LOCUS NM_133663 5662 bp mRNA linear ROD 11-DEC-2024
DEFINITION Mus musculus integrin beta 4 (Itgb4), transcript variant 2, mRNA.
ACCESSION NM_133663 NM_001005607
VERSION NM_133663.3
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 5662)
AUTHORS Liu,H., Su,P., Li,Y., Hoover,A., Hu,S., King,S.A., Zhao,J.,
Guan,J.L., Chen,S.Y., Zhao,Y., Tan,M. and Wu,X.
TITLE VAMP2 controls murine epidermal differentiation and carcinogenesis
by regulation of nucleophagy
JOURNAL Dev Cell 59 (15), 2005-2016 (2024)
PUBMED 38810653
REFERENCE 2 (bases 1 to 5662)
AUTHORS Ayyangar,U., Karkhanis,A., Tay,H., Afandi,A.F.B., Bhattacharjee,O.,
Ks,L., Lee,S.H., Chan,J. and Raghavan,S.
TITLE Metabolic rewiring of macrophages by epidermal-derived lactate
promotes sterile inflammation in the murine skin
JOURNAL EMBO J 43 (7), 1113-1134 (2024)
PUBMED 38418556
REFERENCE 3 (bases 1 to 5662)
AUTHORS Schwartz,B., Levi,H., Menon,G., Maria,R., Upcher,A., Kotlovski,Y.,
Oss-Ronen,L. and Cohen,I.
TITLE ZNF750 Regulates Skin Barrier Function by Driving Cornified
Envelope and Lipid Processing Pathways
JOURNAL J Invest Dermatol 144 (2), 296-306 (2024)
PUBMED 37660780
REFERENCE 4 (bases 1 to 5662)
AUTHORS Zhou,R., Wang,Q., Zeng,S., Liang,Y. and Wang,D.
TITLE METTL14-mediated N6-methyladenosine modification of
Col17a1/Itgalpha6/Itgbeta4 governs epidermal homeostasis
JOURNAL J Dermatol Sci 112 (3), 138-147 (2023)
PUBMED 37951776
REFERENCE 5 (bases 1 to 5662)
AUTHORS Chen,Y., Jiang,W., Wang,J.M., Ma,X.D., Wu,D., Liu,L.X., Ji,M.,
Qu,X.P., Liu,C., Liu,H.J., Qin,X.Q. and Xiang,Y.
TITLE Conditional knockout of ITGB4 in bronchial epithelial cells directs
bronchopulmonary dysplasia
JOURNAL J Cell Mol Med 27 (23), 3760-3772 (2023)
PUBMED 37698050
REMARK GeneRIF: Conditional knockout of ITGB4 in bronchial epithelial
cells directs bronchopulmonary dysplasia.
REFERENCE 6 (bases 1 to 5662)
AUTHORS Morse,H.C. 3rd.
TITLE Genetic nomenclature for loci controlling surface antigens of mouse
hemopoietic cells
JOURNAL J Immunol 149 (10), 3129-3134 (1992)
PUBMED 1431091
REMARK Review article
Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE 7 (bases 1 to 5662)
AUTHORS Gomez,M., Navarro,P., Quintanilla,M. and Cano,A.
TITLE Expression of alpha 6 beta 4 integrin increases during malignant
conversion of mouse epidermal keratinocytes: association of beta 4
subunit to the cytokeratin fraction
JOURNAL Exp Cell Res 201 (2), 250-261 (1992)
PUBMED 1379191
REFERENCE 8 (bases 1 to 5662)
AUTHORS Wadsworth,S., Halvorson,M.J. and Coligan,J.E.
TITLE Developmentally regulated expression of the beta 4 integrin on
immature mouse thymocytes
JOURNAL J Immunol 149 (2), 421-428 (1992)
PUBMED 1385605
REFERENCE 9 (bases 1 to 5662)
AUTHORS Kennel,S.J., Godfrey,V., Ch'ang,L.Y., Lankford,T.K., Foote,L.J. and
Makkinje,A.
TITLE The beta 4 subunit of the integrin family is displayed on a
restricted subset of endothelium in mice
JOURNAL J Cell Sci 101 (Pt 1), 145-150 (1992)
PUBMED 1569120
REFERENCE 10 (bases 1 to 5662)
AUTHORS Sonnenberg,A., Linders,C.J., Daams,J.H. and Kennel,S.J.
TITLE The alpha 6 beta 1 (VLA-6) and alpha 6 beta 4 protein complexes:
tissue distribution and biochemical properties
JOURNAL J Cell Sci 96 (Pt 2), 207-217 (1990)
PUBMED 1698797
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AL645647.8 and AL607108.17.
