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Homo sapiens myogenin (MYOG), mRNA

NCBI Reference Sequence: NM_002479.5

FASTA Graphics 

LOCUS       NM_002479               1576 bp    mRNA    linear   PRI 25-JUN-2018
DEFINITION  Homo sapiens myogenin (MYOG), mRNA.
ACCESSION   NM_002479
VERSION     NM_002479.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1576)
  AUTHORS   Lee SW, Won JY, Yang J, Lee J, Kim SY, Lee EJ and Kim HS.
  TITLE     AKAP6 inhibition impairs myoblast differentiation and muscle
            regeneration: Positive loop between AKAP6 and myogenin
  JOURNAL   Sci Rep 5, 16523 (2015)
   PUBMED   26563778
  REMARK    GeneRIF: Findings indicate a interplay between A-kinase anchoring
            protein 6 (AKAP6) and myogenin.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1576)
  AUTHORS   Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J,
            Yang F, Peng J, Weile J, Karras GI, Wang Y, Kovacs IA, Kamburov A,
            Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie
            N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot
            A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A,
            Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ,
            Sunyaev S, Berger B, Barabasi AL, Charloteaux B, Hill DE, Hao T,
            Roth FP, Xia Y, Walhout AJM, Lindquist S and Vidal M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   3  (bases 1 to 1576)
  AUTHORS   Park SY, Yun Y, Kim MJ and Kim IS.
  TITLE     Myogenin is a positive regulator of MEGF10 expression in skeletal
            muscle
  JOURNAL   Biochem. Biophys. Res. Commun. 450 (4), 1631-1637 (2014)
   PUBMED   25044114
  REMARK    GeneRIF: results indicate that myogenin is a positive regulator in
            transcriptional regulation of MEGF10 in skeletal muscle
REFERENCE   4  (bases 1 to 1576)
  AUTHORS   Snijders T, Wall BT, Dirks ML, Senden JM, Hartgens F, Dolmans J,
            Losen M, Verdijk LB and van Loon LJ.
  TITLE     Muscle disuse atrophy is not accompanied by changes in skeletal
            muscle satellite cell content
  JOURNAL   Clin. Sci. 126 (8), 557-566 (2014)
   PUBMED   24215591
  REMARK    GeneRIF: Data indicate that muscle MYOG mRNA expression doubled,
            whereas MSTN protein expression decreased following immobilization.
REFERENCE   5  (bases 1 to 1576)
  AUTHORS   Dionyssiou MG, Ehyai S, Avrutin E, Connor MK and McDermott JC.
  TITLE     Glycogen synthase kinase 3beta represses MYOGENIN function in
            alveolar rhabdomyosarcoma
  JOURNAL   Cell Death Dis 5, e1094 (2014)
   PUBMED   24577092
  REMARK    GeneRIF: Sustained GSK3beta activity represses a critical
            regulatory step in the myogenic cascade, contributing to the
            undifferentiated, proliferative phenotype in alveolar
            rhabdomyosarcoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1576)
  AUTHORS   Funk WD and Wright WE.
  TITLE     Cyclic amplification and selection of targets for multicomponent
            complexes: myogenin interacts with factors recognizing binding
            sites for basic helix-loop-helix, nuclear factor 1,
            myocyte-specific enhancer-binding factor 2, and COMP1 factor
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89 (20), 9484-9488 (1992)
   PUBMED   1329097
REFERENCE   7  (bases 1 to 1576)
  AUTHORS   Chakraborty T, Martin JF and Olson EN.
  TITLE     Analysis of the oligomerization of myogenin and E2A products in
            vivo using a two-hybrid assay system
  JOURNAL   J. Biol. Chem. 267 (25), 17498-17501 (1992)
   PUBMED   1325437
REFERENCE   8  (bases 1 to 1576)
  AUTHORS   Salminen A, Braun T, Buchberger A, Jurs S, Winter B and Arnold HH.
  TITLE     Transcription of the muscle regulatory gene Myf4 is regulated by
            serum components, peptide growth factors and signaling pathways
            involving G proteins
  JOURNAL   J. Cell Biol. 115 (4), 905-917 (1991)
   PUBMED   1659574
REFERENCE   9  (bases 1 to 1576)
  AUTHORS   Lassar AB, Davis RL, Wright WE, Kadesch T, Murre C, Voronova A,
            Baltimore D and Weintraub H.
  TITLE     Functional activity of myogenic HLH proteins requires
            hetero-oligomerization with E12/E47-like proteins in vivo
  JOURNAL   Cell 66 (2), 305-315 (1991)
   PUBMED   1649701
REFERENCE   10 (bases 1 to 1576)
  AUTHORS   Weintraub H, Davis R, Tapscott S, Thayer M, Krause M, Benezra R,
            Blackwell TK, Turner D, Rupp R, Hollenberg S et al.
  TITLE     The myoD gene family: nodal point during specification of the
            muscle cell lineage
  JOURNAL   Science 251 (4995), 761-766 (1991)
   PUBMED   1846704
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC053899.1 and AC105940.2.
            
