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Rattus norvegicus kalirin, RhoGEF kinase (Kalrn), mRNA

NCBI Reference Sequence: NM_032062.2

FASTA Graphics 

LOCUS       NM_032062               8980 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus kalirin, RhoGEF kinase (Kalrn), mRNA.
ACCESSION   NM_032062
VERSION     NM_032062.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8980)
  AUTHORS   Huang,H., Chen,L., Yuan,J., Zhang,H., Yang,J., Xu,Z. and Chen,Y.
  TITLE     Role and mechanism of EphB3 in epileptic seizures and
            epileptogenesis through Kalirin
  JOURNAL   Mol Cell Neurosci 128, 103915 (2024)
   PUBMED   38143048
  REMARK    GeneRIF: Role and mechanism of EphB3 in epileptic seizures and
            epileptogenesis through Kalirin.
REFERENCE   2  (bases 1 to 8980)
  AUTHORS   Wang,X., Weng,M., Ke,Y., Sapp,E., DiFiglia,M. and Li,X.
  TITLE     Kalirin Interacts with TRAPP and Regulates Rab11 and Endosomal
            Recycling
  JOURNAL   Cells 9 (5), 1132 (2020)
   PUBMED   32375403
  REMARK    GeneRIF: Kalirin Interacts with TRAPP and Regulates Rab11 and
            Endosomal Recycling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8980)
  AUTHORS   Paskus,J.D., Tian,C., Fingleton,E., Shen,C., Chen,X., Li,Y.,
            Myers,S.A., Badger,J.D. 2nd, Bemben,M.A., Herring,B.E. and
            Roche,K.W.
  TITLE     Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF
            Protein-Dependent Neuroligin-1 Mechanism of Action
  JOURNAL   Cell Rep 29 (10), 2944-2952 (2019)
   PUBMED   31801062
REFERENCE   4  (bases 1 to 8980)
  AUTHORS   Li,M.X., Qiao,H., Zhang,M. and Ma,X.M.
  TITLE     Role of Cdk5 in Kalirin7-Mediated Formation of Dendritic Spines
  JOURNAL   Neurochem Res 44 (5), 1243-1251 (2019)
   PUBMED   30875016
  REMARK    GeneRIF: that Cdk5 affects the function of Kal-7 on spine
            morphology and function via GluN2B and GluA1 receptors during
            dendritic spine formation
REFERENCE   5  (bases 1 to 8980)
  AUTHORS   Xie,Z., Shapiro,L.P., Cahill,M.E., Russell,T.A., Lacor,P.N.,
            Klein,W.L. and Penzes,P.
  TITLE     Kalirin-7 prevents dendritic spine dysgenesis induced by amyloid
            beta-derived oligomers
  JOURNAL   Eur J Neurosci 49 (9), 1091-1101 (2019)
   PUBMED   30565792
  REMARK    GeneRIF: our results suggest that kalirin-7 may play a role in the
            early events leading to synapse degeneration
REFERENCE   6  (bases 1 to 8980)
  AUTHORS   Penzes,P., Johnson,R.C., Alam,M.R., Kambampati,V., Mains,R.E. and
            Eipper,B.A.
  TITLE     An isoform of kalirin, a brain-specific GDP/GTP exchange factor, is
            enriched in the postsynaptic density fraction
  JOURNAL   J Biol Chem 275 (9), 6395-6403 (2000)
   PUBMED   10692441
REFERENCE   7  (bases 1 to 8980)
  AUTHORS   Mains,R.E., Alam,M.R., Johnson,R.C., Darlington,D.N., Back,N.,
            Hand,T.A. and Eipper,B.A.
  TITLE     Kalirin, a multifunctional PAM COOH-terminal domain interactor
            protein, affects cytoskeletal organization and ACTH secretion from
            AtT-20 cells
  JOURNAL   J Biol Chem 274 (5), 2929-2937 (1999)
   PUBMED   9915831
REFERENCE   8  (bases 1 to 8980)
  AUTHORS   Colomer,V., Engelender,S., Sharp,A.H., Duan,K., Cooper,J.K.,
            Lanahan,A., Lyford,G., Worley,P. and Ross,C.A.