On Apr 20, 2022 this sequence version replaced NM_133663.2.
Summary: Integrins are heterodimers comprised of alpha and beta
subunits, that are noncovalently associated transmembrane
glycoprotein receptors. Different combinations of alpha and beta
polypeptides form complexes that vary in their ligand-binding
specificities. Integrins mediate cell-matrix or cell-cell adhesion,
and transduced signals that regulate gene expression and cell
growth. This gene encodes the integrin beta 4 subunit, a receptor
for the laminins. This subunit tends to associate with alpha 6
subunit and is likely to play a pivotal role in the biology of
invasive carcinoma. Multiple alternatively spliced transcript
variants encoding distinct isoforms have been found for this gene.
[provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK147424.1, SRR10223971.12412.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849374, SAMN00849375
[ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-81 AL645647.8 137235-137315
82-173 AL645647.8 139947-140038
174-256 AL645647.8 141237-141319
257-358 AL645647.8 141522-141623
359-563 AL645647.8 141775-141979
564-660 AL645647.8 142836-142932
661-832 AL645647.8 143102-143273
833-1096 AL645647.8 144862-145125
1097-1186 AL645647.8 145420-145509
1187-1309 AL645647.8 145804-145926
1310-1474 AL645647.8 146198-146362
1475-1551 AL645647.8 147183-147259
1552-1754 AL607108.17 2974-3176
1755-1858 AL607108.17 4817-4920
1859-1957 AL607108.17 5014-5112
1958-2087 AL607108.17 5247-5376
2088-2207 AL607108.17 6079-6198
2208-2314 AL607108.17 6295-6401
2315-2348 AL607108.17 7032-7065
2349-2540 AL607108.17 7241-7432
2541-2644 AL607108.17 7666-7769
2645-2703 AL607108.17 8015-8073
2704-2727 AL607108.17 8243-8266
2728-2876 AL607108.17 9412-9560
2877-3056 AL607108.17 9634-9813
3057-3205 AL607108.17 10619-10767
3206-3410 AL607108.17 14307-14511
3411-3568 AL607108.17 16155-16312
3569-3749 AL607108.17 16596-16776
3750-3887 AL607108.17 16900-17037
3888-4070 AL607108.17 19699-19881
4071-4202 AL607108.17 19960-20091
4203-4439 AL607108.17 21888-22124
4440-4589 AL607108.17 22818-22967
4590-4778 AL607108.17 23343-23531
4779-4934 AL607108.17 23616-23771
4935-5099 AL607108.17 23858-24022
5100-5210 AL607108.17 24112-24222
5211-5662 AL607108.17 24318-24769
FEATURES Location/Qualifiers
source 1..5662
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="11"
/map="11 80.91 cM"
gene 1..5662
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/note="integrin beta 4"
/db_xref="GeneID:192897"
/db_xref="MGI:MGI:96613"
exon 1..81
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 82..173
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
CDS 92..5350
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/note="isoform 2 precursor is encoded by transcript
variant 2; Integrin beta-4"
/codon_start=1
/product="integrin beta-4 isoform 2 precursor"
/protein_id="NP_598424.2"
/db_xref="GeneID:192897"
/db_xref="MGI:MGI:96613"
/translation="MAGPCCSPWVKLLLLAAMLSASLPGDLANRCKKAQVKSCTECIR
VDKSCAYCTDELFKERRCNTQAELLAAGCRGESILVMESSLEITENTQIDTSLHRSQV
SPQGLQVRLRPGEERSFVFQVFEPLESPVDLYILMDFSNSMSDDLDNLKQMGQNLAKI
LRQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTENVEEFW
NKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLLVFSTESAFHYEADGAN
VLAGIMNRNDEKCHLDASGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYY
EKLHKYFPVSSLGVLQEDSSNIVELLEEAFYRIRSNLDIRALDSPRGLRTEVTSDTLQ
KTETGSFHIKRGEVGTYNVHLRAVEDIDGTHVCQLAKEDQGGNIHLKPSFSDGLRMDA
SVICDVCPCELQKEVRSARCHFRGDFMCGHCVCNEGWSGKTCNCSTGSLSDTQPCLRE
GEDKPCSGHGECQCGRCVCYGEGRYEGHFCEYDNFQCPRTSGFLCNDRGRCSMGECVC
