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Drosophila melanogaster dilute class unconventional myosin (didum), transcript variant B, mRNA

NCBI Reference Sequence: NM_165536.3

FASTA Graphics 

LOCUS       NM_165536               5992 bp    mRNA    linear   INV 26-DEC-2023
DEFINITION  Drosophila melanogaster dilute class unconventional myosin (didum),
            transcript variant B, mRNA.
ACCESSION   NM_165536
VERSION     NM_165536.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5992)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5992)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5992)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5992)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5992)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5992)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5992)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5992)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5992)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5992)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5992)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5992)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5992)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5992)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5992)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5992)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5992)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5992)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5992)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5992)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-OCT-2015) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   21 (bases 1 to 5992)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5992)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   23 (bases 1 to 5992)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   24 (bases 1 to 5992)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NT_033778).
            
            On Jan 16, 2013 this sequence version replaced NM_165536.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5992
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="2R"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5992
                     /gene="didum"
                     /locus_tag="Dmel_CG2146"
                     /gene_synonym="43CD; CG2146; Didum; Dmel\CG2146; dmM5;
                     DmV; M5; Myo1C; Myo5; myoV; MyoV; MYOV; MyoV43CD;
                     NEST:bs14c05; NMC7; soy"
                     /note="dilute class unconventional myosin"
                     /map="43C7-43D1"
                     /db_xref="FLYBASE:FBgn0261397"
                     /db_xref="GeneID:35680"
     CDS             333..3923
                     /gene="didum"
                     /locus_tag="Dmel_CG2146"
                     /gene_synonym="43CD; CG2146; Didum; Dmel\CG2146; dmM5;
                     DmV; M5; Myo1C; Myo5; myoV; MyoV; MYOV; MyoV43CD;
                     NEST:bs14c05; NMC7; soy"
                     /EC_number="5.6.1.8"
                     /note="CG2146 gene product from transcript CG2146-RB;
                     CG2146-PB; didum-PB; MyosinV; myosin-5; shorty; myosin-V;
                     myosin V; Myosin5"
                     /codon_start=1
                     /product="dilute class unconventional myosin, isoform B"
                     /protein_id="NP_724570.1"
                     /db_xref="FLYBASE:FBpp0088685"
                     /db_xref="GeneID:35680"
                     /db_xref="FLYBASE:FBgn0261397"
                     /translation="MSSEEMLYAQGAKIWVPHADLVWESATLEESYRKGAGFLKICTD
                     SGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYT
                     YCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSI
                     IVSGESGAGKTVSAKYAMRYFAAVGGSESETQVERKVLASSPIMEAFGNAKTTRNDNS
                     SRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCAARSKY
                     PELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILAGI
                     LHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIES
                     VNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYG
                     FETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDL
                     IESRLGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPRFGTTSFFIKHFSDTV
                     EYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVV
                     ISAGRKQVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETA
                     KIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIVM
                     KWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQ
                     KVINGIQKHARGYLARERTQKMREARAGLILSKYARGWLCRRRYLRLRHSISGIQTYA
                     RGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFK
                     RMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKK
                     TLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQKQTWRQE
                     NEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFM
                     LKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLSKNYSYNDS
                     TSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRTACRLAGRGT"
ORIGIN      
        1 agtcagtcag tcaggcggtg acagggacgg aagtttgttt gtttttctca cactttggcg
       61 ttgcgatcta aaaattatca atgtttttat aaattattcc tggctaattt taagtaattt
      121 aggacagtac atttacataa acccaaaaaa agaccacgaa aatggtaatt taaataggct
      181 gtcagagcca gaaaaaaaac gtaccaccaa ggaaattaaa cctaacggga tttatgcacc
      241 caactcactc ccacgcggag taggaagaag gagaggagag aaagaaggag cgcgaagcgg
      301 aacctggagt aggaggagga gccagtggaa ccatgtctag cgaggagatg ctatacgcgc
      361 agggcgccaa gatctgggtg ccccatgcgg atctggtgtg ggagagcgcc accttggagg
      421 agagctaccg caagggcgcc ggcttcttga agatatgtac ggactccgga aaactgaaag
      481 aggtcaagct aaaggccgat ggcagcgatc tgcctccact gcgcaatccg gccattctgg
      541 tgggacagaa cgacttgacc accctgtcct acctgcatga gccgggggtg ttgcacaatc
      601 tgcgtgtccg cttctgcgag cgccagatta tctacaccta ctgcggcatc attctggtgg
      661 ccatcaaccc gtacgcggag atgcctcttt acgggcccag cataatccga gcgtatcggg
      721 gtcatgctat gggtgatctg gagccgcaca tctttgccct ggcggaggag gcgtacacga
      781 aactggagcg cgagaactgc aacctgagca tcatcgtcag tggggagtcg ggtgcgggca
      841 agacggtgtc cgccaaatac gccatgaggt actttgccgc tgttggaggt tccgagtcgg
      901 agacccaggt cgaacgcaag gtgctggcat cttcgccgat catggaagcc ttcggaaatg
      961 ccaagacgac ccggaatgac aacagttccc gctttggaaa gtttaccaag ctgctgttcc
     1021 ggaaccagat gggtgtgatg ttcctgcagg gagccactat gcacacctac ctactggaga
     1081 agtcacgtgt ggtgtaccag gcccagggag agcgcaacta tcacatattc tatcagctgt
     1141 gcgcggcgcg atcgaagtac cctgaactgg tgctggatca ccaggacaaa ttccagtttc
     1201 tgaacatggg tggcgctcct gaaattgaac gagtttcgga tgcggagcag tttaacgaaa
     1261 ccgtgcaggc catgacagtt ctgggcttct ccattcaaca gatcgctgat atcgtaaaga
     1321 tcctggcagg aatactccat ttaggaaaca ttcaggtttc caagaagttc aacgagggca
     1381 gcgaagagga ggacagtgac tcttgcgata tatttcataa cgacatccac ctgcagatca
     1441 ccgccgatct actgcgggtg agcgccgatg atctgcgccg gtggcttttg atgcgtaaga
     1501 tagagtcggt caatgaatat gtgctgatac cgaatagcat tgaggcggct caggcggctc
     1561 gagacgctct ggccaagcac atctatgcga aactgtttca gtatatagtc ggtgtgctga
     1621 acaagagcct caacaacggt agcaagcagt gcagcttcat tggcgtcctc gatatctacg
     1681 gcttcgaaac gttcgaggtg aactcctttg aacaattttg cataaactat gcgaacgaaa
     1741 agcttcagca gcagttcaac cagcatgtct tcaagctgga gcaggaggag tatcttaagg
     1801 aaggaatcac ctggacgatg attgactttt acgacaatca accgtgtatc gatctaattg
     1861 aatctcgctt gggagtgctg gacctgctcg acgaggagtg tcgaatgcca aagggctcgg
     1921 acgagagctg ggctggcaag ctcatcggaa agtgcaataa atttccgcat ttcgagaagc
     1981 cacgctttgg cacaaccagc ttctttatca aacatttctc ggacacggtc gagtatgacg
     2041 tgaacggatt cttggaaaag aatcgtgaca cagtctccaa ggagttgacg caagtgctaa
     2101 gcgagtccaa catgtctctg gccaagcagg tgatgaccct ggaggaaata gatactctgt
     2161 gcgtggattc cgctaaatcc tccaccttgg gcggccgcgt cgtgatcagt gctggccgca
     2221 aacaggtggt gccatccaag cagcatagaa aaacggtggg atcgcagttc caggagagtc
     2281 tggcgtcgct gatatctacg ttacatgcca caactccgca ctatgtgcgc tgcatcaagc
     2341 ccaacgatga caaagtcgcc tttaagtggg agacggccaa gatcatacag cagttaaggg
     2401 cctgtggtgt gctggaaacg gtgcgcatct ccgcagcggg attcccctcg agatggctct
     2461 atcccgactt ctatatgcgg taccagctgc tggtttaccg ctccaaactc gacaaaaacg
     2521 acatgaagct gtcgtgccgg aacattgtga tgaagtggat ccaagacgaa gataagtacc
     2581 gatttggcaa cacgcagatt ttcttccgcg ccggccaagt ggccttcctt gaacaggttc
