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TLR-pathway-mouse_R848 ligand_NFkB readout
Assay data:147 Active, 756 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Effective dose against LPS-stimulated Tumor necrosis factor, alpha release in mice dosed orally, 30 min prior to LPS challenge (0.1 mg/kg, ip)
Assay data:9 Tested
SummaryPubMed CitationRelated BioAssays by Target
Effective dose against LPS-stimulated Tumor necrosis factor, alpha release in mice dosed orally, 30 min prior to LPS challenge (0.1 mg/kg, ip); ND is No Data
Assay data:1 Tested
Effective dose against LPS-stimulated Tumor necrosis factor, alpha release in mice dosed orally, 30 min prior to LPS challenge (0.1 mg/kg, ip); ND is No Data.
Effective dose against LPS-stimulated Tumor necrosis factor, alpha release in mice dosed orally, 30 min prior to LPS challenge (0.1 mg/kg, ip); value ranges from 3-10
In vitro percent inhibition of tumor necrosis factor, alpha secreted by macrophage at the dose 1 ug/mL
Assay data:16 Tested
In vitro percent inhibition of tumor necrosis factor, alpha secreted by macrophage at the dose 10 ug/mL
In vitro percent inhibition of tumor necrosis factor, alpha secreted by macrophage at the dose 100 ug/mL
Inhibition of TNFalpha in LPS-stimulated mouse RAW264.7 cells at 10 uM after 2 hrs treated after 14 hrs of LPS challenge by FACS analysis
Assay data:6 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
TLR-pathway-mouse_P3C ligand_NFkB readout
Assay data:128 Active, 756 Tested
TLR-pathway-mouse_R848 ligand_TNF readout
Assay data:130 Active, 756 Tested
Inhibition of mouse TNF-alpha in mouse L929 cells incubated for 18 hrs by CellTitreGlo assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
TLR-pathway-mouse_LPS ligand_NFkB readout
Assay data:137 Active, 756 Tested
TLR-pathway-mouse_P3C ligand_TNF readout
Assay data:115 Active, 756 Tested
TLR-pathway-mouse_LPS ligand_TNF readout
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
Inhibition of mouse recombinant TNF-alpha binding to antibody preincubated for 30 mins followed by antibody addition measured after 2 hrs by ELISA
Inhibition of TNF-alpha in mouse RAW264.7 cells assessed as inhibition of LPS-induced IKBalpha phosphorylation at 5 to 20 uM pre-incubated for 12 hrs before LPS stimulation for 2 hrs by Western blot analysis
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