BioAssay by Target (List) for Gene (Select 13548) - PubChem BioAssay - NCBI

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Links from Gene

Items: 14

Select item 18611421.

Inhibition of mouse glutathione S-transferase-tagged Dyrk1A expressed in Escherichia coli DH5alpha using NH2-RSPSYGRSRSRSRSRSRSRSRSNSRSRSY-OH peptide as substrate in presence of [gamma 32P-ATP] and ATP by liquid scintillation counting method

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1861142

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 15469622.

Inhibition of DYRK1A in mouse R7T1 cells expressing expressing NFAT2-GFP assessed as induction of NFAT2- GFP nuclear translocation at 10 uM incubated for 24 hrs

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Assay data:6 Active, 6 Tested

AID:: 1546962

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 12248283.

Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout

Source:: Iain Fraser

Assay data:762 Active, 16821 Tested

AID:: 1224828

Summary Related BioAssays by Same Project

Select item 12248264.

Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout

Source:: Iain Fraser

Assay data:1106 Active, 16821 Tested

AID:: 1224826

Summary Related BioAssays by Same Project

Select item 10566295.

Binding affinity to DYRK1A in mouse brain extracts by Western blot analysis

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Assay data:3 Active, 3 Tested

AID:: 1056629

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 10532086.

A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:788 Active, 16789 Tested

AID:: 1053208

Summary PubMed Citation

Select item 7074717.

Binding affinity to DYRK1A in mouse brain homogenate after 3 hrs by competition affinity chromatographic analysis

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 707471

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 7074648.

Binding affinity to DYRK1A in mouse HT22 cell lysate by Western blot analysis

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Assay data:1 Active, 1 Tested

AID:: 707464

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 7074559.

Binding affinity to DYRK1A in mouse brain homogenate by Western blot analysis

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Assay data:1 Active, 1 Tested

AID:: 707455

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 70744310.

Inhibition of DYRK1A isolated from mouse HT22 cells

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Assay data:1 Tested

AID:: 707443

Summary PubMed Citation Related BioAssays by Target

Select item 70726711.

Inhibition of DYRK1A in mouse HT22 cells at 10 uM after 4 hrs

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Assay data:1 Active, 2 Tested

AID:: 707267

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 48074212.

Inhibition of mouse DYRK1A expressed in Escherichia coli after 20 mins

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Assay data:2 Active, 2 Tested

AID:: 480742

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 26814413.

Inhibition of mouse Dyrk1A autophosphorylation in HEk293 cells at 10 uM

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Assay data:12 Tested

AID:: 268144

Summary PubMed Citation Related BioAssays by Target

Select item 26814314.

Inhibition of mouse Dyrk1A autophosphorylation in HEk293 cells

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Assay data:5 Active, 12 Tested

AID:: 268143

Summary Compounds, Active PubMed Citation Related BioAssays by Target

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BioActivity

Active Compounds (9)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 µM (2)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (2)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (4)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (1)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (11)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (3)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (2)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (11)
BioAssays extracted from the literature
Other (3)
BioAssays deposited by other experimentalists

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BioAssay by Target (List) for Gene (Select 13548) (14)
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