LOCUS NR_027113 1729 bp RNA linear PRI 07-JUN-2021
DEFINITION Homo sapiens PHACTR2 antisense RNA 1 (PHACTR2-AS1), transcript
variant 2, long non-coding RNA.
ACCESSION NR_027113
VERSION NR_027113.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1729)
AUTHORS Yuan F, Miao Z, Chen W, Wu F, Wei C, Yong J and Xiao C.
TITLE Long non-coding RNA PHACTR2-AS1 promotes tongue squamous cell
carcinoma metastasis by regulating Snail
JOURNAL J Biochem 168 (6), 651-657 (2020)
PUBMED 32702100
REMARK GeneRIF: Long non-coding RNA PHACTR2-AS1 promotes tongue squamous
cell carcinoma metastasis by regulating Snail.
REFERENCE 2 (bases 1 to 1729)
AUTHORS Chu W, Zhang X, Qi L, Fu Y, Wang P, Zhao W, Du J, Zhang J, Zhan J,
Wang Y, Zhu WG, Yu Y and Zhang H.
TITLE The EZH2-PHACTR2-AS1-Ribosome Axis induces Genomic Instability and
Promotes Growth and Metastasis in Breast Cancer
JOURNAL Cancer Res 80 (13), 2737-2750 (2020)
PUBMED 32312833
REMARK GeneRIF: The EZH2-PHACTR2-AS1-Ribosome Axis induces Genomic
Instability and Promotes Growth and Metastasis in Breast Cancer.
REFERENCE 3 (bases 1 to 1729)
AUTHORS Chen Z, Yu W, Zhou Q, Zhang J, Jiang H, Hao D, Wang J, Zhou Z, He C
and Xiao Z.
TITLE A Novel lncRNA IHS Promotes Tumor Proliferation and Metastasis in
HCC by Regulating the ERK- and AKT/GSK-3beta-Signaling Pathways
JOURNAL Mol Ther Nucleic Acids 16, 707-720 (2019)
PUBMED 31128422
REFERENCE 4 (bases 1 to 1729)
AUTHORS Chen QF, Hu CF, Sun K and Lang YP.
TITLE LncRNA NR027113 promotes malignant progression of gastric carcinoma
via EMT signaling pathway
JOURNAL Eur Rev Med Pharmacol Sci 23 (11), 4746-4755 (2019)
PUBMED 31210301
REMARK GeneRIF: LncRNA NR027113 promotes malignant progression of gastric
carcinoma via EMT signaling pathway.
REFERENCE 5 (bases 1 to 1729)
AUTHORS Chen Z, Zhou ZY, He CC, Zhang JL, Wang J and Xiao ZY.
TITLE Down-regulation of LncRNA NR027113 inhibits cell proliferation and
metastasis via PTEN/PI3K/AKT signaling pathway in hepatocellular
carcinoma
JOURNAL Eur Rev Med Pharmacol Sci 22 (21), 7222-7232 (2018)
PUBMED 30468465
REMARK GeneRIF: lncRNA NR027113 can promote the proliferation, invasion
and metastasis of hepatocellular carcinoma via the PTEN/PI3K/AKT
signaling pathway.
REFERENCE 6 (bases 1 to 1729)
AUTHORS Geller F, Feenstra B, Carstensen L, Pers TH, van Rooij IA, Korberg
IB, Choudhry S, Karjalainen JM, Schnack TH, Hollegaard MV, Feitz
WF, Roeleveld N, Hougaard DM, Hirschhorn JN, Franke L, Baskin LS,
Nordenskjold A, van der Zanden LF and Melbye M.
TITLE Genome-wide association analyses identify variants in developmental
genes associated with hypospadias
JOURNAL Nat Genet 46 (9), 957-963 (2014)
PUBMED 25108383
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AK098520.1, HY207533.1, AK093151.1 and HY183893.1.
On Jan 7, 2014 this sequence version replaced NR_027113.1.
Transcript Variant: This variant (2) contains an alternate 5' exon,
compared to variant 1.
