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Homo sapiens zinc finger protein 268 (ZNF268), transcript variant 3, mRNA

NCBI Reference Sequence: NM_152943.3

FASTA Graphics 

LOCUS       NM_152943              13496 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens zinc finger protein 268 (ZNF268), transcript variant
            3, mRNA.
ACCESSION   NM_152943
VERSION     NM_152943.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13496)
  AUTHORS   Liu,Y., Yin,W., Wang,J., Lei,Y., Sun,G., Li,W., Huang,Z. and Guo,M.
  TITLE     KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the
            Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex
            Assembly
  JOURNAL   Cells 8 (12), 1604 (2019)
   PUBMED   31835635
  REMARK    GeneRIF: KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the
            Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex
            Assembly.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13496)
  AUTHORS   Wang,W., Cai,J., Wu,Y., Hu,L., Chen,Z., Hu,J., Chen,Z., Li,W.,
            Guo,M. and Huang,Z.
  TITLE     Novel activity of KRAB domain that functions to reinforce nuclear
            localization of KRAB-containing zinc finger proteins by interacting
            with KAP1
  JOURNAL   Cell Mol Life Sci 70 (20), 3947-3958 (2013)
   PUBMED   23665872
  REMARK    GeneRIF: The nuclear localization activity of KRAB domain is a
            conserved feature of ZNF268.
REFERENCE   3  (bases 1 to 13496)
  AUTHORS   Hu,L., Wang,W., Cai,J., Luo,J., Huang,Y., Xiong,S., Li,W. and
            Guo,M.
  TITLE     Aberrant expression of ZNF268 alters the growth and migration of
            ovarian cancer cells
  JOURNAL   Oncol Lett 6 (1), 49-54 (2013)
   PUBMED   23946776
REFERENCE   4  (bases 1 to 13496)
  AUTHORS   Wang,W., Guo,M., Hu,L., Cai,J., Zeng,Y., Luo,J., Shu,Z., Li,W. and
            Huang,Z.
  TITLE     The zinc finger protein ZNF268 is overexpressed in human cervical
            cancer and contributes to tumorigenesis via enhancing NF-kappaB
            signaling
  JOURNAL   J Biol Chem 287 (51), 42856-42866 (2012)
   PUBMED   23091055
  REMARK    GeneRIF: These results reveal a novel role of ZNF268b2 that
            contributes to cervical carcinogenesis in part through enhancing
            NF-kappaB signaling.
REFERENCE   5  (bases 1 to 13496)
  AUTHORS   Zeng,Y., Wang,W., Ma,J., Wang,X., Guo,M. and Li,W.
  TITLE     Knockdown of ZNF268, which is transcriptionally downregulated by
            GATA-1, promotes proliferation of K562 cells
  JOURNAL   PLoS One 7 (1), e29518 (2012)
   PUBMED   22235304
  REMARK    GeneRIF: ZNF268 is a crucial downstream target and effector of
            GATA-1
REFERENCE   6  (bases 1 to 13496)
  AUTHORS   Sun,C., Zhao,Z.Z., Gao,L., Sun,Y., Shao,H.J. and Li,W.X.
  TITLE     [Cloning and characterization of two novel alternatively spliced
            transcripts of ZNF268]
  JOURNAL   Yi Chuan 28 (5), 513-517 (2006)
   PUBMED   16735226
  REMARK    GeneRIF: 4 alternative transcripts of ZNF268 were detected in the
            human blood cells.
REFERENCE   7  (bases 1 to 13496)
  AUTHORS   Sun,Y., Shao,H., Li,Z., Liu,J., Gao,L., Peng,X., Meng,Y. and Li,W.
  TITLE     ZNF268, a novel kruppel-like zinc finger protein, is implicated in
            early human liver development
  JOURNAL   Int J Mol Med 14 (6), 971-975 (2004)
   PUBMED   15547661
  REMARK    GeneRIF: ZNF268 plays a role in early human liver development most
            likely by functioning through a cytoplasmic mechanism
REFERENCE   8  (bases 1 to 13496)
  AUTHORS   Sun,Y., Gou,D.M., Liu,H., Peng,X. and Li,W.X.
