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Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Inhibition of wild type LRRK2 phosphorylation at Ser910 in mouse 3T3 cells after 90 mins by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of wild type LRRK2 phosphorylation at Ser935 in mouse 3T3 cells after 90 mins by Western blot analysis
Inhibition of LRRK2 G2019S mutant phosphorylation at Ser910 in mouse 3T3 cells after 90 mins by Western blot analysis
Inhibition of LRRK2 G2019S mutant phosphorylation at Ser935 in mouse 3T3 cells after 90 mins by Western blot analysis
Inhibition of LRRK2 autophosphorylation at Ser910 and Ser935 Swiss mouse 3T3 cells by immunoblotting analysis
Inhibition of LRRK2 autophosphorylation at Ser910 and Ser935 mouse embryonic fibroblast cells by immunoblotting analysis
Inhibition of LRRK2 in Swiss mouse 3T3 cells assessed as inhibition of Ser935 autophosphorylation after 90 mins by immunoblot method
Inhibition of LRRK2 in Swiss mouse 3T3 cells assessed as inhibition of Ser910 autophosphorylation after 90 mins by immunoblot method
Binding affinity to LRRK2 in C57BL/6 mouse brain at 1 uM after 30 mins by competition pull down assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to LRRK2 in mouse C2C12 cells at 1 uM after 30 mins by competition pull down assay
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Inhibition of mouse full-length wild type LRRK2 transfected in HEK293 cells assessed as residual activity at 30 uM using LRRKtide as substrate incubated for 1 hr in presence of ATP by TR-FRET based ADAPTA assay
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
Inhibition of LRRK2 in C57/BL6 mouse neural stem cells derived neurospheres isolated from adult ventricular-subventricular zone assessed as decrease in neurosphere proliferation at 1 uM measured after 4 days presence of FGF or EGF by bright field microscopy analysis
Assay data:2 Active, 2 Tested
Inhibition of LRRK2 in C57/BL6 mouse neural stem cells derived neurospheres isolated from adult ventricular-subventricular zone assessed as differentiation of neurospheres forming CNPase positive oligodendrocytes at 1 uM treated for 6 days and measured on day 7 by bisbenzimide staining based confocal microscopy
Inhibition of LRRK2 in C57/BL6 mouse neural stem cells derived neurospheres isolated from adult ventricular-subventricular zone assessed as reduction in Rab10 phosphorylation at 10 uM using Rab10 as substrate measured after 7 days in presence of mitogens by Western blot analysis
Protac activity at CRBN/LRRK2 in mouse MEF cells assessed as induction of LRRK2 degradation by measuring reduction in LRRK2 phosphorylation at S935 residue by Invitrogen Adapta assay
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of LRRK2-WT-pSER935 in C57BL/6 mouse brain at 10 to 150 mg/kg and measured after 1 hrs by western blotting
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of LRRK2-WT in C57BL/6 mouse brain at 10 to 150 mg/kg and measured after 1 hrs by western blotting
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