EPGWTGRSCDCPLSNATCIDSNGGICNGRGYCECGRCHCNQQSLYTDTTCEINYSAIR
LGLCEDLRSCVQCQAWGTGEKKGRACDDCPFKVKMVDELKKEEVVEYCSFRDEDDDCT
YSYNVEGDGSPGPNSTVLVHKKKDCPPGSFWWLIPLLIFLLLLLALLLLLCWKYCACC
KACLGLLPCCNRGHMVGFKEDHYMLRENLMASDHLDTPMLRSGNLKGRDTVRWKITNN
VQRPGFATHAASTSPTELVPYGLSLRLGRLCTENLMKPGTRECDQLRQEVEENLNEVY
RQVSGAHKLQQTKFRQQPNTGKKQDHTIVDTVLLAPRSAKQMLLKLTEKQVEQGSFHE
LKVAPGYYTVTAEQDARGMVEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAIDVPVGT
ATLGRRLVNITIIKEQASGVVSFEQPEYSVSRGDQVARIPVIRHILDNGKSQVSYSTQ
DNTAHGHRDYVPVEGELLFHPGETWKELQVKLLELQEVDSLLRGRQVRRFQVQLSNPK
FGARLGQPSTTTVILGEHDETDRSLINQTLSSPPPPHGDLGAPQNPNAKAAGSRKIHF
NWLPPPGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG
EGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVN
EDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIINLATQ
PKRPMSIPIIPDIPIVDAQGGEDYENFLMYSDDVLRSPASSQRPSVSDDTEHLVNGRM
DFAYPGSANSLHRMTAANVAYGTHLSPHLSHRVLSTSSTLTRDYHSLTRTEHSHSGTL
PRDYSTLTSLSSQDSRGAVGVPDTPTRLVFSALGPTSLKVSWQEPQCDRMLLGYSVEY
QLLNGGEMHRLNIPNPGQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQV
HPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDILGYLVTCEM
AQGGAPARTFRVDGDNPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQV
GGPFPQLGSHSGLFQNPVQSEFSSVTSTHSTTTEPFLMDGLTLGTQRLEAGGSLTRHV
TQEFVTRTLTASGSLSTHMDQQFFQT"
sig_peptide 92..175
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="COORDINATES: ab initio prediction:SignalP:6.0"
exon 174..256
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 257..358
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 359..563
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 564..660
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 661..832
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 833..1096
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 1097..1186
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 1187..1309
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 1310..1474
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 1475..1551
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 1552..1754
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 1755..1858
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 1859..1957
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 1958..2087
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 2088..2207
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 2208..2314
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 2315..2348
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 2349..2540
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 2541..2644
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 2645..2703
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 2704..2727
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 2728..2876
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 2877..3056
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 3057..3205
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 3206..3410
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 3411..3568
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 3569..3749
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 3750..3887
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 3888..4070
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 4071..4202
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 4203..4439
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 4440..4589
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 4590..4778
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 4779..4934
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 4935..5099