  TITLE     The KRAB domain of zinc finger gene ZNF268: a potential
            transcriptional repressor
  JOURNAL   IUBMB Life 55 (3), 127-131 (2003)
   PUBMED   12822888
  REMARK    GeneRIF: This protein has a conserved KRAB domain which localizes
            to the nucleus and has transcriptional repressor activity.
REFERENCE   9  (bases 1 to 13496)
  AUTHORS   Gou,D.M., Sun,Y., Gao,L., Chow,L.M., Huang,J., Feng,Y.D.,
            Jiang,D.H. and Li,W.X.
  TITLE     Cloning and characterization of a novel Kruppel-like zinc finger
            gene, ZNF268, expressed in early human embryo
  JOURNAL   Biochim Biophys Acta 1518 (3), 306-310 (2001)
   PUBMED   11311945
REFERENCE   10 (bases 1 to 13496)
  AUTHORS   Abrink,M., Aveskogh,M. and Hellman,L.
  TITLE     Isolation of cDNA clones for 42 different Kruppel-related zinc
            finger proteins expressed in the human monoblast cell line U-937
  JOURNAL   DNA Cell Biol 14 (2), 125-136 (1995)
   PUBMED   7865130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF317549.1, AF385187.1, AC226150.5 and KF455750.1.
            
            On Jun 2, 2019 this sequence version replaced NM_152943.2.
            
            Transcript Variant: This variant (3) contains an alternate coding
            exon, which causes a frameshift compared to variant 1. The
            resulting isoform (b) has a shorter and distinct C-terminus
            compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.223729.1,
                                           SRR1660807.89095.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AF317549.1         87-150
            65-3311             AF385187.1         1-3247
            3312-7146           AC226150.5         28292-32126         c
            7147-7500           KF455750.1         1-354
            7501-13496          AC226150.5         21942-27937         c
FEATURES             Location/Qualifiers
     source          1..13496
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.33"
     gene            1..13496
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /note="zinc finger protein 268"
                     /db_xref="GeneID:10795"
                     /db_xref="HGNC:HGNC:13061"
                     /db_xref="MIM:604753"
     exon            1..192
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /inference="alignment:Splign:2.1.0"
     exon            193..277
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..826
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /note="isoform b is encoded by transcript variant 3; zinc
                     finger protein 3; zinc finger protein HZF3"
                     /codon_start=1
                     /product="zinc finger protein 268 isoform b"
                     /protein_id="NP_694422.2"
                     /db_xref="CCDS:CCDS59239.1"
                     /db_xref="GeneID:10795"
                     /db_xref="HGNC:HGNC:13061"
                     /db_xref="MIM:604753"
                     /translation="MATRVRTASIWVPPLQERNSSWDRIRKLQGQESILGQGTPGLQP
                     LPGTPRQKQKSRRIEKVLEWLFISQEQPKITKSWGPLSFMDVFVDFTWEEWQLLDPAQ
