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Rat mGlu5 receptor (Metabotropic glutamate receptors)
Assay data:62 Active, 62 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: BioAssay Summary, ML 353
SummaryRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: Fold-shift Assay
Assay data:20 Active, 31 Activity ≤ 1 µM, 34 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: full Ki determination
Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested
Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: 3pt binding Assay
Assay data:11 Active, 18 Activity ≤ 1 µM, 19 Tested
Identification of a glycine sulfonamide based non-MPEP site positive allosteric potentiator (PAM) of mGlu5 (binding_assay)
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Identification of a glycine sulfonamide based non-MPEP site positive allosteric potentiator (PAM) of mGlu5 (calcium_assay)
Assay data:16 Active, 6 Activity ≤ 1 µM, 32 Tested
ML332 Competition in Radioligand Binding assays (Ricerca)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Chemical Optimization of Advanced mGlu4 Lead Candidates (rat_mGlu5_Selectivity)
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
ML254 and ML273 Competition in Radioligand Binding assays (Riserca)
Assay data:2 Tested
rmGluR5_Calcium_Fold_Shift
Assay data:2 Active, 2 Tested
Optimization of novel mGluR5 positive allosteric modulators (PAM)s
Optimization of novel mGluR5 positive allosteric modulators with different mechanisms of action and modes of efficacy
Assay data:23 Active, 17 Activity ≤ 1 µM, 36 Tested
mGluR5_3H_methoxyPEPy_Binding
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Modulation of the Metabotropic Glutamate Receptor mGluR4: Selectivity at mGluR5
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
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