  TITLE     Huntingtin-associated protein 1 (HAP1) binds to a Trio-like
            polypeptide, with a rac1 guanine nucleotide exchange factor domain
  JOURNAL   Hum Mol Genet 6 (9), 1519-1525 (1997)
   PUBMED   9285789
REFERENCE   9  (bases 1 to 8980)
  AUTHORS   Alam,M.R., Johnson,R.C., Darlington,D.N., Hand,T.A., Mains,R.E. and
            Eipper,B.A.
  TITLE     Kalirin, a cytosolic protein with spectrin-like and GDP/GTP
            exchange factor-like domains that interacts with peptidylglycine
            alpha-amidating monooxygenase, an integral membrane
            peptide-processing enzyme
  JOURNAL   J Biol Chem 272 (19), 12667-12675 (1997)
   PUBMED   9139723
REFERENCE   10 (bases 1 to 8980)
  AUTHORS   Alam,M.R., Caldwell,B.D., Johnson,R.C., Darlington,D.N., Mains,R.E.
            and Eipper,B.A.
  TITLE     Novel proteins that interact with the COOH-terminal cytosolic
            routing determinants of an integral membrane peptide-processing
            enzyme
  JOURNAL   J Biol Chem 271 (45), 28636-28640 (1996)
   PUBMED   8910496
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF230644.1 and AF232669.1.
            
            On Apr 23, 2010 this sequence version replaced NM_032062.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-399               AF230644.1         1-399
            400-8980            AF232669.1         370-8950
FEATURES             Location/Qualifiers
     source          1..8980
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..8980
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /note="kalirin, RhoGEF kinase"
                     /db_xref="GeneID:84009"
                     /db_xref="RGD:621865"
     CDS             1..8934
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /EC_number="2.7.11.1"
                     /note="P-CIP10; protein Duo; PAM COOH-terminal interactor
                     protein 10; huntingtin-associated protein-interacting
                     protein; serine/threonine kinase with Dbl- and pleckstrin
                     homology domain; serine/threonine-protein kinase with Dbl-
                     and pleckstrin homology domain; huntingtin-associated
                     protein interacting protein (duo); cyclin B1"
                     /codon_start=1
                     /product="kalirin"
                     /protein_id="NP_114451.2"
                     /db_xref="GeneID:84009"
                     /db_xref="RGD:621865"
                     /translation="MTDRFWDQWYLWYLRLLRLLDRGSFRNDGLKASDVLPILKEKVA
                     FVSGGRDKRGGPILTFPARTNHDRIRQEDLRKLVTNLASVPSEDVCKRGFTVIIDMRG
                     SKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMVSVEGLT
                     KLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPV
                     DVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQS
                     LVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFL
                     QSHTEIGVSYQHALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQI
                     STQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDL
                     ELAIHHHQSLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVL
                     DVVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGV
                     GKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEV
                     RIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEVLEDVCADSVDAVQELIKQ
                     FQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPTEARDSAVSNNKTPHSSSISHI
                     ESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMND
                     FNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYIMEVQASGIELICEKDVD
                     LAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLN
