LOCUS NM_005120 6985 bp mRNA linear PRI 28-OCT-2018
DEFINITION Homo sapiens mediator complex subunit 12 (MED12), mRNA.
ACCESSION NM_005120
VERSION NM_005120.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6985)
AUTHORS Xie J, Ubango J, Ban Y, Chakravarti D, Kim JJ and Wei JJ.
TITLE Comparative analysis of AKT and the related biomarkers in uterine
leiomyomas with MED12, HMGA2, and FH mutations
JOURNAL Genes Chromosomes Cancer 57 (10), 485-494 (2018)
PUBMED 29790226
REMARK GeneRIF: we aimed in this study to examine these common functional
pathways in uterine leiomyomas (ULM)with different driver
mutations. We collected ULM with MED12, HMGA2, and FH mutations and
examined the selected markers by immunohistochemistry.
REFERENCE 2 (bases 1 to 6985)
AUTHORS Galindo LJ, Hernandez-Beeftink T, Salas A, Jung Y, Reyes R, de Oca
FM, Hernandez M and Almeida TA.
TITLE HMGA2 and MED12 alterations frequently co-occur in uterine
leiomyomas
JOURNAL Gynecol. Oncol. 150 (3), 562-568 (2018)
PUBMED 30017537
REMARK GeneRIF: Here, we observed that overexpression of HMGA2 mRNA in
tumors measured by quantitative PCR and compared to myometrium is a
common phenomenon in fibroids and is frequently associated with
MED12 mutations. In addition, the common clonal origin of tumors
overexpressing HMGA2 mRNA and its expression in few myometrial
tissue points to HMGA2 up-regulation as an early event in leiomyoma
tumorigenesis.
REFERENCE 3 (bases 1 to 6985)
AUTHORS Lee M, Cheon K, Chae B, Hwang H, Kim HK, Chung YJ, Song JY, Cho HH,
Kim JH and Kim MR.
TITLE Analysis of MED12 Mutation in Multiple Uterine Leiomyomas in South
Korean patients
JOURNAL Int J Med Sci 15 (2), 124-128 (2018)
PUBMED 29333096
REMARK GeneRIF: High frequency of the MED12 mutation in uterine leiomyomas
of South Korean patients.
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 6985)
AUTHORS Wu B, Slabicki M, Sellner L, Dietrich S, Liu X, Jethwa A, Hullein
J, Walther T, Wagner L, Huang Z, Zapatka M and Zenz T.
TITLE MED12 mutations and NOTCH signalling in chronic lymphocytic
leukaemia
JOURNAL Br. J. Haematol. 179 (3), 421-429 (2017)
PUBMED 28771672
REMARK GeneRIF: The results suggest that MED12 mutations may contribute to
chronic lymphocytic leukaemia pathogenesis by activating NOTCH
signalling.
REFERENCE 5 (bases 1 to 6985)
AUTHORS Kol'tsova AS, Pendina AA, Efimova OA, Kaminskaya AN, Tikhonov AV,
Osinovskaya NS, Sultanov IY, Shved NY, Kakhiani MI and Baranov VS.
TITLE Differential DNA Hydroxymethylation in Human Uterine Leiomyoma
Cells Depending on the Phase of Menstrual Cycle and Presence of
MED12 Gene Mutations
JOURNAL Bull. Exp. Biol. Med. 163 (5), 646-649 (2017)
PUBMED 28944423
REMARK GeneRIF: Hormonal status changing at various phases of menstrual
cycle is a factor affecting DNA hydroxymethylation in leiomyoma
cells.
REFERENCE 6 (bases 1 to 6985)
AUTHORS Briault S, Hill R, Shrimpton A, Zhu D, Till M, Ronce N,
Margaritte-Jeannin P, Baraitser M, Middleton-Price H, Malcolm S,
Thompson E, Hoo J, Wilson G, Romano C, Guichet A, Pembrey M, Fontes
M, Poustka A and Moraine C.
TITLE A gene for FG syndrome maps in the Xq12-q21.31 region
JOURNAL Am. J. Med. Genet. 73 (1), 87-90 (1997)
PUBMED 9375929
REFERENCE 7 (bases 1 to 6985)
AUTHORS Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel
TS, Stine OC, Callahan C, McInnis MG and Ross CA.
