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Inhibition of His6-tagged human recombinant DNMT3A/DNMT3L expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-biotinylated 45-bp unmethylated or hemimethylated oligonucleotide substrates and [3H]-AdoMet by liquid scintillation counting method
Assay data:1 Active, 1 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of DNMT3A/3L (unknown origin) at 1 uM using biotin-labeled peptide as substrate and [3H]-SAM measured after 1 hr by filter based assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of DNMT3B/3L (unknown origin) at 10 uM using biotin-labeled peptide as substrate and [3H]-SAM measured after 1 hr by filter based assay
Inhibition of DNMT3A/3L (unknown origin) at 10 uM using biotin-labeled peptide as substrate and [3H]-SAM measured after 1 hr by filter based assay
Inhibition of DNMT3B/3L (unknown origin) at 50 uM using biotin-labeled peptide as substrate and [3H]-SAM measured after 1 hr by scintillation proximity assay
Inhibition of DNMT3A/3L (unknown origin) at 50 uM using biotin-labeled peptide as substrate and [3H]-SAM measured after 1 hr by scintillation proximity assay
Inhibition of DNMT3B/3L (unknown origin) at 1 to 50 uM by TCA precipitation assay
Inhibition of DNMT3A/3L (unknown origin) at 1 to 50 uM by TCA precipitation assay
Inhibition of human DNMT3B/3L at 10 and 50 uM
Inhibition of human DNMT3A/3L at 10 and 50 uM
Inhibition of DNMT3A/3L (unknown origin) using IDT-01 sequence 1/IDT-01 sequence 2 as substrate at 100 uM preincubated for 15 mins followed by substrate addition measured after 4 hrs by liquid scintillation counting analysis relative to control
Inhibition of DNMT3B/3L (unknown origin) at 1 uM after 1 hr by filter-based assay
Inhibition of DNMT3A/3L (unknown origin) at 1 uM after 1 hr by filter-based assay
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
Inhibition of DNMT3B/3L (unknown origin) at 1 uM using biotin-labeled peptide as substrate and [3H]-SAM measured after 1 hr by filter based assay
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
Summary
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
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