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Homo sapiens sterile alpha motif domain containing 14 (SAMD14), transcript variant 1, mRNA

NCBI Reference Sequence: NM_174920.4

FASTA Graphics 

LOCUS       NM_174920               4847 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens sterile alpha motif domain containing 14 (SAMD14),
            transcript variant 1, mRNA.
ACCESSION   NM_174920
VERSION     NM_174920.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4847)
  AUTHORS   Xu,X., Chang,X., Xu,Y., Deng,P., Wang,J., Zhang,C., Zhu,X., Chen,S.
            and Dai,D.
  TITLE     SAMD14 promoter methylation is strongly associated with gene
            expression and poor prognosis in gastric cancer
  JOURNAL   Int J Clin Oncol 25 (6), 1105-1114 (2020)
   PUBMED   32206938
  REMARK    GeneRIF: SAMD14 promoter hyper-methylation was significantly
            associated with a poor prognosis in gastric cancer.
REFERENCE   2  (bases 1 to 4847)
  AUTHORS   Thurner,L., Preuss,K.D., Bewarder,M., Kemele,M., Fadle,N.,
            Regitz,E., Altmeyer,S., Schormann,C., Poeschel,V., Ziepert,M.,
            Walter,S., Roth,P., Weller,M., Szczepanowski,M., Klapper,W.,
            Monoranu,C., Rosenwald,A., Moller,P., Hartmann,S., Hansmann,M.L.,
            Mackensen,A., Schafer,H., Schorb,E., Illerhaus,G., Buslei,R.,
            Bohle,R.M., Stilgenbauer,S., Kim,Y.J. and Pfreundschuh,M.
  TITLE     Hyper-N-glycosylated SAMD14 and neurabin-I as driver autoantigens
            of primary central nervous system lymphoma
  JOURNAL   Blood 132 (26), 2744-2753 (2018)
   PUBMED   30249786
  REMARK    GeneRIF: Hyper-N-glycosylated SAMD14 and neurabin-I as driver
            autoantigens of primary central nervous system lymphoma.
REFERENCE   3  (bases 1 to 4847)
  AUTHORS   Shen,Y., Takahashi,M., Byun,H.M., Link,A., Sharma,N., Balaguer,F.,
            Leung,H.C., Boland,C.R. and Goel,A.
  TITLE     Boswellic acid induces epigenetic alterations by modulating DNA
            methylation in colorectal cancer cells
  JOURNAL   Cancer Biol Ther 13 (7), 542-552 (2012)
   PUBMED   22415137
REFERENCE   4  (bases 1 to 4847)
  AUTHORS   Fehrmann,R.S., Jansen,R.C., Veldink,J.H., Westra,H.J., Arends,D.,
            Bonder,M.J., Fu,J., Deelen,P., Groen,H.J., Smolonska,A.,
            Weersma,R.K., Hofstra,R.M., Buurman,W.A., Rensen,S., Wolfs,M.G.,
            Platteel,M., Zhernakova,A., Elbers,C.C., Festen,E.M., Trynka,G.,
            Hofker,M.H., Saris,C.G., Ophoff,R.A., van den Berg,L.H., van
            Heel,D.A., Wijmenga,C., Te Meerman,G.J. and Franke,L.
  TITLE     Trans-eQTLs reveal that independent genetic variants associated
            with a complex phenotype converge on intermediate genes, with a
            major role for the HLA
  JOURNAL   PLoS Genet 7 (8), e1002197 (2011)
   PUBMED   21829388
REFERENCE   5  (bases 1 to 4847)
  AUTHORS   Sun,W., Iijima,T., Kano,J., Kobayashi,H., Li,D., Morishita,Y.,
            Okubo,C., Anami,Y. and Noguchi,M.
  TITLE     Frequent aberrant methylation of the promoter region of sterile
            alpha motif domain 14 in pulmonary adenocarcinoma
  JOURNAL   Cancer Sci 99 (11), 2177-2184 (2008)
   PUBMED   18823374
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC002401.2, CN369613.1, AY148482.1, AF035306.1 and BM973393.1.
