LOCUS NM_152943 13496 bp mRNA linear PRI 09-JUN-2024
DEFINITION Homo sapiens zinc finger protein 268 (ZNF268), transcript variant
3, mRNA.
ACCESSION NM_152943
VERSION NM_152943.3
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 13496)
AUTHORS Liu,Y., Yin,W., Wang,J., Lei,Y., Sun,G., Li,W., Huang,Z. and Guo,M.
TITLE KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the
Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex
Assembly
JOURNAL Cells 8 (12), 1604 (2019)
PUBMED 31835635
REMARK GeneRIF: KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the
Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex
Assembly.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 13496)
AUTHORS Wang,W., Cai,J., Wu,Y., Hu,L., Chen,Z., Hu,J., Chen,Z., Li,W.,
Guo,M. and Huang,Z.
TITLE Novel activity of KRAB domain that functions to reinforce nuclear
localization of KRAB-containing zinc finger proteins by interacting
with KAP1
JOURNAL Cell Mol Life Sci 70 (20), 3947-3958 (2013)
PUBMED 23665872
REMARK GeneRIF: The nuclear localization activity of KRAB domain is a
conserved feature of ZNF268.
REFERENCE 3 (bases 1 to 13496)
AUTHORS Hu,L., Wang,W., Cai,J., Luo,J., Huang,Y., Xiong,S., Li,W. and
Guo,M.
TITLE Aberrant expression of ZNF268 alters the growth and migration of
ovarian cancer cells
JOURNAL Oncol Lett 6 (1), 49-54 (2013)
PUBMED 23946776
REFERENCE 4 (bases 1 to 13496)
AUTHORS Wang,W., Guo,M., Hu,L., Cai,J., Zeng,Y., Luo,J., Shu,Z., Li,W. and
Huang,Z.
TITLE The zinc finger protein ZNF268 is overexpressed in human cervical
cancer and contributes to tumorigenesis via enhancing NF-kappaB
signaling
JOURNAL J Biol Chem 287 (51), 42856-42866 (2012)
PUBMED 23091055
REMARK GeneRIF: These results reveal a novel role of ZNF268b2 that
contributes to cervical carcinogenesis in part through enhancing
NF-kappaB signaling.
REFERENCE 5 (bases 1 to 13496)
AUTHORS Zeng,Y., Wang,W., Ma,J., Wang,X., Guo,M. and Li,W.
TITLE Knockdown of ZNF268, which is transcriptionally downregulated by
GATA-1, promotes proliferation of K562 cells
JOURNAL PLoS One 7 (1), e29518 (2012)
PUBMED 22235304
REMARK GeneRIF: ZNF268 is a crucial downstream target and effector of
GATA-1
REFERENCE 6 (bases 1 to 13496)
AUTHORS Sun,C., Zhao,Z.Z., Gao,L., Sun,Y., Shao,H.J. and Li,W.X.
TITLE [Cloning and characterization of two novel alternatively spliced
transcripts of ZNF268]
JOURNAL Yi Chuan 28 (5), 513-517 (2006)
PUBMED 16735226
REMARK GeneRIF: 4 alternative transcripts of ZNF268 were detected in the
human blood cells.
REFERENCE 7 (bases 1 to 13496)
AUTHORS Sun,Y., Shao,H., Li,Z., Liu,J., Gao,L., Peng,X., Meng,Y. and Li,W.
TITLE ZNF268, a novel kruppel-like zinc finger protein, is implicated in
early human liver development
JOURNAL Int J Mol Med 14 (6), 971-975 (2004)
PUBMED 15547661
REMARK GeneRIF: ZNF268 plays a role in early human liver development most
likely by functioning through a cytoplasmic mechanism
REFERENCE 8 (bases 1 to 13496)
AUTHORS Sun,Y., Gou,D.M., Liu,H., Peng,X. and Li,W.X.
TITLE The KRAB domain of zinc finger gene ZNF268: a potential
transcriptional repressor
JOURNAL IUBMB Life 55 (3), 127-131 (2003)
PUBMED 12822888
REMARK GeneRIF: This protein has a conserved KRAB domain which localizes
to the nucleus and has transcriptional repressor activity.
REFERENCE 9 (bases 1 to 13496)
AUTHORS Gou,D.M., Sun,Y., Gao,L., Chow,L.M., Huang,J., Feng,Y.D.,
Jiang,D.H. and Li,W.X.
