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Agonist activity at AF1 deleted human HNF4alpha7 nuclear receptor expressed in human HepG2/C3A cells co-transfected with LexADBD assessed as increase in transcriptional activity after 16 hrs by beta-galactosidase one hybrid assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization
Assay data:1736 Active, 2249 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Effect on HNF4A(NR2A1) dependent reporter activity in HEK293 cells at 20 uM
Assay data:2 Tested
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
SummaryPubMed Citation
Inhibition of HNF4alpha mRNA expression in human HepG2 cells after 24 hrs by Western blotting
Assay data:6 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of HNF4alpha mRNA expression in human HepG2 cells after 24 hrs by RT-PCR analysis
Late stage assay provider results from the probe development effort to identify inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors
Assay data:1 Active, 1 Tested
Activation of HNFalpha transcriptional activity in human HepG3/C3A cells transfected with ApoCIII-luc assessed as activation of luciferase reporter gene after 24 hrs
Activation of HNFalpha transcriptional activity in human HepG3/C3A cells transfected with ApoB-luc assessed as activation of luciferase reporter gene after 24 hrs
Stabilization of thermal denaturation-induced conformational change in human HNF4alpha nuclear receptor ligand binding domain assessed as change in transition temperature by thermofluor assay
Agonist activity at human HNF4alpha7 nuclear receptor LBDdetaF expressed in human HepG2/C3A cells co-transfected with LexADBD assessed as increase in transcriptional activity after 16 hrs by beta-galactosidase one hybrid assay
Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization
Assay data:133 Active, 4 Activity ≤ 1 µM, 234 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Agonist activity at human full length HNF4alpha nuclear receptor expressed in human HepG2/C3A cells co-transfected with LexADBD assessed as increase in transcriptional activity at 100 uM by beta-galactosidase one hybrid assay relative to control
Agonist activity at human full length HNF4alpha nuclear receptor expressed in human HepG2/C3A cells co-transfected with LexADBD assessed as increase in transcriptional activity at 6.2 uM by beta-galactosidase one hybrid assay relative to control
Agonist activity at human full length HNF4alpha nuclear receptor expressed in human HepG2/C3A cells co-transfected with LexADBD assessed as increase in transcriptional activity at 18.7 uM by beta-galactosidase one hybrid assay relative to control
Agonist activity at human full length HNF4alpha nuclear receptor expressed in human HepG2/C3A cells co-transfected with LexADBD assessed as increase in transcriptional activity at 12.5 uM by beta-galactosidase one hybrid assay relative to control
Agonist activity at human full length HNF4alpha nuclear receptor expressed in human HepG2/C3A cells co-transfected with LexADBD assessed as increase in transcriptional activity at 9.3 uM by beta-galactosidase one hybrid assay relative to control
Assay data:3 Tested
Agonist activity at human full length HNF4alpha nuclear receptor expressed in human HepG2/C3A cells co-transfected with LexADBD assessed as increase in transcriptional activity after 16 hrs by beta-galactosidase one hybrid assay
Assay data:7 Active, 8 Tested
Increase in transcriptional activity of HNF-4alpha ligand binding domain expressed in human Hep G2 cells co-transfected with Gal4-DBD by luciferase reporter gene assay
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors.
Assay data:14 Active, 14 Tested
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