                     ASLVNASSLSEAEQLQREHEQFQLAIEKTHQSALQVQQKAEALLQAGHYDADAIRECA
                     EKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKL
                     GPAAEMDHVIPLLSKHLEQKEAFLKACTLARRNAEVFLKYIHRNNVSMPSVASHTRGP
                     EQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEYYLS
                     THTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWV
                     TTVDKHYRDFSLRMGKYRYTLEKALGVNTEDNKDLELDIIPASLSDREVKLRDANHEV
                     NEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHII
                     FGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLIL
                     EHAGTFFDEIQQRHGLANSISSYLIKPVQRVTKYQLLLKELLTCCEEGKGELKDGLEV
                     MLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFLFEI
                     SLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLK
                     ASNIETKQEWIKNIREVIQERIIHLKGALKEPIQLPKTPAKLRNNSKRDGVEDGDSQG
                     DGSSQPDTISIASRTSQNTVESDKLSGGCELTVVLQDFSAAHSSELSIQVGQTVELLE
                     RPSERPGWCLVRTTERSPPQEGLVPSSTLCISHSRSSVEMDCFFPLVKDSYSHSSGEN
                     GGKSESVANLQSQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRLNSGKADGNIKKQKKV
                     RDGRKSFDLGSPKPGDETTPQGDSADEKSKKGWGEDEPDEESHTPLPPPMKIFDNDPT
                     QDEMSSLLAARQAPTDVPTAADLVSAIEKLVKSKLTLEGGSYRGSLKDPTVCLNEGMA
                     PPTPPRNLEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDM
                     RGKEKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKP
                     RSEYIVAEYDAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLEC
                     SDIEKAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRT
                     KERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEEDVDDDPCKFALMNRET
                     SERVILQAANSDIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERSTAVIRSQPPRV
                     PQASPRPYSSVPVGSEKPPKGSSYNPPLPPLKISTSNGSPGFDYHQPGDKFDASKQND
                     LGGCNGTSTMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEG
                     WVPGSILAPLTKATAPAESSDESIKKSCSWHTLRMRKRADVENTGKNEATGPRKPKDI
                     LGNKASVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVL
                     LQCKACGRPKPTITWKGPDQNILDTDNSSATYTISSCDSGESTLKICNLMPQDSGIYT
                     CIATNDHGTASTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPASTGNCTISGYTV
                     EYREEGSQVWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVHLP
                     EYDAAADGATISWKENFDSAYTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKK
                     KEQAAHEAALLQHLQHPQYVTLHDTYESPTSYILILELMDDGRLLDYLMNHDELMEEK
                     VAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHI
                     HHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRV
                     DFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWLQPHNGSYSKIPLDTS
                     RLACFIERRKHQNDVRPIPNVKSYIVNRVNQGT"
     exon            1..67
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            68..142
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            143..257
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            258..450
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            451..963
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1086
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1278
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1410
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1641
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1764
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1956
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2165
