U.S. flag

An official website of the United States government

Homo sapiens eukaryotic translation initiation factor 3 subunit L (EIF3L), transcript variant 1, mRNA

NCBI Reference Sequence: NM_016091.3

FASTA Graphics 

LOCUS       NM_016091               2091 bp    mRNA    linear   PRI 21-OCT-2018
DEFINITION  Homo sapiens eukaryotic translation initiation factor 3 subunit L
            (EIF3L), transcript variant 1, mRNA.
ACCESSION   NM_016091
VERSION     NM_016091.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2091)
  AUTHORS   Lee AS, Kranzusch PJ and Cate JH.
  TITLE     eIF3 targets cell-proliferation messenger RNAs for translational
            activation or repression
  JOURNAL   Nature 522 (7554), 111-114 (2015)
   PUBMED   25849773
REFERENCE   2  (bases 1 to 2091)
  AUTHORS   Jefferson M, Donaszi-Ivanov A, Pollen S, Dalmay T, Saalbach G and
            Powell PP.
  TITLE     Host factors that interact with the pestivirus N-terminal protease,
            Npro, are components of the ribonucleoprotein complex
  JOURNAL   J. Virol. 88 (18), 10340-10353 (2014)
   PUBMED   24965446
REFERENCE   3  (bases 1 to 2091)
  AUTHORS   Morais ATs, Terzian AC, Duarte DV, Bronzoni RV, Madrid MC, Gavioli
            AF, Gil LH, Oliveira AG, Zanelli CF, Valentini SR, Rahal P and
            Nogueira ML.
  TITLE     The eukaryotic translation initiation factor 3 subunit L protein
            interacts with Flavivirus NS5 and may modulate yellow fever virus
            replication
  JOURNAL   Virol. J. 10, 205 (2013)
   PUBMED   23800076
  REMARK    GeneRIF: These results indicate an interaction of human eIF3L with
            yellow fever virus NS5 and that eIF3L overexpression facilitates
            translation, which has potential implications for virus
            replication.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2091)
  AUTHORS   Querol-Audi J, Sun C, Vogan JM, Smith MD, Gu Y, Cate JH and Nogales
            E.
  TITLE     Architecture of human translation initiation factor 3
  JOURNAL   Structure 21 (6), 920-928 (2013)
   PUBMED   23623729
REFERENCE   5  (bases 1 to 2091)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol. Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 2091)
  AUTHORS   Damoc E, Fraser CS, Zhou M, Videler H, Mayeur GL, Hershey JW,
            Doudna JA, Robinson CV and Leary JA.
  TITLE     Structural characterization of the human eukaryotic initiation
            factor 3 protein complex by mass spectrometry
  JOURNAL   Mol. Cell Proteomics 6 (7), 1135-1146 (2007)
   PUBMED   17322308
REFERENCE   7  (bases 1 to 2091)
  AUTHORS   Lehner B and Sanderson CM.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res. 14 (7), 1315-1323 (2004)
   PUBMED   15231747
REFERENCE   8  (bases 1 to 2091)
  AUTHORS   Yuan X, Zhao J, Zentgraf H, Hoffmann-Rohrer U and Grummt I.
  TITLE     Multiple interactions between RNA polymerase I, TIF-IA and TAF(I)
            subunits regulate preinitiation complex assembly at the ribosomal
            gene promoter
  JOURNAL   EMBO Rep. 3 (11), 1082-1087 (2002)
   PUBMED   12393749
REFERENCE   9  (bases 1 to 2091)
  AUTHORS   Morris-Desbois C, Rety S, Ferro M, Garin J and Jalinot P.
  TITLE     The human protein HSPC021 interacts with Int-6 and is associated
            with eukaryotic translation initiation factor 3
  JOURNAL   J. Biol. Chem. 276 (49), 45988-45995 (2001)
   PUBMED   11590142
REFERENCE   10 (bases 1 to 2091)
  AUTHORS   Seither P, Iben S, Thiry M and Grummt I.
  TITLE     PAF67, a novel protein that is associated with the
            initiation-competent form of RNA polymerase I
  JOURNAL   Biol. Chem. 382 (8), 1163-1170 (2001)
   PUBMED   11592397
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA051005.1, BC029265.1 and AL022311.5.
            