TITLE cDNAs with long CAG trinucleotide repeats from human brain
JOURNAL Hum. Genet. 100 (1), 114-122 (1997)
PUBMED 9225980
REFERENCE 8 (bases 1 to 6985)
AUTHORS Fondell JD, Ge H and Roeder RG.
TITLE Ligand induction of a transcriptionally active thyroid hormone
receptor coactivator complex
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (16), 8329-8333 (1996)
PUBMED 8710870
REFERENCE 9 (bases 1 to 6985)
AUTHORS Yamagata K, Takeda J, Menzel S, Chen X, Eng S, Lim LR, Concannon P,
Hanis CL, Spielman RS, Cox NJ and Bell GI.
TITLE Searching for NIDDM susceptibility genes: studies of genes with
triplet repeats expressed in skeletal muscle
JOURNAL Diabetologia 39 (6), 725-730 (1996)
PUBMED 8781769
REFERENCE 10 (bases 1 to 6985)
AUTHORS Lyons,M.J.
TITLE MED12-Related Disorders
JOURNAL (in) Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens
K and Amemiya A (Eds.);
GENEREVIEWS((R));
(1993)
PUBMED 20301719
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB069668.1, AF117755.1,
AF071309.1 and BM662470.1.
This sequence is a reference standard in the RefSeqGene project.
[WARNING] On Nov 23, 2018 this sequence was replaced by
NM_005120.3.
On Jul 14, 2006 this sequence version replaced NM_005120.1.
Summary: The initiation of transcription is controlled in part by a
large protein assembly known as the preinitiation complex. A
component of this preinitiation complex is a 1.2 MDa protein
aggregate called Mediator. This Mediator component binds with a
CDK8 subcomplex which contains the protein encoded by this gene,
mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase,
and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II
interactions and thereby regulates transcription initiation and
reinitation rates. The MED12 protein is essential for activating
CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia
syndrome, also known as FG syndrome, and Lujan-Fryns syndrome.
[provided by RefSeq, Aug 2009].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
RNAseq introns :: mixed/partial sample support SAMEA1965299,
SAMEA1966682 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-167 DB069668.1 1-167
168-254 AF117755.1 107-193
255-5947 AF071309.1 68-5760
5948-6812 AF117755.1 5893-6757
6813-6985 BM662470.1 1-173 c
FEATURES Location/Qualifiers
source 1..6985
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq13.1"
gene 1..6985
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/note="mediator complex subunit 12"
/db_xref="GeneID:9968"
/db_xref="HGNC:HGNC:11957"
/db_xref="MIM:300188"
exon 1..298
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
CDS 200..6733
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/note="thyroid hormone receptor-associated protein, 230
kDa subunit; trinucleotide repeat containing 11
(THR-associated protein, 230 kDa subunit); putative
mediator subunit 12; activator-recruited cofactor 240 kDa
component; CAG repeat protein 45; human opposite paired;
OPA-containing protein; trinucleotide repeat-containing
gene 11 protein; thyroid hormone receptor-associated
protein complex 230 kDa component; mediator of RNA
polymerase II transcription, subunit 12 homolog"
/codon_start=1
/product="mediator of RNA polymerase II transcription
subunit 12"
/protein_id="NP_005111.2"
/db_xref="CCDS:CCDS43970.1"
/db_xref="GeneID:9968"
/db_xref="HGNC:HGNC:11957"
/db_xref="MIM:300188"
/translation="MAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQG
FNNQPAVSGDEHGSAKNVSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNF
WLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLI
KMTCAYYAAISETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGST
IGPLPHDVEVAIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLL
LPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSTLPTTPAP
QPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGS
PLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAG
FTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLC
EWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIF
QDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDL
AFGAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKP
DFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPI
PQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVP
LNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQI
TSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDL
VGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCIL
AYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPA
AHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSL
SAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDL
IRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCD
RHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRR
QGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRL
MQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSL
LENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLP
TSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDE
QREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQ
QTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENK
RAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGF
DSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLY
HTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKK
KSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLY
TQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQ
QQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTG
PAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRF
SHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQ
QQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQ
SQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY"
misc_feature 437..439
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine. {ECO:0000250|UniProtKB:A2AGH6};
propagated from UniProtKB/Swiss-Prot (Q93074.4);
acetylation site"
misc_feature 695..697
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine. {ECO:0000244|PubMed:18669648};
propagated from UniProtKB/Swiss-Prot (Q93074.4);
phosphorylation site"
misc_feature 2102..2104
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:17081983,
ECO:0000244|PubMed:18691976, ECO:0000244|PubMed:19369195,
ECO:0000244|PubMed:19690332, ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}; propagated from
UniProtKB/Swiss-Prot (Q93074.4); phosphorylation site"
misc_feature 2192..2194
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:24275569};
propagated from UniProtKB/Swiss-Prot (Q93074.4);
phosphorylation site"
misc_feature 2291..2293
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}; propagated from
UniProtKB/Swiss-Prot (Q93074.4); phosphorylation site"
misc_feature 2297..2299
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:23186163};
propagated from UniProtKB/Swiss-Prot (Q93074.4);
phosphorylation site"
misc_feature 3971..3973
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:18691976,
ECO:0000244|PubMed:19369195}; propagated from
UniProtKB/Swiss-Prot (Q93074.4); phosphorylation site"
misc_feature 4004..4006
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:19369195};
propagated from UniProtKB/Swiss-Prot (Q93074.4);
phosphorylation site"
misc_feature 5045..6352
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q93074.4);
Region: Interaction with CTNNB1 and GLI3.
{ECO:0000269|PubMed:17000779}"
misc_feature 5591..5593
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine. {ECO:0000250|UniProtKB:A2AGH6};
propagated from UniProtKB/Swiss-Prot (Q93074.4);
acetylation site"
misc_feature 5894..5896
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/experiment="experimental evidence, no additional details
recorded"
/note="Asymmetric dimethylarginine, alternate.
{ECO:0000250|UniProtKB:A2AGH6}; Omega-N-methylarginine,
alternate. {ECO:0000250|UniProtKB:A2AGH6}; propagated from
UniProtKB/Swiss-Prot (Q93074.4); methylation site"
misc_feature 5927..5929
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/experiment="experimental evidence, no additional details
recorded"
/note="Omega-N-methylarginine.