            
            On Jun 2, 2019 this sequence version replaced NM_174920.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY148482.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2158569
                                           [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-278               AC002401.2         25388-25665
            279-357             CN369613.1         3-81
            358-2216            AY148482.1         1-1859
            2217-3495           AF035306.1         727-2005
            3496-3578           BM973393.1         17-99               c
            3579-4847           AC002401.2         44240-45508
FEATURES             Location/Qualifiers
     source          1..4847
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..4847
                     /gene="SAMD14"
                     /note="sterile alpha motif domain containing 14"
                     /db_xref="GeneID:201191"
                     /db_xref="HGNC:HGNC:27312"
                     /db_xref="MIM:619233"
     exon            1..644
                     /gene="SAMD14"
                     /inference="alignment:Splign:2.1.0"
     exon            645..699
                     /gene="SAMD14"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    651..653
                     /gene="SAMD14"
                     /note="upstream in-frame stop codon"
     CDS             657..1994
                     /gene="SAMD14"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sterile alpha motif domain-containing protein 14; SAM
                     domain-containing protein 14"
                     /codon_start=1
                     /product="sterile alpha motif domain-containing protein 14
                     isoform 1"
                     /protein_id="NP_777580.1"
                     /db_xref="CCDS:CCDS11560.1"
                     /db_xref="GeneID:201191"
                     /db_xref="HGNC:HGNC:27312"
                     /db_xref="MIM:619233"
                     /translation="MASSKLREPVDEVFDLDLAVPETARLDSSLHKARAQLLAKGRRH
                     RPSRSRLRDSASSAEDGEGSDGPGGKVTDGCGSPLHRLRSPLHSGPGSPAGGSFCLDP
                     PGLRRSLDEDEPPPSPLTRYRPLHNAASHEGLAAASCSPPRSAPSSDSSPSFVRRHPR
                     AEPHSEDDSRDASPPEPASPTIGLDKKTRRKFLDLGVTLRRASTGKSRKEKGSNRLSM
                     GSRESVEGSGRSGGSPFLPFSWFTDSGKGSASSGSTTSPTCSPKHEGFSPKKSASQAQ
                     LLAHAQEALSNSWCLVQDFGSTQIGMESTLSDDSTPPSSSPKIPSGPWQEAKCSYPYH
                     TLSQSSDEFLDEPLPPVHHWTSQQVGQWLQSLNLEQYAAEFAARQVDGPQLLQLDGSK
                     LKSLGLSNSHDRALVKRKLKEMAAAAEKERKAQEKAARQREKLRRREQEAKKS"
     exon            700..866
                     /gene="SAMD14"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1155
                     /gene="SAMD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1243
                     /gene="SAMD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1318
                     /gene="SAMD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1478
                     /gene="SAMD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1562
                     /gene="SAMD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1682
                     /gene="SAMD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1838