##Evidence-Data-START##
Transcript exon combination :: AK098520.1, HY207533.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1968968, SAMEA2148093
[ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-379 AK098520.1 1-379
380-654 HY207533.1 53-327
655-856 AK098520.1 655-856
857-1514 AK093151.1 1230-1887
1515-1729 HY183893.1 1-215 c
FEATURES Location/Qualifiers
source 1..1729
/organism="Homo sapiens"
/mol_type="transcribed RNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6q24.2"
gene 1..1729
/gene="PHACTR2-AS1"
/gene_synonym="lncIHS; NR027113"
/note="PHACTR2 antisense RNA 1"
/db_xref="GeneID:285740"
/db_xref="HGNC:HGNC:40943"
ncRNA 1..1729
/ncRNA_class="lncRNA"
/gene="PHACTR2-AS1"
/gene_synonym="lncIHS; NR027113"
/product="PHACTR2 antisense RNA 1, transcript variant 2"
/db_xref="GeneID:285740"
/db_xref="HGNC:HGNC:40943"
exon 1..480
/gene="PHACTR2-AS1"
/gene_synonym="lncIHS; NR027113"
/inference="alignment:Splign:2.1.0"
exon 481..613
/gene="PHACTR2-AS1"
/gene_synonym="lncIHS; NR027113"
/inference="alignment:Splign:2.1.0"
exon 614..1729
/gene="PHACTR2-AS1"
/gene_synonym="lncIHS; NR027113"
/inference="alignment:Splign:2.1.0"
ORIGIN
1 agagttgagg ccaatggcgg ctccaccatc ctgtggctat gattcctgaa cttgtggtct
61 cctcagttga tgaggtgaag aaagaaagcc tggagaatta tgcacgagct tctcactgtc
121 tcagcccaca agtaacacac ctctttccct cacagcccac actggctgga accaatcaca
181 tagccctgcc taactgcaag ggaggccaga aagtgcaaca ctttctcatg gtcacgggtg
241 agcacgaaac atctctccaa atatgggttg ggaagattaa gagactagtc cagaagaaaa
301 cagtctccag ggagaaatat atctgggaat aggaatcgag aaagcaacca agagagcaga
361 actgagtgga tgagaggaac tgtcagacca catctgcagc tctgattagt caaatccgaa
421 atgtgcctgt tgatctacta ttccgtggaa atactggaat caccagctca ataataagag
481 gcgctggatc cagggcaaaa atgaagacat aagggacctt aggtgacaag gaagaagctc
541 ccaggcagca tgtgggatgg acccaaggag aacgtcagag agaaagagtt cagtctggtg
601 tctcctgaag caggttaaaa ttaagctcgg caggctcgac gtaaatgtgc agacaaagca
661 aagcaggaag cctcccacac taaaaaggga agataagaat cacagaagct gggatggttt
721 ttattgaagg gcatttcaaa gcaaatacag acatctacag catatttgta aatcctccgt
781 atgtgtatgg aaacacacac cttcacacat caaaactgga tttgttcctg agtaacaaaa
841 cgtcctaaga acaaaatgaa agaaaaccaa atagcagaaa aatacttcca atgtatatac
901 cacaaaggat tatttatcaa ctcaacacac caagagttaa gaaaataatg caacaggaac
961 aaagggcaaa ggatatgtac tgggaagacc acagagaaag aaaatgcaaa tggctaataa
1021 tataaaatat ttcctaggtt caatagtaat cagggaaaga caaaattaca cttttgacct
1081 cttagactgg cagtgacaaa gattatttga gtgaccaagc tttagtcagg ctcctggatc
1141 ttctaggccc atctgggcac ttcctcgtaa aatacagttt taacaaaagc cctgctaaat
1201 tggtttaccg agaactccca ccctcaatcg agttccttag cccttcacct ttcctcaggt
1261 gagggctgat catcctgtcc tgtcttcagc aagactgctc taacgctgac gtttcctttt
1321 agtaattttc catccactga cacccacttg taatttatag ccaaggagca agatacactg
1381 ctccttggct ataagttatt ttccctgtta cattcagagt tgagcccaat cccactcccc
1441 gactacaaaa tcgatagcag tggtccctat acctattgca atggtcctaa ataaaacctg
1501 ccttaccgtg cttgaacaag tgtcatcgaa taatttttta acagcaaatt gttggaggta
1561 aagacatttt taaatgtctt caattagttt agctacttcc acgtaatgtt aaaatctcca
1621 tcaattggct agttactgtc ccttcctgag aagaagcaga caccatagcc ctgcatactg
1681 tggattcact cctaagttga tattgatatg aatgaaatag ttatctccc
//