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Homo sapiens PHACTR2 antisense RNA 1 (PHACTR2-AS1), transcript variant 2, long non-coding RNA

NCBI Reference Sequence: NR_027113.2

FASTA Graphics 

LOCUS       NR_027113               1729 bp    RNA     linear   PRI 07-JUN-2021
DEFINITION  Homo sapiens PHACTR2 antisense RNA 1 (PHACTR2-AS1), transcript
            variant 2, long non-coding RNA.
ACCESSION   NR_027113
VERSION     NR_027113.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1729)
  AUTHORS   Yuan F, Miao Z, Chen W, Wu F, Wei C, Yong J and Xiao C.
  TITLE     Long non-coding RNA PHACTR2-AS1 promotes tongue squamous cell
            carcinoma metastasis by regulating Snail
  JOURNAL   J Biochem 168 (6), 651-657 (2020)
   PUBMED   32702100
  REMARK    GeneRIF: Long non-coding RNA PHACTR2-AS1 promotes tongue squamous
            cell carcinoma metastasis by regulating Snail.
REFERENCE   2  (bases 1 to 1729)
  AUTHORS   Chu W, Zhang X, Qi L, Fu Y, Wang P, Zhao W, Du J, Zhang J, Zhan J,
            Wang Y, Zhu WG, Yu Y and Zhang H.
  TITLE     The EZH2-PHACTR2-AS1-Ribosome Axis induces Genomic Instability and
            Promotes Growth and Metastasis in Breast Cancer
  JOURNAL   Cancer Res 80 (13), 2737-2750 (2020)
   PUBMED   32312833
  REMARK    GeneRIF: The EZH2-PHACTR2-AS1-Ribosome Axis induces Genomic
            Instability and Promotes Growth and Metastasis in Breast Cancer.
REFERENCE   3  (bases 1 to 1729)
  AUTHORS   Chen Z, Yu W, Zhou Q, Zhang J, Jiang H, Hao D, Wang J, Zhou Z, He C
            and Xiao Z.
  TITLE     A Novel lncRNA IHS Promotes Tumor Proliferation and Metastasis in
            HCC by Regulating the ERK- and AKT/GSK-3beta-Signaling Pathways
  JOURNAL   Mol Ther Nucleic Acids 16, 707-720 (2019)
   PUBMED   31128422
REFERENCE   4  (bases 1 to 1729)
  AUTHORS   Chen QF, Hu CF, Sun K and Lang YP.
  TITLE     LncRNA NR027113 promotes malignant progression of gastric carcinoma
            via EMT signaling pathway
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (11), 4746-4755 (2019)
   PUBMED   31210301
  REMARK    GeneRIF: LncRNA NR027113 promotes malignant progression of gastric
            carcinoma via EMT signaling pathway.
REFERENCE   5  (bases 1 to 1729)
  AUTHORS   Chen Z, Zhou ZY, He CC, Zhang JL, Wang J and Xiao ZY.
  TITLE     Down-regulation of LncRNA NR027113 inhibits cell proliferation and
            metastasis via PTEN/PI3K/AKT signaling pathway in hepatocellular
            carcinoma
  JOURNAL   Eur Rev Med Pharmacol Sci 22 (21), 7222-7232 (2018)
   PUBMED   30468465
  REMARK    GeneRIF: lncRNA NR027113 can promote the proliferation, invasion
            and metastasis of hepatocellular carcinoma via the PTEN/PI3K/AKT
            signaling pathway.
REFERENCE   6  (bases 1 to 1729)
  AUTHORS   Geller F, Feenstra B, Carstensen L, Pers TH, van Rooij IA, Korberg
            IB, Choudhry S, Karjalainen JM, Schnack TH, Hollegaard MV, Feitz
            WF, Roeleveld N, Hougaard DM, Hirschhorn JN, Franke L, Baskin LS,
            Nordenskjold A, van der Zanden LF and Melbye M.
  TITLE     Genome-wide association analyses identify variants in developmental
            genes associated with hypospadias
  JOURNAL   Nat Genet 46 (9), 957-963 (2014)
   PUBMED   25108383
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK098520.1, HY207533.1, AK093151.1 and HY183893.1.
            
            On Jan 7, 2014 this sequence version replaced NR_027113.1.
            
