LOCUS NM_174920 4847 bp mRNA linear PRI 04-AUG-2024
DEFINITION Homo sapiens sterile alpha motif domain containing 14 (SAMD14),
transcript variant 1, mRNA.
ACCESSION NM_174920
VERSION NM_174920.4
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4847)
AUTHORS Xu,X., Chang,X., Xu,Y., Deng,P., Wang,J., Zhang,C., Zhu,X., Chen,S.
and Dai,D.
TITLE SAMD14 promoter methylation is strongly associated with gene
expression and poor prognosis in gastric cancer
JOURNAL Int J Clin Oncol 25 (6), 1105-1114 (2020)
PUBMED 32206938
REMARK GeneRIF: SAMD14 promoter hyper-methylation was significantly
associated with a poor prognosis in gastric cancer.
REFERENCE 2 (bases 1 to 4847)
AUTHORS Thurner,L., Preuss,K.D., Bewarder,M., Kemele,M., Fadle,N.,
Regitz,E., Altmeyer,S., Schormann,C., Poeschel,V., Ziepert,M.,
Walter,S., Roth,P., Weller,M., Szczepanowski,M., Klapper,W.,
Monoranu,C., Rosenwald,A., Moller,P., Hartmann,S., Hansmann,M.L.,
Mackensen,A., Schafer,H., Schorb,E., Illerhaus,G., Buslei,R.,
Bohle,R.M., Stilgenbauer,S., Kim,Y.J. and Pfreundschuh,M.
TITLE Hyper-N-glycosylated SAMD14 and neurabin-I as driver autoantigens
of primary central nervous system lymphoma
JOURNAL Blood 132 (26), 2744-2753 (2018)
PUBMED 30249786
REMARK GeneRIF: Hyper-N-glycosylated SAMD14 and neurabin-I as driver
autoantigens of primary central nervous system lymphoma.
REFERENCE 3 (bases 1 to 4847)
AUTHORS Shen,Y., Takahashi,M., Byun,H.M., Link,A., Sharma,N., Balaguer,F.,
Leung,H.C., Boland,C.R. and Goel,A.
TITLE Boswellic acid induces epigenetic alterations by modulating DNA
methylation in colorectal cancer cells
JOURNAL Cancer Biol Ther 13 (7), 542-552 (2012)
PUBMED 22415137
REFERENCE 4 (bases 1 to 4847)
AUTHORS Fehrmann,R.S., Jansen,R.C., Veldink,J.H., Westra,H.J., Arends,D.,
Bonder,M.J., Fu,J., Deelen,P., Groen,H.J., Smolonska,A.,
Weersma,R.K., Hofstra,R.M., Buurman,W.A., Rensen,S., Wolfs,M.G.,
Platteel,M., Zhernakova,A., Elbers,C.C., Festen,E.M., Trynka,G.,
Hofker,M.H., Saris,C.G., Ophoff,R.A., van den Berg,L.H., van
Heel,D.A., Wijmenga,C., Te Meerman,G.J. and Franke,L.
TITLE Trans-eQTLs reveal that independent genetic variants associated
with a complex phenotype converge on intermediate genes, with a
major role for the HLA
JOURNAL PLoS Genet 7 (8), e1002197 (2011)
PUBMED 21829388
REFERENCE 5 (bases 1 to 4847)
AUTHORS Sun,W., Iijima,T., Kano,J., Kobayashi,H., Li,D., Morishita,Y.,
Okubo,C., Anami,Y. and Noguchi,M.
TITLE Frequent aberrant methylation of the promoter region of sterile
alpha motif domain 14 in pulmonary adenocarcinoma
JOURNAL Cancer Sci 99 (11), 2177-2184 (2008)
PUBMED 18823374
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC002401.2, CN369613.1, AY148482.1, AF035306.1 and BM973393.1.
On Jun 2, 2019 this sequence version replaced NM_174920.3.
Transcript Variant: This variant (1) represents the longer
transcript and encodes the longer isoform (1).