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 5100..5210
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
exon 5211..5662
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/inference="alignment:Splign:2.1.0"
regulatory 5639..5644
/regulatory_class="polyA_signal_sequence"
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/note="hexamer: AATAAA"
polyA_site 5662
/gene="Itgb4"
/gene_synonym="C230078O20; CD104"
/note="major polyA site"
ORIGIN
1 gcccgccctg ctgtcccgcc gggctcgccc gcgcgctcag ctcgacccaa cgcagcccaa
61 gtccgaggta gtctcactaa ggaggaggag gatggcaggg ccctgttgca gcccatgggt
121 gaagctgctg ctgctggcag caatgctgag tgccagcctc cctggagacc tggccaaccg
181 ctgcaagaag gctcaggtga agagctgtac cgagtgcatc cgggtggaca agagctgtgc
241 ctactgcaca gacgagctgt tcaaggagag gcgctgcaac acccaggcgg agcttctggc
301 tgcaggctgc aggggagaga gcatcctggt catggagagc agccttgaaa tcacagagaa
361 cacccagatc gacaccagcc tgcaccgcag ccaggtatct ccccaaggcc tgcaagtccg
421 gctgcggccg ggtgaggagc gcagctttgt gttccaggtg tttgagcccc tggagagccc
481 cgtggatctg tatatcctca tggacttctc caactccatg tctgacgatc tggacaacct
541 caagcagatg gggcagaacc tggccaagat cctgcgccag ctcaccagcg actacaccat
601 tggatttgga aagtttgtgg acaaagtcag cgtcccacag acagacatga ggcccgagaa
661 actgaaggag ccctggccca acagtgatcc cccgttctcc ttcaagaacg ttatcagctt
721 aacggagaat gtggaagaat tctggaacaa actgcaagga gaacgcatct caggcaacct
781 ggacgctcct gaagggggct ttgatgccat cctgcagaca gctgtgtgca caagggacat
841 tggctggagg gctgacagca cccacctgct ggtgttctcc accgagtctg ccttccacta
901 cgaggctgat ggtgccaacg tgctggccgg catcatgaac cgcaatgatg agaaatgcca
961 cctggacgcc tcgggcgcct acacccaata caagacacag gactacccat cagtgcccac
1021 gctggttcgc ctgcttgcca agcataacat catccccatc tttgctgtca ccaactactc
1081 ttacagctac tatgagaagc tccataagta tttccccgtc tcctctctgg gcgtcctgca
1141 ggaggattca tccaacatcg tggagctgct ggaggaggcc ttctatcgaa ttcgctccaa
1201 cctggacatc cgggctctgg acagccccag aggcctgaga acagaggtca cctccgatac
1261 tctccagaag acggagactg ggtcctttca catcaagcgg ggggaagtgg gcacatacaa
1321 tgtgcatctc cgggcagtgg aggacataga tgggacacat gtgtgccagc tggctaaaga
1381 agaccaaggg ggcaacatcc acctgaaacc ctccttctct gatggcctcc ggatggacgc
1441 gagtgtgatc tgtgacgtgt gcccctgtga gctgcaaaag gaagttcgat cagctcgctg
1501 tcacttcaga ggagacttca tgtgtggaca ctgtgtgtgc aatgagggct ggagtggcaa
1561 aacctgcaac tgctccaccg gctctctgag tgacacacag ccctgcctgc gtgagggtga
1621 ggacaaaccg tgctcgggcc acggcgagtg ccagtgcgga cgctgtgtgt gctatggtga
1681 aggccgctac gagggtcact tctgcgagta tgacaacttc cagtgtcccc ggacctctgg
1741 attcctgtgc aatgaccggg gtcgctgttc tatgggagag tgtgtgtgtg agcctggttg
1801 gacaggccgc agctgtgact gtcccctcag caatgccacc tgcatcgata gcaacggggg
1861 catctgcaac ggccgaggct actgtgagtg tggccgttgt cactgcaacc agcagtcgct
1921 ctacacggac accacctgtg agatcaacta ctctgcgata cgcctgggtc tctgtgagga
1981 tctccgctcc tgcgtacagt gccaggcctg gggcaccggg gagaagaaag ggcgcgcgtg
2041 tgacgattgc ccctttaaag tcaagatggt agacgagctt aagaaagaag aggtggtgga
2101 gtactgctcc ttccgggatg aggatgacga ctgcacttac agctacaacg tggagggcga
2161 tggcagccct gggcccaaca gcacagtcct ggtccacaaa aagaaagact gccctcccgg
2221 ctccttctgg tggctcatcc ccctgctcat cttcctcctg ttgctcctgg cgttgcttct
2281 gctgctctgc tggaaatact gtgcctgctg caaagcctgc ctggggcttc ttccttgctg
2341 caaccgaggt cacatggtgg gctttaagga agatcactat atgcttcggg agaacctgat
2401 ggcctctgac cacctggaca cgcccatgct acgaagcggg aacctcaagg gacgagacac
2461 agtccgctgg aagatcacca acaatgtgca gcgccctggc tttgccaccc atgccgccag
2521 caccagcccc acggagctcg taccctacgg gctgtccctg cgccttggcc gcctctgcac
2581 tgagaacctt atgaagccgg gcacccgaga gtgtgaccag ctacgccagg aggtggagga
