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Inhibition of PORCN in mouse Leydig cells overexpressing Wnt3A co-cultured with TM3 cells transfected with Wnt-luciferase gene after 24 hrs by luminescence assay
Assay data:20 Active, 12 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 22 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of mouse PORCN expressed in human HT1080 cells coexpressing Wnt/beta-catenin assessed as decrease in beta-catenin-mediated transcriptional activity at 1 to 1000 nM after 24 hrs in presence of Wnt3a by luciferase reporter gene assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of mouse PORCN expressed in human HT1080 cells coexpressing Wnt/beta-catenin assessed as decrease in beta-catenin-mediated transcriptional activity at 0.2 to 625 nM after 24 hrs in presence of Wnt3a by luciferase reporter gene assay
Inhibition of porcupine in mouse L Wnt3A cells co-cultured with HEK293 cells assessed as suppression of Wnt signaling after 48 hrs by Super-top flash reporter gene assay
Assay data:5 Active, 2 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 6 Tested
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells at 1 uM after 24 hrs by springerImage-Topflash reporter assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay
Assay data:35 Active, 16 Activity ≤ 1 nM, 36 Activity ≤ 1 µM, 40 Tested
Inhibition of porcupine in mouse L Wnt3A cells co-cultured with HEK293 cells after 48 hrs by Super-top flash reporter gene assay
Assay data:23 Active, 3 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 26 Tested
Inhibition of mouse porcupine expressed in human HT1080 cells assessed as reduction in beta catenin reporter activity using firefly luciferase substrate STF reporter assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay
Assay data:54 Active, 6 Activity ≤ 1 nM, 53 Activity ≤ 1 µM, 63 Tested
Inhibition of porcupine in E11.5 mouse embryo kidney assessed as inhibition of Wnt-mediated branching morphogenesis at 10 to 50 nM measured every 24 hrs by fluorescent stereoscopic analysis relative to control
Inhibition of porcn-mediated Wnt5A palmitoylation in mouse L cell expressing Wnt5A and STF by detergent solubility fractionation assessed as [3H]palmitate incorporation at 2 uM by autoradiography method
Effect on porcn Endoplasmic reticulum localization in mouse L cell expressing Wnt and STF
Increase in porcn levels in mouse L cell expressing Wnt and STF
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