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Homo sapiens mediator complex subunit 12 (MED12), mRNA

NCBI Reference Sequence: NM_005120.2

FASTA Graphics 

LOCUS       NM_005120               6985 bp    mRNA    linear   PRI 28-OCT-2018
DEFINITION  Homo sapiens mediator complex subunit 12 (MED12), mRNA.
ACCESSION   NM_005120
VERSION     NM_005120.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6985)
  AUTHORS   Xie J, Ubango J, Ban Y, Chakravarti D, Kim JJ and Wei JJ.
  TITLE     Comparative analysis of AKT and the related biomarkers in uterine
            leiomyomas with MED12, HMGA2, and FH mutations
  JOURNAL   Genes Chromosomes Cancer 57 (10), 485-494 (2018)
   PUBMED   29790226
  REMARK    GeneRIF: we aimed in this study to examine these common functional
            pathways in uterine leiomyomas (ULM)with different driver
            mutations. We collected ULM with MED12, HMGA2, and FH mutations and
            examined the selected markers by immunohistochemistry.
REFERENCE   2  (bases 1 to 6985)
  AUTHORS   Galindo LJ, Hernandez-Beeftink T, Salas A, Jung Y, Reyes R, de Oca
            FM, Hernandez M and Almeida TA.
  TITLE     HMGA2 and MED12 alterations frequently co-occur in uterine
            leiomyomas
  JOURNAL   Gynecol. Oncol. 150 (3), 562-568 (2018)
   PUBMED   30017537
  REMARK    GeneRIF: Here, we observed that overexpression of HMGA2 mRNA in
            tumors measured by quantitative PCR and compared to myometrium is a
            common phenomenon in fibroids and is frequently associated with
            MED12 mutations. In addition, the common clonal origin of tumors
            overexpressing HMGA2 mRNA and its expression in few myometrial
            tissue points to HMGA2 up-regulation as an early event in leiomyoma
            tumorigenesis.
REFERENCE   3  (bases 1 to 6985)
  AUTHORS   Lee M, Cheon K, Chae B, Hwang H, Kim HK, Chung YJ, Song JY, Cho HH,
            Kim JH and Kim MR.
  TITLE     Analysis of MED12 Mutation in Multiple Uterine Leiomyomas in South
            Korean patients
  JOURNAL   Int J Med Sci 15 (2), 124-128 (2018)
   PUBMED   29333096
  REMARK    GeneRIF: High frequency of the MED12 mutation in uterine leiomyomas
            of South Korean patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6985)
  AUTHORS   Wu B, Slabicki M, Sellner L, Dietrich S, Liu X, Jethwa A, Hullein
            J, Walther T, Wagner L, Huang Z, Zapatka M and Zenz T.
  TITLE     MED12 mutations and NOTCH signalling in chronic lymphocytic
            leukaemia
  JOURNAL   Br. J. Haematol. 179 (3), 421-429 (2017)
   PUBMED   28771672
  REMARK    GeneRIF: The results suggest that MED12 mutations may contribute to
            chronic lymphocytic leukaemia pathogenesis by activating NOTCH
            signalling.
REFERENCE   5  (bases 1 to 6985)
  AUTHORS   Kol'tsova AS, Pendina AA, Efimova OA, Kaminskaya AN, Tikhonov AV,
            Osinovskaya NS, Sultanov IY, Shved NY, Kakhiani MI and Baranov VS.
  TITLE     Differential DNA Hydroxymethylation in Human Uterine Leiomyoma
            Cells Depending on the Phase of Menstrual Cycle and Presence of
            MED12 Gene Mutations
  JOURNAL   Bull. Exp. Biol. Med. 163 (5), 646-649 (2017)
   PUBMED   28944423
  REMARK    GeneRIF: Hormonal status changing at various phases of menstrual
            cycle is a factor affecting DNA hydroxymethylation in leiomyoma
            cells.
REFERENCE   6  (bases 1 to 6985)
  AUTHORS   Briault S, Hill R, Shrimpton A, Zhu D, Till M, Ronce N,
            Margaritte-Jeannin P, Baraitser M, Middleton-Price H, Malcolm S,
            Thompson E, Hoo J, Wilson G, Romano C, Guichet A, Pembrey M, Fontes
            M, Poustka A and Moraine C.