##Evidence-Data-START##
Transcript exon combination :: AY148482.1 [ECO:0000332]
RNAseq introns :: partial sample support SAMEA2158569
[ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-278 AC002401.2 25388-25665
279-357 CN369613.1 3-81
358-2216 AY148482.1 1-1859
2217-3495 AF035306.1 727-2005
3496-3578 BM973393.1 17-99 c
3579-4847 AC002401.2 44240-45508
FEATURES Location/Qualifiers
source 1..4847
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q21.33"
gene 1..4847
/gene="SAMD14"
/note="sterile alpha motif domain containing 14"
/db_xref="GeneID:201191"
/db_xref="HGNC:HGNC:27312"
/db_xref="MIM:619233"
exon 1..644
/gene="SAMD14"
/inference="alignment:Splign:2.1.0"
exon 645..699
/gene="SAMD14"
/inference="alignment:Splign:2.1.0"
misc_feature 651..653
/gene="SAMD14"
/note="upstream in-frame stop codon"
CDS 657..1994
/gene="SAMD14"
/note="isoform 1 is encoded by transcript variant 1;
sterile alpha motif domain-containing protein 14; SAM
domain-containing protein 14"
/codon_start=1
/product="sterile alpha motif domain-containing protein 14
isoform 1"
/protein_id="NP_777580.1"
/db_xref="CCDS:CCDS11560.1"
/db_xref="GeneID:201191"
/db_xref="HGNC:HGNC:27312"
/db_xref="MIM:619233"
/translation="MASSKLREPVDEVFDLDLAVPETARLDSSLHKARAQLLAKGRRH
RPSRSRLRDSASSAEDGEGSDGPGGKVTDGCGSPLHRLRSPLHSGPGSPAGGSFCLDP
PGLRRSLDEDEPPPSPLTRYRPLHNAASHEGLAAASCSPPRSAPSSDSSPSFVRRHPR
AEPHSEDDSRDASPPEPASPTIGLDKKTRRKFLDLGVTLRRASTGKSRKEKGSNRLSM
GSRESVEGSGRSGGSPFLPFSWFTDSGKGSASSGSTTSPTCSPKHEGFSPKKSASQAQ
LLAHAQEALSNSWCLVQDFGSTQIGMESTLSDDSTPPSSSPKIPSGPWQEAKCSYPYH
TLSQSSDEFLDEPLPPVHHWTSQQVGQWLQSLNLEQYAAEFAARQVDGPQLLQLDGSK
LKSLGLSNSHDRALVKRKLKEMAAAAEKERKAQEKAARQREKLRRREQEAKKS"
exon 700..866
/gene="SAMD14"
/inference="alignment:Splign:2.1.0"
exon 867..1155
/gene="SAMD14"
/inference="alignment:Splign:2.1.0"
exon 1156..1243
/gene="SAMD14"
/inference="alignment:Splign:2.1.0"
exon 1244..1318
/gene="SAMD14"
/inference="alignment:Splign:2.1.0"
exon 1319..1478
/gene="SAMD14"
/inference="alignment:Splign:2.1.0"
exon 1479..1562
/gene="SAMD14"
/inference="alignment:Splign:2.1.0"
exon 1563..1682
/gene="SAMD14"
/inference="alignment:Splign:2.1.0"
exon 1683..1838
/gene="SAMD14"
/inference="alignment:Splign:2.1.0"
exon 1839..4847
/gene="SAMD14"
/inference="alignment:Splign:2.1.0"
regulatory 3547..3552
/regulatory_class="polyA_signal_sequence"
/gene="SAMD14"
/note="hexamer: AATAAA"
polyA_site 3578
/gene="SAMD14"
/note="major polyA site"
ORIGIN
1 gcgccgcgtc tcccgcgggc agagaagtag ctgcaactcc gctccccggc cccagccgcc
61 tcctccccgc cgccctcccc cgcccccgcc ccctcgctcc ctcccgctct ttgtctcctg
121 ggcgcccggc ttctccgcca cgcgcccccc accccgacgc cccttccccg gagacccccg
181 cggacccctg ccgacgcgac gccgcgcgaa tcggccctgc caggcggggg ccccgcgtcc
