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espin [Rattus norvegicus]

NCBI Reference Sequence: NP_062568.2

Identical Proteins FASTA Graphics 

LOCUS       NP_062568                 32 aa            linear   ROD 30-MAR-2024
DEFINITION  espin [Rattus norvegicus].
ACCESSION   NP_062568 REGION: 35..66
VERSION     NP_062568.2
DBSOURCE    REFSEQ: accession NM_019622.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues )
  AUTHORS   Ahmed,Z.M., Jaworek,T.J., Sarangdhar,G.N., Zheng,L., Gul,K.,
            Khan,S.N., Friedman,T.B., Sisk,R.A., Bartles,J.R., Riazuddin,S. and
            Riazuddin,S.
  TITLE     Inframe deletion of human ESPN is associated with deafness,
            vestibulopathy and vision impairment
  JOURNAL   J Med Genet 55 (7), 479-488 (2018)
   PUBMED   29572253
REFERENCE   2  (residues )
  AUTHORS   Lelli,A., Michel,V., Boutet de Monvel,J., Cortese,M.,
            Bosch-Grau,M., Aghaie,A., Perfettini,I., Dupont,T., Avan,P.,
            El-Amraoui,A. and Petit,C.
  TITLE     Class III myosins shape the auditory hair bundles by limiting
            microvilli and stereocilia growth
  JOURNAL   J Cell Biol 212 (2), 231-244 (2016)
   PUBMED   26754646
REFERENCE   3  (residues )
  AUTHORS   Merritt,R.C., Manor,U., Salles,F.T., Grati,M., Dose,A.C.,
            Unrath,W.C., Quintero,O.A., Yengo,C.M. and Kachar,B.
  TITLE     Myosin IIIB uses an actin-binding motif in its espin-1 cargo to
            reach the tips of actin protrusions
  JOURNAL   Curr Biol 22 (4), 320-325 (2012)
   PUBMED   22264607
REFERENCE   4  (residues )
  AUTHORS   Revenu,C., Ubelmann,F., Hurbain,I., El-Marjou,F., Dingli,F.,
            Loew,D., Delacour,D., Gilet,J., Brot-Laroche,E., Rivero,F.,
            Louvard,D. and Robine,S.
  TITLE     A new role for the architecture of microvillar actin bundles in
            apical retention of membrane proteins
  JOURNAL   Mol Biol Cell 23 (2), 324-336 (2012)
   PUBMED   22114352
REFERENCE   5  (residues )
  AUTHORS   Schwander,M., Kachar,B. and Muller,U.
  TITLE     Review series: The cell biology of hearing
  JOURNAL   J Cell Biol 190 (1), 9-20 (2010)
   PUBMED   20624897
  REMARK    Review article
REFERENCE   6  (residues )
  AUTHORS   Sekerkova,G., Loomis,P.A., Changyaleket,B., Zheng,L., Eytan,R.,
            Chen,B., Mugnaini,E. and Bartles,J.R.
  TITLE     Novel espin actin-bundling proteins are localized to Purkinje cell
            dendritic spines and bind the Src homology 3 adapter protein
            insulin receptor substrate p53
  JOURNAL   J Neurosci 23 (4), 1310-1319 (2003)
   PUBMED   12598619
REFERENCE   7  (residues )
  AUTHORS   Zheng,L., Sekerkova,G., Vranich,K., Tilney,L.G., Mugnaini,E. and
            Bartles,J.R.
  TITLE     The deaf jerker mouse has a mutation in the gene encoding the espin
            actin-bundling proteins of hair cell stereocilia and lacks espins
  JOURNAL   Cell 102 (3), 377-385 (2000)
   PUBMED   10975527
REFERENCE   8  (residues )
  AUTHORS   Chen,B., Li,A., Wang,D., Wang,M., Zheng,L. and Bartles,J.R.
  TITLE     Espin contains an additional actin-binding site in its N terminus
            and is a major actin-bundling protein of the Sertoli cell-spermatid
            ectoplasmic specialization junctional plaque
  JOURNAL   Mol Biol Cell 10 (12), 4327-4339 (1999)
   PUBMED   10588661
REFERENCE   9  (residues )
  AUTHORS   Bartles,J.R., Zheng,L., Li,A., Wierda,A. and Chen,B.
  TITLE     Small espin: a third actin-bundling protein and potential forked
            protein ortholog in brush border microvilli
  JOURNAL   J Cell Biol 143 (1), 107-119 (1998)
   PUBMED   9763424
REFERENCE   10 (residues )
  AUTHORS   Bartles,J.R., Wierda,A. and Zheng,L.
  TITLE     Identification and characterization of espin, an actin-binding
            protein localized to the F-actin-rich junctional plaques of Sertoli
            cell ectoplasmic specializations
  JOURNAL   J Cell Sci 109 (Pt 6), 1229-1239 (1996)
   PUBMED   8799813
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Feb 5, 2015 this sequence version replaced NP_062568.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U46007.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..32
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     Protein         <1..>32
                     /product="espin"
                     /note="Jerker, deafness locus; actin cytoskeletal
                     regulatory protein; ectoplasmic specialization protein"
                     /calculated_mol_wt=90525
     Region          1..32
                     /region_name="ANK 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63618.2)"
     Region          5..>32
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          18..>32
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     CDS             1..838
                     /gene="Espn"
                     /gene_synonym="Je"
                     /coded_by="NM_019622.2:16..2532"
                     /db_xref="GeneID:56227"
                     /db_xref="RGD:620652"
ORIGIN      
        1 ldalpvhhaa rsgklhclry lveevalpav sr
//
1..838
/gene="Espn"
/gene_synonym="Je"
/coded_by="NM_019622.2:16..2532"
/db_xref="GeneID:56227"
/db_xref="RGD:620652"
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Feature NP_062568 : 1 segment
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