                     /gene="SAMD14"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..4847
                     /gene="SAMD14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3547..3552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SAMD14"
                     /note="hexamer: AATAAA"
     polyA_site      3578
                     /gene="SAMD14"
                     /note="major polyA site"
ORIGIN      
        1 gcgccgcgtc tcccgcgggc agagaagtag ctgcaactcc gctccccggc cccagccgcc
       61 tcctccccgc cgccctcccc cgcccccgcc ccctcgctcc ctcccgctct ttgtctcctg
      121 ggcgcccggc ttctccgcca cgcgcccccc accccgacgc cccttccccg gagacccccg
      181 cggacccctg ccgacgcgac gccgcgcgaa tcggccctgc caggcggggg ccccgcgtcc
      241 ggccaggcct ggcgggcggc aggggcgggg agggaggtgg cgctcgctct tcgctcttct
      301 ctctctctct ctctctgtca cacacacaca cacgcacacg cacacgcaca cacacacgga
      361 gcatcctccc gtcaggtctc ctggtccagc cccgcccgcg cctcctgctt ccagcgaacc
      421 tgttccctct ccccacatcc cccgccctcc atctcccccg gctctgggac ccttcccgcc
      481 gacctcaccc ccacccccgg gatggagcgg ctcgagcccg cccggagccc cccgcggccg
      541 gggtgacggt ccccccaccc ctctcctgcc cggcccccgc ctcgagcacc atgggcctga
      601 ggggttcccg gggcgccaga cgctgaagat gaccgatgcc ggagctctct tgagtcatgg
      661 cttcttcaaa gctccgagaa cccgtggatg aagtttttga cctggacttg gctgtgccag
      721 agacggccag actggacagc agtttacaca aggcccgggc ccaactgttg gccaagggcc
      781 ggagacaccg gccatcccgc tccaggcttc gggacagtgc cagctccgcg gaggatggtg
      841 aaggctcgga tgggcccgga ggcaaggtga ccgatggctg cgggagcccc ctgcaccggc
      901 tgcgctcgcc tttgcactca ggcccggggt ccccggccgg gggctctttc tgcctggatc
      961 ctccggggtt gcggcgcagc ctggacgagg acgagccgcc gccctcgccg ctcacacgct
     1021 accggcccct gcacaacgct gcgtcgcacg agggcctggc cgccgcctcc tgctctccgc
     1081 cgcgctccgc gccctcctcc gacagctccc ccagcttcgt gcgccgccac ccgcgcgcag
     1141 agccgcacag cgaagatgac agccgtgacg ccagtcctcc tgagcccgcc agccccacca
     1201 tcggcctcga taagaagact cgccgaaagt tcctggacct gggggtcacc ctgcgccgag
     1261 catccacggg caagagccgg aaggagaaag gcagcaaccg actgtccatg ggcagcaggg
     1321 agtcagtgga ggggtccggc aggtcagggg gctccccgtt cctgcctttt tcctggttca
     1381 cggacagcgg caagggctca gcatcctcgg gtagcaccac ctcccccacc tgctccccta
     1441 aacacgaggg cttcagccct aagaagtcag cttcccaggc ccagctcctg gctcatgcac
     1501 aggaggcact gagcaactcc tggtgcctag tccaggactt cggctccacc cagataggga
     1561 tggaatccac tctgagtgat gactccacgc cccccagcag cagccccaag atccccagtg
     1621 ggccctggca ggaggccaaa tgttcttacc cctaccacac gctgtctcag tcttcagatg
     1681 agttcctgga tgaacccctc ccccctgtcc accactggac cagccagcag gtgggccagt
     1741 ggctgcagag cctcaacctg gaacagtatg ctgctgagtt tgctgcacgg caggtagacg
     1801 ggccgcagct gctgcagctg gacggaagca aactaaagag cctggggctc agcaactctc
     1861 atgaccgggc actggtgaag cgcaagttga aggagatggc agcagctgcc gagaaggagc
     1921 gcaaggccca ggagaaggct gcgcggcagc gggagaagct ccggcgccga gagcaggagg
     1981 ccaagaagag ctaggggagg gtgcacaggc gctggcaccc ggcaggggca gccactggct
     2041 ccgcgggcac aggcctcacc agggaggctg gacctgggcg ctgcacttgg gctagcctgg
     2101 tcccacgctc tcagggggga catgctctct cttaccctgt cacttggtct agacccagag
     2161 accccagaaa gggagacccc agggagaggg cctagtaata aatcctattt tgaggacttg
     2221 tttggcacag agttcctggg ggaggagcag atgaagggga gagggcagag aggccagggc