241 ggccaggcct ggcgggcggc aggggcgggg agggaggtgg cgctcgctct tcgctcttct
301 ctctctctct ctctctgtca cacacacaca cacgcacacg cacacgcaca cacacacgga
361 gcatcctccc gtcaggtctc ctggtccagc cccgcccgcg cctcctgctt ccagcgaacc
421 tgttccctct ccccacatcc cccgccctcc atctcccccg gctctgggac ccttcccgcc
481 gacctcaccc ccacccccgg gatggagcgg ctcgagcccg cccggagccc cccgcggccg
541 gggtgacggt ccccccaccc ctctcctgcc cggcccccgc ctcgagcacc atgggcctga
601 ggggttcccg gggcgccaga cgctgaagat gaccgatgcc ggagctctct tgagtcatgg
661 cttcttcaaa gctccgagaa cccgtggatg aagtttttga cctggacttg gctgtgccag
721 agacggccag actggacagc agtttacaca aggcccgggc ccaactgttg gccaagggcc
781 ggagacaccg gccatcccgc tccaggcttc gggacagtgc cagctccgcg gaggatggtg
841 aaggctcgga tgggcccgga ggcaaggtga ccgatggctg cgggagcccc ctgcaccggc
901 tgcgctcgcc tttgcactca ggcccggggt ccccggccgg gggctctttc tgcctggatc
961 ctccggggtt gcggcgcagc ctggacgagg acgagccgcc gccctcgccg ctcacacgct
1021 accggcccct gcacaacgct gcgtcgcacg agggcctggc cgccgcctcc tgctctccgc
1081 cgcgctccgc gccctcctcc gacagctccc ccagcttcgt gcgccgccac ccgcgcgcag
1141 agccgcacag cgaagatgac agccgtgacg ccagtcctcc tgagcccgcc agccccacca
1201 tcggcctcga taagaagact cgccgaaagt tcctggacct gggggtcacc ctgcgccgag
1261 catccacggg caagagccgg aaggagaaag gcagcaaccg actgtccatg ggcagcaggg
1321 agtcagtgga ggggtccggc aggtcagggg gctccccgtt cctgcctttt tcctggttca
1381 cggacagcgg caagggctca gcatcctcgg gtagcaccac ctcccccacc tgctccccta
1441 aacacgaggg cttcagccct aagaagtcag cttcccaggc ccagctcctg gctcatgcac
1501 aggaggcact gagcaactcc tggtgcctag tccaggactt cggctccacc cagataggga
1561 tggaatccac tctgagtgat gactccacgc cccccagcag cagccccaag atccccagtg
1621 ggccctggca ggaggccaaa tgttcttacc cctaccacac gctgtctcag tcttcagatg
1681 agttcctgga tgaacccctc ccccctgtcc accactggac cagccagcag gtgggccagt
1741 ggctgcagag cctcaacctg gaacagtatg ctgctgagtt tgctgcacgg caggtagacg
1801 ggccgcagct gctgcagctg gacggaagca aactaaagag cctggggctc agcaactctc
1861 atgaccgggc actggtgaag cgcaagttga aggagatggc agcagctgcc gagaaggagc
1921 gcaaggccca ggagaaggct gcgcggcagc gggagaagct ccggcgccga gagcaggagg
1981 ccaagaagag ctaggggagg gtgcacaggc gctggcaccc ggcaggggca gccactggct
2041 ccgcgggcac aggcctcacc agggaggctg gacctgggcg ctgcacttgg gctagcctgg
2101 tcccacgctc tcagggggga catgctctct cttaccctgt cacttggtct agacccagag
2161 accccagaaa gggagacccc agggagaggg cctagtaata aatcctattt tgaggacttg
2221 tttggcacag agttcctggg ggaggagcag atgaagggga gagggcagag aggccagggc
2281 tgaggcaagt ctgggaggct gggtcaggct gtcccattgc cctcaggcca tcgtggggct
2341 ggggtggagg ggagctagga ggcctgcctg cctgcttgcc tgccagaggc cctgaggccg
2401 ggccccaggg ctcagagctg ggctgggcat ttcagcagga gcccatgtgg gagcggctcc
2461 tctccactct tccagggggc tgtgtggtgg gagagctctg tcctgctccc ccaagaggcc
2521 agtgggcgct gcagcaagtc gcactcaggg tagactccca gccaaactcc tcaacaggag