  TITLE     A gene for FG syndrome maps in the Xq12-q21.31 region
  JOURNAL   Am. J. Med. Genet. 73 (1), 87-90 (1997)
   PUBMED   9375929
REFERENCE   7  (bases 1 to 6985)
  AUTHORS   Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel
            TS, Stine OC, Callahan C, McInnis MG and Ross CA.
  TITLE     cDNAs with long CAG trinucleotide repeats from human brain
  JOURNAL   Hum. Genet. 100 (1), 114-122 (1997)
   PUBMED   9225980
REFERENCE   8  (bases 1 to 6985)
  AUTHORS   Fondell JD, Ge H and Roeder RG.
  TITLE     Ligand induction of a transcriptionally active thyroid hormone
            receptor coactivator complex
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 93 (16), 8329-8333 (1996)
   PUBMED   8710870
REFERENCE   9  (bases 1 to 6985)
  AUTHORS   Yamagata K, Takeda J, Menzel S, Chen X, Eng S, Lim LR, Concannon P,
            Hanis CL, Spielman RS, Cox NJ and Bell GI.
  TITLE     Searching for NIDDM susceptibility genes: studies of genes with
            triplet repeats expressed in skeletal muscle
  JOURNAL   Diabetologia 39 (6), 725-730 (1996)
   PUBMED   8781769
REFERENCE   10 (bases 1 to 6985)
  AUTHORS   Lyons,M.J.
  TITLE     MED12-Related Disorders
  JOURNAL   (in) Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens
            K and Amemiya A (Eds.);
            GENEREVIEWS((R));
            (1993)
   PUBMED   20301719
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB069668.1, AF117755.1,
            AF071309.1 and BM662470.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            [WARNING] On Nov 23, 2018 this sequence was replaced by
            NM_005120.3.
            
            On Jul 14, 2006 this sequence version replaced NM_005120.1.
            
            Summary: The initiation of transcription is controlled in part by a
            large protein assembly known as the preinitiation complex. A
            component of this preinitiation complex is a 1.2 MDa protein
            aggregate called Mediator. This Mediator component binds with a
            CDK8 subcomplex which contains the protein encoded by this gene,
            mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase,
            and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II
            interactions and thereby regulates transcription initiation and
            reinitation rates. The MED12 protein is essential for activating
            CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia
            syndrome, also known as FG syndrome, and Lujan-Fryns syndrome.
            [provided by RefSeq, Aug 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed/partial sample support SAMEA1965299,
                              SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               DB069668.1         1-167
            168-254             AF117755.1         107-193
            255-5947            AF071309.1         68-5760
            5948-6812           AF117755.1         5893-6757
            6813-6985           BM662470.1         1-173               c
FEATURES             Location/Qualifiers
     source          1..6985
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..6985
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /note="mediator complex subunit 12"
                     /db_xref="GeneID:9968"
                     /db_xref="HGNC:HGNC:11957"
                     /db_xref="MIM:300188"
     exon            1..298
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..6733
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /note="thyroid hormone receptor-associated protein, 230
                     kDa subunit; trinucleotide repeat containing 11
                     (THR-associated protein, 230 kDa subunit); putative
                     mediator subunit 12; activator-recruited cofactor 240 kDa
                     component; CAG repeat protein 45; human opposite paired;
                     OPA-containing protein; trinucleotide repeat-containing
                     gene 11 protein; thyroid hormone receptor-associated
                     protein complex 230 kDa component; mediator of RNA
                     polymerase II transcription, subunit 12 homolog"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 12"
                     /protein_id="NP_005111.2"
                     /db_xref="CCDS:CCDS43970.1"
                     /db_xref="GeneID:9968"
                     /db_xref="HGNC:HGNC:11957"
                     /db_xref="MIM:300188"
                     /translation="MAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQG
                     FNNQPAVSGDEHGSAKNVSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNF
                     WLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLI
                     KMTCAYYAAISETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGST
                     IGPLPHDVEVAIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLL
                     LPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSTLPTTPAP
                     QPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGS
                     PLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAG
                     FTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLC
                     EWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIF
                     QDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDL
                     AFGAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKP
                     DFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPI
                     PQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVP
                     LNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQI
                     TSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDL
                     VGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCIL
                     AYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPA
                     AHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSL
                     SAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDL
                     IRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCD
                     RHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRR
                     QGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRL
                     MQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSL
                     LENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLP
                     TSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDE
                     QREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQ
                     QTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENK
                     RAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGF
                     DSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLY
                     HTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKK
                     KSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLY
                     TQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQ
                     QQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTG
                     PAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRF
                     SHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQ
                     QQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQ
                     SQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY"
     misc_feature    437..439
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000250|UniProtKB:A2AGH6};
                     propagated from UniProtKB/Swiss-Prot (Q93074.4);
                     acetylation site"
     misc_feature    695..697
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine. {ECO:0000244|PubMed:18669648};
                     propagated from UniProtKB/Swiss-Prot (Q93074.4);
                     phosphorylation site"
     misc_feature    2102..2104
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:17081983,
                     ECO:0000244|PubMed:18691976, ECO:0000244|PubMed:19369195,
                     ECO:0000244|PubMed:19690332, ECO:0000244|PubMed:23186163,
                     ECO:0000244|PubMed:24275569}; propagated from
                     UniProtKB/Swiss-Prot (Q93074.4); phosphorylation site"
     misc_feature    2192..2194
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:24275569};
                     propagated from UniProtKB/Swiss-Prot (Q93074.4);
                     phosphorylation site"
     misc_feature    2291..2293
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163,
                     ECO:0000244|PubMed:24275569}; propagated from
                     UniProtKB/Swiss-Prot (Q93074.4); phosphorylation site"
     misc_feature    2297..2299
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q93074.4);
                     phosphorylation site"
     misc_feature    3971..3973
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:18691976,
                     ECO:0000244|PubMed:19369195}; propagated from
                     UniProtKB/Swiss-Prot (Q93074.4); phosphorylation site"
     misc_feature    4004..4006
