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A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Effect on Spermidine/Spermine-Acetyltransferase (SSAT ) at 10 uM at 48 hour in L1210 cells
Assay data:27 Tested
SummaryPubMed CitationRelated BioAssays by Target
Percent of Spermidine/spermine-N1- acetyltransferase enzyme activity in L1210 cells after 48 hr of treatment with 10 uM of dose
Assay data:2 Tested
Percent of Spermidine/spermine-N1- acetyltransferase enzyme activity in L1210 cells after 48 hr of treatment with 10 uM dose of compound
Assay data:1 Tested
Impact on polyamine biosynthetic enzyme Spermidine N-acetyl-transferase in L1210 cells treated with the compound for 48 hr.
Assay data:6 Tested
Inhibition of spermidine/spermine N1-Acetyltransferase (SSAT) activity
Assay data:15 Tested
Compound was tested for the enzyme activity against Spermidine/spermine N1-acetyl transferase (SSAT) in L1210 cells and expressed as percent compound found in untreated controls.
Assay data:4 Tested
Compound was tested for the enzyme activity against Spermidine/spermine N1-acetyl transferase (SSAT) in murine L1210 cells and expressed as percent compound found in untreated controls.
Effect on Spermidine/spermine N1-acetyl transferase (SSAT) activity in L1210 cells at 10 uM for 48h
Assay data:3 Tested
Inhibition of recombinant mouse SSAT using spm as substrate at 500 uM relative to control
Drug metabolism assessed as mouse SSAT1-mediated metabolite formation
Drug metabolism in mouse primary hepatocytes assessed as SSAT1-mediated (N1-acetyl)-1,12-diamino-3,6,9-triazadodecane formation at 100 uM for 4 hrs in presence of SSAT2 siRNA
Drug level in mouse primary hepatocytes assessed as SSAT1-mediated compound formation treated with 100 uM SpmTrien for 4 hrs in presence of SSAT2 siRNA
Drug level in mouse primary hepatocytes assessed as SSAT1-mediated compound formation per ug DNA treated with SpmTrien at 100 uM for 24 hrs
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
Substrate activity at recombinant mouse SSAT assessed as Vmax at 2000 to 6000 uM
Substrate activity at recombinant mouse SSAT assessed as Km at 2000 to 6000 uM
Substrate activity at recombinant mouse SSAT at 5 mM
Assay data:3 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
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