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Homo sapiens Pvt1 oncogene (PVT1), transcript variant 24, long non-coding RNA

NCBI Reference Sequence: NR_186142.1

FASTA Graphics 

LOCUS       NR_186142               2124 bp    RNA     linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens Pvt1 oncogene (PVT1), transcript variant 24, long
            non-coding RNA.
ACCESSION   NR_186142
VERSION     NR_186142.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2124)
  AUTHORS   Wu,K., Li,Y., Nie,B., Guo,C., Ma,X., Li,L., Cheng,S., Li,Y.,
            Luo,S., Zeng,Y., Yu,J. and Shi,M.
  TITLE     MEF2A is a transcription factor for circPVT1 and contributes to the
            malignancy of acute myeloid leukemia
  JOURNAL   Int J Oncol 65 (5) (2024)
   PUBMED   39329212
  REMARK    GeneRIF: MEF2A is a transcription factor for circPVT1 and
            contributes to the malignancy of acute myeloid leukemia.
REFERENCE   2  (bases 1 to 2124)
  AUTHORS   Zhao,Y., Zhao,L., Li,M., Meng,Z., Wang,S., Li,J., Li,L. and Gong,L.
  TITLE     Long non-coding RNA PVT1 regulates TGF-beta and promotes the
            proliferation, migration and invasion of hypopharyngeal carcinoma
            FaDu cells
  JOURNAL   World J Surg Oncol 22 (1), 254 (2024)
   PUBMED   39300515
  REMARK    GeneRIF: Long non-coding RNA PVT1 regulates TGF-beta and promotes
            the proliferation, migration and invasion of hypopharyngeal
            carcinoma FaDu cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2124)
  AUTHORS   Tolomeo,D., Agostini,A., Visci,G., Traversa,D. and Storlazzi,C.T.
  TITLE     PVT1: A long non-coding RNA recurrently involved in
            neoplasia-associated fusion transcripts
  JOURNAL   Gene 779, 145497 (2021)
   PUBMED   33600954
  REMARK    GeneRIF: PVT1: A long non-coding RNA recurrently involved in
            neoplasia-associated fusion transcripts.
            Review article
REFERENCE   4  (bases 1 to 2124)
  AUTHORS   Ghafouri-Fard,S., Omrani,M.D. and Taheri,M.
  TITLE     Long noncoding RNA PVT1: A highly dysregulated gene in malignancy
  JOURNAL   J Cell Physiol 235 (2), 818-835 (2020)
   PUBMED   31297833
  REMARK    GeneRIF: Long noncoding RNA PVT1: A highly dysregulated gene in
            malignancy.
            Review article
REFERENCE   5  (bases 1 to 2124)
  AUTHORS   Tseng,Y.Y., Moriarity,B.S., Gong,W., Akiyama,R., Tiwari,A.,
            Kawakami,H., Ronning,P., Reuland,B., Guenther,K., Beadnell,T.C.,
            Essig,J., Otto,G.M., O'Sullivan,M.G., Largaespada,D.A.,
            Schwertfeger,K.L., Marahrens,Y., Kawakami,Y. and Bagchi,A.
  TITLE     PVT1 dependence in cancer with MYC copy-number increase
  JOURNAL   Nature 512 (7512), 82-86 (2014)
   PUBMED   25043044
  REMARK    GeneRIF: Gain of PVT1 long non-coding RNA expression was required
            for high MYC protein levels in 8q24-amplified human cancer cells
REFERENCE   6  (bases 1 to 2124)
  AUTHORS   Barsotti,A.M., Beckerman,R., Laptenko,O., Huppi,K., Caplen,N.J. and
            Prives,C.
  TITLE     p53-Dependent induction of PVT1 and miR-1204
  JOURNAL   J Biol Chem 287 (4), 2509-2519 (2012)
   PUBMED   22110125
  REMARK    GeneRIF: p53-Dependent induction of PVT1 and miR-1204.