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:19369195};
                     propagated from UniProtKB/Swiss-Prot (Q93074.4);
                     phosphorylation site"
     misc_feature    5045..6352
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q93074.4);
                     Region: Interaction with CTNNB1 and GLI3.
                     {ECO:0000269|PubMed:17000779}"
     misc_feature    5591..5593
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000250|UniProtKB:A2AGH6};
                     propagated from UniProtKB/Swiss-Prot (Q93074.4);
                     acetylation site"
     misc_feature    5894..5896
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Asymmetric dimethylarginine, alternate.
                     {ECO:0000250|UniProtKB:A2AGH6}; Omega-N-methylarginine,
                     alternate. {ECO:0000250|UniProtKB:A2AGH6}; propagated from
                     UniProtKB/Swiss-Prot (Q93074.4); methylation site"
     misc_feature    5927..5929
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Omega-N-methylarginine.
                     {ECO:0000250|UniProtKB:A2AGH6}; propagated from
                     UniProtKB/Swiss-Prot (Q93074.4); methylation site"
     misc_feature    6179..6181
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Asymmetric dimethylarginine.
                     {ECO:0000244|PubMed:24129315}; propagated from
                     UniProtKB/Swiss-Prot (Q93074.4); methylation site"
     misc_feature    6242..6244
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Asymmetric dimethylarginine.
                     {ECO:0000244|PubMed:24129315}; propagated from
                     UniProtKB/Swiss-Prot (Q93074.4); methylation site"
     exon            299..403
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            404..595
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            596..752
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            753..934
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1045
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1300
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1447
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1547
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1684
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1816
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1943
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2173
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2254
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2425
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2570
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2621
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            2622..2740
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            2741..2884
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            2885..3048
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            3049..3180
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            3181..3408
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            3409..3553
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            3554..3674
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            3675..3776
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            3777..3890
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            3891..4066
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            4067..4246
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            4247..4318
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            4319..4452
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            4453..4614
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            4615..4726
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            4727..4816
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            4817..4926
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            4927..5062
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            5063..5224
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            5225..5599
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            5600..5750
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            5751..5947
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            5948..6025
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            6026..6243
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            6244..6466
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            6467..6607