TITLE Cloning and characterization of a novel Kruppel-like zinc finger
gene, ZNF268, expressed in early human embryo
JOURNAL Biochim Biophys Acta 1518 (3), 306-310 (2001)
PUBMED 11311945
REFERENCE 10 (bases 1 to 13496)
AUTHORS Abrink,M., Aveskogh,M. and Hellman,L.
TITLE Isolation of cDNA clones for 42 different Kruppel-related zinc
finger proteins expressed in the human monoblast cell line U-937
JOURNAL DNA Cell Biol 14 (2), 125-136 (1995)
PUBMED 7865130
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AF317549.1, AF385187.1, AC226150.5 and KF455750.1.
On Jun 2, 2019 this sequence version replaced NM_152943.2.
Transcript Variant: This variant (3) contains an alternate coding
exon, which causes a frameshift compared to variant 1. The
resulting isoform (b) has a shorter and distinct C-terminus
compared to isoform a.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1660809.223729.1,
SRR1660807.89095.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1968540
[ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-64 AF317549.1 87-150
65-3311 AF385187.1 1-3247
3312-7146 AC226150.5 28292-32126 c
7147-7500 KF455750.1 1-354
7501-13496 AC226150.5 21942-27937 c
FEATURES Location/Qualifiers
source 1..13496
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q24.33"
gene 1..13496
/gene="ZNF268"
/gene_synonym="HZF3"
/note="zinc finger protein 268"
/db_xref="GeneID:10795"
/db_xref="HGNC:HGNC:13061"
/db_xref="MIM:604753"
exon 1..192
/gene="ZNF268"
/gene_synonym="HZF3"
/inference="alignment:Splign:2.1.0"
exon 193..277
/gene="ZNF268"
/gene_synonym="HZF3"
/inference="alignment:Splign:2.1.0"
CDS 245..826
/gene="ZNF268"
/gene_synonym="HZF3"
/note="isoform b is encoded by transcript variant 3; zinc
finger protein 3; zinc finger protein HZF3"
/codon_start=1
/product="zinc finger protein 268 isoform b"
/protein_id="NP_694422.2"
/db_xref="CCDS:CCDS59239.1"
/db_xref="GeneID:10795"
/db_xref="HGNC:HGNC:13061"
/db_xref="MIM:604753"
/translation="MATRVRTASIWVPPLQERNSSWDRIRKLQGQESILGQGTPGLQP
LPGTPRQKQKSRRIEKVLEWLFISQEQPKITKSWGPLSFMDVFVDFTWEEWQLLDPAQ
KCLYRSVMLENYSNLVSLGYQHTKPDIIFKLEQGEELCMVQAQVPNQTCPILKAGKSK
AKVLAGLVSGEGLLCASKMTPCCCILWRHSLEN"
exon 278..478
/gene="ZNF268"
/gene_synonym="HZF3"
/inference="alignment:Splign:2.1.0"
exon 479..605
/gene="ZNF268"
/gene_synonym="HZF3"
/inference="alignment:Splign:2.1.0"
exon 606..701
/gene="ZNF268"
/gene_synonym="HZF3"
/inference="alignment:Splign:2.1.0"
exon 702..807
/gene="ZNF268"
/gene_synonym="HZF3"
/inference="alignment:Splign:2.1.0"
exon 808..13496
/gene="ZNF268"
/gene_synonym="HZF3"
/inference="alignment:Splign:2.1.0"
regulatory 1085..1090
/regulatory_class="polyA_signal_sequence"
/gene="ZNF268"
/gene_synonym="HZF3"
/note="hexamer: AATAAA"
polyA_site 1104
/gene="ZNF268"
/gene_synonym="HZF3"
/note="major polyA site"
regulatory 3762..3767
