LOCUS NR_186121 2193 bp RNA linear PRI 15-OCT-2024
DEFINITION Homo sapiens Pvt1 oncogene (PVT1), transcript variant 4, long
non-coding RNA.
ACCESSION NR_186121
VERSION NR_186121.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2193)
AUTHORS Wu,K., Li,Y., Nie,B., Guo,C., Ma,X., Li,L., Cheng,S., Li,Y.,
Luo,S., Zeng,Y., Yu,J. and Shi,M.
TITLE MEF2A is a transcription factor for circPVT1 and contributes to the
malignancy of acute myeloid leukemia
JOURNAL Int J Oncol 65 (5) (2024)
PUBMED 39329212
REMARK GeneRIF: MEF2A is a transcription factor for circPVT1 and
contributes to the malignancy of acute myeloid leukemia.
REFERENCE 2 (bases 1 to 2193)
AUTHORS Zhao,Y., Zhao,L., Li,M., Meng,Z., Wang,S., Li,J., Li,L. and Gong,L.
TITLE Long non-coding RNA PVT1 regulates TGF-beta and promotes the
proliferation, migration and invasion of hypopharyngeal carcinoma
FaDu cells
JOURNAL World J Surg Oncol 22 (1), 254 (2024)
PUBMED 39300515
REMARK GeneRIF: Long non-coding RNA PVT1 regulates TGF-beta and promotes
the proliferation, migration and invasion of hypopharyngeal
carcinoma FaDu cells.
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 2193)
AUTHORS Tolomeo,D., Agostini,A., Visci,G., Traversa,D. and Storlazzi,C.T.
TITLE PVT1: A long non-coding RNA recurrently involved in
neoplasia-associated fusion transcripts
JOURNAL Gene 779, 145497 (2021)
PUBMED 33600954
REMARK GeneRIF: PVT1: A long non-coding RNA recurrently involved in
neoplasia-associated fusion transcripts.
Review article
REFERENCE 4 (bases 1 to 2193)
AUTHORS Ghafouri-Fard,S., Omrani,M.D. and Taheri,M.
TITLE Long noncoding RNA PVT1: A highly dysregulated gene in malignancy
JOURNAL J Cell Physiol 235 (2), 818-835 (2020)
PUBMED 31297833
REMARK GeneRIF: Long noncoding RNA PVT1: A highly dysregulated gene in
malignancy.
Review article
REFERENCE 5 (bases 1 to 2193)
AUTHORS Tseng,Y.Y., Moriarity,B.S., Gong,W., Akiyama,R., Tiwari,A.,
Kawakami,H., Ronning,P., Reuland,B., Guenther,K., Beadnell,T.C.,
Essig,J., Otto,G.M., O'Sullivan,M.G., Largaespada,D.A.,
Schwertfeger,K.L., Marahrens,Y., Kawakami,Y. and Bagchi,A.
TITLE PVT1 dependence in cancer with MYC copy-number increase
JOURNAL Nature 512 (7512), 82-86 (2014)
PUBMED 25043044
REMARK GeneRIF: Gain of PVT1 long non-coding RNA expression was required
for high MYC protein levels in 8q24-amplified human cancer cells
REFERENCE 6 (bases 1 to 2193)
AUTHORS Barsotti,A.M., Beckerman,R., Laptenko,O., Huppi,K., Caplen,N.J. and
Prives,C.
TITLE p53-Dependent induction of PVT1 and miR-1204
JOURNAL J Biol Chem 287 (4), 2509-2519 (2012)
PUBMED 22110125
REMARK GeneRIF: p53-Dependent induction of PVT1 and miR-1204.
REFERENCE 7 (bases 1 to 2193)
AUTHORS Guan,Y., Kuo,W.L., Stilwell,J.L., Takano,H., Lapuk,A.V.,
Fridlyand,J., Mao,J.H., Yu,M., Miller,M.A., Santos,J.L.,
Kalloger,S.E., Carlson,J.W., Ginzinger,D.G., Celniker,S.E.,
Mills,G.B., Huntsman,D.G. and Gray,J.W.
