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Inhibition of NMDA receptor in mouse cortical neurons assessed as effect on NMDA currents
Assay data:1 Tested
SummaryRelated BioAssays by Target
Antagonist activity at mouse recombinant NR1/NR2B receptor expressed in frog oocytes assessed as inhibition of glutamate/glycine-induced current by two electrode voltage clamp method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at mouse recombinant NR1/NR2B receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current at 3 uM by two electrode voltage clamp method
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at mouse NR1/NR2B receptor D101A mutant expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current by two electrode voltage clamp method
Antagonist activity at GluN2B/NMDA in FVB mouse CA1 pyramidal neurons assessed as reduction in NMDA-mediated inward current at 10 uM measured for 5 mins by whole-cell patch clamp assay in presence of glycine and tetrodotoxin
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at NMDA receptor GluN2B subunit in FVB mouse CA1 pyramidal neurons assessed as decrease in EPSC amplitude at holding potential of -60 mV at 100 nM measured at 5 mins by patch clamp electrophysiological assay in presence of Mg2+ free ACSF containing CNQX, glycine, bicuculline relative to control
Antagonist activity at NMDA receptor GluN2B subunit in FVB mouse CA1 pyramidal neurons assessed as decrease in EPSC amplitude at holding potential of -60 mV at 6 uM measured at 5 mins by patch clamp electrophysiological assay in presence of Mg2+ free ACSF containing CNQX, glycine, bicuculline relative to control
Modulation of NMDA receptor GluN2B subunit in FVB mouse CA1 pyramidal neurons assessed as decrease in EPSC amplitude at holding potential of -60 mV at 10 uM measured at 5 mins by patch clamp electrophysiological assay in presence of Mg2+ free ACSF containing CNQX, glycine, bicuculline relative to control
Modulation of NMDA receptor GluN2B subunit in FVB mouse CA1 pyramidal neurons assessed as increase in EPSC amplitude at holding potential of -60 mV at 10 uM measured at 5 mins by patch clamp electrophysiological assay in presence of Mg2+ free ACSF containing CNQX, glycine, bicuculline relative to control
Antagonist activity at NMDA receptor GluN2B subunit in FVB mouse CA1 pyramidal neurons assessed as decrease in EPSC amplitude at holding potential of -60 mV at 50 uM measured at 5 mins by patch clamp electrophysiological assay in presence of Mg2+ free ACSF containing CNQX, glycine, bicuculline relative to control
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Antagonist activity at NMDA receptor GluN2B subunit in FVB mouse CA1 pyramidal neurons assessed as reversible reduction of excitatory post synaptic current amplitude at 50 nM at holding potential of -60 mV measured for 5 mins by patch clamp technique in presence of Mg2+free ACSF relative to control
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
Blocking of NMDA receptor in mouse fibroblast assessed as inhibition of NMDA-induced excitotoxicity by LDH release assay
Antagonist activity at rat GluN1a/mouse GluN2B receptors expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glucine induced current amplitude at holding potential of -60 mV by patch clamp assay
Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracellular Ca2+ levels measured after 1 day post induction by Fluo-3/AM dye-based fluorescence assay
Assay data:27 Active, 4 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 27 Tested
Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced calcium ion influx by fluorescence based assay
Assay data:26 Active, 2 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 32 Tested
Positive allosteric modulation of C57BL/6 mouse NMDA receptor assessed as potentiation of NMDA-induced current by measuring peak current amplitude at 30 uM measured after 15 to 30 mins by patch-clamp method (Rvb = 54.6 +/- 4.6 pA)
Assay data:2 Tested
Positive allosteric modulation of C57BL/6 mouse NMDA receptor assessed as fold change in compound potentiated NMDA-induced current relative to NMDA current alone at 30 uM measured after 15 to 30 mins by patch-clamp method
Assay data:61 Tested
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