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Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Inhibition of PEP in C57BL/6 mouse BMMC assessed as decrease in anti-DNP-IgE-induced NFAT expression at 20 uM after 1 hr by luciferase reporter gene assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of PEP in C57BL/6 mouse BMMC assessed as decrease in anti-DNP-IgE-induced NFAT expression at 5 uM after 1 hr by luciferase reporter gene assay
Inhibition of PEP in C57BL/6 mouse BMMC assessed as decrease in anti-DNP-IgE-induced NFAT expression after 1 hr by luciferase reporter gene assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of PEP in C57BL/6 mouse BMMC assessed as decrease in NFAT expression after 1 hr by luciferase reporter gene assay
Inhibition of PEP in mouse CD4 and CD8 double positive thymocytes assessed as increase in CD69 expression at 15 uM after 3.5 hrs by FACS analysis
Inhibition of PEP in mouse CD4 and CD8 double positive thymocytes assessed as increase in Nur77 expression at 15 uM after 3.5 hrs by GFP-based FACS analysis
Inhibition of PEP in C57BL/6 mouse BMMC assessed as reduction in anti-DNP-IgE-induced degranulation by measuring beta-hexosaminidase release at 5 to 20 uM after 1 hr by spectrophotometric analysis
Inhibition of LYP in anti-CD3 and antiCD28 antibody-stimulated C57BL/6 mouse CD8+ splenocytes assessed as increase in TCR signaling-stimulated CD69 expression at 100 uM incubated for 24 hrs (Rvb = 5.3%)
Inhibition of LYP-mediated TCR signaling in C305 antibody stimulated mouse Ptpn22+/+ T cells assessed as increase in Lck Y394 dephosphorylation at 50 uM by Western blotting
Inhibition of LYP in anti-CD3 and antiCD28 antibody-stimulated C57BL/6 mouse CD4+ splenocytes assessed as increase in TCR signaling-stimulated CD69 expression at 50 uM incubated for 24 hrs (Rvb = 29.2%)
Inhibition of LYP in anti-CD3 and antiCD28 antibody-stimulated C57BL/6 mouse CD4+ splenocytes assessed as increase in TCR signaling-stimulated CD69 expression at 100 uM incubated for 24 hrs (Rvb = 29.2%)
Inhibition of LYP in anti-CD3 and antiCD28 antibody-stimulated C57BL/6 mouse CD8+ splenocytes assessed as increase in TCR signaling-stimulated CD69 expression at 50 uM incubated for 24 hrs (Rvb = 5.3%)
Inhibition of LYP-mediated TCR signaling in C305 antibody stimulated mouse Ptpn22+/+ T cells assessed as increase in Src Y416 phosphorylation at 50 uM by Western blotting relative to untreated control
Assay data:28 Tested
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