/regulatory_class="polyA_signal_sequence"
/gene="ZNF268"
/gene_synonym="HZF3"
/note="hexamer: AATAAA"
polyA_site 3790
/gene="ZNF268"
/gene_synonym="HZF3"
/note="major polyA site"
regulatory 4726..4731
/regulatory_class="polyA_signal_sequence"
/gene="ZNF268"
/gene_synonym="HZF3"
/note="hexamer: AATACA"
polyA_site 4751
/gene="ZNF268"
/gene_synonym="HZF3"
/note="major polyA site"
regulatory 5562..5567
/regulatory_class="polyA_signal_sequence"
/gene="ZNF268"
/gene_synonym="HZF3"
/note="hexamer: AATAAA"
polyA_site 5580
/gene="ZNF268"
/gene_synonym="HZF3"
regulatory 9825..9830
/regulatory_class="polyA_signal_sequence"
/gene="ZNF268"
/gene_synonym="HZF3"
/note="hexamer: AATAAA"
polyA_site 9844
/gene="ZNF268"
/gene_synonym="HZF3"
regulatory 13473..13478
/regulatory_class="polyA_signal_sequence"
/gene="ZNF268"
/gene_synonym="HZF3"
/note="hexamer: AATAAA"
polyA_site 13496
/gene="ZNF268"
/gene_synonym="HZF3"
ORIGIN
1 atacgtagcg gccgccattg ttccgcgccg atggcgagat ccttgttcct cagatagcgt
61 tcatcgcccg tcgtggtcaa cgggccagcc gagtctggag tggttgcgaa cccttctggc
121 tgcagatctg gaggtggagg cagtaccctg gactctattc tgctgcccct tcagggtttg
181 gaggagccgg agcatccctc gcgtcctgtc acttccagcg aggcacacaa aactgaccgt
241 agggatggcc accagggtcc ggacagcttc tatttgggtc ccacctctcc aagaacgaaa
301 cagttcatgg gataggatca gaaagctcca aggtcaggaa tccatcttgg gccaagggac
361 tcctggtctg caacctctcc ctggaacacc caggcagaag cagaagagtc gcagaataga
421 gaaagtccta gagtggctgt ttatttccca agagcagcca aaaatcacca agtcctgggg
481 acctttgtca ttcatggatg tgtttgtgga ttttacctgg gaggagtggc agctgctaga
541 cccagcacag aagtgcctgt acaggagtgt gatgttggag aactatagca acctggtgtc
601 cctagggtac caacacacca aacctgatat catcttcaag ttggaacaag gagaagagct
661 gtgtatggtg caggcccaag ttccaaatca gacctgtcca attttgaagg ctggaaagtc
721 caaagccaag gtgctggcag gtttggtgtc tggtgagggc ctgctctgtg cttccaagat
781 gacgccttgt tgctgcatcc tctggagaca cagtctggaa aattgatgat cttatggatt
841 ggcatcagga aaataaagac aagctgggaa gtacggcaaa aagctttgaa tgcactacat
901 ttggaaaact atgtcttctt agtacaaagt atctttcaag acaaaaacct cataaatgtg
961 gcacgcatgg aaagagtttg aaatatatag atttcactag tgattatgct agaaataatc
1021 ctaatgggtt tcaggtacat ggaaaatcat tcttccattc taaacatgag caaactgtta
1081 ttggaataaa atactgtgaa agtattgaat ctggaaaaac cgtcaataag aaatcgcaac
1141 ttatgtgcca acaaatgtat atgggcgaaa aaccctttgg atgcagctgt tgtgagaaag
1201 ccttcagcag caagtcatac cttctagtgc atcagcaaac tcatgccgaa gagaaaccct
1261 atggttgtaa tgaatgtggg aaagacttca gtagtaaatc atacctcatt gtacatcaga
1321 gaattcatac aggagagaaa ctacatgaat gcagtgaatg caggaaaaca ttcagtttcc
1381 attcacagct tgttatacat cagagaattc acacaggtga gaatccctat gagtgctgtg
1441 aatgtgggaa agtcttcagt aggaaagacc agcttgtttc acaccagaaa actcattcag
1501 gacagaaacc atatgtgtgt aatgaatgtg ggaaagcttt tggtttaaaa tcacagctca
1561 ttatacatga aagaattcat acaggagaga aaccatatga atgcaatgaa tgtcagaaag