TITLE Amplification of PVT1 contributes to the pathophysiology of ovarian
and breast cancer
JOURNAL Clin Cancer Res 13 (19), 5745-5755 (2007)
PUBMED 17908964
REMARK GeneRIF: MYC and PVT1 contribute independently to ovarian and
breast pathogenesis when overexpressed because of genomic
abnormalities
REFERENCE 8 (bases 1 to 2193)
AUTHORS Shtivelman,E. and Bishop,J.M.
TITLE Effects of translocations on transcription from PVT
JOURNAL Mol Cell Biol 10 (4), 1835-1839 (1990)
PUBMED 2181290
REFERENCE 9 (bases 1 to 2193)
AUTHORS Shtivelman,E., Henglein,B., Groitl,P., Lipp,M. and Bishop,J.M.
TITLE Identification of a human transcription unit affected by the
variant chromosomal translocations 2;8 and 8;22 of Burkitt lymphoma
JOURNAL Proc Natl Acad Sci U S A 86 (9), 3257-3260 (1989)
PUBMED 2470097
REFERENCE 10 (bases 1 to 2193)
AUTHORS Shtivelman,E. and Bishop,J.M.
TITLE The PVT gene frequently amplifies with MYC in tumor cells
JOURNAL Mol Cell Biol 9 (3), 1148-1154 (1989)
PUBMED 2725491
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC103819.3, AC084123.9,
AC103705.5 and AC026248.7.
Summary: This gene represents a long non-coding RNA locus that has
been identified as a candidate oncogene. Increased copy number and
overexpression of this gene are associated with many types of
cancers including breast and ovarian cancers, acute myeloid
leukemia and Hodgkin lymphoma. Allelic variants of this gene are
also associated with end-stage renal disease attributed to type 1
diabetes. Consistent with its association with various types of
cancer, transcription of this gene is regulated by the tumor
suppressor p53 through a canonical p53-binding site, and it has
been implicated in regulating levels of the proto-oncogene MYC to
promote tumorigenesis. [provided by RefSeq, Sep 2015].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR14038193.3751459.1 [ECO:0000332]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-211 AC103819.3 146108-146318
212-368 AC084123.9 59132-59288
369-778 AC084123.9 94558-94967
779-947 AC103705.5 81545-81713
948-1077 AC103705.5 131199-131328
1078-1206 AC103705.5 151627-151755
1207-1333 AC103705.5 152355-152481
1334-1446 AC026248.7 52029-52141
1447-1535 AC026248.7 55272-55360
1536-1631 AC026248.7 64622-64717
1632-1672 AC026248.7 72117-72157
1673-1779 AC026248.7 73116-73222
1780-1916 AC026248.7 78387-78523
1917-2193 AC026248.7 82849-83125
FEATURES Location/Qualifiers
source 1..2193
/organism="Homo sapiens"
/mol_type="transcribed RNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8q24.21"
gene 1..2193
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/note="Pvt1 oncogene"
/db_xref="GeneID:5820"
/db_xref="HGNC:HGNC:9709"
/db_xref="MIM:165140"
ncRNA 1..2193
/ncRNA_class="lncRNA"
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/product="Pvt1 oncogene, transcript variant 4"
/db_xref="GeneID:5820"
/db_xref="HGNC:HGNC:9709"
/db_xref="MIM:165140"
exon 1..211
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/inference="alignment:Splign:2.1.0"
exon 212..368
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/inference="alignment:Splign:2.1.0"
exon 369..778
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/inference="alignment:Splign:2.1.0"
exon 779..947
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/inference="alignment:Splign:2.1.0"
exon 948..1077
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/inference="alignment:Splign:2.1.0"
exon 1078..1206
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/inference="alignment:Splign:2.1.0"
exon 1207..1333
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/inference="alignment:Splign:2.1.0"