{ECO:0000250|UniProtKB:A2AGH6}; propagated from
UniProtKB/Swiss-Prot (Q93074.4); methylation site"
misc_feature 6179..6181
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/experiment="experimental evidence, no additional details
recorded"
/note="Asymmetric dimethylarginine.
{ECO:0000244|PubMed:24129315}; propagated from
UniProtKB/Swiss-Prot (Q93074.4); methylation site"
misc_feature 6242..6244
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/experiment="experimental evidence, no additional details
recorded"
/note="Asymmetric dimethylarginine.
{ECO:0000244|PubMed:24129315}; propagated from
UniProtKB/Swiss-Prot (Q93074.4); methylation site"
exon 299..403
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 404..595
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 596..752
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 753..934
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 935..1045
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 1046..1300
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 1301..1447
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 1448..1547
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 1548..1684
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 1685..1816
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 1817..1943
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 1944..2173
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 2174..2254
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 2255..2425
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 2426..2570
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 2571..2621
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 2622..2740
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 2741..2884
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 2885..3048
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 3049..3180
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 3181..3408
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 3409..3553
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 3554..3674
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 3675..3776
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 3777..3890
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 3891..4066
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 4067..4246
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 4247..4318
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 4319..4452
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 4453..4614
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 4615..4726
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 4727..4816
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 4817..4926
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 4927..5062
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 5063..5224
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 5225..5599
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 5600..5750
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 5751..5947
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 5948..6025
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 6026..6243
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 6244..6466
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 6467..6607
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 6608..6689
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
exon 6690..6969
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
/inference="alignment:Splign:2.1.0"
polyA_site 6969
/gene="MED12"
/gene_synonym="ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX;
OKS; OPA1; TNRC11; TRAP230"
ORIGIN
1 attgtccgat ggttcccggc gtacctcggc ttccctcggt agtttccggc aatggtcgag
61 agtttctaac gtgccccctt gttgtctctc ggccgccgtc ctctcaacca ccgcccccct
121 tttcggctcc ctctccccct tcccgttccc ccagtcagcc tggccctgct ggtgcctccg
181 gcgctacggg ctgggcaaga tggcggcctt cgggatcttg agctacgaac accggcccct