1621 cctttaatac aaagtcaaac cttatggtac atcagagaac ccatacaggg gagaaacctt
1681 atgtttgtag tgattgtgga aaagccttta cattcaagtc acagctcatt gtacatcagg
1741 ggattcacac aggagtaaag ccctatgggt gtattcagtg tggtaaagga ttcagtttga
1801 aatcacagct cattgtacat cagagaagtc acacaggaat gaaaccttat gtatgcaatg
1861 aatgtggcaa agccttcagg agcaagtcat accttattat acatacaagg actcatacag
1921 gagaaaaact ccatgaatgc aacaattgtg ggaaagcctt cagttttaaa tcacagctca
1981 ttatacatca gaggattcat acaggagaga acccctatga atgccatgaa tgtgggaaag
2041 ccttcagtcg gaaataccag cttatttcac accagagaac tcatgcagga gagaagcctt
2101 atgaatgcac cgactgtgga aaggcttttg gtttaaagtc acagcttatt atacaccaga
2161 gaactcatac aggggagaaa ccatttgaat gtagtgagtg tcagaaagcc tttaatacaa
2221 agtcaaacct gattgtacat cagagaactc atacaggaga gaaaccctat agttgtaatg
2281 aatgtggaaa agcctttacg ttcaaatcac agctcattgt acataaagga gtgcacactg
2341 gagtaaaacc ctatggatgc agtcaatgtg caaaaacctt tagtttgaag tcccagctca
2401 ttgtacatca gagaagtcac acaggagtaa aaccatatgg atgcagtgag tgtgggaaag
2461 ccttcaggag caagtcatac cttattatac atatgagaac tcatacagga gagaaaccac
2521 atgagtgcag ggaatgcggg aaatccttta gtttcaattc acaactcatt gtgcatcaga
2581 gaattcacac aggagaaaat ccctatgaat gcagtgaatg tgggaaagcc tttaatagga
2641 aagaccagct catttcacat cagcgaactc atgcagggga aaagccttat gggtgcagtg
2701 aatgtgggaa agcttttagc agcaagtcat acctaattat acacatgaga actcattcag
2761 gtgaaaaacc atatgaatgt aatgaatgtg ggaaagcctt catttggaaa tcactactca
2821 ttgtacatga gcgaactcat gcaggggtca acccttataa atgcagtcaa tgtgagaaat
2881 ccttcagtgg gaaattacgc cttcttgtac accagagaat gcacacaaga gagaaaccat
2941 atgaatgcag tgagtgtgga aaagccttca ttaggaattc tcaactcatt gtacatcaaa
3001 gaactcattc aggagagaaa ccctatgggt gcaatgaatg tgggaaaacc ttctctcaaa
3061 aatcaattct cagtgcacat cagagaacac atacaggaga gaagccttgt aagtgcactg
3121 aatgtgggaa agccttttgt tggaagtcac agctcattat gcatcagaga actcatgtag
3181 atgacaaaca ttgataattt tacgaaactc tgaaaagtgg attcacaaga gatagaaaca
3241 atcatatata aagagaaact ctgtaagtgg aatcatcttg tcatcttcca gaaaactcat
3301 actgaataga aactttatga atgcacagca tatggaaagg catccacaga aagctgttct
3361 ttacatgcaa aaagatagta gacaatacac aggaaaactg aatttagtaa ccactctgaa
3421 aatttttagc agcaagtcat accttttttt aaaaagttca tacaggtgag gaaccatgtt
3481 aaacgttgta aagtcatttt actaaaataa gattcacaaa gaggaaactt catgaaccag
3541 atgaatatag aatagacttc tttgaaattc atagtttaca gaattttaat gagagaaatt
3601 attgagctaa tgaatggcag aattaacaaa attacaaaca ttttatgtat cggaagcata
3661 taccttggag ggaccatgct ataagggaaa gtgtaaatct agaaatgaga aacccctagg
3721 gaaaaaatat atataggagt gaacatctta tgaatgtacc aaataaacca cagctggact
3781 gttaacctca ccttagaagc ttcattctaa aaaaaaaaaa aaaaaaaaaa aaaaaaacca
3841 acctgttatt atatcttaat attaattttg aagaattatt tcttttagga atcattttaa
3901 gaaattttat tccaggtgtt ccaaaatttc aggaaaaggt ttgagaaaat tctcaattat
3961 aaataataag atacagatta tttcattgta caagtgaatc tagtaaggag gttaagaata