     2281 tgaggcaagt ctgggaggct gggtcaggct gtcccattgc cctcaggcca tcgtggggct
     2341 ggggtggagg ggagctagga ggcctgcctg cctgcttgcc tgccagaggc cctgaggccg
     2401 ggccccaggg ctcagagctg ggctgggcat ttcagcagga gcccatgtgg gagcggctcc
     2461 tctccactct tccagggggc tgtgtggtgg gagagctctg tcctgctccc ccaagaggcc
     2521 agtgggcgct gcagcaagtc gcactcaggg tagactccca gccaaactcc tcaacaggag
     2581 cgcagagaaa gcagcctggg gcgagtgcag tctttgccag gactcaagag gggaggatga
     2641 acatcccctt ctccctctcc cctcctctgt cctgtgggtc ccagggggcg agatgacacc
     2701 acacaggtct gcctctcagg gcccattcaa gacctggtct ttgacccatt ctccaagcca
     2761 ggactccctt cacttcctgc tgcttcctca gagggcacct aagtcctctt tgggagctga
     2821 gcaaacagga actgataggg acagaggaca ccacttccac cagccaaggc ctaggagctg
     2881 ctgacctggt cagccctcac cccagccagg cagagaggca aaacctgggg gtccccggca
     2941 gctacgagat tggaaaggtt catcagccct cccccatctg ccccaggcat tgtcagggaa
     3001 tcagtgggct cagaactggc aggcggtgca agctctgctt ccctgggcca cactgagggc
     3061 tggggccagc tccctggatg ggggtggagt ttaccagcag cctggggaca gcatgtgtcc
     3121 tttttaggaa atgtccttgg aggaagtgtt catgtgtggc gctggtcagc agctagtccc
     3181 gcttccagga cactggtcag agttaccgat gaggcctggg ggctcccgct tggaaacccc
     3241 tccagctcct cccatctgcc cagacagagc ggcagatggc accaatgcat gctggctccc
     3301 tcattcctgc ccaggggctg tggcttacgg ccagcaccct gtacctggga ctcagccctt
     3361 atcccccctc tgctatctgt gctgggagag gggcttcgga gggaaacaga tatgaggaca
     3421 ctggcaccat ctgggcctgg tggcagggcc atgggaggtt ggaaggcacc cacatcctta
     3481 aagccatcag tagctatagt gggtgcccac ctgcatgtga aggggaggca gttctcaatt
     3541 tatttcaata aatccttatg atgtgccagt gaccagaatt tctgtctgct ccagttgttg
     3601 ggttggccgg actctgctgg gccctgagta tggtgggaca acaggtctgt caccaggtgc
     3661 tgggccatcc ggcgttctga acagatggct ttgcccagtg ttttactcac agtcctgagc
     3721 tgggccggac gtccccggtg cgtcatgtgg tggtcacagg gcaccgcagt gtgcgtgtgt
     3781 acgtgcgcac gtgtgggtcc cctcccccag ggatgcagcc aggccagtct cattcagtct
     3841 cctctttact gtgggtgtgg gtgtcactgt cactgccaca gccactggga gggacacaca
     3901 gctttaaccc ctgtgtgctt aggggaaggg tgggggcatt cagggttata aaactaacta
     3961 tatacacaga aggtcctagg gagaaagcca ccctgagcac acatgtctgg gcacagtggg
     4021 ggctgggggc tggagctcag gcaggatgga ctaggcttgt ggaggagcgg gtgggcatga
     4081 gcatgtgagg acatgctggg agggctcagg aggtggcaca gacattgcca aggccactgc
     4141 agggcctcga gcagcttggc tggatggcaa gctctcggtc taacaaggtt cttccacttt
     4201 agagttgggc cctgtgagag ccaccccctc cgccaccgac cttcaagccc tgagcggagg
     4261 gagaggctgc aggaccagcc tcattcccca ctcacgggtg taactccttt ccccactcag
     4321 tccccaggtc tggagggcac ccaccctctt cctaacactt cagcaggcca aggccagggt
     4381 gcctttgtgg gctgggggaa taaggcaacg ggacatccac ttggaaggcc tgtgctgtgg
     4441 agggtgctga gggggaccca gtacccctgg cagaaaagtg acagccctgg tctcagagag
     4501 gaggactgcc atgggaaaat gtctctggga caccccatca gggtggagac atccctaacc
     4561 ctcaggcatc gcccacagag atagggaggc caccgagggg tctccacaga gatggactgg
     4621 cacttaggga ccatcacaga cctatcaccg cagtgacttc catagagaca gaacctggtc
     4681 atcagggaga acccaccccc tgctccccca ggaggatggt gaggggcacc acggtggggg
     4741 gacccagagg cggcagtccg tcctctcagg tgcagatgca cggcggccct tagctgacgc
     4801 ggtacgtgga cgtgttcttg ggctccgtgc tgggcacaca ccagtcg
//
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