                     KCLYRSVMLENYSNLVSLGYQHTKPDIIFKLEQGEELCMVQAQVPNQTCPILKAGKSK
                     AKVLAGLVSGEGLLCASKMTPCCCILWRHSLEN"
     exon            278..478
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /inference="alignment:Splign:2.1.0"
     exon            479..605
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /inference="alignment:Splign:2.1.0"
     exon            606..701
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /inference="alignment:Splign:2.1.0"
     exon            702..807
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /inference="alignment:Splign:2.1.0"
     exon            808..13496
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1085..1090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /note="hexamer: AATAAA"
     polyA_site      1104
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /note="major polyA site"
     regulatory      3762..3767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /note="hexamer: AATAAA"
     polyA_site      3790
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /note="major polyA site"
     regulatory      4726..4731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /note="hexamer: AATACA"
     polyA_site      4751
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /note="major polyA site"
     regulatory      5562..5567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /note="hexamer: AATAAA"
     polyA_site      5580
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
     regulatory      9825..9830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /note="hexamer: AATAAA"
     polyA_site      9844
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
     regulatory      13473..13478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
                     /note="hexamer: AATAAA"
     polyA_site      13496
                     /gene="ZNF268"
                     /gene_synonym="HZF3"
ORIGIN      
        1 atacgtagcg gccgccattg ttccgcgccg atggcgagat ccttgttcct cagatagcgt
       61 tcatcgcccg tcgtggtcaa cgggccagcc gagtctggag tggttgcgaa cccttctggc
      121 tgcagatctg gaggtggagg cagtaccctg gactctattc tgctgcccct tcagggtttg
      181 gaggagccgg agcatccctc gcgtcctgtc acttccagcg aggcacacaa aactgaccgt
      241 agggatggcc accagggtcc ggacagcttc tatttgggtc ccacctctcc aagaacgaaa
      301 cagttcatgg gataggatca gaaagctcca aggtcaggaa tccatcttgg gccaagggac
      361 tcctggtctg caacctctcc ctggaacacc caggcagaag cagaagagtc gcagaataga
      421 gaaagtccta gagtggctgt ttatttccca agagcagcca aaaatcacca agtcctgggg
      481 acctttgtca ttcatggatg tgtttgtgga ttttacctgg gaggagtggc agctgctaga
      541 cccagcacag aagtgcctgt acaggagtgt gatgttggag aactatagca acctggtgtc
      601 cctagggtac caacacacca aacctgatat catcttcaag ttggaacaag gagaagagct
      661 gtgtatggtg caggcccaag ttccaaatca gacctgtcca attttgaagg ctggaaagtc
      721 caaagccaag gtgctggcag gtttggtgtc tggtgagggc ctgctctgtg cttccaagat
      781 gacgccttgt tgctgcatcc tctggagaca cagtctggaa aattgatgat cttatggatt
      841 ggcatcagga aaataaagac aagctgggaa gtacggcaaa aagctttgaa tgcactacat
      901 ttggaaaact atgtcttctt agtacaaagt atctttcaag acaaaaacct cataaatgtg
      961 gcacgcatgg aaagagtttg aaatatatag atttcactag tgattatgct agaaataatc
