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Homo sapiens Pvt1 oncogene (PVT1), transcript variant 4, long non-coding RNA

NCBI Reference Sequence: NR_186121.1

FASTA Graphics 

LOCUS       NR_186121               2193 bp    RNA     linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens Pvt1 oncogene (PVT1), transcript variant 4, long
            non-coding RNA.
ACCESSION   NR_186121
VERSION     NR_186121.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2193)
  AUTHORS   Wu,K., Li,Y., Nie,B., Guo,C., Ma,X., Li,L., Cheng,S., Li,Y.,
            Luo,S., Zeng,Y., Yu,J. and Shi,M.
  TITLE     MEF2A is a transcription factor for circPVT1 and contributes to the
            malignancy of acute myeloid leukemia
  JOURNAL   Int J Oncol 65 (5) (2024)
   PUBMED   39329212
  REMARK    GeneRIF: MEF2A is a transcription factor for circPVT1 and
            contributes to the malignancy of acute myeloid leukemia.
REFERENCE   2  (bases 1 to 2193)
  AUTHORS   Zhao,Y., Zhao,L., Li,M., Meng,Z., Wang,S., Li,J., Li,L. and Gong,L.
  TITLE     Long non-coding RNA PVT1 regulates TGF-beta and promotes the
            proliferation, migration and invasion of hypopharyngeal carcinoma
            FaDu cells
  JOURNAL   World J Surg Oncol 22 (1), 254 (2024)
   PUBMED   39300515
  REMARK    GeneRIF: Long non-coding RNA PVT1 regulates TGF-beta and promotes
            the proliferation, migration and invasion of hypopharyngeal
            carcinoma FaDu cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2193)
  AUTHORS   Tolomeo,D., Agostini,A., Visci,G., Traversa,D. and Storlazzi,C.T.
  TITLE     PVT1: A long non-coding RNA recurrently involved in
            neoplasia-associated fusion transcripts
  JOURNAL   Gene 779, 145497 (2021)
   PUBMED   33600954
  REMARK    GeneRIF: PVT1: A long non-coding RNA recurrently involved in
            neoplasia-associated fusion transcripts.
            Review article
REFERENCE   4  (bases 1 to 2193)
  AUTHORS   Ghafouri-Fard,S., Omrani,M.D. and Taheri,M.
  TITLE     Long noncoding RNA PVT1: A highly dysregulated gene in malignancy
  JOURNAL   J Cell Physiol 235 (2), 818-835 (2020)
   PUBMED   31297833
  REMARK    GeneRIF: Long noncoding RNA PVT1: A highly dysregulated gene in
            malignancy.
            Review article
REFERENCE   5  (bases 1 to 2193)
  AUTHORS   Tseng,Y.Y., Moriarity,B.S., Gong,W., Akiyama,R., Tiwari,A.,
            Kawakami,H., Ronning,P., Reuland,B., Guenther,K., Beadnell,T.C.,
            Essig,J., Otto,G.M., O'Sullivan,M.G., Largaespada,D.A.,
            Schwertfeger,K.L., Marahrens,Y., Kawakami,Y. and Bagchi,A.
  TITLE     PVT1 dependence in cancer with MYC copy-number increase
  JOURNAL   Nature 512 (7512), 82-86 (2014)
   PUBMED   25043044
  REMARK    GeneRIF: Gain of PVT1 long non-coding RNA expression was required
            for high MYC protein levels in 8q24-amplified human cancer cells
REFERENCE   6  (bases 1 to 2193)
  AUTHORS   Barsotti,A.M., Beckerman,R., Laptenko,O., Huppi,K., Caplen,N.J. and
            Prives,C.
  TITLE     p53-Dependent induction of PVT1 and miR-1204
  JOURNAL   J Biol Chem 287 (4), 2509-2519 (2012)
   PUBMED   22110125
  REMARK    GeneRIF: p53-Dependent induction of PVT1 and miR-1204.