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2340
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2536
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2703
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2823
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..3015
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            3016..3165
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            3166..3280
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            3281..3396
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            3397..3519
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            3520..3702
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            3703..3821
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            3822..3888
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            3889..3998
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            3999..4068
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            4069..4158
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            4159..4251
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            4252..4363
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            4364..4554
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            4555..4656
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            4657..4799
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            4800..4902
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            4903..5149
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            5150..5433
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            5434..5538
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            5539..5631
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            5632..5762
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            5763..5829
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            5830..5933
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            5934..6003
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            6004..6090
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            6091..6183
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            6184..6234
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            6235..6312
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            6313..6498
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            6499..6670
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            6671..6909
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            6910..7166
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            7167..7290
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            7291..7350
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            7351..7378
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            7379..7550
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            7551..7672
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            7673..7804
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            7805..7969
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            7970..8048
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            8049..8249
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            8250..8388
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
     exon            8389..8980
                     /gene="Kalrn"
                     /gene_synonym="Duo; Hapip; Kalirin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgacggacc gcttctggga ccagtggtat ctttggtatc tccgcttgct tcggcttctg
       61 gatcgaggat cttttcggaa tgatggtttg aaagcttctg atgtccttcc tatcctaaag
      121 gagaaagtgg cctttgtgtc tgggggtcgt gataagcgag gtggacccat cctgaccttc
      181 cctgcccgaa ccaatcatga cagaataaga caggaagacc tacggaaact cgtgacgaat
      241 ttggccagcg tgccaagcga ggacgtttgc aaacgtggct tcaccgtcat catcgacatg
      301 cggggctcca agtgggacct catcaagccc ctcctcaaga cgctgcagga agcctttccc
      361 gccgagatcc atgtggccct catcatcaag cctgacaact tctggcagaa gcagaagacc
      421 aactttggca gctccaaatt catctttgag acgagcatgg tgtctgtgga gggcctcacg
      481 aagctggtgg acccctccca gctgacagaa gagtttgacg gttccctgga ttacaaccac
      541 gaggagtgga ttgagttgcg cctctccctg gaggagttct tcaacagtgc ggtccacctg
      601 ctctcacgcc tcgaggacct gcaggagatg ctggcccgga aggagttccc tgtggatgtg
      661 gagggctctc ggaggcttat cgacgagcac acacaactta agaaaaaggt gctgaaggcc
      721 cccgtggaag agctggaccg ggaggggcag cggctactgc agtgtatccg ctgcagtgat
      781 ggcttctcag ggcgcaactg catcccagga agtgccgact tccagagcct tgtacccaag
      841 atcaccagcc tcctggacaa gctgcattcc acccgacaac acctgcacca gatgtggcac
      901 gtccgaaagc tcaagctgga tcagtgcttc cagctgcggc tcttcgagca ggatgccgag
      961 aagatgttcg actggataag ccacaacaag gagttatttc ttcagagcca cacagagatc
     1021 ggagtcagct accagcatgc actagacctc cagacacagc acaatcactt tgccatgaac
     1081 tccatgaatg cctatgtcaa catcaaccgc atcatgtctg tcgcatcccg cctctcagag
     1141 gctggccatt atgcctccca gcaaatcaag cagatctcca cgcagctaga ccaggagtgg
     1201 aagagctttg ctgctgccct ggatgaacgc agtacaatcc tggccatgtc tgctgtgttc
     1261 caccagaagg cagagcagtt cctgtcagga gtggatgcct ggtgtaagat gtgcagtgaa
     1321 ggcggccttc cttctgagat gcaggacctg gagctggcaa tccaccatca ccagtccttg
     1381 tatgagcagg tgacccaggc ctacacagag gtcagccagg atgggaaagc actcctggat
     1441 gtcctgcagc gtcccctgag ccctgggaac tccgagtccc tcacagccac agccaactac
     1501 tccaaggcgg tacaccaggt gctggatgtg gtacatgagg tgctgcacca ccagcggcgg
     1561 ctcgagagca tctggcagca ccgtaaagtg cggcttcacc agcggctgca gctgtgcgtc
     1621 ttccagcagg atgtgcagca ggtgctggac tggattgaaa accacggtga ggcctttctc
     1681 agcaaacaca ctggggtcgg caagtccctg catcgggcac gggcattgca gaagaggcat
     1741 gatgactttg aagaggtggc tcagaataca tacaccaatg cggacaagct cctagaggca
     1801 gcagagcagc tggctcagac tggggaatgt gacccggaag agatctacaa ggctgcccga
     1861 cacctggagg tgcgcatcca agacttcgtg cgcagagtgg agcagcggaa gcttcttctg
     1921 gacatgtccg tctctttcca cacgcacacc aaagagctgt ggacatggat ggaagacctt
     1981 cagaaggagg tgctggagga tgtctgtgca gactctgtgg atgcggtcca ggaactgatc
     2041 aagcagttcc agcagcagca gaccgctacc ctggacgcca ctctcaacgt catcaaggaa
     2101 ggcgaagacc ttatccagca gctcaggtca gcgcctccct ccctggggga gcccaccgag
     2161 gccagggact cagctgtatc caacaacaag acgccccaca gtagttccat cagccatatc
     2221 gagtctgtcc tccagcagct ggacgatgct caggtacaga tggaggagct gtttcacgag
     2281 cggaagatca agctggacat cttcctgcag ctgcgcatct tcgaacagta caccattgag
     2341 gtcaccgcag agctggatgc ctggaatgag gacttgctcc ggcagatgaa tgacttcaac
     2401 acagaggacc tgaccctggc agagcagcgg ctacagcgcc acacagaacg gaagcttgcc
     2461 atgaacaaca tgacattcga ggtcatccag cagggccagg acctgcacca atatatcatg
     2521 gaagtccaag cctcaggaat cgagttaatc tgtgagaagg acgttgacct ggcagctcag
     2581 gtgcaagagc tactggaatt tctccatgag aagcagcacg aactggagct caatgcggag
     2641 cagacgcaca agcggctaga gcagtgtctc cagctgcggc acctccaggc tgaggtcaaa
     2701 caggttctgg gatggatccg caatggagag tccatgctca acgccagcct ggtcaatgcc
     2761 agctctttgt ctgaggcaga gcagctacag cgggagcacg aacagttcca gctagccatc
     2821 gagaagacgc accagagcgc cctgcaggta cagcagaagg cagaggcact gctccaggcc
     2881 ggccactatg acgccgatgc tatccgggaa tgtgcggaga aggtggccct ccactggcaa
     2941 cagctcatgc taaagatgga ggaccggctg aaactcgtca atgcctctgt ggccttttac
     3001 aagacctctg agcaggtgtg cagcgttctg gagagcttag agcaggagta ccggagagac