     1021 ctaatgggtt tcaggtacat ggaaaatcat tcttccattc taaacatgag caaactgtta
     1081 ttggaataaa atactgtgaa agtattgaat ctggaaaaac cgtcaataag aaatcgcaac
     1141 ttatgtgcca acaaatgtat atgggcgaaa aaccctttgg atgcagctgt tgtgagaaag
     1201 ccttcagcag caagtcatac cttctagtgc atcagcaaac tcatgccgaa gagaaaccct
     1261 atggttgtaa tgaatgtggg aaagacttca gtagtaaatc atacctcatt gtacatcaga
     1321 gaattcatac aggagagaaa ctacatgaat gcagtgaatg caggaaaaca ttcagtttcc
     1381 attcacagct tgttatacat cagagaattc acacaggtga gaatccctat gagtgctgtg
     1441 aatgtgggaa agtcttcagt aggaaagacc agcttgtttc acaccagaaa actcattcag
     1501 gacagaaacc atatgtgtgt aatgaatgtg ggaaagcttt tggtttaaaa tcacagctca
     1561 ttatacatga aagaattcat acaggagaga aaccatatga atgcaatgaa tgtcagaaag
     1621 cctttaatac aaagtcaaac cttatggtac atcagagaac ccatacaggg gagaaacctt
     1681 atgtttgtag tgattgtgga aaagccttta cattcaagtc acagctcatt gtacatcagg
     1741 ggattcacac aggagtaaag ccctatgggt gtattcagtg tggtaaagga ttcagtttga
     1801 aatcacagct cattgtacat cagagaagtc acacaggaat gaaaccttat gtatgcaatg
     1861 aatgtggcaa agccttcagg agcaagtcat accttattat acatacaagg actcatacag
     1921 gagaaaaact ccatgaatgc aacaattgtg ggaaagcctt cagttttaaa tcacagctca
     1981 ttatacatca gaggattcat acaggagaga acccctatga atgccatgaa tgtgggaaag
     2041 ccttcagtcg gaaataccag cttatttcac accagagaac tcatgcagga gagaagcctt
     2101 atgaatgcac cgactgtgga aaggcttttg gtttaaagtc acagcttatt atacaccaga
     2161 gaactcatac aggggagaaa ccatttgaat gtagtgagtg tcagaaagcc tttaatacaa
     2221 agtcaaacct gattgtacat cagagaactc atacaggaga gaaaccctat agttgtaatg
     2281 aatgtggaaa agcctttacg ttcaaatcac agctcattgt acataaagga gtgcacactg
     2341 gagtaaaacc ctatggatgc agtcaatgtg caaaaacctt tagtttgaag tcccagctca
     2401 ttgtacatca gagaagtcac acaggagtaa aaccatatgg atgcagtgag tgtgggaaag
     2461 ccttcaggag caagtcatac cttattatac atatgagaac tcatacagga gagaaaccac
     2521 atgagtgcag ggaatgcggg aaatccttta gtttcaattc acaactcatt gtgcatcaga
     2581 gaattcacac aggagaaaat ccctatgaat gcagtgaatg tgggaaagcc tttaatagga
     2641 aagaccagct catttcacat cagcgaactc atgcagggga aaagccttat gggtgcagtg
     2701 aatgtgggaa agcttttagc agcaagtcat acctaattat acacatgaga actcattcag
     2761 gtgaaaaacc atatgaatgt aatgaatgtg ggaaagcctt catttggaaa tcactactca
     2821 ttgtacatga gcgaactcat gcaggggtca acccttataa atgcagtcaa tgtgagaaat
     2881 ccttcagtgg gaaattacgc cttcttgtac accagagaat gcacacaaga gagaaaccat
     2941 atgaatgcag tgagtgtgga aaagccttca ttaggaattc tcaactcatt gtacatcaaa
     3001 gaactcattc aggagagaaa ccctatgggt gcaatgaatg tgggaaaacc ttctctcaaa
     3061 aatcaattct cagtgcacat cagagaacac atacaggaga gaagccttgt aagtgcactg
     3121 aatgtgggaa agccttttgt tggaagtcac agctcattat gcatcagaga actcatgtag
     3181 atgacaaaca ttgataattt tacgaaactc tgaaaagtgg attcacaaga gatagaaaca
     3241 atcatatata aagagaaact ctgtaagtgg aatcatcttg tcatcttcca gaaaactcat
     3301 actgaataga aactttatga atgcacagca tatggaaagg catccacaga aagctgttct
     3361 ttacatgcaa aaagatagta gacaatacac aggaaaactg aatttagtaa ccactctgaa
     3421 aatttttagc agcaagtcat accttttttt aaaaagttca tacaggtgag gaaccatgtt
     3481 aaacgttgta aagtcatttt actaaaataa gattcacaaa gaggaaactt catgaaccag
