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Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as drug level required for fourfold increase in Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay
Assay data:28 Active, 20 Activity ≤ 1 µM, 38 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
siRNA Circadian Assay
Assay data:527 Active, 33364 Tested
SummaryPubMed CitationRelated BioAssays by Depositor
Inhibition of human sFRP1 expressed in human U2OS assessed as fold induction in luciferase activity at 15 uM by TCF-luciferase reporter gene assay relative to control
Assay data:11 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human sFRP1 expressed in human U2OS assessed as fold induction in luciferase activity at 30 uM by TCF-luciferase reporter gene assay relative to control
Assay data:2 Tested
Inhibition of human sFRP1 expressed in human U2OS assessed as luciferase activity by TCF-luciferase reporter gene assay
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to human sFRP1 by fluorescence spectroscopy
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to human purified SARP2 by fluorescent polarization assay
Assay data:31 Active, 30 Activity ≤ 1 µM, 31 Tested
Inhibition of human SFRP1 transfected in human U20S cells by TCF-luciferase reporter gene assay
Assay data:1 Active, 1 Tested
Inhibition of human SFRP1 transfected in human U20S cells at 15 uM by TCF-luciferase reporter gene assay relative to control
Assay data:20 Tested
Inhibition of human SFRP1 transfected in human U20S cells at 30 uM by TCF-luciferase reporter gene assay relative to control
Assay data:5 Tested
Inhibition of human SFRP1
Binding affinity to human SFRP1 by fluorescence spectroscopy
Displacement of fluorescence probe compound from human SFRP1 after 30 mins by fluorescence polarization assay
Assay data:40 Active, 40 Activity ≤ 1 µM, 40 Tested
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay
Assay data:40 Active, 36 Activity ≤ 1 µM, 40 Tested
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as drug level required for twofold increase in Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Selectivity ratio of EC50 for human recombinant SFRP1 expressed in human U2OS cells to IC50 for human SFRP1
Assay data:1 Tested
Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as drug level required for threefold increase in Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
SummaryPubMed Citation
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
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