REFERENCE   7  (bases 1 to 2124)
  AUTHORS   Guan,Y., Kuo,W.L., Stilwell,J.L., Takano,H., Lapuk,A.V.,
            Fridlyand,J., Mao,J.H., Yu,M., Miller,M.A., Santos,J.L.,
            Kalloger,S.E., Carlson,J.W., Ginzinger,D.G., Celniker,S.E.,
            Mills,G.B., Huntsman,D.G. and Gray,J.W.
  TITLE     Amplification of PVT1 contributes to the pathophysiology of ovarian
            and breast cancer
  JOURNAL   Clin Cancer Res 13 (19), 5745-5755 (2007)
   PUBMED   17908964
  REMARK    GeneRIF: MYC and PVT1 contribute independently to ovarian and
            breast pathogenesis when overexpressed because of genomic
            abnormalities
REFERENCE   8  (bases 1 to 2124)
  AUTHORS   Shtivelman,E. and Bishop,J.M.
  TITLE     Effects of translocations on transcription from PVT
  JOURNAL   Mol Cell Biol 10 (4), 1835-1839 (1990)
   PUBMED   2181290
REFERENCE   9  (bases 1 to 2124)
  AUTHORS   Shtivelman,E., Henglein,B., Groitl,P., Lipp,M. and Bishop,J.M.
  TITLE     Identification of a human transcription unit affected by the
            variant chromosomal translocations 2;8 and 8;22 of Burkitt lymphoma
  JOURNAL   Proc Natl Acad Sci U S A 86 (9), 3257-3260 (1989)
   PUBMED   2470097
REFERENCE   10 (bases 1 to 2124)
  AUTHORS   Shtivelman,E. and Bishop,J.M.
  TITLE     The PVT gene frequently amplifies with MYC in tumor cells
  JOURNAL   Mol Cell Biol 9 (3), 1148-1154 (1989)
   PUBMED   2725491
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC103819.3, AC084123.9,
            AC103705.5 and AC026248.7.
            
            Summary: This gene represents a long non-coding RNA locus that has
            been identified as a candidate oncogene. Increased copy number and
            overexpression of this gene are associated with many types of
            cancers including breast and ovarian cancers, acute myeloid
            leukemia and Hodgkin lymphoma. Allelic variants of this gene are
            also associated with end-stage renal disease attributed to type 1
            diabetes. Consistent with its association with various types of
            cancer, transcription of this gene is regulated by the tumor
            suppressor p53 through a canonical p53-binding site, and it has
            been implicated in regulating levels of the proto-oncogene MYC to
            promote tumorigenesis. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.2885472.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154529 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               AC103819.3         146108-146318
            212-621             AC084123.9         94558-94967
            622-790             AC103705.5         81545-81713
            791-910             AC103705.5         124397-124516
            911-1211            AC103705.5         125941-126241
            1212-1341           AC103705.5         131199-131328
            1342-1470           AC103705.5         151627-151755
            1471-1597           AC103705.5         152355-152481
            1598-1710           AC026248.7         52029-52141
            1711-1847           AC026248.7         78387-78523
            1848-2124           AC026248.7         82849-83125
FEATURES             Location/Qualifiers
     source          1..2124
                     /organism="Homo sapiens"
                     /mol_type="transcribed RNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.21"
     gene            1..2124
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /note="Pvt1 oncogene"
                     /db_xref="GeneID:5820"
                     /db_xref="HGNC:HGNC:9709"
                     /db_xref="MIM:165140"
     ncRNA           1..2124
                     /ncRNA_class="lncRNA"
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /product="Pvt1 oncogene, transcript variant 24"
                     /db_xref="GeneID:5820"
                     /db_xref="HGNC:HGNC:9709"
                     /db_xref="MIM:165140"
