BioAssay by Target (List) for Gene (Select 5030) - PubChem BioAssay - NCBI

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Select item 4608111.

Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as concentration required to 50% maximal response of compound 3 at 10 uM by fura2/AM assay

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 4

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 460811

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 3159662.

Antagonist activity at human P2Y4 receptor

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 4

Assay data:1 Tested

AID:: 315966

Summary PubMed Citation Related BioAssays by Target

Select item 3525393.

Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells coexpressing phospholipase C-activating G protein assessed as inositol phosphate production at 10 uM by scintillation proximity assay

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 4

Assay data:7 Tested

AID:: 352539

Summary PubMed Citation Related BioAssays by Target

Select item 3662594.

Antagonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as inhibition of UTP-induced receptor activation at 100 uM relative to UTP

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 4

Assay data:6 Tested

AID:: 366259

Summary PubMed Citation Related BioAssays by Target

Select item 3665045.

Antagonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as inhibition of UTP-induced intracellular calcium mobilization at 100 uM by FLUOstar plate reader

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 4

Assay data:14 Tested

AID:: 366504

Summary PubMed Citation Related BioAssays by Target

Select item 3665076.

Antagonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as inhibition of UTP-induced intracellular calcium mobilization by FLUOstar plate reader

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 4

Assay data:1 Active, 2 Tested

AID:: 366507

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 3737087.

Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by dual-excitation spectrofluorimetric analysis

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 4

Assay data:1 Active, 1 Activity ≤ 1 µM, 4 Tested

AID:: 373708

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 3737128.

Antagonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as inhibition of UTP-induced increase in intracellular calcium concentration by dual-excitation spectrofluorimetric analysis

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 4

Assay data:3 Tested

AID:: 373712

Summary PubMed Citation Related BioAssays by Target

Select item 4048349.

Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assay

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 4

Assay data:29 Active, 10 Activity ≤ 1 µM, 32 Tested

AID:: 404834

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 40483510.

Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation at 10 uM by scintillation proximity assay

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 4

Assay data:4 Tested

AID:: 404835

Summary PubMed Citation Related BioAssays by Target

Select item 40715411.

Agonist activity at P2Y4 receptor expressed in HEK293 cells at 10 uM to 1 nM

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 4

Assay data:6 Tested

AID:: 407154

Summary PubMed Citation Related BioAssays by Target

Select item 46057612.

Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as calcium elevation by fura2/AM assay

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 4

Assay data:2 Active, 1 Activity ≤ 1 µM, 7 Tested

AID:: 460576

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 46057713.

Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as calcium elevation at 10 uM by fura2/AM assay

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 4

Assay data:1 Active, 1 Tested

AID:: 460577

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 31576114.

Agonist activity at P2Y4 receptor expressed in human 1321 cells at 100 uM by calcium mobilization assay

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 4

Assay data:16 Tested

AID:: 315761

Summary PubMed Citation Related BioAssays by Target

Select item 46177615.

Antagonist activity at human P2Y4 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 4

Assay data:2 Active, 6 Tested

AID:: 461776

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 48477716.

Agonist activity at human recombinant P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production by scintillation proximity assay

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 4

Assay data:11 Active, 8 Activity ≤ 1 µM, 11 Tested

AID:: 484777

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 48477917.

Agonist activity at human recombinant P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production up to 10 uM by scintillation proximity assay

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 4

Assay data:10 Tested

AID:: 484779

Summary PubMed Citation Related BioAssays by Target

Select item 57012918.

Antagonist activity against human P2Y4 receptor expressed in 1321N1 astrocytoma cells by calcium mobilization assay

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 4

Assay data:7 Active, 14 Tested

AID:: 570129

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 59312519.

Agonist activity at human recombinant P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate intracellular accumulation by scintillation proximity assay

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 4

Assay data:13 Active, 2 Activity ≤ 1 µM, 27 Tested

AID:: 593125

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 59313520.

Agonist activity at P2Y4 receptor

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 4

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 593135

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Target

Proteins (1)
BioAssays with protein sequences specified as targets
RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (34)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 µM (23)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (33)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (9)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (89)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (84)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (17)
BioAssays deposited by other experimentalists

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