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Ratio of Vmax to Km for human aldo-keto reductase 1A1
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
siRNA Circadian Assay
Assay data:527 Active, 33364 Tested
SummaryPubMed CitationRelated BioAssays by Depositor
Tested for in vitro inhibition activity against human aldehyde reductase (AHR)
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibitory concentration against human ALR1 Aldehyde reductase using DL-glyceraldehyde
In vitro inhibition of recombinant human aldehyde reductase
Assay data:17 Active, 40 Tested
In vitro inhibition of recombinant human aldehyde reductase; Not determined
Inhibition of N-terminal 6His-tagged human aldehyde reductase expressed in Escherichia coli BL21(DE3) mediated D-glucuronate reduction
Assay data:5 Active, 2 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of AK1A1
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
SummaryPubMed Citation
Inhibition of human AKR1A1 at 30 uM
Inhibition of human recombinant AKR1A1 expressed in Escherichia coli BL21 cells using D-glucuronate as substrate by spectrophotometry
Assay data:4 Active, 14 Tested
Inhibition of human recombinant AKR1A1 expressed in Escherichia coli BL21 cells using D-glucuronate as substrate at 20 uM by spectrophotometry
Assay data:7 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
Activity of human AKR1A1 expressed in Escherichia coli BL21 assessed per mg protein in presence of 0.2 mM NADPH
Assay data:2 Tested
Activity of GST-tagged aldo-keto reductase 1A1
Enzyme Inhibition Assay from Article 10.1021/jm0492094: "Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications."
Assay data:41 Active, 40 Activity ≤ 1 µM, 41 Tested
Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells
Assay data:167 Active, 26449 Tested
Summary
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Inhibition of AKR1A1 (unknown origin) using DL-glyceraldehyde as substrate at 15 uM after 5 mins by spectrophotometry
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