            [WARNING] On Nov 24, 2018 this sequence was replaced by
            NM_002479.6.
            
            On Aug 10, 2012 this sequence version replaced NM_002479.4.
            
            Summary: Myogenin is a muscle-specific transcription factor that
            can induce myogenesis in a variety of cell types in tissue culture.
            It is a member of a large family of proteins related by sequence
            homology, the helix-loop-helix (HLH) proteins. It is essential for
            the development of functional skeletal muscle. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053899.1, ERR279849.7471.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158800, SAMEA2162946
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: lack of evidence for use of
                                                upstream AUG
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                BC053899.1         1-65
            66-66               AC105940.2         27334-27334         c
            67-1429             BC053899.1         67-1429
            1430-1479           AC105940.2         24544-24593         c
            1480-1576           BC053899.1         1477-1573
FEATURES             Location/Qualifiers
     source          1..1576
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..1576
                     /gene="MYOG"
                     /gene_synonym="bHLHc3; myf-4; MYF4"
                     /note="myogenin"
                     /db_xref="GeneID:4656"
                     /db_xref="HGNC:HGNC:7612"
                     /db_xref="MIM:159980"
     exon            1..548
                     /gene="MYOG"
                     /gene_synonym="bHLHc3; myf-4; MYF4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    28
                     /gene="MYOG"
                     /gene_synonym="bHLHc3; myf-4; MYF4"
                     /note="transcription start site (PMID:1659574)"
     CDS             78..752
                     /gene="MYOG"
                     /gene_synonym="bHLHc3; myf-4; MYF4"
                     /note="myogenic factor 4; class C basic helix-loop-helix
                     protein 3"
                     /codon_start=1
                     /product="myogenin"
                     /protein_id="NP_002470.2"
                     /db_xref="CCDS:CCDS1433.1"
                     /db_xref="GeneID:4656"
                     /db_xref="HGNC:HGNC:7612"
                     /db_xref="MIM:159980"
                     /translation="MELYETSPYFYQEPRFYDGENYLPVHLQGFEPPGYERTELTLSP
                     EAPGPLEDKGLGTPEHCPGQCLPWACKVCKRKSVSVDRRRAATLREKRRLKKVNEAFE
                     ALKRSTLLNPNQRLPKVEILRSAIQYIERLQALLSSLNQEERDLRYRGGGGPQPGVPS
                     ECSSHSASCSPEWGSALEFSANPGDHLLTADPTDAHNLHSLTSIVDSITVEDVSVAFP
                     DETMPN"
     misc_feature    306..308
                     /gene="MYOG"
                     /gene_synonym="bHLHc3; myf-4; MYF4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by CaMK2G.
                     {ECO:0000250|UniProtKB:P20428}; propagated from
                     UniProtKB/Swiss-Prot (P15173.2); phosphorylation site"
     misc_feature    312..314
                     /gene="MYOG"