     3541 atgaatatag aatagacttc tttgaaattc atagtttaca gaattttaat gagagaaatt
     3601 attgagctaa tgaatggcag aattaacaaa attacaaaca ttttatgtat cggaagcata
     3661 taccttggag ggaccatgct ataagggaaa gtgtaaatct agaaatgaga aacccctagg
     3721 gaaaaaatat atataggagt gaacatctta tgaatgtacc aaataaacca cagctggact
     3781 gttaacctca ccttagaagc ttcattctaa aaaaaaaaaa aaaaaaaaaa aaaaaaacca
     3841 acctgttatt atatcttaat attaattttg aagaattatt tcttttagga atcattttaa
     3901 gaaattttat tccaggtgtt ccaaaatttc aggaaaaggt ttgagaaaat tctcaattat
     3961 aaataataag atacagatta tttcattgta caagtgaatc tagtaaggag gttaagaata
     4021 agaaataaca tcccagagcc tacagggata tttagatatc ttcctatgtg tactacataa
     4081 tatgaatttt gcagtttggc attttacttg cgaatgccat atgtgagaca aaaatcatct
     4141 tccagagatt tcagtatctc tgatactgac aatatctctg atatgacaat atcatcttcc
     4201 agagatttct actctgcata ccaacattgt ttctttgtgt cttaccaaat gcaacttgtt
     4261 actagaatat gacttactaa aaatgcattt ccacactgca aacatttttt agggctatct
     4321 tctgcccttt ggaagcagtc ttggcagcaa cctctttagt aatcaatata aggcacactt
     4381 catgtgtttg tgtagcctgg aatctattct accttcacag gttagaacat cttgatttcc
     4441 tcttaacgaa acattcccta acggtgtatg tagtcatgag ggaaccacca ttcaagatgc
     4501 cctgctcagg acttggcatg agcactatgg tcagctgagg ctcagaactg tacattgtta
     4561 atgggttttt caagttcaga aaagcaacat gagcttttgt tctgtggtag catgttgatg
     4621 taataagtag ctatttcaat agaggttccc agaacagctt ttgttactgt cattttctta
     4681 actttgttca cttgtctttt attttgagct attgggtgtg cttttaatac attccttgtt
     4741 tgattgcatt agccattgtg tatcttttgc atacagctta ctaaatcaga tggcttcaga
     4801 aatgggtggt agaggagtag gcagaaactt gcaaggatat gtggatattt ggaaatggtt
     4861 gtttcccaag acaggatgga agtcttttaa gcaagaaact tggcccatgc tatgaagtca
     4921 tgaaatgaat tgttggcatc atgtgctcac tgaggctttg gggaaatgga taagttgtca
     4981 ttgaaaaatt ttaaacagaa ttctggagtg gtcaagaggg gaatgctttt gatacccatg
     5041 tataacatgg agaataatga tcttaaaact tcaatttaag attatgtgtc agtgatacta
     5101 cttagttaca tgtagctata gagtcacagt ggtgaaaaac tctgccagtt gcttactcac
     5161 aaagttagtt ttcttcacta cctcatcagg tttgttatgt gagtgggcat taatctggga
     5221 agagtgggac cctgccagtt agattagggc tatcttggag gaatatgcgg attcaatact
     5281 gcaaatattt ctgaaacacc ttctgctttg tactctatta gatacccaaa gaaattttca
     5341 tccttgaagc ggaggaattt aatgatacct gaatgcctaa ctgttgtatt ctgcttatac
     5401 agaatccaat ctcaagatac ttggggtgaa gaatgatgat tcacagaagg gaagggacat
     5461 cttacataaa caaataatcg cagatacttg ctaaagtgta tcccccaatc tgggaaatac
     5521 tgtaaaggtg tatattatta ttgatgtacc aaagaagaca gaataaattc ataagagaaa
     5581 gtttatattc agtttactac tacctagggt tagattttag tttgttgttt tttcagatgc
     5641 aaatctacat gcagccttgc ctggtagaag ccagaagtgt tgacagtatt gaggacagca
     5701 ctcacatact gtgggaaaga ataatacttg attaggactt attatttaat gaaatgaaaa
     5761 ttttacaaaa cagaaattga gttactggtt tgtaaatcta tctagtcctt ctaccccagc
     5821 cccagaaaag aaagacattc cagagacttt tcaggaatag ttattataag gaaaatccaa
     5881 ggaaaaataa ccccaatatt ttacaacttc cccatcaaat agaaatttag gagaaaaaat
     5941 gacttgcaaa ccatatttgt gaacataggt ttaaaaatcc atatttgtga acataggttt
