaaaag gtagctttct acattcgaga catcatggaa
8341 gctctgcagt accttcacaa ctgcagggtg gcacatttgg acataaagcc tgaaaacctc
8401 ctcattgacc tccggatccc agtgcctcga gtgaaactca tcgacttgga agatgctgtc
8461 cagatctcag gccacttcca catccaccat ctgctgggga accctgagtt tgctgccccg
8521 gaagtgatcc aaggcatccc tgtctccctg ggcacagaca tctggagcat cggggttctg
8581 acctacgtca tgcttagcgg ggtctccccc ttcttagatg agagcaaaga ggagacctgc
8641 atcaacgtgt gcagggtgga cttcagcttc ccccacgaat acttctgcgg tgtaagcaat
8701 gctgccaggg acttcatcaa cgtcatctta caggaagact tccggaggcg gcccacagca
8761 gccacgtgcc tgcagcatcc gtggctgcag ccccacaacg gcagctactc caagatcccc
8821 ttggatacct cccgcctggc ctgcttcata gagcgccgca agcaccagaa tgacgtgcgg
8881 cccattccca atgtcaaaag ttacatcgtc aacagggtga accaggggac ctagctatcc
8941 caccgtccct ccaccccgag gtttcacata gacgtgcagt
//