                     /gene_synonym="bHLHc3; myf-4; MYF4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by CaMK2G.
                     {ECO:0000250|UniProtKB:P20428}; propagated from
                     UniProtKB/Swiss-Prot (P15173.2); phosphorylation site"
     misc_feature    336..338
                     /gene="MYOG"
                     /gene_synonym="bHLHc3; myf-4; MYF4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by CaMK2G.
                     {ECO:0000250|UniProtKB:P20428}; propagated from
                     UniProtKB/Swiss-Prot (P15173.2); phosphorylation site"
     exon            549..630
                     /gene="MYOG"
                     /gene_synonym="bHLHc3; myf-4; MYF4"
                     /inference="alignment:Splign:2.1.0"
     exon            631..1533
                     /gene="MYOG"
                     /gene_synonym="bHLHc3; myf-4; MYF4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1513..1518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYOG"
                     /gene_synonym="bHLHc3; myf-4; MYF4"
     polyA_site      1533
                     /gene="MYOG"
                     /gene_synonym="bHLHc3; myf-4; MYF4"
ORIGIN      
        1 aaatggcacc cagcagttgg cgtgaggggc tgctggagct tgggggctgg tggcaggaac
       61 aagccttttc cgaccccatg gagctgtatg agacatcccc ctacttctac caggaacccc
      121 gcttctatga tggggaaaac tacctgcctg tccacctcca gggcttcgaa ccaccaggct
      181 acgagcggac ggagctcacc ctgagccccg aggccccagg gccccttgag gacaaggggc
      241 tggggacccc cgagcactgt ccaggccagt gcctgccgtg ggcgtgtaag gtgtgtaaga
      301 ggaagtcggt gtccgtggac cggcggcggg cggccacact gagggagaag cgcaggctca
      361 agaaggtgaa tgaggccttc gaggccctga agagaagcac cctgctcaac cccaaccagc
      421 ggctgcccaa ggtggagatc ctgcgcagtg ccatccagta catcgagcgc ctccaggccc
      481 tgctcagctc cctcaaccag gaggagcgtg acctccgcta ccggggcggg ggcgggcccc
      541 agccaggggt gcccagcgaa tgcagctctc acagcgcctc ctgcagtcca gagtggggca
      601 gtgcactgga gttcagcgcc aacccagggg atcatctgct cacggctgac cctacagatg
      661 cccacaacct gcactccctc acctccatcg tggacagcat cacagtggaa gatgtgtctg
      721 tggccttccc agatgaaacc atgcccaact gagattgtct tccaagccgg gcatccttgc
      781 gagcccccca agctggccac agatgccact acttctgtag caggggcctc ctaagccagg
      841 ctgccctgat gctaggaagc cagctctggg gtgccatagg ccagactatc cccttcctca
      901 tccatgtaag gttaacccac cccccagcaa gggactggac gccctcattc agctgcctcc
      961 ttagaggaga gggcatcccc tttccaggga ggtaaagcag gggaccagag cgccccctcg
     1021 tgtatgcccc agctcagggg gcaaactcag gagcttcctt tttatcataa cgcggcctct
     1081 aattccaccc cccaagtgaa acggtttgag agacgcagtg ccctgacctg gacaagctgt
     1141 gcacgtctcc tgttctggtc tcttcccgat gccagtggct gggctgggcc tgccctgaat
     1201 tgagagagaa gaaggggaga ggaacagccc tctgttccca agtccctggg gggccaaact
     1261 tttgcagtga atattgggaa ccttccagtg gttttatgtt ttgttttgtt tcgtgtgttg
     1321 tttgtaaagc tgccatccga ccaaggtctc ctgtgctgaa gttgccgggg acaggcaggg
     1381 aaaaggggtt ggggcctctt gggggtgatt tcttttgtta acaaagcatt gtgtggtttt
     1441 gccattgttt tgtatttttt tttttttttt ttttttttgc taacttattt ggatttcctt
     1501 ttttaaaaaa tgaataaaga ctggttgcca gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1561 aaaaaaaaaa aaaaaa
//
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