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Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
siRNA Circadian Assay
Assay data:527 Active, 33364 Tested
SummaryPubMed CitationRelated BioAssays by Depositor
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
SummaryPubMed Citation
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
Break-induced replication repair of damaged forks induces genomic duplications in human cells
Assay data:478 Active, 1380 Tested
Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells
Assay data:167 Active, 26449 Tested
Summary
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Binding affinity to recombinant human REV1 UBM1/UBM2 domain (137 residues) expressed in Escherichia coli BL21(DE3) assessed as increase in NOE peaks at 200 uM by STD NMR spectral analysis
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to recombinant human REV1 UBM2 domain assessed as chemical shift changes by [1H,15N]-HSQC NMR spectral analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to recombinant human REV1 UBM2 domain assessed as chemical shift perturbations on alpha-helix at REV1 UBM2 to compound molar ratio of 1:10 by [1H,15N]-HSQC NMR spectral analysis
Assay data:1 Active, 1 Tested
Inhibition of UbPCNA binding to EGFP-tagged REV1 (unknown origin) expressed in human U2OS cells assessed as reduction in cisplatin-induced recruitment of EGFP-REV1 to PCNA foci on chromatin at 150 uM treated after 3.5 hrs cisplatin exposure and measured 6 hrs after post dose by immunostaining based confocal microscopic analysis
Inhibition of REV1 in human HeLa cells assessed as reduction in 2.5 J/m2 UV light-induced cyclopyrimidine dimer removal at 150 uM by epi-fluorescence microscopic analysis
Inhibition of REV1 in human WTK1 cells assessed as suppression of 0 to 128 J/m2 UV light-induced HPRT gene mutation by measuring reduction in number of resistant clones at 150 uM dosed Immediately following UVC treatment and measured after 21 hrs
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