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            6608..6689
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            6690..6969
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      6969
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
                     OKS; OPA1; TNRC11; TRAP230"
ORIGIN      
        1 attgtccgat ggttcccggc gtacctcggc ttccctcggt agtttccggc aatggtcgag
       61 agtttctaac gtgccccctt gttgtctctc ggccgccgtc ctctcaacca ccgcccccct
      121 tttcggctcc ctctccccct tcccgttccc ccagtcagcc tggccctgct ggtgcctccg
      181 gcgctacggg ctgggcaaga tggcggcctt cgggatcttg agctacgaac accggcccct
      241 gaagcggccg cggctggggc ctcccgatgt ttaccctcag gaccccaaac agaaggagga
      301 tgaactgacg gccttgaatg taaaacaagg tttcaataac cagcctgctg tctctgggga
      361 tgagcatggc agtgccaaga acgtcagctt caatcctgcc aagatcagtt ccaacttcag
      421 cagcattatt gcagagaaat tacgttgtaa tacccttcct gacactggtc gcaggaagcc
      481 ccaagtgaac cagaaggata acttctggct ggtgactgca cgatcccaga gtgccattaa
      541 cacttggttc actgacttgg ctggcaccaa gccactcacg caactagcca aaaaggtccc
      601 cattttcagt aagaaggaag aggtgtttgg gtacttagcc aaatacacag tgcctgtgat
      661 gcgggctgcc tggctcatta agatgacctg tgcctactat gcagcaatct ctgagaccaa
      721 ggttaagaag agacatgttg accctttcat ggaatggact cagatcatca ccaagtactt
      781 atgggagcag ttacagaaga tggctgaata ctaccggcca gggcctgcag gaagtggggg
      841 ctgtggttcc acgatagggc ccttgcccca tgatgtagag gtggcaatcc ggcagtggga
      901 ttacaccgag aagctggcca tgttcatgtt tcaggatgga atgctggaca gacatgagtt
      961 cctgacctgg gtgcttgagt gttttgagaa gatccgccct ggagaggatg aattgcttaa
     1021 actgctgctg cctctgcttc tccgatactc tggggaattt gttcagtctg catacctgtc
     1081 ccgccggctt gcctacttct gtacacggag actggccctg cagctggatg gtgtgagcag
     1141 tcactcatct catgttatat ctgctcagtc aacaagcacg ctacccacca cccctgctcc
     1201 tcagccccca actagcagca caccctcgac tccctttagt gacctgctta tgtgccctca
     1261 gcaccggccc ctggtttttg gcctcagctg tatcctacag accatcctcc tgtgctgtcc
     1321 tagtgccttg gtttggcact actcactgac tgatagcaga attaagaccg gctcaccact
     1381 tgaccacttg cctattgccc cgtccaacct gcccatgcca gagggtaaca gtgccttcac
     1441 tcagcaggtc cgtgcaaagt tgcgggagat cgagcagcag atcaaggagc ggggacaggc
     1501 agttgaagtt cgctggtctt tcgataaatg ccaggaagct actgcaggct tcaccattgg
     1561 acgggtactt catactttgg aagtgctgga cagccatagt tttgaacgct ctgacttcag
     1621 caactctctt gactcccttt gtaaccgaat ctttggattg ggacctagca aggatgggca
     1681 tgagatctcc tcagatgatg atgctgtggt gtcattgcta tgtgaatggg ctgtcagctg
     1741 caagcgttct ggtcggcatc gtgctatggt ggtagccaag ctcctggaga agagacaggc
     1801 ggagattgag gctgagcgtt gtggagaatc agaagccgca gatgagaagg gttccatcgc
     1861 ctctggctcc ctttctgctc ccagtgctcc cattttccag gatgtcctcc tgcagtttct
     1921 ggatacacag gctcccatgc tgacggaccc tcgaagtgag agtgagcggg tggaattctt
     1981 taacttagta ctgctgttct gtgaactgat tcgacatgat gttttctccc acaacatgta
     2041 tacttgcact ctcatctccc gaggggacct tgcctttgga gcccctggtc cccggcctcc
     2101 ctctcccttt gatgatcctg ccgatgaccc agagcacaag gaggctgaag gcagcagcag
     2161 cagcaagctg gaagatccag ggctctcaga atctatggac attgacccta gttccagtgt
     2221 tctctttgag gacatggaga agcctgattt ctcattgttc tcccctacta tgccctgtga
     2281 ggggaagggc agtccatccc ctgagaagcc agatgtcgag aaggaggtga agcccccacc
     2341 caaggagaag attgaaggga cccttggggt tctttacgac cagccacgac acgtgcagta
     2401 cgccacccat tttcccatcc cccaggagga gtcatgcagc catgagtgca accagcggtt
     2461 ggtcgtactg tttggggtgg gaaagcagcg agatgatgcc cgccatgcca tcaagaaaat
     2521 caccaaggat atcttgaagg ttctgaaccg caaagggaca gcagaaactg accagcttgc
     2581 tcctattgtg cctctgaatc ctggagacct gacattctta ggtggggagg atgggcagaa
     2641 gcggcgacgc aaccggcctg aagccttccc cactgctgaa gatatctttg ctaagttcca
     2701 gcacctttca cattatgacc aacaccaggt cacggctcag gtctcccgga atgttctgga
     2761 gcagatcacg agctttgccc ttggcatgtc ataccacttg cctctggtgc agcatgtgca
     2821 gttcatcttc gacctcatgg aatattcact cagcatcagt ggcctcatcg actttgccat
     2881 tcagctgctg aatgaactga gtgtagttga ggctgagctg cttctcaaat cctcggatct
     2941 ggtgggcagc tacactacta gcctgtgcct gtgcatcgtg gctgtcctgc ggcactatca
     3001 tgcctgcctc atcctcaacc aggaccagat ggcacaggtc tttgaggggc tgtgtggcgt
     3061 cgtgaagcat gggatgaacc ggtccgatgg ctcctctgca gagcgctgta tccttgctta
     3121 tctctatgat ctgtacacct cctgtagcca tttaaagaac aaatttgggg agctcttcag
     3181 cgacttttgc tcaaaggtga agaacaccat ctactgcaac gtggagccat cggaatcaaa
     3241 tatgcgctgg gcacctgagt tcatgatcga cactctagag aaccctgcag ctcacacctt
     3301 cacctacacg gggctaggca agagtcttag tgagaaccct gctaaccgct acagctttgt
