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Inhibition of recombinant human N-terminal His6-tagged TRAP1 (60 to 561 residues) ATPase activity expressed in Escherichia coli BL21(DE3) up to 20 uM preincubated for 30 mins followed by ATP addition measured after 3 hrs by inorganic phosphate color lock gold reagent based assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Displacement of PU-FITC3 from recombinant TRAP-1 (unknown origin) after 24 hrs by fluorescence polarization assay
Assay data:10 Active, 1 Activity ≤ 1 µM, 69 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
Inhibition of TRAP1 in human HeLa cells assessed as induction of mitochondrial membrane potential loss after 4 hrs by JC-1 staining based flow cytometry
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of FITC3-labeled PU-H71 binding to recombinant human N-terminal His6-tagged TRAP1 (60 to 561 residues) expressed in Escherichia coli BL21(DE3) after 24 hrs by fluorescence polarization assay
Assay data:6 Active, 4 Activity ≤ 1 µM, 7 Tested
Inhibition of TRAP1 in human HeLa cells assessed as induction of mitochondrial membrane potential loss at 20 uM after 4 hrs by JC-1 staining based flow cytometry (Rvb = 10.7%)
Assay data:3 Tested
Inhibition of TRAP1 in human HeLa cells assessed as induction of mitochondrial ROS production after 6 hrs by Mito-Sox staining based flow cytometry
Assay data:1 Active, 2 Tested
Inhibition of TRAP1 in human HeLa cells assessed as elevation of CHOP protein expression at 20 uM after 6 hrs by Western blot method
Inhibition of TRAP1 in human HeLa cells assessed as cytochrome c release at 20 uM after 4 hrs by Western blot method
Inhibition of TRAP1 in human HeLa cells assessed as elevation of CHOP protein expression after 6 hrs by Western blot method
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
Inhibition of recombinant human N-terminal His6-tagged TRAP1 (60 to 704 residues) ATPase activity expressed in Escherichia coli BL21-CodonPlus-RIL after overnight incubation by BioMol green dye-based assay
Assay data:7 Active, 4 Activity ≤ 1 µM, 9 Tested
Inhibition of FITC-geldanamycin binding to recombinant human N-terminal His6-tagged TRAP1 (60 to 704 residues) expressed in Escherichia coli BL21-CodonPlus-RIL by fluorescence anisotropy method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of FITC-geldanamycin binding to N-terminal His-tagged recombinant human TRAP1 (60 to 704 residues) expressed in Escherichia coli preincubated for 2 hrs followed by Geldanamycin-FITC addition and measured after 5 hrs by fluorescence polarization competitive binding assay
Inhibition of recombinant wild-type human TRAP1 ATPase activity expressed in Escherichia coli BL21 (DE3) preincubated for 0.5 hrs followed by ATP addition and measured after 3 hrs by PiColorLock Gold reagent based colorimetric assay
Assay data:5 Active, 5 Tested
Inhibition of PU-H71-FITC binding to recombinant wild-type human TRAP1 expressed in Escherichia coli BL21 (DE3) measured after 2 hrs by fluorescence polarization assay
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
Stimulation of recombinant wild-type human TRAP1 ATPase activity expressed in Escherichia coli BL21 (DE3) at 2 to 5 uM preincubated for 0.5 hrs followed by 0.2 mM ATP addition and measured after 3 hrs by PiColorLock Gold reagent based colorimetric assay relative to control
Stimulation of recombinant wild-type human TRAP1 ATPase activity expressed in Escherichia coli BL21 (DE3) at 2 to 5 uM preincubated for 0.5 hrs followed by 2 mM ATP addition and measured after 3 hrs by PiColorLock Gold reagent based colorimetric assay relative to control
Binding affinity to TRAP1 (unknown origin)
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