241 gaagcggccg cggctggggc ctcccgatgt ttaccctcag gaccccaaac agaaggagga
301 tgaactgacg gccttgaatg taaaacaagg tttcaataac cagcctgctg tctctgggga
361 tgagcatggc agtgccaaga acgtcagctt caatcctgcc aagatcagtt ccaacttcag
421 cagcattatt gcagagaaat tacgttgtaa tacccttcct gacactggtc gcaggaagcc
481 ccaagtgaac cagaaggata acttctggct ggtgactgca cgatcccaga gtgccattaa
541 cacttggttc actgacttgg ctggcaccaa gccactcacg caactagcca aaaaggtccc
601 cattttcagt aagaaggaag aggtgtttgg gtacttagcc aaatacacag tgcctgtgat
661 gcgggctgcc tggctcatta agatgacctg tgcctactat gcagcaatct ctgagaccaa
721 ggttaagaag agacatgttg accctttcat ggaatggact cagatcatca ccaagtactt
781 atgggagcag ttacagaaga tggctgaata ctaccggcca gggcctgcag gaagtggggg
841 ctgtggttcc acgatagggc ccttgcccca tgatgtagag gtggcaatcc ggcagtggga
901 ttacaccgag aagctggcca tgttcatgtt tcaggatgga atgctggaca gacatgagtt
961 cctgacctgg gtgcttgagt gttttgagaa gatccgccct ggagaggatg aattgcttaa
1021 actgctgctg cctctgcttc tccgatactc tggggaattt gttcagtctg catacctgtc
1081 ccgccggctt gcctacttct gtacacggag actggccctg cagctggatg gtgtgagcag
1141 tcactcatct catgttatat ctgctcagtc aacaagcacg ctacccacca cccctgctcc
1201 tcagccccca actagcagca caccctcgac tccctttagt gacctgctta tgtgccctca
1261 gcaccggccc ctggtttttg gcctcagctg tatcctacag accatcctcc tgtgctgtcc
1321 tagtgccttg gtttggcact actcactgac tgatagcaga attaagaccg gctcaccact
1381 tgaccacttg cctattgccc cgtccaacct gcccatgcca gagggtaaca gtgccttcac
1441 tcagcaggtc cgtgcaaagt tgcgggagat cgagcagcag atcaaggagc ggggacaggc
1501 agttgaagtt cgctggtctt tcgataaatg ccaggaagct actgcaggct tcaccattgg
1561 acgggtactt catactttgg aagtgctgga cagccatagt tttgaacgct ctgacttcag
1621 caactctctt gactcccttt gtaaccgaat ctttggattg ggacctagca aggatgggca
1681 tgagatctcc tcagatgatg atgctgtggt gtcattgcta tgtgaatggg ctgtcagctg
1741 caagcgttct ggtcggcatc gtgctatggt ggtagccaag ctcctggaga agagacaggc
1801 ggagattgag gctgagcgtt gtggagaatc agaagccgca gatgagaagg gttccatcgc
1861 ctctggctcc ctttctgctc ccagtgctcc cattttccag gatgtcctcc tgcagtttct
1921 ggatacacag gctcccatgc tgacggaccc tcgaagtgag agtgagcggg tggaattctt
1981 taacttagta ctgctgttct gtgaactgat tcgacatgat gttttctccc acaacatgta
2041 tacttgcact ctcatctccc gaggggacct tgcctttgga gcccctggtc cccggcctcc
2101 ctctcccttt gatgatcctg ccgatgaccc agagcacaag gaggctgaag gcagcagcag
2161 cagcaagctg gaagatccag ggctctcaga atctatggac attgacccta gttccagtgt
2221 tctctttgag gacatggaga agcctgattt ctcattgttc tcccctacta tgccctgtga
2281 ggggaagggc agtccatccc ctgagaagcc agatgtcgag aaggaggtga agcccccacc
2341 caaggagaag attgaaggga cccttggggt tctttacgac cagccacgac acgtgcagta
2401 cgccacccat tttcccatcc cccaggagga gtcatgcagc catgagtgca accagcggtt
2461 ggtcgtactg tttggggtgg gaaagcagcg agatgatgcc cgccatgcca tcaagaaaat
2521 caccaaggat atcttgaagg ttctgaaccg caaagggaca gcagaaactg accagcttgc
2581 tcctattgtg cctctgaatc ctggagacct gacattctta ggtggggagg atgggcagaa
2641 gcggcgacgc aaccggcctg aagccttccc cactgctgaa gatatctttg ctaagttcca
2701 gcacctttca cattatgacc aacaccaggt cacggctcag gtctcccgga atgttctgga
2761 gcagatcacg agctttgccc ttggcatgtc ataccacttg cctctggtgc agcatgtgca
2821 gttcatcttc gacctcatgg aatattcact cagcatcagt ggcctcatcg actttgccat
2881 tcagctgctg aatgaactga gtgtagttga ggctgagctg cttctcaaat cctcggatct
2941 ggtgggcagc tacactacta gcctgtgcct gtgcatcgtg gctgtcctgc ggcactatca
3001 tgcctgcctc atcctcaacc aggaccagat ggcacaggtc tttgaggggc tgtgtggcgt
3061 cgtgaagcat gggatgaacc ggtccgatgg ctcctctgca gagcgctgta tccttgctta
3121 tctctatgat ctgtacacct cctgtagcca tttaaagaac aaatttgggg agctcttcag
3181 cgacttttgc tcaaaggtga agaacaccat ctactgcaac gtggagccat cggaatcaaa
3241 tatgcgctgg gcacctgagt tcatgatcga cactctagag aaccctgcag ctcacacctt
3301 cacctacacg gggctaggca agagtcttag tgagaaccct gctaaccgct acagctttgt
3361 ctgcaatgcc cttatgcacg tctgtgtggg gcaccatgat cccgataggg tgaatgacat
3421 cgcaatcctg tgtgcagagc tgaccggcta ttgcaagtca ctgagtgcag aatggctagg
3481 agtgcttaag gccttgtgct gctcctctaa caatggcact tgtggtttca acgatctcct
3541 ctgcaatgtt gatgtcagtg acctatcttt tcatgactcg ctggctactt ttgttgccat