            Transcript Variant: This variant (2) contains an alternate 5' exon,
            compared to variant 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK098520.1, HY207533.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-379               AK098520.1         1-379
            380-654             HY207533.1         53-327
            655-856             AK098520.1         655-856
            857-1514            AK093151.1         1230-1887
            1515-1729           HY183893.1         1-215               c
FEATURES             Location/Qualifiers
     source          1..1729
                     /organism="Homo sapiens"
                     /mol_type="transcribed RNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q24.2"
     gene            1..1729
                     /gene="PHACTR2-AS1"
                     /gene_synonym="lncIHS; NR027113"
                     /note="PHACTR2 antisense RNA 1"
                     /db_xref="GeneID:285740"
                     /db_xref="HGNC:HGNC:40943"
     ncRNA           1..1729
                     /ncRNA_class="lncRNA"
                     /gene="PHACTR2-AS1"
                     /gene_synonym="lncIHS; NR027113"
                     /product="PHACTR2 antisense RNA 1, transcript variant 2"
                     /db_xref="GeneID:285740"
                     /db_xref="HGNC:HGNC:40943"
     exon            1..480
                     /gene="PHACTR2-AS1"
                     /gene_synonym="lncIHS; NR027113"
                     /inference="alignment:Splign:2.1.0"
     exon            481..613
                     /gene="PHACTR2-AS1"
                     /gene_synonym="lncIHS; NR027113"
                     /inference="alignment:Splign:2.1.0"
     exon            614..1729
                     /gene="PHACTR2-AS1"
                     /gene_synonym="lncIHS; NR027113"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagttgagg ccaatggcgg ctccaccatc ctgtggctat gattcctgaa cttgtggtct
       61 cctcagttga tgaggtgaag aaagaaagcc tggagaatta tgcacgagct tctcactgtc
      121 tcagcccaca agtaacacac ctctttccct cacagcccac actggctgga accaatcaca
      181 tagccctgcc taactgcaag ggaggccaga aagtgcaaca ctttctcatg gtcacgggtg
      241 agcacgaaac atctctccaa atatgggttg ggaagattaa gagactagtc cagaagaaaa
      301 cagtctccag ggagaaatat atctgggaat aggaatcgag aaagcaacca agagagcaga
      361 actgagtgga tgagaggaac tgtcagacca catctgcagc tctgattagt caaatccgaa
      421 atgtgcctgt tgatctacta ttccgtggaa atactggaat caccagctca ataataagag
      481 gcgctggatc cagggcaaaa atgaagacat aagggacctt aggtgacaag gaagaagctc
      541 ccaggcagca tgtgggatgg acccaaggag aacgtcagag agaaagagtt cagtctggtg
      601 tctcctgaag caggttaaaa ttaagctcgg caggctcgac gtaaatgtgc agacaaagca
      661 aagcaggaag cctcccacac taaaaaggga agataagaat cacagaagct gggatggttt
      721 ttattgaagg gcatttcaaa gcaaatacag acatctacag catatttgta aatcctccgt
      781 atgtgtatgg aaacacacac cttcacacat caaaactgga tttgttcctg agtaacaaaa
      841 cgtcctaaga acaaaatgaa agaaaaccaa atagcagaaa aatacttcca atgtatatac
      901 cacaaaggat tatttatcaa ctcaacacac caagagttaa gaaaataatg caacaggaac
      961 aaagggcaaa ggatatgtac tgggaagacc acagagaaag aaaatgcaaa tggctaataa
     1021 tataaaatat ttcctaggtt caatagtaat cagggaaaga caaaattaca cttttgacct
     1081 cttagactgg cagtgacaaa gattatttga gtgaccaagc tttagtcagg ctcctggatc
     1141 ttctaggccc atctgggcac ttcctcgtaa aatacagttt taacaaaagc cctgctaaat
     1201 tggtttaccg agaactccca ccctcaatcg agttccttag cccttcacct ttcctcaggt
     1261 gagggctgat catcctgtcc tgtcttcagc aagactgctc taacgctgac gtttcctttt
     1321 agtaattttc catccactga cacccacttg taatttatag ccaaggagca agatacactg
     1381 ctccttggct ataagttatt ttccctgtta cattcagagt tgagcccaat cccactcccc
     1441 gactacaaaa tcgatagcag tggtccctat acctattgca atggtcctaa ataaaacctg
     1501 ccttaccgtg cttgaacaag tgtcatcgaa taatttttta acagcaaatt gttggaggta
     1561 aagacatttt taaatgtctt caattagttt agctacttcc acgtaatgtt aaaatctcca
     1621 tcaattggct agttactgtc ccttcctgag aagaagcaga caccatagcc ctgcatactg
     1681 tggattcact cctaagttga tattgatatg aatgaaatag ttatctccc
//
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