2581 cgcagagaaa gcagcctggg gcgagtgcag tctttgccag gactcaagag gggaggatga
2641 acatcccctt ctccctctcc cctcctctgt cctgtgggtc ccagggggcg agatgacacc
2701 acacaggtct gcctctcagg gcccattcaa gacctggtct ttgacccatt ctccaagcca
2761 ggactccctt cacttcctgc tgcttcctca gagggcacct aagtcctctt tgggagctga
2821 gcaaacagga actgataggg acagaggaca ccacttccac cagccaaggc ctaggagctg
2881 ctgacctggt cagccctcac cccagccagg cagagaggca aaacctgggg gtccccggca
2941 gctacgagat tggaaaggtt catcagccct cccccatctg ccccaggcat tgtcagggaa
3001 tcagtgggct cagaactggc aggcggtgca agctctgctt ccctgggcca cactgagggc
3061 tggggccagc tccctggatg ggggtggagt ttaccagcag cctggggaca gcatgtgtcc
3121 tttttaggaa atgtccttgg aggaagtgtt catgtgtggc gctggtcagc agctagtccc
3181 gcttccagga cactggtcag agttaccgat gaggcctggg ggctcccgct tggaaacccc
3241 tccagctcct cccatctgcc cagacagagc ggcagatggc accaatgcat gctggctccc
3301 tcattcctgc ccaggggctg tggcttacgg ccagcaccct gtacctggga ctcagccctt
3361 atcccccctc tgctatctgt gctgggagag gggcttcgga gggaaacaga tatgaggaca
3421 ctggcaccat ctgggcctgg tggcagggcc atgggaggtt ggaaggcacc cacatcctta
3481 aagccatcag tagctatagt gggtgcccac ctgcatgtga aggggaggca gttctcaatt
3541 tatttcaata aatccttatg atgtgccagt gaccagaatt tctgtctgct ccagttgttg
3601 ggttggccgg actctgctgg gccctgagta tggtgggaca acaggtctgt caccaggtgc
3661 tgggccatcc ggcgttctga acagatggct ttgcccagtg ttttactcac agtcctgagc
3721 tgggccggac gtccccggtg cgtcatgtgg tggtcacagg gcaccgcagt gtgcgtgtgt
3781 acgtgcgcac gtgtgggtcc cctcccccag ggatgcagcc aggccagtct cattcagtct
3841 cctctttact gtgggtgtgg gtgtcactgt cactgccaca gccactggga gggacacaca
3901 gctttaaccc ctgtgtgctt aggggaaggg tgggggcatt cagggttata aaactaacta
3961 tatacacaga aggtcctagg gagaaagcca ccctgagcac acatgtctgg gcacagtggg
4021 ggctgggggc tggagctcag gcaggatgga ctaggcttgt ggaggagcgg gtgggcatga
4081 gcatgtgagg acatgctggg agggctcagg aggtggcaca gacattgcca aggccactgc
4141 agggcctcga gcagcttggc tggatggcaa gctctcggtc taacaaggtt cttccacttt
4201 agagttgggc cctgtgagag ccaccccctc cgccaccgac cttcaagccc tgagcggagg
4261 gagaggctgc aggaccagcc tcattcccca ctcacgggtg taactccttt ccccactcag
4321 tccccaggtc tggagggcac ccaccctctt cctaacactt cagcaggcca aggccagggt
4381 gcctttgtgg gctgggggaa taaggcaacg ggacatccac ttggaaggcc tgtgctgtgg
4441 agggtgctga gggggaccca gtacccctgg cagaaaagtg acagccctgg tctcagagag
4501 gaggactgcc atgggaaaat gtctctggga caccccatca gggtggagac atccctaacc
4561 ctcaggcatc gcccacagag atagggaggc caccgagggg tctccacaga gatggactgg
4621 cacttaggga ccatcacaga cctatcaccg cagtgacttc catagagaca gaacctggtc
4681 atcagggaga acccaccccc tgctccccca ggaggatggt gaggggcacc acggtggggg
4741 gacccagagg cggcagtccg tcctctcagg tgcagatgca cggcggccct tagctgacgc
4801 ggtacgtgga cgtgttcttg ggctccgtgc tgggcacaca ccagtcg
//