     6001 aaaaatccat atttgtgaac ataggtttaa aaattctaaa tggaattata gcaaaccaat
     6061 gtatagctaa caagaaagtc atgatattag gtttaacaga ctattagtgg atccagcatc
     6121 ctttgttcat taccagcaga atcactatta tttataatgg cagtatgccc acttaaaaag
     6181 agatatatgg ggccaggcac ggtggctcac acctataatc ccagcacttc aggaggctga
     6241 gatggtggat cacctgaggt caggagtttg agaccagcct ggccaacatg gtgaaacccc
     6301 tctctactaa aaatacaaaa aaatagcagg gcatggtaac tgacacctat aatcccagct
     6361 acttgggagg ctgggacggg agaatcactt gaatctagga ggcggaagtt gcagtgagct
     6421 gagatcgtac cactgtactc caccctgggt gacagaacta gaccctgtct caaaaaacag
     6481 aagagtatgt ttggaagatt taatattaga aaatatttta attaactacc agataaaact
     6541 cataaggatt atctcagtat atgctgataa atcacttgat ggaatttaac acccatagat
     6601 gacactaaaa tactattaag ttgggaatta aaattaactc ctgtaacttg gtagggaata
     6661 tatgttctga aaacacaaat gtcatactta atgataaaat agtagaaaga ttcctttaaa
     6721 gtaaaattag ccaggtgcag tggctcatcc atgtaatacc agcacttggg aaggctgagg
     6781 ctggaggatt gctggaaccc aggagttcga gacaagcctg accaatatag ggagaccctg
     6841 tctgtacaaa aactttttaa aaagattagc caggtgtggt caggcgccgt ggctcatgcc
     6901 tgtaatccca gcactttggg aggccgaggt gggcagatca cttgaggtca ggatttcaag
     6961 accagtgtgg ctaacatggt gaaaccccgt ctctactaaa aatacaaaag tcagccaggt
     7021 gtggtggcac gtgcctgtaa tcccatctac tcgggaggct gaggcagaag aattgcttga
     7081 acctaggagg tggcagttgc agtgagccaa gattgcacca ctgcactcca ggctgggcga
     7141 cagaacaagc ctccatctca aaaaaaagat cagccaggtg tagtggcaag tgccggtagt
     7201 cccacctact gaggaggctg aggcaggagg ttagcttgag tccagtagtt caaggctaca
     7261 gtgagctatg atcatgcccc tgcactccat cctgggcaac aaagtgagac cctgtctgta
     7321 aaaaacaaag caaaattaca agaatgcgca tcacttttat gaaatgagta acatctagcc
     7381 aaggtgtgaa aacaaggaat gtgaggaatt agggatgggt gcagaaacaa ctgccatgaa
     7441 ttggagatgt gatcgtgtaa ttaggaaacc caaaataaac cacaaacaaa tgtttggaac
     7501 tgccagtaga gtagcaagta tgcagttgtc agtattcatg gaggaccccc ccgcaaccac
     7561 agatactccc tgtggatgct caagctcctt atatggcata gtatttgcat tttttttttt
     7621 ttttttgaga tggagtctcg ctgtattgcc aggctggagt gcagtggtgt gttcttggct
     7681 cactgcaacc tctgcctcct gggttcaagc aattctcctg cctcagcctc cctagtagct
     7741 ggaattacag gcacacgcca ccacgcccag ctaatttttg tgtttttagt agagatgggg
     7801 tttcaccatg ttggccaggc tggtcttgaa ctcctgacct cgtgatccac cctcagcctc
     7861 ccaaagtgct gggattacag gtgtgagcca ctggtctgta ttgatttttc ttaattcttt
     7921 gctaaagggc caggtagagt tatttatttc ttgtagagat ggggttttac catgttttcc
     7981 agtctggttt caaactcctg ggctcaagca gtccacctgc cttggcctcc caaagtgcta
     8041 ggattacagg tgtgagccaa gcacccagcc ataaatctta aataaattct gattttggta
     8101 taaatgatat atttaaattt aaatgaagtt gcaagtttta acatgtctac tctttaattt
     8161 tcaacattgt ttcaactact tgttagaaac acaggccatt aaaacattaa taaaaaggct
     8221 gggcatggtg gctcatgcct gtaatctcag cattttgtga ggctgaggca ggtggatgac
     8281 ttgaggtcag gagttcgaga ccagcctggt gaaaccccgt ctctactaaa aatacaaaaa
     8341 ttggccagct gtggtggcat gcatctataa tccaagctac tcaggagaat tgcttgaact
     8401 ggagaggcgg aggttgcagt gagctgagat tgtgccattg cactccagcc cgggcagcag
     8461 agtgagactc cttcaaaaaa aattaataaa agcaagcaca tagggtgcac atttgccctt