exon 1334..1446
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/inference="alignment:Splign:2.1.0"
exon 1447..1535
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/inference="alignment:Splign:2.1.0"
exon 1536..1631
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/inference="alignment:Splign:2.1.0"
exon 1632..1672
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/inference="alignment:Splign:2.1.0"
exon 1673..1779
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/inference="alignment:Splign:2.1.0"
exon 1780..1916
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/inference="alignment:Splign:2.1.0"
exon 1917..2193
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/inference="alignment:Splign:2.1.0"
regulatory 2171..2176
/regulatory_class="polyA_signal_sequence"
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/note="hexamer: ATTAAA"
polyA_site 2193
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/note="major polyA site"
ORIGIN
1 cccgcgctcc tccgggcaga gcgcgtgtgg cggccgagca catgggcccg cgggccgggc
61 gggctcgggg cggccgggac gaggaggggc gacgacgagc tgcgagcaaa gatgtgcccc
121 gggacccccg gcaccttcca gtggatttcc ttgcggaaag gatgttggcg gtccctgtga
181 cctgtggaga cacggccaga tctgccctcc actgtctgca gtgcaggaag ccaactatta
241 aggggaaaca aaagtgttct taggagtcct gctgtcactg tggattgagc cggtgaagcc
301 ctgagggatt tcatcgctga ggtggatgga gaagcagctg ggggccttgg ctgtaaggac
361 ccctaagggc ctgatctttt ggccagaagg agattaaaaa gatgcccctc aagatggctg
421 tgcctgtcag ctgcatggag cttcgttcaa gtattttctg agcctgatgg atttacagtg
481 atcttcagtg gtctggggaa taacgctggt ggaaccatgc actggaatga cacacgcccg
541 gcacatttca ggatactaaa agtggtttta agggaggctg tggctgaatg cctcatggat
601 tcttacagct tggatgtcca tgggggacga aggactgcag ctggctgaga gggttgagat
661 ctctgtttac ttagatctct gccaacttcc tttgggtctc cctatggaat gtaagacccc
721 gactcttcct ggtgaagcat ctgatgcacg ttccatccgg cgctcagctg ggcttgagct
781 gaccatactc cctggagcct tctcccgagg tgcgcgggtg accttggcac atacagccat
841 catgatggta ctttaagtgg aggctgaatc atctcccctt tgagctgctt ggcacgtggc
901 tcccttggtg ttcccctttt actgccagga cactgagatt tggagagaat cctgttacac
961 ctgggattta ggcactttca atctgaaaaa atacatatcc tttcagcact ctggacggac
1021 ttgagaactg tccttacgtg acctaaagct ggagtatttt gagattggag aattaaggcc
1081 aacagagatt ttgagaaaca cattgaagga tctgttaaca cttgatatac ccaataaaag
1141 cagtggttgt gccagtgctg atctgtcttg atgtgaatgt gaacaatggg aacctgagct
1201 gagcagttaa tgctagggtg acagaaactg gacctctccc aagacatgtg acagagtaat
1261 acagcagcca acttcttcgc caaattaaag ttttacaaga tttaacctgt catcaagacc
1321 tgggattttg gtgagccagt cttggtgctc tgtgttcacc tggttcatct gaggagctgc
1381 atctaccctg cccatgccat agatcctgcc ctgtttgctt ctcctgttgc tgctagtgga
1441 catgaggtca cccgatatag aatcacacac ctgggagatg gcaccagcca gtgaggctca
1501 aatttgaacc acacacaaat ctccaggggt acttgatctt ggacatgata cctggatgtg
1561 cagcagccat ctggtaatta tgaggtgaca agtcaataga ctgagatggt ggagcagcaa
1621 agatagaaaa ggtttgggta actccacgca agactgtctt tacctgcctt tggttgccct
1681 ggtgctctgc agtggcaggg ctgagatgat tatacaacct gcactccagg ccaagtccgg
1741 tactcgtccc agctgtcggc taagcctgca ctgctatgga aggacagaat aacgggctcc
1801 cagattcaca agccccacca agaggatcac cccaggaacg cttggaggct gaggagttca
1861 ctgaggctac tgcatcttga gactcaggat gaagacccag cttggggctg tcaaaggttt
1921 tttgcatgtc tgacacccat gactccacct ggaccttatg gctccaccca gaagcaattc
1981 agcccaacag gaggacagct tcaacccatt acgatttcat ctctgcccca accactcagc
2041 agcaagcacc tgttacctgt ccacccccac cccttccccc aaactgcctt tgaaaaatcc
2101 ctaacctatg agctttgaat aagatgagta cgaacttcat cgcccacgtg gcgtggccgg
2161 cctcgtgtct attaaattct ttttctacta caa
//