LOCUS NR_186142 2124 bp RNA linear PRI 15-OCT-2024
DEFINITION Homo sapiens Pvt1 oncogene (PVT1), transcript variant 24, long
non-coding RNA.
ACCESSION NR_186142
VERSION NR_186142.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2124)
AUTHORS Wu,K., Li,Y., Nie,B., Guo,C., Ma,X., Li,L., Cheng,S., Li,Y.,
Luo,S., Zeng,Y., Yu,J. and Shi,M.
TITLE MEF2A is a transcription factor for circPVT1 and contributes to the
malignancy of acute myeloid leukemia
JOURNAL Int J Oncol 65 (5) (2024)
PUBMED 39329212
REMARK GeneRIF: MEF2A is a transcription factor for circPVT1 and
contributes to the malignancy of acute myeloid leukemia.
REFERENCE 2 (bases 1 to 2124)
AUTHORS Zhao,Y., Zhao,L., Li,M., Meng,Z., Wang,S., Li,J., Li,L. and Gong,L.
TITLE Long non-coding RNA PVT1 regulates TGF-beta and promotes the
proliferation, migration and invasion of hypopharyngeal carcinoma
FaDu cells
JOURNAL World J Surg Oncol 22 (1), 254 (2024)
PUBMED 39300515
REMARK GeneRIF: Long non-coding RNA PVT1 regulates TGF-beta and promotes
the proliferation, migration and invasion of hypopharyngeal
carcinoma FaDu cells.
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 2124)
AUTHORS Tolomeo,D., Agostini,A., Visci,G., Traversa,D. and Storlazzi,C.T.
TITLE PVT1: A long non-coding RNA recurrently involved in
neoplasia-associated fusion transcripts
JOURNAL Gene 779, 145497 (2021)
PUBMED 33600954
REMARK GeneRIF: PVT1: A long non-coding RNA recurrently involved in
neoplasia-associated fusion transcripts.
Review article
REFERENCE 4 (bases 1 to 2124)
AUTHORS Ghafouri-Fard,S., Omrani,M.D. and Taheri,M.
TITLE Long noncoding RNA PVT1: A highly dysregulated gene in malignancy
JOURNAL J Cell Physiol 235 (2), 818-835 (2020)
PUBMED 31297833
REMARK GeneRIF: Long noncoding RNA PVT1: A highly dysregulated gene in
malignancy.
Review article
REFERENCE 5 (bases 1 to 2124)
AUTHORS Tseng,Y.Y., Moriarity,B.S., Gong,W., Akiyama,R., Tiwari,A.,
Kawakami,H., Ronning,P., Reuland,B., Guenther,K., Beadnell,T.C.,
Essig,J., Otto,G.M., O'Sullivan,M.G., Largaespada,D.A.,
Schwertfeger,K.L., Marahrens,Y., Kawakami,Y. and Bagchi,A.
TITLE PVT1 dependence in cancer with MYC copy-number increase
JOURNAL Nature 512 (7512), 82-86 (2014)
PUBMED 25043044
REMARK GeneRIF: Gain of PVT1 long non-coding RNA expression was required
for high MYC protein levels in 8q24-amplified human cancer cells
REFERENCE 6 (bases 1 to 2124)
AUTHORS Barsotti,A.M., Beckerman,R., Laptenko,O., Huppi,K., Caplen,N.J. and
Prives,C.
TITLE p53-Dependent induction of PVT1 and miR-1204
JOURNAL J Biol Chem 287 (4), 2509-2519 (2012)
PUBMED 22110125
REMARK GeneRIF: p53-Dependent induction of PVT1 and miR-1204.
REFERENCE 7 (bases 1 to 2124)
AUTHORS Guan,Y., Kuo,W.L., Stilwell,J.L., Takano,H., Lapuk,A.V.,
Fridlyand,J., Mao,J.H., Yu,M., Miller,M.A., Santos,J.L.,
Kalloger,S.E., Carlson,J.W., Ginzinger,D.G., Celniker,S.E.,
Mills,G.B., Huntsman,D.G. and Gray,J.W.