     8521 ccctcttggg atccagggtg atcccacagg tgctgttcat ccccaacttt gacctggact
     8581 gttgcagtgt tttgtcgcag tgtttctccc tttttttgta ctgggatttc tccccagaaa
     8641 caaacccata tgtataaaaa gtagttgggc ttgctataaa gatgactagt ggaaacctca
     8701 atagaggtac gatttcctaa aataaatctt gttcagatat tacagggcaa agtgaaacag
     8761 caaagctccc tcctcagcac tcagggtgca ggcctcactt ttcctcatct tttcctcctg
     8821 tggcctccat gtatcccaaa ggtgagatga catcgcccca gattggtccg gaaagtgcac
     8881 tggtcgtcac tgtgggtgta ccctacagga gtcttcagat atggaagctc tggatctcac
     8941 tgtgatgtat ccccctaggg ggtccccagg ttgtgaggaa aaggaagctt tagtcctcac
     9001 tgtggttgca tcccccacca cgggtcagtc ctgaggagga tactctggtc atcactgtga
     9061 tctacctccc aggggtcccc aggttggtcc tgaggagaag gaagctcaga acctcactgt
     9121 ggatttgccc cactagggtc cctaggtcag tcctgaagag aaacaagctc cagtcttcac
     9181 tgtggttgtg ccccacagtg gtcctcaggt tggccagtgg agaaggaagc tctggttctc
     9241 agtgtgatgc atcccccagg ttggtcctga gatgaggtaa attctggtca tcactgtgaa
     9301 gtgccctcgg gggtctccgg gtcctgagta gaagcaaggt ctgtttgtca ctgtggattc
     9361 ccccctgcca agggtcccca ggtcagtcct gaggagaagg cagctcagtc tttactgtga
     9421 tgcagcctct agtgatcccc aggtcctgag tagaaggaag gcctggtcct ctgtggattc
     9481 aacccagagg tctgtgagca gaatgcaggt actgcaagca ggctagacaa ggtgtgtgct
     9541 tgcacccctt ccttactacc taggcacagt gttggatggt cagtgcttcc tgttttgtga
     9601 tggccatgtg ccccctcttg cagtcccagt gaacccctga aattcaatct tacgattttc
     9661 catgccataa ttttggaaaa cgaaactgaa atagagtcca tcattccatg ccttaattgg
     9721 aatggataga gataataaaa ggcaaagtag atggccatag acaaaagtca agtgatttcc
     9781 tatatatttg aaataatgta tagcaataat tggaatttgt aatgaataaa atcattcaaa
     9841 aaaatctgaa aaagtgtttg tatgcaaaat ataaaaaaaa aaccctaaaa ttgaacaaga
     9901 agacaaccca attaaaaatg gggacagatc caaatacata ctttccaaag atatacagat
     9961 ggtggccagg cacggtggct cacgcctgta atcccagcac tttgggaggc cgaggcgggc
    10021 agatcacctg aggtccggag ttcgagacca gcctgaccaa catggagaaa ccctgtctct
    10081 actaaaaata caaaattagc caggcgtggt ggcgctactc tgccaccaag tggtagctac
    10141 tccggaggcg gaggcaggag aatggcttga acccgggagg cggaggttgc tgtgagccga
    10201 gatcgcgcca ttgcactcca gcctgggcaa caagagtgaa actccgtctc aaaaaaaaaa
    10261 aaaagaagat atacagatgg caaataagca taccaaataa tgctcagtga cacttgtcat
    10321 gagggaaaag caaattaaaa caacgagata gcaccgcaca tctattaaag tgactataat
    10381 ctaaaaataa gtaaatttgc aattgcaaca ggaactctca ttcattgctg gtgcaatgca
    10441 taatagtata gccactttgg aagatagttt gacttttccc caaagctaaa caaagcttca
    10501 caatatgagc caacaatcac actcctaggt atttagataa ctgctttgaa aacataggag
    10561 tttgatctaa acaaaaccca gcatgtactc acgtacagca gctcttttca taacagacaa
    10621 atactttaag gaatcaggat aaccttcaat aggtgaatga ctaactaggc tggggtacat
    10681 ccatgcaatg gagtcctgtt cagcaagagc aagctctgag gccatgcagg acatggatga
    10741 atctgatagg catattgcta agtgaaagag accagtgtga aaaggctgta tgatcctatt
    10801 tctatgatgt tatggaaaag cagaaactac aggggtagca aacatatctg tgattgatga
    10861 cggtttgtag agggcaggga gtgagttaaa taggaggata taatgataga aacaggcaca
    10921 aatgggcctt tggagagtgt actccctctg cttggtgaaa ttatgctggg tgtgtgtgga
    10981 agagcctggg atgtataatg ccagcatgaa caaaaaggcc acttatcact ccaggagagc
