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Inhibition of SHIP2 in serum-starved mouse Mm1 cells assessed as reduction in Akt phosphorylation incubated for 30 mins by Western blot analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of SHIP2 in H2O2-stimulated mouse HT22 cells assessed as decrease in PI(3,4)P2 production at 10 uM incubated for 30 mins followed by H2O2 stimulation for 5 mins in presence of PTEN inhibitor VO-Ohpic trihydrate by ELISA
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of SHIP2 in mouse HT22 cells assessed as decrease in PI(3,4)P2 production at 10 uM after 24 hrs by mKate2-TAPP1-PH based fluorescence imaging method
Assay data:3 Active, 3 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Secondary screen NFkB readout
Assay data:1483 Active, 3847 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Secondary screen TNF readout
Assay data:2176 Active, 3847 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Inhibition of SHIP2 in mouse 3T3L1 cells assessed as reduction of TNF-alpha induced decrease in insulin-stimulated Akt phosphorylation at Thr308 at 10 uM treated for 15 mins after TNF alpha challenge for 16 hrs and prior to insulin stimulation measured after 2 hrs by Western blot analysis
Assay data:12 Active, 12 Tested
Inhibition of SHIP2 in TNF alpha-treated mouse 3T3L1 cells assessed as potentiation of insulin-stimulated Akt phosphorylation at Thr308 at 10 uM treated for 15 mins after TNF alpha challenge for 16 hrs and prior to insulin stimulation measured after 2 hrs by Western blot analysis relative to untreated control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
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