LOCUS NP_062568 32 aa linear ROD 30-MAR-2024
DEFINITION espin [Rattus norvegicus].
ACCESSION NP_062568 REGION: 35..66
VERSION NP_062568.2
DBSOURCE REFSEQ: accession NM_019622.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (residues )
AUTHORS Ahmed,Z.M., Jaworek,T.J., Sarangdhar,G.N., Zheng,L., Gul,K.,
Khan,S.N., Friedman,T.B., Sisk,R.A., Bartles,J.R., Riazuddin,S. and
Riazuddin,S.
TITLE Inframe deletion of human ESPN is associated with deafness,
vestibulopathy and vision impairment
JOURNAL J Med Genet 55 (7), 479-488 (2018)
PUBMED 29572253
REFERENCE 2 (residues )
AUTHORS Lelli,A., Michel,V., Boutet de Monvel,J., Cortese,M.,
Bosch-Grau,M., Aghaie,A., Perfettini,I., Dupont,T., Avan,P.,
El-Amraoui,A. and Petit,C.
TITLE Class III myosins shape the auditory hair bundles by limiting
microvilli and stereocilia growth
JOURNAL J Cell Biol 212 (2), 231-244 (2016)
PUBMED 26754646
REFERENCE 3 (residues )
AUTHORS Merritt,R.C., Manor,U., Salles,F.T., Grati,M., Dose,A.C.,
Unrath,W.C., Quintero,O.A., Yengo,C.M. and Kachar,B.
TITLE Myosin IIIB uses an actin-binding motif in its espin-1 cargo to
reach the tips of actin protrusions
JOURNAL Curr Biol 22 (4), 320-325 (2012)
PUBMED 22264607
REFERENCE 4 (residues )
AUTHORS Revenu,C., Ubelmann,F., Hurbain,I., El-Marjou,F., Dingli,F.,
Loew,D., Delacour,D., Gilet,J., Brot-Laroche,E., Rivero,F.,
Louvard,D. and Robine,S.
TITLE A new role for the architecture of microvillar actin bundles in
apical retention of membrane proteins
JOURNAL Mol Biol Cell 23 (2), 324-336 (2012)
PUBMED 22114352
REFERENCE 5 (residues )
AUTHORS Schwander,M., Kachar,B. and Muller,U.
TITLE Review series: The cell biology of hearing
JOURNAL J Cell Biol 190 (1), 9-20 (2010)
PUBMED 20624897
REMARK Review article
REFERENCE 6 (residues )
AUTHORS Sekerkova,G., Loomis,P.A., Changyaleket,B., Zheng,L., Eytan,R.,
Chen,B., Mugnaini,E. and Bartles,J.R.
TITLE Novel espin actin-bundling proteins are localized to Purkinje cell
dendritic spines and bind the Src homology 3 adapter protein
insulin receptor substrate p53
JOURNAL J Neurosci 23 (4), 1310-1319 (2003)
PUBMED 12598619
REFERENCE 7 (residues )
AUTHORS Zheng,L., Sekerkova,G., Vranich,K., Tilney,L.G., Mugnaini,E. and
Bartles,J.R.
TITLE The deaf jerker mouse has a mutation in the gene encoding the espin
actin-bundling proteins of hair cell stereocilia and lacks espins
JOURNAL Cell 102 (3), 377-385 (2000)
PUBMED 10975527
REFERENCE 8 (residues )
AUTHORS Chen,B., Li,A., Wang,D., Wang,M., Zheng,L. and Bartles,J.R.
TITLE Espin contains an additional actin-binding site in its N terminus
and is a major actin-bundling protein of the Sertoli cell-spermatid
ectoplasmic specialization junctional plaque
JOURNAL Mol Biol Cell 10 (12), 4327-4339 (1999)
PUBMED 10588661
REFERENCE 9 (residues )
AUTHORS Bartles,J.R., Zheng,L., Li,A., Wierda,A. and Chen,B.
TITLE Small espin: a third actin-bundling protein and potential forked
protein ortholog in brush border microvilli
JOURNAL J Cell Biol 143 (1), 107-119 (1998)
PUBMED 9763424
REFERENCE 10 (residues )
AUTHORS Bartles,J.R., Wierda,A. and Zheng,L.
TITLE Identification and characterization of espin, an actin-binding
protein localized to the F-actin-rich junctional plaques of Sertoli
cell ectoplasmic specializations
JOURNAL J Cell Sci 109 (Pt 6), 1229-1239 (1996)
PUBMED 8799813
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAXUCZ010000005.1.
On Feb 5, 2015 this sequence version replaced NP_062568.1.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: U46007.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA5760383,
SAMEA5760389 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..32
/organism="Rattus norvegicus"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="5"
/map="5q36"
Protein <1..>32
/product="espin"
/note="Jerker, deafness locus; actin cytoskeletal
regulatory protein; ectoplasmic specialization protein"
/calculated_mol_wt=90525
Region 1..32
/region_name="ANK 2"
/note="propagated from UniProtKB/Swiss-Prot (Q63618.2)"
Region 5..>32
/region_name="ANK repeat"
/note="ANK repeat [structural motif]"
/db_xref="CDD:293786"
Region 18..>32
/region_name="ANKYR"
/note="Ankyrin repeat [Signal transduction mechanisms];
COG0666"
/db_xref="CDD:440430"
CDS 1..838
/gene="Espn"
/gene_synonym="Je"
/coded_by="NM_019622.2:16..2532"
/db_xref="GeneID:56227"
/db_xref="RGD:620652"
ORIGIN
1 ldalpvhhaa rsgklhclry lveevalpav sr
//