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Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
siRNA Circadian Assay
Assay data:527 Active, 33364 Tested
SummaryPubMed CitationRelated BioAssays by Depositor
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
SummaryPubMed Citation
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
Summary
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
Induction of human recombinant Hsp72 expressed in Escherichia coli interaction with His-tagged human HOP assessed as inhibition of luciferase refolding at 50 uM preincubated for 1 to 2 hrs in presence of Hsp72 followed by denatured luciferase and HOP addition in absence of DnaJ/Hsp90/GrpE by bright-glo luminescence based assay relative to control
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Induction of human recombinant Hsp72 expressed in Escherichia coli interaction with His-tagged HOP (unknown origin) at 5 to 50 uM preincubated for 2 hrs in presence of Hsp72 followed by HOP addition and measured after 1 hr by Western blot analysis
Assay data:2 Active, 12 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Induction of human recombinant Hsp72 expressed in Escherichia coli interaction with His-tagged HOP (unknown origin) at 50 uM preincubated for 2 hrs in presence of Hsp72 followed by HOP addition and measured after 1 hr by Western blot analysis
Assay data:3 Tested
Induction of human recombinant Hsp72 expressed in Escherichia coli interaction with His-tagged human HOP assessed as inhibition of luciferase refolding at 50 uM preincubated for 1 to 2 hrs in presence of Hsp72 followed by denatured luciferase and HOP addition in presence of DnaJ/Hsp90/GrpE by bright-glo luminescence based assay relative to control
Assay data:2 Active, 7 Tested
Induction of human recombinant Hsp72 expressed in Escherichia coli interaction with His-tagged human HOP assessed as inhibition of luciferase refolding at 10 uM preincubated for 1 to 2 hrs in presence of Hsp72 followed by denatured luciferase and HOP addition in presence of DnaJ/Hsp90/GrpE by bright-glo luminescence based assay
Assay data:1 Active, 1 Tested
Inhibition of (2S,8S,11S,14S)-2-(4-aminobutyl)-14-(3-guanidinopropyl)-8-(4-hydroxybenzyl)-11-(hydroxymethyl)-4,7,10,13,16,32-hexaoxo-36-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-19,22,25,28-tetraoxa-3,6,9,12,15,31-hexaazahexatriacontan-1-oic acid binding to His-tagged human HOP expressed in Escherichia coli up to 200 uM by Western blot analysis
Inhibition of (2S,8S,11S,14S)-2-(4-aminobutyl)-14-(3-guanidinopropyl)-8-(4-hydroxybenzyl)-11-(hydroxymethyl)-4,7,10,13,16,32-hexaoxo-36-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-19,22,25,28-tetraoxa-3,6,9,12,15,31-hexaazahexatriacontan-1-oic acid binding to human Hsp72 SBD expressed in Escherichia coli BL21 (DE3)/His-tagged human HOP expressed in Escherichia coli up to 200 uM by Western blot analysis
Modulation of human recombinant Hsp72 expressed in Escherichia coli interaction with His-tagged HOP (unknown origin) at 0.5 to 50 uM preincubated for 2 hrs in presence of Hsp72 followed by HOP addition and measured after 1 hr by Western blot analysis
Assay data:1 Tested
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