TITLE Amplification of PVT1 contributes to the pathophysiology of ovarian
and breast cancer
JOURNAL Clin Cancer Res 13 (19), 5745-5755 (2007)
PUBMED 17908964
REMARK GeneRIF: MYC and PVT1 contribute independently to ovarian and
breast pathogenesis when overexpressed because of genomic
abnormalities
REFERENCE 8 (bases 1 to 2124)
AUTHORS Shtivelman,E. and Bishop,J.M.
TITLE Effects of translocations on transcription from PVT
JOURNAL Mol Cell Biol 10 (4), 1835-1839 (1990)
PUBMED 2181290
REFERENCE 9 (bases 1 to 2124)
AUTHORS Shtivelman,E., Henglein,B., Groitl,P., Lipp,M. and Bishop,J.M.
TITLE Identification of a human transcription unit affected by the
variant chromosomal translocations 2;8 and 8;22 of Burkitt lymphoma
JOURNAL Proc Natl Acad Sci U S A 86 (9), 3257-3260 (1989)
PUBMED 2470097
REFERENCE 10 (bases 1 to 2124)
AUTHORS Shtivelman,E. and Bishop,J.M.
TITLE The PVT gene frequently amplifies with MYC in tumor cells
JOURNAL Mol Cell Biol 9 (3), 1148-1154 (1989)
PUBMED 2725491
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC103819.3, AC084123.9,
AC103705.5 and AC026248.7.
Summary: This gene represents a long non-coding RNA locus that has
been identified as a candidate oncogene. Increased copy number and
overexpression of this gene are associated with many types of
cancers including breast and ovarian cancers, acute myeloid
leukemia and Hodgkin lymphoma. Allelic variants of this gene are
also associated with end-stage renal disease attributed to type 1
diabetes. Consistent with its association with various types of
cancer, transcription of this gene is regulated by the tumor
suppressor p53 through a canonical p53-binding site, and it has
been implicated in regulating levels of the proto-oncogene MYC to
promote tumorigenesis. [provided by RefSeq, Sep 2015].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR18074967.2885472.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA2154529 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-211 AC103819.3 146108-146318
212-621 AC084123.9 94558-94967
622-790 AC103705.5 81545-81713
791-910 AC103705.5 124397-124516
911-1211 AC103705.5 125941-126241
1212-1341 AC103705.5 131199-131328
1342-1470 AC103705.5 151627-151755
1471-1597 AC103705.5 152355-152481
1598-1710 AC026248.7 52029-52141
1711-1847 AC026248.7 78387-78523
1848-2124 AC026248.7 82849-83125
FEATURES Location/Qualifiers
source 1..2124
/organism="Homo sapiens"
/mol_type="transcribed RNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8q24.21"
gene 1..2124
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/note="Pvt1 oncogene"
/db_xref="GeneID:5820"
/db_xref="HGNC:HGNC:9709"
/db_xref="MIM:165140"
ncRNA 1..2124
/ncRNA_class="lncRNA"
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/product="Pvt1 oncogene, transcript variant 24"
/db_xref="GeneID:5820"
/db_xref="HGNC:HGNC:9709"
/db_xref="MIM:165140"
exon 1..211
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/inference="alignment:Splign:2.1.0"
exon 212..621
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/inference="alignment:Splign:2.1.0"
exon 622..790
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/inference="alignment:Splign:2.1.0"
exon 791..910
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/inference="alignment:Splign:2.1.0"
exon 911..1211
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/inference="alignment:Splign:2.1.0"
exon 1212..1341
