Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rβ1 and subsequent signal transduction.
Georgy J, Arlt Y, Moll JM, Ouzin M, Weitz HT, Gremer L, Willbold D, Grötzinger J, Thives-Kurenbach F, Scheller J, et al. J Biol Chem. 2021 Nov; 297(5):101295. Epub 2021 Oct 9.