    11041 agggtgttct ttcatcacac atgaaattat ttcaggatca gttccaaggg agactttcat
    11101 gtgtgatttt atatatatat atatatatat atatatatat atatatatat atatatatat
    11161 atgtatatat acacacacac atacacacat atatacacat atatatacac atatacacat
    11221 atatatacac atatatataa taagaacatt taccatttta actattttta agtgtacact
    11281 tcagtggcat gaagtacatt atttccatta ttgtgcaact atcattttac attccaccag
    11341 cagtgcacaa ggcttccaat ttctccacat acttgccaat attaattagt ttgtttctct
    11401 ctcatttcat aggcatgatc ataactcact gcagccccaa cctcctgggc tcaagggatc
    11461 cttccacctc agcctcctgg gtagctggaa ctacaggtgc cactacaccc aaatagtttt
    11521 ttggtttttt tgaaatggag tttcactctg tcacccaggc tggagtgcag tggcaccatt
    11581 tcagctcact gcaacctccg cctcctaggt ttaagtgatt ctccttcctc ggcctcctga
    11641 gtagctggga ttacaggcat gtgccaccat gtatggctat tttttgtatt tttagtagag
    11701 acagggtttc accatgttgg ccaggccagg ctagtctcaa actcctgtcc tcaagtgatc
    11761 cacttacctt ggcctcccaa agtgctggga ttacaggctt gaaccactgc acttggcctc
    11821 catatttttt ataatagcca ctctaacatg tatgaaatgg tatctcattg tggttttgat
    11881 tttcctttac ctaatggcta gtgatgttga aaatcttttc atgtacttct tggcactgga
    11941 tttggcaatg atttattgga tatgacacca gaagcatggg aaacaaaaga aaaaataggt
    12001 aaattggact tcaccaaaat tgaaaacttt cggcatcagt ggacactatc aagaaagtga
    12061 aaaggagctg ggtgtggtgg ctcacgcctg taattccagc actttgggag gccaaggtgg
    12121 gaggatcact tgaggtcagg agtgcgagac cagcctggtt aacttggtga aaccacgtct
    12181 ctactaaaaa taaaaaaaaa gagaaaaaaa aaagccgggt gtggtggcat gtgcctgtaa
    12241 tcccagcaac tcaggaagct gaggcaggag gatcgcttga agctgtgagg tggaggttgc
    12301 agtgagccga gatcatgcta ctgcactcca gcccaggtga cagagcaaga aagcaaaatt
    12361 ccatctcaaa aaaaaaaaaa aggccgggtg tggtggctca cgcctgtaat cctagcactt
    12421 tgggaggctg aggcaggtgg atcacgaggt caggagatcg aaaccatcct ggctaatgtg
    12481 gtgaaaccct gtctctacaa aaaaatacaa aaaattagcc aggctggtag tggaagcctg
    12541 tagtcccagc tacttgggag gctgaggaag gagaatggcg tgaacctgga accagtgagc
    12601 ccagatctca ccactgcact ccagcctggg cgacagagcg agactccgtc tcaaaaaaaa
    12661 aaaaggtgaa tataggagaa aagacactgt aaaataatat acctgataag ggtctagtat
    12721 ccagaacata taaagaactc ttacaaccca acaacaaaaa gacaacccaa tatcaaaatg
    12781 ggcagaggac ttgaagagac ttttctgtaa agaagatatg caaatagcat atgaaacgat
    12841 actcaacatc actagccatc atggaaatat aaatcaaaaa tacaatgaga taacactcca
    12901 tacccatcag aatgtcttat tattttaaaa acaaaccaga aacaagtatt gacaaagaag
    12961 tggagaaatg tgaacaccgc tgtaaaatgg taaagctgct atgactgacc cttgctacaa
    13021 cgtggaggaa cctcagaaac attgtgctga gaacccagca caaggccaca cacctgtaat
    13081 cccagctact cgggaggctg aggtgggagg gtcgcttgag cctgggagtt caagtccagt
    13141 ctgggcagca tagcaagact ccatgtctac aaagataaaa ataaaagcaa tgtgcagaaa
    13201 gaggctggcc acaaaaaggt cacatactgt atgataccac ttatatgaaa tacccagaat
    13261 gggtaaatcc aaagagagca tattggtggt tgtcaagggt cggagggagg atgaaatgtg
    13321 tgacagctgc ttaatggatg gaggatttcc tttggggtga tgaaactatt ttggaactaa
    13381 gaggtggtgg ctgcacaatg ttgtgcatgg actaaatgtc acagaaatgt acatttttaa
    13441 aagttaattt tatattgtgt aaattttacc tcaataaaaa aatctagtcc acagca
//
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