3601 cctcatcgct cggcagtgtt tgctcctgga agatctgatt cgctgtgctg ccatcccttc
3661 actccttaat gctgcttgta gtgaacagga ctctgagcca ggggcccggc ttacctgccg
3721 catcctcctt caccttttca agacaccgca gctcaatcct tgccagtctg atggaaacaa
3781 gcctacagta ggaatccgct cctcctgcga ccgccacctg ctggctgcct cccagaaccg
3841 catcgtggat ggagccgtgt ttgctgttct caaggctgtg tttgtacttg gggatgcgga
3901 actgaaaggt tcaggcttca ctgtgacagg aggaacagaa gaacttccag aggaggaggg
3961 aggaggtggc agtggtggtc ggaggcaggg tggccgcaac atctctgtgg agacagccag
4021 tctggatgtc tatgccaagt acgtgctgcg cagcatctgc caacaggaat gggtaggaga
4081 acgttgcctt aagtctctgt gtgaggacag caatgacctg caagacccag tgttgagtag
4141 tgcccaggcg cagcgcctca tgcagctcat ttgctatcca catcgactgc tggacaatga
4201 ggatggggaa aacccccagc ggcagcgcat aaagcgcatt ctccagaact tggaccagtg
4261 gaccatgcgc cagtcttcct tggagctgca gctcatgatc aagcagaccc ctaacaatga
4321 gatgaactcc ctcttggaga acatcgccaa ggccacaatc gaggttttcc aacagtcagc
4381 agagacaggg tcatcttctg gaagtactgc aagcaacatg cccagcagca gcaagaccaa
4441 gcctgtgctc agctctctag agcgctctgg tgtatggctg gtggcccccc tcattgctaa
4501 actgcccacc tcagtccagg gacatgtgtt aaaggctgct ggggaagaat tggagaaggg
4561 tcagcacctg ggttcctctt cacgcaaaga acgtgatcga caaaagcaga agagcatgtc
4621 cctattgagc cagcagccct tcttatcgct ggtgctaaca tgtctgaaag ggcaggatga
4681 acaacgcgag ggactcctta cctccctcta cagccaggtg caccagattg tgaataattg
4741 gcgagatgac cagtacttag atgattgcaa accaaagcag cttatgcatg aggcactcaa
4801 actgcggctc aacctggtgg ggggcatgtt tgacacggtg cagcgcagca cccagcagac
4861 cacggagtgg gccatgctcc tcctggagat catcatcagc ggcactgtcg acatgcagtc
4921 caacaatgag ctcttcacta ctgtgttgga catgctgagc gtgctcatca atgggacatt
4981 ggctgcagac atgtctagca tctcgcaagg tagcatggag gaaaacaagc gtgcatacat
5041 gaacctggcg aagaagttgc agaaggagtt gggggagcgc cagtcagaca gtctggaaaa
5101 ggttcgccag ctgctgccac tgcccaagca gacccgagat gtcatcacgt gtgagccaca
5161 gggctccctt atcgatacca agggcaacaa gattgctggc ttcgattcca tcttcaagaa
5221 ggagggtcta caggtttcca ccaaacagaa gatctcgccc tgggatcttt ttgaggggtt
5281 gaagccgtca gcaccactct cttggggctg gtttggaaca gtccgagtgg accggcgagt
5341 ggctcgagga gaggagcagc agcggttgct gctctaccac acacacctga ggccccggcc
5401 ccgcgcctat tacctggagc cactgccact gcccccagaa gatgaggagc cgcctgctcc
5461 taccctgcta gagcctgaga aaaaggctcc agagcccccc aaaactgaca aaccgggggc
5521 tgctccaccc agtactgagg aacgcaagaa gaagtccacc aagggcaaga aacgcagcca
5581 gccagctacc aagacagagg actatggaat gggcccgggt cggagcggcc cttatggtgt
5641 gacagtgcct ccggacctcc tgcaccaccc aaaccctggt tctataacac accttaacta
5701 caggcaaggc tccataggcc tgtacaccca gaaccagcca ctacctgcag gtggccctcg
5761 tgtggaccca taccgtcctg tgcgcttacc aatgcagaag ctgcccaccc gaccaactta
5821 ccctggagtg ctgcccacaa ccatgactgg cgtcatgggt ttagaaccct cctcttataa
5881 gacctctgtg taccggcagc agcaacctgc ggtgccccaa ggacagcgcc ttcgccaaca
5941 gctccagcag agtcagggca tgttgggaca gtcatctgtc catcagatga ctcccagctc
6001 ttcctacggt ttgcagactt cccagggcta tactccttat gtttctcatg tgggattgca
6061 gcaacacaca ggccctgcag gtaccatggt gccccccagc tactccagcc agccttacca
6121 gagcacccac ccttctacca atcctactct tgtagatcct acccgccacc tgcaacagcg
6181 gcccagtggc tatgtgcacc agcaggcccc cacctatgga catggactga cctccactca
6241 aaggttttca caccagacac tgcagcagac acccatgata agtaccatga ctccaatgag
6301 tgcccagggc gtccaggcag gcgtccgttc aacagccatc ctacctgagc agcagcagca
6361 gcagcaacag cagcaacagc aacagcagca gcagcagcaa cagcaacagc agcagcagca
6421 gcagcagtac cacatccggc agcagcagca gcagcagatc ctgcggcagc agcagcaaca
6481 gcaacagcag cagcagcagc agcagcaaca gcaacagcag cagcagcaac agcaacaaca
6541 gcaacaccag cagcaacagc agcaacaggc ggctcctccc caaccccagc cccagtccca
6601 gccccagttc cagcgccagg ggcttcagca gacccagcag cagcaacaga cagcagcttt
6661 ggtccggcaa cttcaacaac agctctctaa tacccagcca cagcccagta ccaacatatt
6721 tggacgctac tgagccacct ggaggaactg cttgtgcact ggatgtggcc ccaccctttc
6781 ctcttaattc ccaatcccat tcctgggcta gcaccagtag tggttggggc cctcccctca
6841 ggctccattt ttaataagtt tttagtattt ttgttaatgt gaggcattga gctgttgggt
6901 tttgtatatt atttatatag agaccccaga gctgttgcac ccaatacaca gagcttcttt
6961 gcaaagggaa aaaaaaaaaa aaaaa
//