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Binding affinity to rat L-type calcium channel
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of L-VDCC in rat H9C2 cells assessed as effect on calcium level by Fluo-4 fluorescence assay
Assay data:5 Active, 8 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Displacement of [3H]verapamil from verapamil binding site of L-type calcium channel in rat cerebral cortex at 10 uM after 120 mins by scintillation counting
Displacement of [3H]diltiazem from benzodiazepine binding site of L-type calcium channel in Wistar rat cardiomyocytes by liquid scintillation counting
Inhibition of [3H]diltiazem binding to benzodiazepine binding site of L-type calcium channel in Wistar rat cardiomyocytes at 100 uM by liquid scintillation counting
Inhibition of [3H]diltiazem binding to benzodiazepine binding site of L-type calcium channel in Wistar rat cardiomyocytes at 1 uM by liquid scintillation counting
Assay data:2 Tested
Blockade of L-type calcium channel in Wistar rat cardiomyocytes assessed as inhibition of peak L-type barium current by whole cell patch clamp method
Assay data:3 Tested
Inhibition of rat L-type calcium channel
Assay data:1 Active, 1 Tested
Inhibition of L-type calcium channel in rat A10 cells assessed as inhibition of depolarization-induced increase in calcium flux after 48 hrs by FLIPR assay
Assay data:9 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [3H](-)D 888 from L-type calcium channel in rat cerebral cortex
Induction of L-type calcium channel-mediated neuroD gene expression in rat HCN cells after 24 hrs by luciferase reporter gene assay in presence of multiple inhibitors
Induction of L-type calcium channel-mediated neuroD gene expression in rat HCN cells after 24 hrs by luciferase reporter gene assay in presence of NMDA receptor antagonist MK801
Induction of L-type calcium channel-mediated neuroD gene expression in rat HCN cells after 24 hrs by luciferase reporter gene assay in presence of NMDA receptor antagonist nifedipine
Inhibition of rat L type calcium channel at verapamil site at 10 uM
Inhibition of rat L-type calcium channel dihydropyridine site at 1 uM relative to control
Inhibition of rat L-type calcium channel diltiazem site at 1 uM relative to control
Inhibition of rat L-type calcium channel verapamil site at 1 uM relative to control
Inhibition of rat L-type Ca2+ channel dihydropyridine site
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of rat L-type Ca2+ channel diltiazem site
Inhibition of rat L-type Ca2+ channel verapamil site
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