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Effect on RXR
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Effect on RXRG(NR2B3) dependent reporter activity in HEK293 cells at 20 uM
Assay data:2 Tested
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
SummaryPubMed Citation
Antagonist activity at human RXRgamma expressed in COS-1 cells assessed as inhibition of PA024-induced transactivation by luciferase reporter gene assay
Agonist activity at human RXR by transactivation assay relative to fenofibric acid
Agonist activity at human RXR by transactivation assay
Activity at RXRgamma ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay
Assay data:7 Tested
Antagonist activity at RXRgamma expressed in african green monkey COS1 cells assessed as inhibition of LGD-1069-induced agonist activity
Assay data:5 Active, 1 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at RXRgamma expressed in african green monkey COS1 cells by luciferase reporter gene assay relative to LGD1069
Assay data:6 Tested
Displacement of radiolabeled 9-cis retinoic acid from human RXR by scintillation proximity assay
Activity at RXR by cell based assay
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
Binding affinity to RXRgamma
Assay data:18 Active, 18 Activity ≤ 1 µM, 21 Tested
Transactivation of RXRgamma in CV1 cells by cotransfection assay
Assay data:15 Active, 14 Activity ≤ 1 µM, 21 Tested
Binding affinity towards Retinoic acid receptor RXR-gamma by displacing 3.4 nM 3[H]-9-cis-RA; No binding competition
SummaryRelated BioAssays by Target
Binding affinity towards Retinoic acid receptor RXR-gamma by displacing 3.4 nM 3[H]-9-cis-RA
Binding affinity towards Retinoic acid receptor RXR-gamma by displacing 3.4 nM 3[H]-9-cis-RA; IA = Inactive
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Binding affinity towards Retinoic acid receptor RXR-gamma
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