     exon            1..211
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /inference="alignment:Splign:2.1.0"
     exon            212..621
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /inference="alignment:Splign:2.1.0"
     exon            622..790
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /inference="alignment:Splign:2.1.0"
     exon            791..910
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1211
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1341
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1470
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1597
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1710
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1847
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..2124
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2102..2107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /note="hexamer: ATTAAA"
     polyA_site      2124
                     /gene="PVT1"
                     /gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
                     onco-lncRNA-100; TP53LC09"
                     /note="major polyA site"
ORIGIN      
        1 cccgcgctcc tccgggcaga gcgcgtgtgg cggccgagca catgggcccg cgggccgggc
       61 gggctcgggg cggccgggac gaggaggggc gacgacgagc tgcgagcaaa gatgtgcccc
      121 gggacccccg gcaccttcca gtggatttcc ttgcggaaag gatgttggcg gtccctgtga
      181 cctgtggaga cacggccaga tctgccctcc agcctgatct tttggccaga aggagattaa
      241 aaagatgccc ctcaagatgg ctgtgcctgt cagctgcatg gagcttcgtt caagtatttt
      301 ctgagcctga tggatttaca gtgatcttca gtggtctggg gaataacgct ggtggaacca
      361 tgcactggaa tgacacacgc ccggcacatt tcaggatact aaaagtggtt ttaagggagg
      421 ctgtggctga atgcctcatg gattcttaca gcttggatgt ccatggggga cgaaggactg
      481 cagctggctg agagggttga gatctctgtt tacttagatc tctgccaact tcctttgggt
      541 ctccctatgg aatgtaagac cccgactctt cctggtgaag catctgatgc acgttccatc
      601 cggcgctcag ctgggcttga gctgaccata ctccctggag ccttctcccg aggtgcgcgg
      661 gtgaccttgg cacatacagc catcatgatg gtactttaag tggaggctga atcatctccc
      721 ctttgagctg cttggcacgt ggctcccttg gtgttcccct tttactgcca ggacactgag
      781 atttggagag tctcttcacc ctctgaaaac aagaggatgt gtagcatagt gagcaacagc
      841 tgtgtgccgg ggactcagca ttaagtagca tgggattact catgacttcg cactcatggc
      901 agcctcacag agtctcactc tgtggtccag gctgaagtac agtggcatga tcccaggtca
      961 ctgcaacccc cacctcccgg gttcaagtga tcctcctgcc tcagcctccc gagtagctgg
     1021 tattacaggc gtgtgccaca aagcctggct aagttttgta tttttagtag agacggggtt
     1081 tcaccatgtt ggccaggttg gtctcgaact cctgacctca agtgatccac tcactttggc
     1141 ctttcaacgt gctgggatta caggcgagag tcaccgcacc cggacgactc tgacattttt
     1201 gaagagtcca gaatcctgtt acacctggga tttaggcact ttcaatctga aaaaatacat
     1261 atcctttcag cactctggac ggacttgaga actgtcctta cgtgacctaa agctggagta
     1321 ttttgagatt ggagaattaa ggccaacaga gattttgaga aacacattga aggatctgtt
     1381 aacacttgat atacccaata aaagcagtgg ttgtgccagt gctgatctgt cttgatgtga
     1441 atgtgaacaa tgggaacctg agctgagcag ttaatgctag ggtgacagaa actggacctc
     1501 tcccaagaca tgtgacagag taatacagca gccaacttct tcgccaaatt aaagttttac
     1561 aagatttaac ctgtcatcaa gacctgggat tttggtgagc cagtcttggt gctctgtgtt
     1621 cacctggttc atctgaggag ctgcatctac cctgcccatg ccatagatcc tgccctgttt
     1681 gcttctcctg ttgctgctag tggacatgag aaggacagaa taacgggctc ccagattcac
     1741 aagccccacc aagaggatca ccccaggaac gcttggaggc tgaggagttc actgaggcta
     1801 ctgcatcttg agactcagga tgaagaccca gcttggggct gtcaaaggtt ttttgcatgt
     1861 ctgacaccca tgactccacc tggaccttat ggctccaccc agaagcaatt cagcccaaca
     1921 ggaggacagc ttcaacccat tacgatttca tctctgcccc aaccactcag cagcaagcac
     1981 ctgttacctg tccaccccca ccccttcccc caaactgcct ttgaaaaatc cctaacctat
     2041 gagctttgaa taagatgagt acgaacttca tcgcccacgt ggcgtggccg gcctcgtgtc
     2101 tattaaattc tttttctact acaa
//
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