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NCBI Reference Sequence: NR_024627.1
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LOCUS NR_024627 1109 bp RNA linear PRI 02-SEP-2020 DEFINITION Homo sapiens KCNQ1 downstream neighbor (KCNQ1DN), long non-coding RNA. ACCESSION NR_024627 XR_039804 XR_039805 XR_039806 VERSION NR_024627.1 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1109) AUTHORS Koch CM and Wagner W. TITLE Epigenetic-aging-signature to determine age in different tissues JOURNAL Aging (Albany NY) 3 (10), 1018-1027 (2011) PUBMED 22067257 REFERENCE 2 (bases 1 to 1109) AUTHORS Engemann S, Strodicke M, Paulsen M, Franck O, Reinhardt R, Lane N, Reik W and Walter J. TITLE Sequence and functional comparison in the Beckwith-Wiedemann region: implications for a novel imprinting centre and extended imprinting JOURNAL Hum. Mol. Genet. 9 (18), 2691-2706 (2000) PUBMED 11063728 REFERENCE 3 (bases 1 to 1109) AUTHORS Xin Z, Soejima H, Higashimoto K, Yatsuki H, Zhu X, Satoh Y, Masaki Z, Kaneko Y, Jinno Y, Fukuzawa R, Hata Ji and Mukai T. TITLE A novel imprinted gene, KCNQ1DN, within the WT2 critical region of human chromosome 11p15.5 and its reduced expression in Wilms' tumors JOURNAL J. Biochem. 128 (5), 847-853 (2000) PUBMED 11056398 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AB039920.1. On or before Jan 2, 2009 this sequence version replaced XR_039804.1, XR_039806.1, XR_039805.1. Summary: Imprinting is a phenomenon in which epigenetic modifications lead to expression or suppression of alleles of some genes based on their parental origin. Wilms tumor-2 (WT2; MIM 194071) is defined by maternal-specific loss of heterozygosity of a critical region on chromosome 11p15.5 that includes several imprinted genes. KCNQ1DN is an imprinted gene located within the WT2 critical region that is expressed from the maternal allele (Xin et al., 2000 [PubMed 11056398]).[supplied by OMIM, Mar 2008]. ##Evidence-Data-START## Transcript exon combination :: AB039920.1, BC098159.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1109 AB039920.1 1-1109 FEATURES Location/Qualifiers source 1..1109 /organism="Homo sapiens" /mol_type="transcribed RNA" /db_xref="taxon:9606" /chromosome="11" /map="11p15.4" gene 1..1109 /gene="KCNQ1DN" /gene_synonym="BWRT; HSA404617" /note="KCNQ1 downstream neighbor" /db_xref="GeneID:55539" /db_xref="HGNC:HGNC:13335" /db_xref="MIM:610980" ncRNA 1..1109 /ncRNA_class="lncRNA" /gene="KCNQ1DN" /gene_synonym="BWRT; HSA404617" /product="KCNQ1 downstream neighbor" /db_xref="GeneID:55539" /db_xref="HGNC:HGNC:13335" /db_xref="MIM:610980" misc_feature 1..1109 /gene="KCNQ1DN" /gene_synonym="BWRT; HSA404617" /note="KCNQ1 downstream neighbor; imprinted gene" exon 1..832 /gene="KCNQ1DN" /gene_synonym="BWRT; HSA404617" /inference="alignment:Splign:2.1.0" exon 833..1093 /gene="KCNQ1DN" /gene_synonym="BWRT; HSA404617" /inference="alignment:Splign:2.1.0" ORIGIN 1 gctgcccgca cgccccgacg ggagctgcgc ccagcctccc ctctggagtc ggcgctccag 61 gctgctgccc ggccggtggc caaggcccca gcaccaccgt ccctcctgca gggcatccag 121 cacctaccct tccactgggc ggctcctggt tctggtcccg gctggctcac tcaggctgcc 181 tttggaccag attcttgaac ttttccacca aggatgttgc tgctgtttgt agcgtcggat 241 cctggaaaat cgctgtgttg gggagcagca ggctctccct tgctccccca gggcctggga 301 aaatcaaccc acctctgccc cccgacccca gggctgtaac ctggtgtctg gtagccccac 361 tgtgataaac cgaagcccag cacagtttgg gactcgcccc gagttgactt atgcagcccc 421 cagaacagag gctgaaaccc ggcgcatcct ggtgaagcca cacccagccg gcctggtccc 481 aggccccggg cacggggtcc cctccactcc catctgcttc cctttcagag ccggggctga 541 gtcggcaggg acgcaggctc agggccctgg attcccgctt tctggacact tgcgtgcatg 601 cccagcacca gctcgccctt ctgagaaagc aatccctcct cagaggggag aagccgtggc 661 tgtgatgggc aggaagtggt caggacccac tgccgagcac caactcccca tgccaccacc 721 aggggtgcgc ctggactcct ggaaaggggt cgcgtcaggg tgcagcccat caaaggcttc 781 ccaagaggca agaggcaagg agaagtgtcc tactttaaac ggccagcctc agtggtcggc 841 cctgttcact ctgccacctc agagagagtg aacccagcag aggtgtgacg ggaggctggg 901 gagagacccc agcaccttga gcacacagga gccaggagga gcccaacaga gcagcagggg 961 ctggggtctt ctcctgaagc ctgactccat gggaccccaa agaagcagat ggaaaactga 1021 aaaagaaaac ccctcaagtg agccactgga aagaaagcaa aacaagagaa aataaatgag 1081 ttgtttgaca taaaaaaaaa aaaaaaaaa //
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