4021 agaaataaca tcccagagcc tacagggata tttagatatc ttcctatgtg tactacataa
4081 tatgaatttt gcagtttggc attttacttg cgaatgccat atgtgagaca aaaatcatct
4141 tccagagatt tcagtatctc tgatactgac aatatctctg atatgacaat atcatcttcc
4201 agagatttct actctgcata ccaacattgt ttctttgtgt cttaccaaat gcaacttgtt
4261 actagaatat gacttactaa aaatgcattt ccacactgca aacatttttt agggctatct
4321 tctgcccttt ggaagcagtc ttggcagcaa cctctttagt aatcaatata aggcacactt
4381 catgtgtttg tgtagcctgg aatctattct accttcacag gttagaacat cttgatttcc
4441 tcttaacgaa acattcccta acggtgtatg tagtcatgag ggaaccacca ttcaagatgc
4501 cctgctcagg acttggcatg agcactatgg tcagctgagg ctcagaactg tacattgtta
4561 atgggttttt caagttcaga aaagcaacat gagcttttgt tctgtggtag catgttgatg
4621 taataagtag ctatttcaat agaggttccc agaacagctt ttgttactgt cattttctta
4681 actttgttca cttgtctttt attttgagct attgggtgtg cttttaatac attccttgtt
4741 tgattgcatt agccattgtg tatcttttgc atacagctta ctaaatcaga tggcttcaga
4801 aatgggtggt agaggagtag gcagaaactt gcaaggatat gtggatattt ggaaatggtt
4861 gtttcccaag acaggatgga agtcttttaa gcaagaaact tggcccatgc tatgaagtca
4921 tgaaatgaat tgttggcatc atgtgctcac tgaggctttg gggaaatgga taagttgtca
4981 ttgaaaaatt ttaaacagaa ttctggagtg gtcaagaggg gaatgctttt gatacccatg
5041 tataacatgg agaataatga tcttaaaact tcaatttaag attatgtgtc agtgatacta
5101 cttagttaca tgtagctata gagtcacagt ggtgaaaaac tctgccagtt gcttactcac
5161 aaagttagtt ttcttcacta cctcatcagg tttgttatgt gagtgggcat taatctggga
5221 agagtgggac cctgccagtt agattagggc tatcttggag gaatatgcgg attcaatact
5281 gcaaatattt ctgaaacacc ttctgctttg tactctatta gatacccaaa gaaattttca
5341 tccttgaagc ggaggaattt aatgatacct gaatgcctaa ctgttgtatt ctgcttatac
5401 agaatccaat ctcaagatac ttggggtgaa gaatgatgat tcacagaagg gaagggacat
5461 cttacataaa caaataatcg cagatacttg ctaaagtgta tcccccaatc tgggaaatac
5521 tgtaaaggtg tatattatta ttgatgtacc aaagaagaca gaataaattc ataagagaaa
5581 gtttatattc agtttactac tacctagggt tagattttag tttgttgttt tttcagatgc
5641 aaatctacat gcagccttgc ctggtagaag ccagaagtgt tgacagtatt gaggacagca
5701 ctcacatact gtgggaaaga ataatacttg attaggactt attatttaat gaaatgaaaa
5761 ttttacaaaa cagaaattga gttactggtt tgtaaatcta tctagtcctt ctaccccagc
5821 cccagaaaag aaagacattc cagagacttt tcaggaatag ttattataag gaaaatccaa
5881 ggaaaaataa ccccaatatt ttacaacttc cccatcaaat agaaatttag gagaaaaaat
5941 gacttgcaaa ccatatttgt gaacataggt ttaaaaatcc atatttgtga acataggttt
6001 aaaaatccat atttgtgaac ataggtttaa aaattctaaa tggaattata gcaaaccaat
6061 gtatagctaa caagaaagtc atgatattag gtttaacaga ctattagtgg atccagcatc
6121 ctttgttcat taccagcaga atcactatta tttataatgg cagtatgccc acttaaaaag
6181 agatatatgg ggccaggcac ggtggctcac acctataatc ccagcacttc aggaggctga
6241 gatggtggat cacctgaggt caggagtttg agaccagcct ggccaacatg gtgaaacccc
6301 tctctactaa aaatacaaaa aaatagcagg gcatggtaac tgacacctat aatcccagct
6361 acttgggagg ctgggacggg agaatcactt gaatctagga ggcggaagtt gcagtgagct
