Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Intrinsic activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay relative to O-(Hydroxy(((2R,3R)-2-(((3-(2-((3-phenoxybenzyl)oxy)phenyl)-propanoyl)oxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)phosphoryl)-L-serine
Assay data:35 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of mouse GPR34 expressed in CHOK1 cells assessed as inhibition of forskolin-induced cAMP production at 0.01 to 10 uM after 30 mins by EIA
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of mouse GPR34 expressed in CHOK1 cells assessed as increase in intracellular calcium level by spectrofluorimetry
Activation of mouse GPR34 expressed in CHOK1 cells assessed as phosphorylated ERK level at 0.01 to 10 uM by Western blotting
Activation of mouse GPR34 expressed in CHOK1 cells assessed as total ERK level at 0.01 to 10 uM by Western blotting
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
Agonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay
Assay data:33 Active, 33 Activity ≤ 1 µM, 44 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with Galphaq/i1 assessed as increase in calcium influx by calcium 5 dye based FLIPR assay
Agonist activity at mouse GPR34 expressed in HEK293A cells cotransfected with chimeric Galphaq/il assessed as increase in intracellular calcium levels at 1 uM measured after 35 secs by calcium 5 dye based fluorescence microplate reader method in presence of probenecid
Assay data:6 Active, 6 Tested
Mouse GPR34 (Class A Orphans)
Assay data:1 Active, 1 Tested
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr
Assay data:36 Active, 23 Activity ≤ 1 µM, 36 Tested
Intrinsic activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/iL assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr relative to O-(Hydroxy(((2R,3R)-2-(((3-(2-((3-phenoxybenzyl)oxy)phenyl)- propanoyl)oxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)phosphoryl)- L-serine
Assay data:30 Tested
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr relative to control
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
Assay data:29 Active, 1 Activity ≤ 1 nM, 25 Activity ≤ 1 µM, 30 Tested
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis relative to control
Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis relative to positive control
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on