2641 aaatctgaat gaggtgtata gacaggtcag cggcgcacac aagctccagc agacgaagtt
2701 ccgacagcag cccaacaccg ggaaaaagca agaccacacc attgtggaca cagtgttgct
2761 ggcgccccgc tccgccaagc agatgctgct gaagctgaca gagaagcagg tggagcaggg
2821 gtccttccat gaactgaagg tggcccctgg ctactacact gtcacggcag agcaggatgc
2881 ccggggcatg gtggagttcc aggagggcgt ggagctggtg gatgtgcgag tgcccctctt
2941 catccggcct gaggatgatg atgagaagca gctgctggtg gaggccattg atgtccctgt
3001 gggcactgcc acccttggtc gccgtctggt aaacatcacc attatcaagg aacaagctag
3061 tggggtagtg tccttcgagc agcctgaata ctcggtgagt cgtggagacc aggtggcccg
3121 catccctgtc atccggcaca tcctggacaa tggcaagtcc caggtctcct atagcacaca
3181 ggataataca gcacacggac accgggatta tgtccctgtg gagggagagc tgctgttcca
3241 tcctggggag acctggaagg agttgcaggt gaagctactg gagctgcagg aggtcgactc
3301 cctcctgcgt ggccgccagg tccgccgctt ccaagtccaa ctcagcaacc ccaagttcgg
3361 agcccgcctg ggccagccca gcacaaccac cgttattctc ggtgagcacg atgaaacgga
3421 caggagtctc ataaatcaaa cactttcatc gcctccgcca ccccatggag acctgggcgc
3481 cccacagaac cccaatgcca aggctgccgg gtccaggaag atccatttca actggctgcc
3541 ccctcctggc aagccaatgg ggtacagggt gaagtactgg atccagggcg actctgagtc
3601 tgaagcccac cttctagaca gcaaggtgcc ctcagtggaa ctcaccaacc tgtatcccta
3661 ttgcgactac gaaatgaagg tgtgtgccta tggggcacag ggtgaggggc cctatagctc
3721 actggtgtcc tgccgcaccc accaggaagt acccagcgag ccagggaggc tggctttcaa
3781 tgtagtctct tctacggtga cgcagctgag ctgggcagag ccagctgaga ccaatggcga
3841 gatcacagcc tacgaggtct gctatggact ggtcaatgag gacaaccgac ccattggacc
3901 tatgaagaag gtgctcgtgg acaaccccaa gaaccggatg ctgctcattg agaatctgcg
3961 agaatcccag ccataccgat acacggttaa ggcgcgcaat ggggcaggat ggggacccga
4021 gagagaggct atcatcaacc tggctacaca gcccaagcgg cccatgtcca tccctatcat
4081 cccagacatc cccatagtgg acgcccaggg tggagaagac tacgaaaact tccttatgta
4141 cagtgatgac gtcctgcggt ccccagccag cagccagagg cccagcgttt ctgatgacac
4201 tgagcacctg gtgaatggcc ggatggactt tgcctatcca ggcagcgcca actccctgca
4261 cagaatgact gcagccaatg tggcctatgg cacgcatctg agcccacacc tgtcccaccg
4321 agtgctgagc acgtcctcca cccttacccg ggactaccac tctctgacac gcacagagca
4381 ctcccactca ggcacacttc ccagggacta ctccaccctc acttcccttt cctcccaaga
4441 ttcccgtggg gctgtgggtg tgcctgacac acccactcgg ctggtgttct ctgccctggg
4501 gcccacgtct ttgaaggtga gctggcagga gccacagtgt gatcggatgc tgctgggcta
4561 cagtgtggaa taccagctac taaacggcgg cgagatgcat cggctcaaca tccctaaccc
4621 tggccaaacc tcggtggtgg tagaggatct cctgcctaac cactcctatg tgttccgggt
4681 acgggcccag agccaggagg gctggggccg agagcgagag ggtgtcatca ccatcgagtc
4741 ccaggtgcac ccgcagagcc ctctctgccc cctgccaggc tcagccttca ctctgagcac
4801 ccccagcgcc ccgggaccgc tggtgttcac tgccctaagc ccagactccc tgcagctcag
4861 ctgggagcgg ccgaggaggc ccaatggaga tatccttggc tacctggtga cctgtgagat
4921 ggcccaagga ggagcaccag ccaggacctt ccgggtggac ggagacaacc ctgagagccg
4981 gttgactgta cctggcctca gtgagaacgt tccttacaag ttcaaggttc aggccaggac
5041 gaccgagggc ttcgggccag agcgtgaggg tatcatcacc atcgagtctc aggttggagg
5101 ccccttccca cagctgggca gccattctgg gctcttccag aacccagtgc aaagcgagtt
5161 cagcagcgtg accagcacgc acagcaccac gactgagccc ttcctcatgg atggtctaac
5221 cctggggacc cagcgcctgg aagcaggagg ctccctcacc cggcatgtga cccaggaatt
5281 cgtgacccgg accttaacgg ccagtggctc tctcagcact catatggacc aacagttctt
5341 ccaaacctga acctcccccg cgccccagcc acctgggccc ctccttgcct cctctcctag
5401 cgccttcttc ctctgctgct ctacccacga gcttgctgac cacagagcca gcccctgtag
5461 tcagagagca ggggtaggtg ctgtccagga accataaagt gggtagaggt gatacaaggt
5521 ctttctgact gcatcccacc ctgggtccaa tcccacatgt aaccaaaaaa aaaaaaaaaa
5581 aaaccaaaaa acaaaaaact ggagctggca caagtcccca gccttttgtt ctgcacttaa
5641 taaaaggttt tgctactgct ta
//