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MMP Enzyme Inhibition Assay from Article 10.1016/s0960-894x(02)00564-4: "Protease inhibitors: synthesis of matrix metalloproteinase and bacterial collagenase inhibitors incorporating 5-amino-2-mercapto-1,3,4-thiadiazole zinc binding functions."
Assay data:10 Active, 3 Activity ≤ 1 µM, 27 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Gelatinase E Assay from US Patent US20230357139: "SMALL MOLECULE INHIBITORS OF BACTERIAL TOXINS"
Assay data:1 Active, 1 Activity ≤ 1 µM, 14 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Reversible inhibition of Clostridium histolyticum collagenase unit of ColG at 7.5 uM using quenched fluorescent FSI-1 as substrate incubated for 2 min by rapid dilution assay
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Reversible inhibition of Clostridium histolyticum peptidase domain of ColH at 1.25 uM using quenched fluorescent FSI-1 as substrate incubated for 2 min by rapid dilution assay
Inhibition of Clostridium histolyticum peptidase unit of CoLH at 100 uM relative to contol
Assay data:6 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Clostridium histolyticum collagenase unit of ColG assessed as inhibition constant incubated for 144 seconds by FRET based assay
Assay data:2 Tested
Inhibition of Clostridium histolyticum peptidase unit of CoLH at 100 uM relative to control
Inhibition of Clostridium histolyticum collagenase unit of CoLH at 100 uM relative to control
Inhibition of Clostridium histolyticum CoLH at 100 uM relative to control
Assay data:1 Tested
Inhibition of Clostridium histolyticum CoLH
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of Clostridium histolyticum CoLH assessed as inhibition constant using M MOCAcPro-Leu-Gly-Leu-A2pr-(DNP)Ala-Arg-NH2 as substrate incubated for 10 mins by fluorescence spectrophotometer analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of Clostridium histolyticum collagenase unit of ColG at 100 uM relative to control
Inhibition of Clostridium histolyticum CoLH using M MOCAcPro-Leu-Gly-Leu-A2pr-(DNP)Ala-Arg-NH2 as substrate incubated for 10 mins by fluorescence spectrophotometer analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of Clostridium histolyticum peptidase unit of ColH assessed as inhibition constant incubated for 144 seconds by FRET based assay
Assay data:1 Active, 2 Tested
Inhibition of Clostridium histolyticum collagenase-induced degradation of human molar dentin assessed as reduction in degradation after 24 hrs
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of Clostridium histolyticum collagenase using FALGPA as substrate by spectrophotometric method
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Toxicity in Clostridium histolyticum DSM 1126 assessed as reduction in bacterial growth after 48 hrs
Assay data:5 Tested
SummaryPubMed Citation
Inhibition of Clostridium histolyticum ColG collagenase unit at 100 uM using Mca-Ala-Gly-Pro-Pro-Gly-Pro-Dpa-Gly-Arg-NH2 as substrate preincubated for 1 hr followed by substrate addition measured for 2 mins by FRET assay relative to control
Inhibition of Clostridium histolyticum ColH peptidase domain expressed in Escherichia coli BL21(DE3) cells at 100 uM using Mca-Ala-Gly-Pro-Pro-Gly-Pro-Dpa-Gly-Arg-NH2 as substrate preincubated for 1 hr followed by substrate addition measured for 2 mins by FRET assay relative to control
Inhibition of Clostridium histolyticum ColH peptidase domain expressed in Escherichia coli BL21(DE3) cells at 1 uM using Mca-Ala-Gly-Pro-Pro-Gly-Pro-Dpa-Gly-Arg-NH2 as substrate preincubated for 1 hr followed by substrate addition measured for 2 mins by FRET assay relative to control
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