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/inference="alignment:Splign:2.1.0"
exon 1342..1470
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/inference="alignment:Splign:2.1.0"
exon 1471..1597
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/inference="alignment:Splign:2.1.0"
exon 1598..1710
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/inference="alignment:Splign:2.1.0"
exon 1711..1847
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/inference="alignment:Splign:2.1.0"
exon 1848..2124
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/inference="alignment:Splign:2.1.0"
regulatory 2102..2107
/regulatory_class="polyA_signal_sequence"
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/note="hexamer: ATTAAA"
polyA_site 2124
/gene="PVT1"
/gene_synonym="LINC00079; MIR1204HG; NCRNA00079;
onco-lncRNA-100; TP53LC09"
/note="major polyA site"
ORIGIN
1 cccgcgctcc tccgggcaga gcgcgtgtgg cggccgagca catgggcccg cgggccgggc
61 gggctcgggg cggccgggac gaggaggggc gacgacgagc tgcgagcaaa gatgtgcccc
121 gggacccccg gcaccttcca gtggatttcc ttgcggaaag gatgttggcg gtccctgtga
181 cctgtggaga cacggccaga tctgccctcc agcctgatct tttggccaga aggagattaa
241 aaagatgccc ctcaagatgg ctgtgcctgt cagctgcatg gagcttcgtt caagtatttt
301 ctgagcctga tggatttaca gtgatcttca gtggtctggg gaataacgct ggtggaacca
361 tgcactggaa tgacacacgc ccggcacatt tcaggatact aaaagtggtt ttaagggagg
421 ctgtggctga atgcctcatg gattcttaca gcttggatgt ccatggggga cgaaggactg
481 cagctggctg agagggttga gatctctgtt tacttagatc tctgccaact tcctttgggt
541 ctccctatgg aatgtaagac cccgactctt cctggtgaag catctgatgc acgttccatc
601 cggcgctcag ctgggcttga gctgaccata ctccctggag ccttctcccg aggtgcgcgg
661 gtgaccttgg cacatacagc catcatgatg gtactttaag tggaggctga atcatctccc
721 ctttgagctg cttggcacgt ggctcccttg gtgttcccct tttactgcca ggacactgag
781 atttggagag tctcttcacc ctctgaaaac aagaggatgt gtagcatagt gagcaacagc
841 tgtgtgccgg ggactcagca ttaagtagca tgggattact catgacttcg cactcatggc
901 agcctcacag agtctcactc tgtggtccag gctgaagtac agtggcatga tcccaggtca
961 ctgcaacccc cacctcccgg gttcaagtga tcctcctgcc tcagcctccc gagtagctgg
1021 tattacaggc gtgtgccaca aagcctggct aagttttgta tttttagtag agacggggtt
1081 tcaccatgtt ggccaggttg gtctcgaact cctgacctca agtgatccac tcactttggc
1141 ctttcaacgt gctgggatta caggcgagag tcaccgcacc cggacgactc tgacattttt
1201 gaagagtcca gaatcctgtt acacctggga tttaggcact ttcaatctga aaaaatacat
1261 atcctttcag cactctggac ggacttgaga actgtcctta cgtgacctaa agctggagta
1321 ttttgagatt ggagaattaa ggccaacaga gattttgaga aacacattga aggatctgtt
1381 aacacttgat atacccaata aaagcagtgg ttgtgccagt gctgatctgt cttgatgtga
1441 atgtgaacaa tgggaacctg agctgagcag ttaatgctag ggtgacagaa actggacctc
1501 tcccaagaca tgtgacagag taatacagca gccaacttct tcgccaaatt aaagttttac
1561 aagatttaac ctgtcatcaa gacctgggat tttggtgagc cagtcttggt gctctgtgtt
1621 cacctggttc atctgaggag ctgcatctac cctgcccatg ccatagatcc tgccctgttt
1681 gcttctcctg ttgctgctag tggacatgag aaggacagaa taacgggctc ccagattcac
1741 aagccccacc aagaggatca ccccaggaac gcttggaggc tgaggagttc actgaggcta
1801 ctgcatcttg agactcagga tgaagaccca gcttggggct gtcaaaggtt ttttgcatgt
1861 ctgacaccca tgactccacc tggaccttat ggctccaccc agaagcaatt cagcccaaca
1921 ggaggacagc ttcaacccat tacgatttca tctctgcccc aaccactcag cagcaagcac
1981 ctgttacctg tccaccccca ccccttcccc caaactgcct ttgaaaaatc cctaacctat
2041 gagctttgaa taagatgagt acgaacttca tcgcccacgt ggcgtggccg gcctcgtgtc
2101 tattaaattc tttttctact acaa
//