            [WARNING] On Nov 23, 2018 this sequence was replaced by
            NM_016091.4.
            
            On Jul 2, 2011 this sequence version replaced NM_016091.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.36239.1,
                                           SRR1660807.132366.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                DA051005.1         1-60
            61-1223             BC029265.1         1-1163
            1224-1224           AL022311.5         6183-6183
            1225-1938           BC029265.1         1165-1878
            1939-2091           AL022311.5         17071-17223
FEATURES             Location/Qualifiers
     source          1..2091
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..2091
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /note="eukaryotic translation initiation factor 3 subunit
                     L"
                     /db_xref="GeneID:51386"
                     /db_xref="HGNC:HGNC:18138"
     exon            1..111
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1773
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /note="isoform 1 is encoded by transcript variant 1; eIEF
                     associated protein HSPC021; eukaryotic translation
                     initiation factor 3 subunit 6-interacting protein;
                     eukaryotic translation initiation factor 3 subunit
                     E-interacting protein"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 3
                     subunit L isoform 1"
                     /protein_id="NP_057175.1"
                     /db_xref="CCDS:CCDS13960.1"
                     /db_xref="GeneID:51386"
                     /db_xref="HGNC:HGNC:18138"
                     /translation="MSYPADDYESEAAYDPYAYPSDYDMHTGDPKQDLAYERQYEQQT
                     YQVIPEVIKNFIQYFHKTVSDLIDQKVYELQASRVSSDVIDQKVYEIQDIYENSWTKL
                     TERFFKNTPWPEAEAIAPQVGNDAVFLILYKELYYRHIYAKVSGGPSLEQRFESYYNY
                     CNLFNYILNADGPAPLELPNQWLWDIIDEFIYQFQSFSQYRCKTAKKSEEEIDFLRSN
                     PKIWNVHSVLNVLHSLVDKSNINRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFSLVG
                     LLRLHSLLGDYYQAIKVLENIELNKKSMYSRVPECQVTTYYYVGFAYLMMRRYQDAIR
                     VFANILLYIQRTKSMFQRTTYKYEMINKQNEQMHALLAIALTMYPMRIDESIHLQLRE
                     KYGDKMLRMQKGDPQVYEELFSYSCPKFLSPVVPNYDNVHPNYHKEPFLQQLKVFSDE
                     VQQQAQLSTIRSFLKLYTTMPVAKLAGFLDLTEQEFRIQLLVFKHKMKNLVWTSGISA
                     LDGEFQSASEVDFYIDKDMIHIADTKVARRYGDFFIRQIHKFEELNRTLKKMGQRP"
     misc_feature    82..84
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N-acetylserine. {ECO:0000244|PubMed:19413330,
                     ECO:0000244|PubMed:22223895,
                     ECO:0000255|HAMAP-Rule:MF_03011,
                     ECO:0000269|PubMed:17322308}; propagated from
                     UniProtKB/Swiss-Prot (Q9Y262.1); other site"
     misc_feature    139..141
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:24275569};
                     propagated from UniProtKB/Swiss-Prot (Q9Y262.1); other
                     site"
     misc_feature    1471..1473
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000244|PubMed:19608861};
                     propagated from UniProtKB/Swiss-Prot (Q9Y262.1); other
                     site"
     misc_feature    1723..1725
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000244|PubMed:19608861};
                     propagated from UniProtKB/Swiss-Prot (Q9Y262.1); other
                     site"
     exon            112..160
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /inference="alignment:Splign:2.1.0"
     exon            161..371
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /inference="alignment:Splign:2.1.0"