     3061 gaagactggt gcggcgggag agacaagctg gggccggcgg cagagatgga ccacgtcatt
     3121 ccactcctca gcaagcatct ggagcagaag gaggccttcc tgaaggcctg cactctggca
     3181 cggcggaatg ccgaggtgtt cctcaagtac atccacagga acaatgtgag catgcccagt
     3241 gttgccagcc acaccagggg acccgaacag caagtaaaag ccatcttgag tgagctcttg
     3301 cagagagaga atcgcgtcct gcacttctgg accttgaaga agcggcggtt agaccagtgt
     3361 cagcaatatg tggtgtttga acgcagtgct aaacaggcac tagactggat ccaagaaaca
     3421 ggagaatatt acctctcaac ccatacctcc actggagaga ccacagagga gactcaggag
     3481 ctgctgaaag agtatggaga attcagggtg cctgccaagc aaacaaaaga gaaggtgaag
     3541 cttctgatcc agctagcaga cagctttgtg gaaaagggcc acatccatgc cacagagata
     3601 cggaaatggg tgaccacggt ggacaagcac taccgggatt tctccctgag gatggggaag
     3661 taccggtaca ccctggagaa agccctggga gtcaacacgg aggataacaa ggacctagag
     3721 ctggacatta tcccagcaag cctttcagac cgggaggtca agctccggga tgctaaccac
     3781 gaggtcaatg aagagaaacg gaagtcagct cgaaagaaag aattcattat ggctgaactg
     3841 ctccagaccg agaaggctta tgtaagagac ctacacgagt gcttggagac ctacctgtgg
     3901 gaaatgacca gtggtgtgga agagatacca cctgggatcc tcaataagga gcacatcatc
     3961 ttcggcaaca tccaggagat ctatgacttc cacaacaaca tcttcctcaa agagctggag
     4021 aagtacgagc agctgcctga ggatgtggga cactgctttg ttacctgggc agacaaattt
     4081 cagatgtatg tcacctactg taaaaacaag cctgattcca accagctgat cctggagcac
     4141 gcaggcacct tctttgatga gatccagcag cggcacgggc tggccaactc catctcttcc
     4201 tacttaatta agcctgtcca gagagttacg aagtaccagc tgctcctgaa ggaactttta
     4261 acttgctgtg aagaagggaa aggggagctc aaggatggcc tggaggtgat gctcagtgtc
     4321 cccaagaaag ccaatgatgc catgcatgtc agcatgcttg aagggttcga tgagaacttg
     4381 gatgtacagg gggagttgat tctccaggat gcctttcaag tgtgggaccc aaagtcgctg
     4441 atccggaagg ggcgggaacg gcatctgttc ctctttgaga tctccttggt gtttagcaaa
     4501 gagatcaaag actcttcagg acacacgaaa tatgtttaca agaacaagct actgacctca
     4561 gagctgggtg tgaccgagca cgtagaaggt gacccctgca aattcgcctt gtggtctggg
     4621 cgcaccccat cctcagacaa taaaacagtg ctcaaagctt ccaacatcga aaccaagcag
     4681 gaatggatca agaacattcg ggaagtgatt caggaaagga tcattcatct taaaggagct
     4741 ttaaaggagc caatccagct ccccaaaaca ccagccaaac tgaggaacaa tagtaagagg
     4801 gatggggtag aggatggtga cagccagggg gacgggagca gccagcccga taccatatcc
     4861 attgcctcca ggacctctca gaacacagtg gagagtgaca agctctcagg tggatgtgag
     4921 ctgaccgtgg tcctccagga cttcagcgcg gcccacagca gtgagctgag catccaggtg
     4981 gggcagactg tggagctgtt ggaacgaccc agtgagagac ccggctggtg tctggtccgc
     5041 accacagagc ggagcccccc acaggaaggc ctggtcccca gcagcacctt gtgcatctca
     5101 cactcgagaa gcagcgtgga aatggactgc ttcttccccc tggtgaaaga ttcatactct
     5161 cattcctccg gtgagaatgg aggcaagtct gagtccgtgg ccaacctgca gtctcagccc
     5221 tccctgaact ccatccacag ttcccctggt cccaagcgct ccaccaacac ccttaagaag
     5281 tggctgacga gccctgtgcg tcggctcaac agcgggaaag cagacggaaa catcaaaaag
     5341 cagaagaaag tacgggatgg gcggaagagc ttcgacctgg gctcacccaa gccaggggac
     5401 gagacaaccc ctcagggaga cagcgctgat gagaagagca agaaaggttg gggagaagat
     5461 gagccagatg aagagtcaca cacacctctc cccccgccca tgaagatctt tgacaacgac
     5521 cccacccagg atgagatgtc ctctttgcta gcagcccggc aggctcccac tgacgtgcct
     5581 actgctgcag accttgtcag tgcaatagaa aagttggtca aaagtaagct gactctggaa
     5641 ggaggctctt accgggggag cttgaaggac cctacagtct gcctgaatga ggggatggcc
     5701 cctcccacac ctcctagaaa cctggaagaa gaacagaaag ccaaggctct aagaggcagg
     5761 atgtttgtcc tgaatgagtt ggtgcagaca gagaaggact acgtcaagga cctggggatt
     5821 gtggtggagg gcttcatgaa aagaatagaa gagaaggggg tccccgagga catgcgaggg
     5881 aaggaaaaga tcgtgtttgg aaacatccac cagatttacg actggcataa agattttttc
     5941 ctggctgaac tggaaaaatg catccaagag caagacagat tggcccagct cttcattaaa
     6001 catgagcgga agctgcacat ctatgtgtgg tactgccaga acaaaccacg ttccgaatac
