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Invivo antagonist activity at TSHR in Wistar rat assessed as inhibition of M22-induced FT4 level at 50 to 100 micromol/kg,po measured upto 24 hrs by LC-MS/MS analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Invivo antagonist activity at TSHR in Wistar rat assessed as inhibition of M22-induced FT4 level at 25 to 100 micromol/kg,po measured upto 8 hrs by LC-MS/MS analysis
Invivo antagonist activity at TSHR in Wistar rat assessed as inhibition of M22-induced FT4 level at 12.5 micromol/kg,po measured upto 8 hrs by LC-MS/MS analysis
Assay data:1 Tested
SummaryPubMed Citation
Antagonist activity at TSHR in rat FRTL-5 cells assessed as inhibition of M22-induced cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antagonist activity at TSHR in rat FRTL-5 cells assessed as reduction in cAMP production by measuring its efficacy at 10 uM incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
Assay data:24 Tested
Antagonist activity at TSHR in rat FRTL-5 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
Assay data:23 Active, 23 Activity ≤ 1 µM, 24 Tested
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