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Inhibition of TGF-beta type 1 receptor in mouse NIH3T3 cells expressing Luc-Smad 2/3 measured after 24 hrs incubation by cell based Bright-Glo Luciferase assay
Assay data:26 Active, 24 Activity ≤ 1 µM, 28 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of TGFBR1 in mouse whole blood assessed as apparent inhibition constant by measuring reduction in TGFbeta-induced SMAD phosphorylation
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of TGFbetaR1 in TGFbeta-stimulated mouse NIH3T3 cells assessed as reduction in SMAD3 phosphorylation
Inhibition of ALK5 in mouse C2C12 assessed as decrease in TGFbeta1-induced Smad1/5 phosphorylation at 0.1 to 10 uM by Western blot method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of ALK5 in mouse C2C12 cells assessed as decrease in TGFbeta1-induced Smad2/3 phosphorylation at 0.1 to 10 uM by Western blot method
Assay data:1 Active, 2 Tested
Inhibition of ALK5 in mouse C2C12 cells assessed as decrease in TGFbeta1-induced Smad1/5 phosphorylation at 10 uM by Western blot method
Inhibition of ALK5 in mouse C2C12 cells assessed as decrease in TGFbeta1-induced Smad1/5 phosphorylation at 0.1 uM by Western blot method
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
Inhibition of ALK5 in mouse 4T1 cells assessed as inhibition of TGFbeta1-induced luciferase activity after 24 hrs by luciferase reporter gene assay
Assay data:3 Active, 4 Activity ≤ 1 µM, 4 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Inhibition of ALK5 activity in mouse NMuMG cells assessed as TGFbeta-induced phosphorylation of Smad2 at 0.1 to 0.5 uM after 1 hr by Western blot analysis
Assay data:2 Active, 2 Tested
Inhibition of ALK5 in mouse NIH/3T3 cells by smad binding element reporter based assay
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
Inhibition of TGFR1-mediated Smad-2 phosphorylation in TGFbeta1-stimulated mouse PASMC at => 20 uM treated 30 mins before TGFbeta1 challenge measured after 30 mins by immunoblot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
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