     6061 atcgtggctg aatatgatgc ctactttgag gaggttaaac aagagatcaa tcaaaggctg
     6121 acccttagtg acttcctcat caagcccatt cagagaataa caaagtacca gctgctactc
     6181 aaggacttcc tgcggtacag cgagaaggct ggtttggagt gttctgatat tgagaaagca
     6241 gtggagttaa tgtgccttgt ccccaagcgc tgtaatgaca tgatgaatct gggacgcctg
     6301 cagggctttg agggcaccct gaccgcccag ggcaagcttc tacagcagga cacgttctat
     6361 gtgattgagc tggatgctgg catgcagtcc cggaccaagg agaggcgtgt gtttctcttt
     6421 gagcagattg tcatctttag tgaactgctc cgaaagggat ccctcacccc aggctacatg
     6481 ttcaagagga gcatcaagat gaattacttg gttctggaag aagatgtgga tgatgacccc
     6541 tgcaaatttg cacttatgaa cagggagact tcagaaaggg tcattctgca ggccgccaac
     6601 tcagacatcc agcaggcctg ggtgcaggac atcaaccaag tcctagaaac acagagggac
     6661 ttcttaaatg ctctgcagtc acccatcgag tatcagcgga aggagaggag cacagctgtg
     6721 atccggtccc agccccctag ggttcctcaa gccagcccca ggccctattc gtctgtccca
     6781 gtgggctcag agaaaccccc caagggctcc agctacaacc cgcccctgcc acccctgaaa
     6841 atatctacct cgaatggcag tccagggttc gactaccacc agcctgggga caagtttgac
     6901 gctagcaagc agaacgacct gggaggctgc aatgggacct caaccatggc cgtaattaaa
     6961 gattactatg cactgaagga gaacgaaatc tgtgtgagcc aaggtgaggt ggtccaggtc
     7021 ctcgccgtca accagcagaa catgtgtctg gtgtaccagc ctgccagcga ccattcccca
     7081 gcagcggagg gctgggtccc aggcagcatc ctggcacccc tcaccaaagc cacagcgccg
     7141 gccgagagta gtgatgagag catcaagaag tcatgctcat ggcacactct acgcatgaga
     7201 aagcgggcag acgtggagaa cacgggtaaa aatgaagcca cagggcctcg taaacccaag
     7261 gatattctgg gcaacaaagc ctctgttaaa gagacgaaca gttccgagga gtcagagtgt
     7321 gatgatcttg accctaatac tagtatggag atcttgaatc cgaatttcat ccaggaagtg
     7381 gctccggaat tccttgtgcc cttggtagat gtgacctgct tgctcggaga cacagtactg
     7441 ctacagtgca aagcctgtgg gcggccaaag cctaccatca cctggaaggg tccagatcag
     7501 aacatcctag acaccgacaa cagttcagcc acatacacca tctcctcctg tgattctggg
     7561 gaaagcaccc tcaagatctg caacctgatg ccccaagaca gcgggattta tacctgcata
     7621 gcaacaaatg accacggaac cgcatccacg tctgctacag ttaaggtgca aggtgtaccc
     7681 gcagccccca atcgcccaat cgcacaggag aggagctgca cctccgtcat cctccgctgg
     7741 ctgcccccag ccagcaccgg aaactgcact atttcggggt acacagtgga gtaccgcgag
     7801 gaaggttcgc aggtctggca gcagtcggta gcttcaacct tggacactta cctagtcatt
     7861 gaagatctta gtccagggtg cccttatcag ttcagggtca gcgccagcaa cccctgggga
     7921 atcagccttc ccagtgagcc ctcggagttt gtgcaccttc cagagtacga tgcagctgct
     7981 gatggtgcca ccatttcttg gaaggaaaat tttgattctg cttacaccga actgaacgag
     8041 attggcagag gccgtttctc tattgtaaag aaatgcattc acaaagctac ccgcaaagac
     8101 gttgctgtga aatttgtgag caagaaaatg aaaaagaagg aacaggctgc gcacgaggcc
     8161 gccctgctcc agcacctgca gcacccccag tacgtcaccc tccacgacac ctacgagtcc
     8221 cccacatcct acatcctgat tttggaactg atggatgacg gccgactctt ggactaccta
     8281 atgaatcacg atgagctgat ggaagaaaag gtagctttct acattcgaga catcatggaa
     8341 gctctgcagt accttcacaa ctgcagggtg gcacatttgg acataaagcc tgaaaacctc
     8401 ctcattgacc tccggatccc agtgcctcga gtgaaactca tcgacttgga agatgctgtc
     8461 cagatctcag gccacttcca catccaccat ctgctgggga accctgagtt tgctgccccg
     8521 gaagtgatcc aaggcatccc tgtctccctg ggcacagaca tctggagcat cggggttctg
     8581 acctacgtca tgcttagcgg ggtctccccc ttcttagatg agagcaaaga ggagacctgc
     8641 atcaacgtgt gcagggtgga cttcagcttc ccccacgaat acttctgcgg tgtaagcaat
     8701 gctgccaggg acttcatcaa cgtcatctta caggaagact tccggaggcg gcccacagca
     8761 gccacgtgcc tgcagcatcc gtggctgcag ccccacaacg gcagctactc caagatcccc
     8821 ttggatacct cccgcctggc ctgcttcata gagcgccgca agcaccagaa tgacgtgcgg
     8881 cccattccca atgtcaaaag ttacatcgtc aacagggtga accaggggac ctagctatcc
     8941 caccgtccct ccaccccgag gtttcacata gacgtgcagt
//
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