     3361 ctgcaatgcc cttatgcacg tctgtgtggg gcaccatgat cccgataggg tgaatgacat
     3421 cgcaatcctg tgtgcagagc tgaccggcta ttgcaagtca ctgagtgcag aatggctagg
     3481 agtgcttaag gccttgtgct gctcctctaa caatggcact tgtggtttca acgatctcct
     3541 ctgcaatgtt gatgtcagtg acctatcttt tcatgactcg ctggctactt ttgttgccat
     3601 cctcatcgct cggcagtgtt tgctcctgga agatctgatt cgctgtgctg ccatcccttc
     3661 actccttaat gctgcttgta gtgaacagga ctctgagcca ggggcccggc ttacctgccg
     3721 catcctcctt caccttttca agacaccgca gctcaatcct tgccagtctg atggaaacaa
     3781 gcctacagta ggaatccgct cctcctgcga ccgccacctg ctggctgcct cccagaaccg
     3841 catcgtggat ggagccgtgt ttgctgttct caaggctgtg tttgtacttg gggatgcgga
     3901 actgaaaggt tcaggcttca ctgtgacagg aggaacagaa gaacttccag aggaggaggg
     3961 aggaggtggc agtggtggtc ggaggcaggg tggccgcaac atctctgtgg agacagccag
     4021 tctggatgtc tatgccaagt acgtgctgcg cagcatctgc caacaggaat gggtaggaga
     4081 acgttgcctt aagtctctgt gtgaggacag caatgacctg caagacccag tgttgagtag
     4141 tgcccaggcg cagcgcctca tgcagctcat ttgctatcca catcgactgc tggacaatga
     4201 ggatggggaa aacccccagc ggcagcgcat aaagcgcatt ctccagaact tggaccagtg
     4261 gaccatgcgc cagtcttcct tggagctgca gctcatgatc aagcagaccc ctaacaatga
     4321 gatgaactcc ctcttggaga acatcgccaa ggccacaatc gaggttttcc aacagtcagc
     4381 agagacaggg tcatcttctg gaagtactgc aagcaacatg cccagcagca gcaagaccaa
     4441 gcctgtgctc agctctctag agcgctctgg tgtatggctg gtggcccccc tcattgctaa
     4501 actgcccacc tcagtccagg gacatgtgtt aaaggctgct ggggaagaat tggagaaggg
     4561 tcagcacctg ggttcctctt cacgcaaaga acgtgatcga caaaagcaga agagcatgtc
     4621 cctattgagc cagcagccct tcttatcgct ggtgctaaca tgtctgaaag ggcaggatga
     4681 acaacgcgag ggactcctta cctccctcta cagccaggtg caccagattg tgaataattg
     4741 gcgagatgac cagtacttag atgattgcaa accaaagcag cttatgcatg aggcactcaa
     4801 actgcggctc aacctggtgg ggggcatgtt tgacacggtg cagcgcagca cccagcagac
     4861 cacggagtgg gccatgctcc tcctggagat catcatcagc ggcactgtcg acatgcagtc
     4921 caacaatgag ctcttcacta ctgtgttgga catgctgagc gtgctcatca atgggacatt
     4981 ggctgcagac atgtctagca tctcgcaagg tagcatggag gaaaacaagc gtgcatacat
     5041 gaacctggcg aagaagttgc agaaggagtt gggggagcgc cagtcagaca gtctggaaaa
     5101 ggttcgccag ctgctgccac tgcccaagca gacccgagat gtcatcacgt gtgagccaca
     5161 gggctccctt atcgatacca agggcaacaa gattgctggc ttcgattcca tcttcaagaa
     5221 ggagggtcta caggtttcca ccaaacagaa gatctcgccc tgggatcttt ttgaggggtt
     5281 gaagccgtca gcaccactct cttggggctg gtttggaaca gtccgagtgg accggcgagt
     5341 ggctcgagga gaggagcagc agcggttgct gctctaccac acacacctga ggccccggcc
     5401 ccgcgcctat tacctggagc cactgccact gcccccagaa gatgaggagc cgcctgctcc
     5461 taccctgcta gagcctgaga aaaaggctcc agagcccccc aaaactgaca aaccgggggc
     5521 tgctccaccc agtactgagg aacgcaagaa gaagtccacc aagggcaaga aacgcagcca
     5581 gccagctacc aagacagagg actatggaat gggcccgggt cggagcggcc cttatggtgt
     5641 gacagtgcct ccggacctcc tgcaccaccc aaaccctggt tctataacac accttaacta
     5701 caggcaaggc tccataggcc tgtacaccca gaaccagcca ctacctgcag gtggccctcg
     5761 tgtggaccca taccgtcctg tgcgcttacc aatgcagaag ctgcccaccc gaccaactta
     5821 ccctggagtg ctgcccacaa ccatgactgg cgtcatgggt ttagaaccct cctcttataa
     5881 gacctctgtg taccggcagc agcaacctgc ggtgccccaa ggacagcgcc ttcgccaaca
     5941 gctccagcag agtcagggca tgttgggaca gtcatctgtc catcagatga ctcccagctc
     6001 ttcctacggt ttgcagactt cccagggcta tactccttat gtttctcatg tgggattgca
     6061 gcaacacaca ggccctgcag gtaccatggt gccccccagc tactccagcc agccttacca
     6121 gagcacccac ccttctacca atcctactct tgtagatcct acccgccacc tgcaacagcg
     6181 gcccagtggc tatgtgcacc agcaggcccc cacctatgga catggactga cctccactca
     6241 aaggttttca caccagacac tgcagcagac acccatgata agtaccatga ctccaatgag
     6301 tgcccagggc gtccaggcag gcgtccgttc aacagccatc ctacctgagc agcagcagca
     6361 gcagcaacag cagcaacagc aacagcagca gcagcagcaa cagcaacagc agcagcagca
     6421 gcagcagtac cacatccggc agcagcagca gcagcagatc ctgcggcagc agcagcaaca
     6481 gcaacagcag cagcagcagc agcagcaaca gcaacagcag cagcagcaac agcaacaaca
     6541 gcaacaccag cagcaacagc agcaacaggc ggctcctccc caaccccagc cccagtccca
     6601 gccccagttc cagcgccagg ggcttcagca gacccagcag cagcaacaga cagcagcttt
     6661 ggtccggcaa cttcaacaac agctctctaa tacccagcca cagcccagta ccaacatatt
     6721 tggacgctac tgagccacct ggaggaactg cttgtgcact ggatgtggcc ccaccctttc
     6781 ctcttaattc ccaatcccat tcctgggcta gcaccagtag tggttggggc cctcccctca
     6841 ggctccattt ttaataagtt tttagtattt ttgttaatgt gaggcattga gctgttgggt
     6901 tttgtatatt atttatatag agaccccaga gctgttgcac ccaatacaca gagcttcttt
     6961 gcaaagggaa aaaaaaaaaa aaaaa
//
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