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PNP Inhibition Assay from Article 10.1021/jm701265n: "Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases."
Assay data:6 Active, 2 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of bovine spleen PNP assessed as dissociation half life using inosine as substrate by xanthine oxidase coupled assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of bovine spleen PNP using inosine as substrate by xanthine oxidase coupled assay
Assay data:3 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to calf recombinant PNP Phe200Trp mutant expressed in Escherichia coli BL21 (DE3) by competitive binding fluorimetric analysis in presence of DFPP-DG
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to calf recombinant PNP Phe200Trp mutant expressed in Escherichia coli BL21 (DE3) by competitive binding fluorimetric analysis in presence of (S)-PMP-Ada
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to calf recombinant PNP Phe200Trp mutant expressed in Escherichia coli BL21 (DE3) by competitive binding fluorimetric analysis in presence of guanine
Binding affinity to calf recombinant PNP Phe159Trp mutant expressed in Escherichia coli BL21 (DE3) by fluorimetric titration analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of bovine PNP Phe200Trp mutant using 7-methylguanosine as substrate by spectrophotometric based coupled assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Binding affinity to calf recombinant PNP Phe200Trp mutant expressed in Escherichia coli BL21 (DE3) by fluorimetric titration analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetry
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by fluorimetric titration analysis
Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetry/ fluorimetric titration analysis
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of bovine PNP using 7-methylguanosine as substrate by spectrophotometric based coupled assay
Assay data:9 Active, 3 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 9 Tested
Inhibition of bovine PNP Phe159Trp mutant using 7-methylguanosine as substrate by spectrophotometric based coupled assay
Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrofluorimetric method in presence of 1 mM inorganic phosphate
Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 50 mM inorganic phosphate
Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 0.025 mM inorganic phosphate
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM inorganic phosphate
Assay data:5 Active, 5 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of calf spleen PNP assessed as inhibition of 25 uM 7-methylguanosine phosphorolysis by spectrophotometry in presence of 1 mM inorganic phosphate
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Selectivity ratio of Ki(app) for calf spleen PNP to Kieq for calf spleen PNP
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