6421 gagatcgtac cactgtactc caccctgggt gacagaacta gaccctgtct caaaaaacag
6481 aagagtatgt ttggaagatt taatattaga aaatatttta attaactacc agataaaact
6541 cataaggatt atctcagtat atgctgataa atcacttgat ggaatttaac acccatagat
6601 gacactaaaa tactattaag ttgggaatta aaattaactc ctgtaacttg gtagggaata
6661 tatgttctga aaacacaaat gtcatactta atgataaaat agtagaaaga ttcctttaaa
6721 gtaaaattag ccaggtgcag tggctcatcc atgtaatacc agcacttggg aaggctgagg
6781 ctggaggatt gctggaaccc aggagttcga gacaagcctg accaatatag ggagaccctg
6841 tctgtacaaa aactttttaa aaagattagc caggtgtggt caggcgccgt ggctcatgcc
6901 tgtaatccca gcactttggg aggccgaggt gggcagatca cttgaggtca ggatttcaag
6961 accagtgtgg ctaacatggt gaaaccccgt ctctactaaa aatacaaaag tcagccaggt
7021 gtggtggcac gtgcctgtaa tcccatctac tcgggaggct gaggcagaag aattgcttga
7081 acctaggagg tggcagttgc agtgagccaa gattgcacca ctgcactcca ggctgggcga
7141 cagaacaagc ctccatctca aaaaaaagat cagccaggtg tagtggcaag tgccggtagt
7201 cccacctact gaggaggctg aggcaggagg ttagcttgag tccagtagtt caaggctaca
7261 gtgagctatg atcatgcccc tgcactccat cctgggcaac aaagtgagac cctgtctgta
7321 aaaaacaaag caaaattaca agaatgcgca tcacttttat gaaatgagta acatctagcc
7381 aaggtgtgaa aacaaggaat gtgaggaatt agggatgggt gcagaaacaa ctgccatgaa
7441 ttggagatgt gatcgtgtaa ttaggaaacc caaaataaac cacaaacaaa tgtttggaac
7501 tgccagtaga gtagcaagta tgcagttgtc agtattcatg gaggaccccc ccgcaaccac
7561 agatactccc tgtggatgct caagctcctt atatggcata gtatttgcat tttttttttt
7621 ttttttgaga tggagtctcg ctgtattgcc aggctggagt gcagtggtgt gttcttggct
7681 cactgcaacc tctgcctcct gggttcaagc aattctcctg cctcagcctc cctagtagct
7741 ggaattacag gcacacgcca ccacgcccag ctaatttttg tgtttttagt agagatgggg
7801 tttcaccatg ttggccaggc tggtcttgaa ctcctgacct cgtgatccac cctcagcctc
7861 ccaaagtgct gggattacag gtgtgagcca ctggtctgta ttgatttttc ttaattcttt
7921 gctaaagggc caggtagagt tatttatttc ttgtagagat ggggttttac catgttttcc
7981 agtctggttt caaactcctg ggctcaagca gtccacctgc cttggcctcc caaagtgcta
8041 ggattacagg tgtgagccaa gcacccagcc ataaatctta aataaattct gattttggta
8101 taaatgatat atttaaattt aaatgaagtt gcaagtttta acatgtctac tctttaattt
8161 tcaacattgt ttcaactact tgttagaaac acaggccatt aaaacattaa taaaaaggct
8221 gggcatggtg gctcatgcct gtaatctcag cattttgtga ggctgaggca ggtggatgac
8281 ttgaggtcag gagttcgaga ccagcctggt gaaaccccgt ctctactaaa aatacaaaaa
8341 ttggccagct gtggtggcat gcatctataa tccaagctac tcaggagaat tgcttgaact
8401 ggagaggcgg aggttgcagt gagctgagat tgtgccattg cactccagcc cgggcagcag
8461 agtgagactc cttcaaaaaa aattaataaa agcaagcaca tagggtgcac atttgccctt
8521 ccctcttggg atccagggtg atcccacagg tgctgttcat ccccaacttt gacctggact
8581 gttgcagtgt tttgtcgcag tgtttctccc tttttttgta ctgggatttc tccccagaaa
8641 caaacccata tgtataaaaa gtagttgggc ttgctataaa gatgactagt ggaaacctca
8701 atagaggtac gatttcctaa aataaatctt gttcagatat tacagggcaa agtgaaacag