REFERENCE   7  (bases 1 to 2193)
  AUTHORS   Guan,Y., Kuo,W.L., Stilwell,J.L., Takano,H., Lapuk,A.V.,
            Fridlyand,J., Mao,J.H., Yu,M., Miller,M.A., Santos,J.L.,
            Kalloger,S.E., Carlson,J.W., Ginzinger,D.G., Celniker,S.E.,
            Mills,G.B., Huntsman,D.G. and Gray,J.W.
  TITLE     Amplification of PVT1 contributes to the pathophysiology of ovarian
            and breast cancer
  JOURNAL   Clin Cancer Res 13 (19), 5745-5755 (2007)
   PUBMED   17908964
  REMARK    GeneRIF: MYC and PVT1 contribute independently to ovarian and
            breast pathogenesis when overexpressed because of genomic
            abnormalities
REFERENCE   8  (bases 1 to 2193)
  AUTHORS   Shtivelman,E. and Bishop,J.M.
  TITLE     Effects of translocations on transcription from PVT
  JOURNAL   Mol Cell Biol 10 (4), 1835-1839 (1990)
   PUBMED   2181290
REFERENCE   9  (bases 1 to 2193)
  AUTHORS   Shtivelman,E., Henglein,B., Groitl,P., Lipp,M. and Bishop,J.M.
  TITLE     Identification of a human transcription unit affected by the
            variant chromosomal translocations 2;8 and 8;22 of Burkitt lymphoma
  JOURNAL   Proc Natl Acad Sci U S A 86 (9), 3257-3260 (1989)
   PUBMED   2470097
REFERENCE   10 (bases 1 to 2193)
  AUTHORS   Shtivelman,E. and Bishop,J.M.
  TITLE     The PVT gene frequently amplifies with MYC in tumor cells
  JOURNAL   Mol Cell Biol 9 (3), 1148-1154 (1989)
   PUBMED   2725491
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC103819.3, AC084123.9,
            AC103705.5 and AC026248.7.
            
            Summary: This gene represents a long non-coding RNA locus that has
            been identified as a candidate oncogene. Increased copy number and
            overexpression of this gene are associated with many types of
            cancers including breast and ovarian cancers, acute myeloid
            leukemia and Hodgkin lymphoma. Allelic variants of this gene are
            also associated with end-stage renal disease attributed to type 1
            diabetes. Consistent with its association with various types of
            cancer, transcription of this gene is regulated by the tumor
            suppressor p53 through a canonical p53-binding site, and it has
            been implicated in regulating levels of the proto-oncogene MYC to
            promote tumorigenesis. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.3751459.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               AC103819.3         146108-146318
            212-368             AC084123.9         59132-59288
            369-778             AC084123.9         94558-94967
            779-947             AC103705.5         81545-81713
            948-1077            AC103705.5         131199-131328
            1078-1206           AC103705.5         151627-151755
            1207-1333           AC103705.5         152355-152481
            1334-1446           AC026248.7         52029-52141
            1447-1535           AC026248.7         55272-55360
            1536-1631           AC026248.7         64622-64717
            1632-1672           AC026248.7         72117-72157
            1673-1779           AC026248.7         73116-73222
            1780-1916           AC026248.7         78387-78523
            1917-2193           AC026248.7         82849-83125
FEATURES             Location/Qualifiers
     source          1..2193
                     /organism="Homo sapiens"
                     /mol_type="transcribed RNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.21"
     gene            1..2193
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /note="Pvt1 oncogene"
                     /db_xref="GeneID:5820"
                     /db_xref="HGNC:HGNC:9709"
                     /db_xref="MIM:165140"
     ncRNA           1..2193
                     /ncRNA_class="lncRNA"
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /product="Pvt1 oncogene, transcript variant 4"
                     /db_xref="GeneID:5820"
                     /db_xref="HGNC:HGNC:9709"
                     /db_xref="MIM:165140"