     2641 gggctaatct gcgcaagaag tatatcacca ttgtgcagtc ggttgtgcgg cgattcgtct
     2701 accggcgcca gttcctgcgc attcagaaag taattaatgg cattcagaaa catgcgcgcg
     2761 gatatcttgc tcgcgagcgt actcagaaaa tgcgcgaagc tcgtgcggga ttaatcctgt
     2821 cgaagtacgc ccgcggttgg ttatgccgtc gtcgttactt gcgcctacgc cactccattt
     2881 ccggcataca gacctacgcc cgcggcatgc tggcgcgcaa caagttccac gcgatgcggg
     2941 atcactaccg ggcagttcag atccagcgtt tcgtgcgtgg tgctttggca cggcgagctt
     3001 accaaaagcg gcgtcgcaac atcatcattt gtcaagcggc gattcggaga ttcttggccc
     3061 gtcgtaagtt taaacgcatg aaggccgagg ccaagaccat ctcgcacatg gaaaacaaat
     3121 acatggggct ggaaaacaag attatttcca tgcagcagcg gatcgatgag ctgaatcgcg
     3181 acaacagtaa tctgaagcac aagaccagcg aaatcagtgt attgaaaatg aagcttgagc
     3241 tgaagaagac cctggaggct gaattcaaaa atgtcaaggc cgcctgccag gacaaggaca
     3301 agctgatcga agcacttaac aagcagttgg aggcggagcg agacgaaaaa atgcagttgc
     3361 tggaggagaa cggacatgct caagaggagt ggatcagcca gaagcagacg tggcgccaag
     3421 agaacgagga gctgcgccgt cagatagacg agataatcga tatggcaaag aacgcagaag
     3481 tcaaccagcg taaccaggag gaccgaatgc tagccgagat tgataacagg gagctcaacg
     3541 aggcctacca acgagctatt aaggacaagg aggtcatcga gaacgaaaac ttcatgctga
     3601 aggaagagct cagtcgatta acggctggca gtttcagttt gcacgcccgc aaggctagca
     3661 acgcctccag ccaaaacgag gacgatgtgg gatacgcctc cgccaagaac actctggata
     3721 tcaatcggcc cccggatttg ttaagcaaaa attactcgta caatgactct accagtctgg
     3781 tggtgaagtt gagatccatt ctcgaggagg agaagcaaaa gcacaaggtc ttgcaggagc
     3841 agtacattaa gttgtccagt cggcataagc ccaccgagga ttccttccgc acagcatgcc
     3901 gccttgcagg aagaggtacg taggcggcgc gaggagtgca tccaattaaa ggcagtcctg
     3961 ctgcagcaga gccagtccat gagatcgctc gagccggaaa gtctacagat gcgtggcaac
     4021 gatgtcaacg aactgatgga agccttccat tcccagaagc taattaatcg tcaattggag
     4081 tctgagctca aggccatcac cgaggagcac aacagtaagc tcgtggagat gacacaggag
     4141 atcgagagat tgaacaatga gaaggatgag ctgcaaaagg taatgttcga gagcatcgac
     4201 gagttcgaag attccaatgt ggatacgctg agacagaacg atcgctatct gcgacgagaa
     4261 ctgcagaagg ctgtagccca gttcctgctc gttcaggagg agctcaaact ggcaaatgcc
     4321 aagcttaaag cttatcggca ggatggaggc cagctggagc acaagataga ggaggagatg
     4381 attcgcaaca agtccaacgg aacgtccgcc gatgtaggcg cgaatgtgac gaagcaaaag
     4441 tctcagaatc cgcaagggct gatgaagttc cacagcagcg atctggacaa gatcttgcaa
     4501 cgcctgctta gcgccttgac tccacgcaca gtggtcgggc tccttcctgg ttttccagca
     4561 tatctcatct ttatgtgtat tcgatacacc gatctgacaa atgccgacga tgatgtgcgc
     4621 gagttgctaa gcaagttcgt tattcagatt aagaaaatgc atcgtacgcc gcatccgatc
     4681 gagaatcgtg ttatttggct cgtcaattcc attacgctgc taaatcttat gaagcaatac
     4741 ggcgacgtgg atgagtacgt caagttcaat actgagaagc agaatcagca gcagctgaag
     4801 aacttcaatc tctttgaata ccgtcgcgta attcttgatt taattgtgaa cctgtaccag
     4861 gcgctgatca tgcagatcca gggtctgttg gacccaaaaa tagtgccagc gattctcaac
     4921 aatgatgaga ttcagcgtgg gcggcaggcg cacggaatgc gtagtcgggc cacgtcgatt
     4981 ggagcatcct cgtcaccgga gcacggtggc ggtccggcct ggaagcaact gatcgggcag
     5041 ctggagcatt tctacaaaca gtttcagcac ttcggcttgg acaactgcta tgcggagcag
     5101 atattccatc aactgcttta cttcatttgc gctgtggccc ttaattgtct gatgcttagg
     5161 ggcgatattt gcatgtggga gactggcatg ataatccgct acaatatcgg ctgcattgag
     5221 gattgggtgc gcagtaaaaa gatgtctaac gatgtgctga cagctttggc gcctctgaat
     5281 caggtctccc aattgctgca gtctcggaag agcgagcagg atgttcagac catttgtgat
     5341 ctgtgtactt ctctgagcac ggcgcaggtc ctcaaggtga tgaagtccta caaactggac
     5401 gattatgaga gcgaaataac gaacgttttt ctggagaaac taaccgagaa actgaacgcc
     5461 cgacaaatgc aaaagagcaa tagtgacgaa ttcaccatag accagaagtt cattcagcca
     5521 tttaaggttg tcttcaggta tagtgacatc aagctggagg atattgaact accgtcgcat
     5581 cttaatctgg acgagttcct tacaaagatt taaacgtcgc gtgcctgcgt cttgccggtc
     5641 gagaactttg ccattttgga tgacattaca ctgcttagtt tttgtgtatt atacgagtat
     5701 aacgattcta gaaatttaat ttgttcttat atttagaaaa tcgattagat aatgaaacat
     5761 tgagtagagc cgttttgccg aaatgtttgt gtagttcctg tttagcttaa atacccgttg
     5821 tttatccact ccaatagtat ccattccgag tatccaatgg cgtacccgtc ccgagatgcc
     5881 aagtgttttt ttttgttgta cgaactattt gtagcaaaag taatggaagg ttaagaacca
     5941 accttaatat gtgaaacgca ataaatgctt ggagttagac tctgaccata ag
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