8761 caaagctccc tcctcagcac tcagggtgca ggcctcactt ttcctcatct tttcctcctg
8821 tggcctccat gtatcccaaa ggtgagatga catcgcccca gattggtccg gaaagtgcac
8881 tggtcgtcac tgtgggtgta ccctacagga gtcttcagat atggaagctc tggatctcac
8941 tgtgatgtat ccccctaggg ggtccccagg ttgtgaggaa aaggaagctt tagtcctcac
9001 tgtggttgca tcccccacca cgggtcagtc ctgaggagga tactctggtc atcactgtga
9061 tctacctccc aggggtcccc aggttggtcc tgaggagaag gaagctcaga acctcactgt
9121 ggatttgccc cactagggtc cctaggtcag tcctgaagag aaacaagctc cagtcttcac
9181 tgtggttgtg ccccacagtg gtcctcaggt tggccagtgg agaaggaagc tctggttctc
9241 agtgtgatgc atcccccagg ttggtcctga gatgaggtaa attctggtca tcactgtgaa
9301 gtgccctcgg gggtctccgg gtcctgagta gaagcaaggt ctgtttgtca ctgtggattc
9361 ccccctgcca agggtcccca ggtcagtcct gaggagaagg cagctcagtc tttactgtga
9421 tgcagcctct agtgatcccc aggtcctgag tagaaggaag gcctggtcct ctgtggattc
9481 aacccagagg tctgtgagca gaatgcaggt actgcaagca ggctagacaa ggtgtgtgct
9541 tgcacccctt ccttactacc taggcacagt gttggatggt cagtgcttcc tgttttgtga
9601 tggccatgtg ccccctcttg cagtcccagt gaacccctga aattcaatct tacgattttc
9661 catgccataa ttttggaaaa cgaaactgaa atagagtcca tcattccatg ccttaattgg
9721 aatggataga gataataaaa ggcaaagtag atggccatag acaaaagtca agtgatttcc
9781 tatatatttg aaataatgta tagcaataat tggaatttgt aatgaataaa atcattcaaa
9841 aaaatctgaa aaagtgtttg tatgcaaaat ataaaaaaaa aaccctaaaa ttgaacaaga
9901 agacaaccca attaaaaatg gggacagatc caaatacata ctttccaaag atatacagat
9961 ggtggccagg cacggtggct cacgcctgta atcccagcac tttgggaggc cgaggcgggc
10021 agatcacctg aggtccggag ttcgagacca gcctgaccaa catggagaaa ccctgtctct
10081 actaaaaata caaaattagc caggcgtggt ggcgctactc tgccaccaag tggtagctac
10141 tccggaggcg gaggcaggag aatggcttga acccgggagg cggaggttgc tgtgagccga
10201 gatcgcgcca ttgcactcca gcctgggcaa caagagtgaa actccgtctc aaaaaaaaaa
10261 aaaagaagat atacagatgg caaataagca taccaaataa tgctcagtga cacttgtcat
10321 gagggaaaag caaattaaaa caacgagata gcaccgcaca tctattaaag tgactataat
10381 ctaaaaataa gtaaatttgc aattgcaaca ggaactctca ttcattgctg gtgcaatgca
10441 taatagtata gccactttgg aagatagttt gacttttccc caaagctaaa caaagcttca
10501 caatatgagc caacaatcac actcctaggt atttagataa ctgctttgaa aacataggag
10561 tttgatctaa acaaaaccca gcatgtactc acgtacagca gctcttttca taacagacaa
10621 atactttaag gaatcaggat aaccttcaat aggtgaatga ctaactaggc tggggtacat
10681 ccatgcaatg gagtcctgtt cagcaagagc aagctctgag gccatgcagg acatggatga
10741 atctgatagg catattgcta agtgaaagag accagtgtga aaaggctgta tgatcctatt
10801 tctatgatgt tatggaaaag cagaaactac aggggtagca aacatatctg tgattgatga
10861 cggtttgtag agggcaggga gtgagttaaa taggaggata taatgataga aacaggcaca
10921 aatgggcctt tggagagtgt actccctctg cttggtgaaa ttatgctggg tgtgtgtgga
10981 agagcctggg atgtataatg ccagcatgaa caaaaaggcc acttatcact ccaggagagc
11041 agggtgttct ttcatcacac atgaaattat ttcaggatca gttccaaggg agactttcat
11101 gtgtgatttt atatatatat atatatatat atatatatat atatatatat atatatatat