     exon            372..451
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /inference="alignment:Splign:2.1.0"
     exon            452..513
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /inference="alignment:Splign:2.1.0"
     exon            514..583
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /inference="alignment:Splign:2.1.0"
     exon            584..657
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /inference="alignment:Splign:2.1.0"
     exon            658..829
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /inference="alignment:Splign:2.1.0"
     exon            830..984
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1155
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1653
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1734
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..2091
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgaacttc cggcctcagg acgcaggcgc gggccgctca tttcgctctt tccggcggtg
       61 ctcgcaagcg aggcagccat gtcttatccc gctgatgatt atgagtctga ggcggcttat
      121 gacccctacg cttatcccag cgactatgat atgcacacag gagatccaaa gcaggacctt
      181 gcttatgaac gtcagtatga acagcaaacc tatcaggtga tccctgaggt gatcaaaaac
      241 ttcatccagt atttccacaa aactgtctca gatttgattg accagaaagt gtatgagcta
      301 caggccagtc gtgtctccag tgatgtcatt gaccagaagg tgtatgagat ccaggacatc
      361 tatgagaaca gctggaccaa gctgactgaa agattcttca agaatacacc ttggcccgag
      421 gctgaagcca ttgctccaca ggttggcaat gatgctgtct tcctgatttt atacaaagaa
      481 ttatactaca ggcacatata tgccaaagtc agtgggggac cttccttgga gcagaggttt
      541 gaatcctatt acaactactg caatctcttc aactacattc ttaatgccga tggtcctgct
      601 ccccttgaac tacccaacca gtggctctgg gatattatcg atgagttcat ctaccagttt
      661 cagtcattca gtcagtaccg ctgtaagact gccaagaagt cagaggagga gattgacttt
      721 cttcgttcca atcccaaaat ctggaatgtt catagtgtcc tcaatgtcct tcattccctg
      781 gtagacaaat ccaacatcaa ccgacagttg gaggtataca caagcggagg tgaccctgag
      841 agtgtggctg gggagtatgg gcggcactcc ctctacaaaa tgcttggtta cttcagcctg
      901 gtcgggcttc tccgcctgca ctccctgtta ggagattact accaggccat caaggtgctg
      961 gagaacatcg aactgaacaa gaagagtatg tattcccgtg tgccagagtg ccaggtcacc
     1021 acatactatt atgttgggtt tgcatatttg atgatgcgtc gttaccagga tgccatccgg
     1081 gtcttcgcca acatcctcct ctacatccag aggaccaaga gcatgttcca gaggaccacg
     1141 tacaagtatg agatgattaa caagcagaat gagcagatgc atgcgctgct ggccattgcc
     1201 ctcacgatgt accccatgcg tattgatgag agcattcacc tccagctgcg ggagaaatat
     1261 ggggacaaga tgttgcgcat gcagaaaggt gacccacaag tctatgaaga acttttcagt
     1321 tactcctgcc ccaagttcct gtcgcctgta gtgcccaact atgataatgt gcaccccaac
     1381 taccacaaag agcccttcct gcagcagctg aaggtgtttt ctgatgaagt acagcagcag
     1441 gcccagcttt caaccatccg cagcttcctg aagctctaca ccaccatgcc tgtggccaag
     1501 ctggctggct tcctggacct cacagagcag gagttccgga tccagcttct tgtcttcaaa
     1561 cacaagatga agaacctcgt gtggaccagc ggtatctcag ccctggatgg tgaatttcag
     1621 tcagcctcag aggttgactt ctacattgat aaggacatga tccacatcgc ggacaccaag
     1681 gtcgccaggc gttatgggga tttcttcatc cgtcagatcc acaaatttga ggagcttaat
     1741 cgaaccctga agaagatggg acagagacct tgatgatatt cacacacatt caggaacctg
     1801 ttttgatgta ttataggcag gaagtgtttt tgctaccgtg aaacctttac ctagatcagc
     1861 catcagcctg tcaactcagt taacaagtta aggaccgaag tgtttcaagt ggatctcagt
     1921 aaaggatctt tggagccaga tttgtcgtct cattattgta ggagagaatt tgtgggttgt
     1981 ggcagtaata catttcccat gtgtcctgat gctttcagga tacatcagtt gttagtgttt
     2041 aaattgagtt atttttattt tgtgcttttg agatggagtc tcactctgtc t
//
Feature
Display: FASTA GenBank Help
Details

Supplemental Content

Change region shown

Customize view

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
External link. Please review our privacy policy.