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A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
SummaryPubMed Citation
Inhibition of porcupine activity (unknown origin) expressed in human HT1080 cells assessed as suppression of Wnt3A-mediated super top flash activity by STF luciferase assay
Assay data:4 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Potency index, ratio of IC50 for LGK974 to IC50 for test compound for inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with HEK293 STF cells by STF reporter gene based paracrine cellular reporter gene assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of porcupine (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of porcupine (unknown origin) expressed in HEK293T cells transfected with pLinbin- Wnt3A plasmid assessed as inhibition of Wnt3A secretion at 0.1 uM incubated for 48 hrs by Western blotting method
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as reduction in Wnt ligand-driven LEF/TCF-dependent transcriptional activity
Assay data:17 Active, 7 Activity ≤ 1 nM, 24 Activity ≤ 1 µM, 24 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
Summary
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
Inhibition of porcupine in human HEK293 cells assessed as reduction in Wnt secretion by measuring suppression of beta-catenin reporter activity after 24 hrs by STF reporter assay
Assay data:3 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 3 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Inhibition of porcupine-mediated phosphorylation of dishevelled 2 in HEK293 cells at 2.5 uM
Assay data:1 Active, 1 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
Inhibition of porcn-mediated Shh palmitoylation in human DLD1 lysate by detergent solubility fractionation assessed as [3H]palmitate incorporation at 2.5 uM by autoradiography method
Assay data:4 Tested
Inhibition of porcn-mediated Lrp6 maturation in human DLD1 lysate by detergent solubility fractionation assessed as [3H]palmitate incorporation at 2.5 uM by autoradiography method
Inhibition of porcn in HEK293 cell lysate by Western blot analysis
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