11161 atgtatatat acacacacac atacacacat atatacacat atatatacac atatacacat
11221 atatatacac atatatataa taagaacatt taccatttta actattttta agtgtacact
11281 tcagtggcat gaagtacatt atttccatta ttgtgcaact atcattttac attccaccag
11341 cagtgcacaa ggcttccaat ttctccacat acttgccaat attaattagt ttgtttctct
11401 ctcatttcat aggcatgatc ataactcact gcagccccaa cctcctgggc tcaagggatc
11461 cttccacctc agcctcctgg gtagctggaa ctacaggtgc cactacaccc aaatagtttt
11521 ttggtttttt tgaaatggag tttcactctg tcacccaggc tggagtgcag tggcaccatt
11581 tcagctcact gcaacctccg cctcctaggt ttaagtgatt ctccttcctc ggcctcctga
11641 gtagctggga ttacaggcat gtgccaccat gtatggctat tttttgtatt tttagtagag
11701 acagggtttc accatgttgg ccaggccagg ctagtctcaa actcctgtcc tcaagtgatc
11761 cacttacctt ggcctcccaa agtgctggga ttacaggctt gaaccactgc acttggcctc
11821 catatttttt ataatagcca ctctaacatg tatgaaatgg tatctcattg tggttttgat
11881 tttcctttac ctaatggcta gtgatgttga aaatcttttc atgtacttct tggcactgga
11941 tttggcaatg atttattgga tatgacacca gaagcatggg aaacaaaaga aaaaataggt
12001 aaattggact tcaccaaaat tgaaaacttt cggcatcagt ggacactatc aagaaagtga
12061 aaaggagctg ggtgtggtgg ctcacgcctg taattccagc actttgggag gccaaggtgg
12121 gaggatcact tgaggtcagg agtgcgagac cagcctggtt aacttggtga aaccacgtct
12181 ctactaaaaa taaaaaaaaa gagaaaaaaa aaagccgggt gtggtggcat gtgcctgtaa
12241 tcccagcaac tcaggaagct gaggcaggag gatcgcttga agctgtgagg tggaggttgc
12301 agtgagccga gatcatgcta ctgcactcca gcccaggtga cagagcaaga aagcaaaatt
12361 ccatctcaaa aaaaaaaaaa aggccgggtg tggtggctca cgcctgtaat cctagcactt
12421 tgggaggctg aggcaggtgg atcacgaggt caggagatcg aaaccatcct ggctaatgtg
12481 gtgaaaccct gtctctacaa aaaaatacaa aaaattagcc aggctggtag tggaagcctg
12541 tagtcccagc tacttgggag gctgaggaag gagaatggcg tgaacctgga accagtgagc
12601 ccagatctca ccactgcact ccagcctggg cgacagagcg agactccgtc tcaaaaaaaa
12661 aaaaggtgaa tataggagaa aagacactgt aaaataatat acctgataag ggtctagtat
12721 ccagaacata taaagaactc ttacaaccca acaacaaaaa gacaacccaa tatcaaaatg
12781 ggcagaggac ttgaagagac ttttctgtaa agaagatatg caaatagcat atgaaacgat
12841 actcaacatc actagccatc atggaaatat aaatcaaaaa tacaatgaga taacactcca
12901 tacccatcag aatgtcttat tattttaaaa acaaaccaga aacaagtatt gacaaagaag
12961 tggagaaatg tgaacaccgc tgtaaaatgg taaagctgct atgactgacc cttgctacaa
13021 cgtggaggaa cctcagaaac attgtgctga gaacccagca caaggccaca cacctgtaat
13081 cccagctact cgggaggctg aggtgggagg gtcgcttgag cctgggagtt caagtccagt
13141 ctgggcagca tagcaagact ccatgtctac aaagataaaa ataaaagcaa tgtgcagaaa
13201 gaggctggcc acaaaaaggt cacatactgt atgataccac ttatatgaaa tacccagaat
13261 gggtaaatcc aaagagagca tattggtggt tgtcaagggt cggagggagg atgaaatgtg
13321 tgacagctgc ttaatggatg gaggatttcc tttggggtga tgaaactatt ttggaactaa
13381 gaggtggtgg ctgcacaatg ttgtgcatgg actaaatgtc acagaaatgt acatttttaa
13441 aagttaattt tatattgtgt aaattttacc tcaataaaaa aatctagtcc acagca
//