     exon            1..211
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /inference="alignment:Splign:2.1.0"
     exon            212..368
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /inference="alignment:Splign:2.1.0"
     exon            369..778
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /inference="alignment:Splign:2.1.0"
     exon            779..947
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1077
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1206
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1333
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1446
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1535
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1631
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1672
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1779
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1916
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2193
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2171..2176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /note="hexamer: ATTAAA"
     polyA_site      2193
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /note="major polyA site"
ORIGIN      
        1 cccgcgctcc tccgggcaga gcgcgtgtgg cggccgagca catgggcccg cgggccgggc
       61 gggctcgggg cggccgggac gaggaggggc gacgacgagc tgcgagcaaa gatgtgcccc
      121 gggacccccg gcaccttcca gtggatttcc ttgcggaaag gatgttggcg gtccctgtga
      181 cctgtggaga cacggccaga tctgccctcc actgtctgca gtgcaggaag ccaactatta
      241 aggggaaaca aaagtgttct taggagtcct gctgtcactg tggattgagc cggtgaagcc
      301 ctgagggatt tcatcgctga ggtggatgga gaagcagctg ggggccttgg ctgtaaggac
      361 ccctaagggc ctgatctttt ggccagaagg agattaaaaa gatgcccctc aagatggctg
      421 tgcctgtcag ctgcatggag cttcgttcaa gtattttctg agcctgatgg atttacagtg
      481 atcttcagtg gtctggggaa taacgctggt ggaaccatgc actggaatga cacacgcccg
      541 gcacatttca ggatactaaa agtggtttta agggaggctg tggctgaatg cctcatggat
      601 tcttacagct tggatgtcca tgggggacga aggactgcag ctggctgaga gggttgagat
      661 ctctgtttac ttagatctct gccaacttcc tttgggtctc cctatggaat gtaagacccc
      721 gactcttcct ggtgaagcat ctgatgcacg ttccatccgg cgctcagctg ggcttgagct
      781 gaccatactc cctggagcct tctcccgagg tgcgcgggtg accttggcac atacagccat
      841 catgatggta ctttaagtgg aggctgaatc atctcccctt tgagctgctt ggcacgtggc
      901 tcccttggtg ttcccctttt actgccagga cactgagatt tggagagaat cctgttacac
      961 ctgggattta ggcactttca atctgaaaaa atacatatcc tttcagcact ctggacggac
     1021 ttgagaactg tccttacgtg acctaaagct ggagtatttt gagattggag aattaaggcc
     1081 aacagagatt ttgagaaaca cattgaagga tctgttaaca cttgatatac ccaataaaag
     1141 cagtggttgt gccagtgctg atctgtcttg atgtgaatgt gaacaatggg aacctgagct
     1201 gagcagttaa tgctagggtg acagaaactg gacctctccc aagacatgtg acagagtaat
     1261 acagcagcca acttcttcgc caaattaaag ttttacaaga tttaacctgt catcaagacc
     1321 tgggattttg gtgagccagt cttggtgctc tgtgttcacc tggttcatct gaggagctgc
     1381 atctaccctg cccatgccat agatcctgcc ctgtttgctt ctcctgttgc tgctagtgga
     1441 catgaggtca cccgatatag aatcacacac ctgggagatg gcaccagcca gtgaggctca
     1501 aatttgaacc acacacaaat ctccaggggt acttgatctt ggacatgata cctggatgtg
     1561 cagcagccat ctggtaatta tgaggtgaca agtcaataga ctgagatggt ggagcagcaa
     1621 agatagaaaa ggtttgggta actccacgca agactgtctt tacctgcctt tggttgccct
     1681 ggtgctctgc agtggcaggg ctgagatgat tatacaacct gcactccagg ccaagtccgg
     1741 tactcgtccc agctgtcggc taagcctgca ctgctatgga aggacagaat aacgggctcc
     1801 cagattcaca agccccacca agaggatcac cccaggaacg cttggaggct gaggagttca
     1861 ctgaggctac tgcatcttga gactcaggat gaagacccag cttggggctg tcaaaggttt
     1921 tttgcatgtc tgacacccat gactccacct ggaccttatg gctccaccca gaagcaattc
     1981 agcccaacag gaggacagct tcaacccatt acgatttcat ctctgcccca accactcagc
     2041 agcaagcacc tgttacctgt ccacccccac cccttccccc aaactgcctt tgaaaaatcc
     2101 ctaacctatg agctttgaat aagatgagta cgaacttcat cgcccacgtg gcgtggccgg
     2161 cctcgtgtct attaaattct ttttctacta caa
//
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