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Inhibition of human BRPF2 (556 to 688 residues) expressed in Escherichia coli BL21 after 1 hr by BROMOscan assay
Assay data:19 Active, 13 Activity ≤ 1 µM, 21 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of synthetic fluorescent ligand binding to recombinant truncated 6HisFlag-Tev-BRPF2 (551 to 673 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells after 30 mins by TR-FRET assay
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to BRD1 (unknown origin) assessed as change in melting temperature at 100 uM by differential scanning fluorimetric assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to human BRD1 (E556 to A688 residues) expressed in bacterial expression system by BROMOScan assay
Binding affinity to human partial length BRD1 (E556 to A688 residues) expressed in bacterial expression system by BROMOscan assay
Assay data:1 Active, 1 Tested
Binding affinity to human partial length DNA-tagged BRD1 expressed in bacterial by BROMOscan method
Binding affinity to BRPF2 bromodomain (unknown origin) by isothermal titration calorimetry
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Binding affinity to human BRD1 expressed in bacterial system assessed as remaining binding level at 1 uM by BROMOscan assay relative to control
Assay data:3 Tested
Inhibition of human BRD1 (E556 to A688 residues) expressed in Escherichia coli BL21 assessed as residual activity at 1 uM after 1 hr by BROMOScan assay relative to control
Binding affinity to N-terminal 6His-tagged BRPF2 (unknown origin) expressed in Escherichia coli BL21-CodonPlus competent cells by isothermal titration calorimetry
Assay data:2 Tested
Inhibition of recombinant human N-terminal GST-tagged BRPF2 (556 to 688 residues) at 200 uM using biotinylated H4(1 to 21)K5/8/12/16Ac peptide as substrate after 30 mins by AlphaScreen assay
Inhibition of human BRD1 (E556 to A688 residues) expressed in bacterial expression system by BROMOscan assay
Assay data:2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human partial length BRD1 (E556 to A688 residues) expressed in bacterial expression system assessed as residual activity at 500 nM relative to control by BROMOscan assay
Binding affinity to BRPF2 (unknown origin) by isothermal titration calorimetric analysis
Inhibition of His-tagged BRPF2 (unknown origin) after 30 mins by alphaScreen assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to BRPF2 (unknown origin) by isothermal titration calorimetry
Inhibition of GFP-BRD1 fusion construct (unknown origin) binding to chromatin by FRAP assay
Inhibition of human BRPF2 (563 to 688 residues) expressed in Escherichia coli BL21 (DE3)-R3-pRARE2 preincubated for 15 mins followed by addition of C-terminal biotinylated synthetic K5,12 diacetylated histone H4 (1 to 20 residues) peptide as substrate measured after 1 hr by TR-FRET assay
Assay data:26 Active, 25 Activity ≤ 1 µM, 27 Tested
Inhibition of Halo-tagged histone H4 binding to C-terminally NanoLuc luciferase conjugated human BRPF2 BD (560 to 666 residues) expressed in human HCT116 cells after 4 to 24 hrs by BRET assay
Assay data:11 Active, 8 Activity ≤ 1 µM, 14 Tested
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