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Antifilarial activity against Dipetalonema viteae after 120 hrs
Assay data:29 Active, 23 Activity ≤ 1 µM, 31 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
In vitro macrofilaricidal activity against Dipetalonema viteae was determined using the leakage of incorporated radiolabeled adenine method.
Tested in vivo for sterilization of female worms
Assay data:13 Tested
SummaryPubMed Citation
Tested in vivo for sterilization of female worms; NA is Not Applicable.
Assay data:1 Tested
In vivo anti-filarial (microfilaricidal) activity at an ip dose of 50 mg/kg (for 5 days) against A. viteae in Mastomys coucha.
Assay data:26 Tested
In vivo anti-filarial (macrofilaricidal) activity at an ip dose of 50 mg/kg (for 5 days) against A. viteae in Mastomys coucha.
Antifilarial activity as percent of surviving A. viteae in Mastomys coucha sterlized after an intraperitoneal dose of 50 mg/kg (for 5 days).
Macrofilarial reduction at 100 mg/kg dosage by subcutaneous administration for a period of 5 days against Acanthocheilonema viteae
Assay data:34 Tested
Tested in vivo for Acanthocheilonema viteae at 200 mg/kg X 5 days(perorally)
Assay data:14 Tested
Antifilarial activity against adult worm of A. viteae in jirds at 100 mg/kg x 5 days administered subcutaneously; No activity
Assay data:25 Tested
Antifilarial activity was measured against the adult worms of Acanthocheilonema viteae in jirds by subcutaneous administration at a dose of 15.6 mg/kg/5 days
Antifilarial activity was measured against the adult worms of Acanthocheilonema viteae in jirds by subcutaneous administration at a concentration of 50 mg/kg/day
Assay data:2 Tested
Antifilarial activity measured against the adult worms of Acanthocheilonema viteae in jirds by subcutaneous administration
Assay data:10 Tested
Antifilarial activity was measured against the adult worms of Acanthocheilonema viteae in jirds by subcutaneous administration at a concentration of 25 mg/Kg/day
Antifilarial activity was measured against the adult worms of Acanthocheilonema viteae in jirds by subcutaneous administration at a concentration of 12.5 mg/Kg/day
Antifilarial activity was measured against the adult worms of Acanthocheilonema viteae in jirds by subcutaneous administration at a concentration of 100 mg/kg/day
Assay data:3 Tested
Antifilarial activity was measured against the adult worms of Acanthocheilonema viteae in jirds by oral administration at a dose of 100 mg/kg/5 days
Antifilarial activity was measured against the adult worms of Acanthocheilonema viteae in jirds by oral administration at a concentration of 100 mg/kg/day
anti-filarial Activity was measured against Acanthocheilonema viteae in jirds at 75 mg/kg/day(5 days) dose
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