BioAssay by Target (List) for Gene (Select 66853) - PubChem BioAssay - NCBI

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Links from Gene

Items: 14

Select item 17213471.

Inhibition of murine ATGL at 200 uM relative to control

Source:: ChEMBL

Protein Target:: Patatin-like phospholipase domain-containing protein 2

Assay data:6 Tested

AID:: 1721347

Summary PubMed Citation Related BioAssays by Target

Select item 17213462.

Inhibition of murine ATGL

Source:: ChEMBL

Protein Target:: Patatin-like phospholipase domain-containing protein 2

Assay data:6 Tested

AID:: 1721346

Summary PubMed Citation Related BioAssays by Target

Select item 17213373.

Inhibition of recombinant murine ATGL expressed in Escherichia coli XL-1 lysates at 200 uM relative to control

Source:: ChEMBL

Protein Target:: Patatin-like phospholipase domain-containing protein 2

Assay data:10 Tested

AID:: 1721337

Summary PubMed Citation Related BioAssays by Target

Select item 17213364.

Inhibition of recombinant murine ATGL expressed in Escherichia coli XL-1 lysates

Source:: ChEMBL

Protein Target:: Patatin-like phospholipase domain-containing protein 2

Assay data:2 Active, 1 Activity ≤ 1 µM, 10 Tested

AID:: 1721336

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 17213355.

Inhibition of murine ATGL expressed in COS-7 cells at 200 uM relative to control

Source:: ChEMBL

Protein Target:: Patatin-like phospholipase domain-containing protein 2

Assay data:68 Tested

AID:: 1721335

Summary PubMed Citation Related BioAssays by Target

Select item 17213346.

Inhibition of murine ATGL expressed in COS-7 cells

Source:: ChEMBL

Protein Target:: Patatin-like phospholipase domain-containing protein 2

Assay data:3 Active, 68 Tested

AID:: 1721334

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 13109877.

Activation of ATGL activity in mouse 3T3L1 cells assessed as isoproterenol-stimulated lipolysis by measuring increase in non-esterified fatty acid release in media at 20 uM preincubated for 4 hrs followed by isoproterenol addition measured after 1 hr by colorimetric assay

Source:: ChEMBL

Protein Target:: Patatin-like phospholipase domain-containing protein 2

Assay data:1 Tested

AID:: 1310987

Summary PubMed Citation Related BioAssays by Target

Select item 13109868.

Inhibition of ATGL in mouse 3T3L1 cells assessed as inhibition of isoproterenol-stimulated lipolysis by measuring reduction in glycerol release in media at 20 uM preincubated for 4 hrs followed by isoproterenol addition measured after 1 hr by colorimetric assay

Source:: ChEMBL

Protein Target:: Patatin-like phospholipase domain-containing protein 2

Assay data:1 Active, 17 Tested

AID:: 1310986

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 13109859.

Inhibition of ATGL in mouse 3T3L1 cells assessed as inhibition of isoproterenol-stimulated lipolysis by measuring reduction in non-esterified fatty acid release in media at 20 uM preincubated for 4 hrs followed by isoproterenol addition measured after 1 hr by colorimetric assay

Source:: ChEMBL

Protein Target:: Patatin-like phospholipase domain-containing protein 2

Assay data:2 Active, 15 Tested

AID:: 1310985

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 122482810.

Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout

Source:: Iain Fraser

Assay data:762 Active, 16821 Tested

AID:: 1224828

Summary Related BioAssays by Same Project

Select item 122482611.

Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout

Source:: Iain Fraser

Assay data:1106 Active, 16821 Tested

AID:: 1224826

Summary Related BioAssays by Same Project

Select item 120548312.

Inhibition of mouse recombinant ATGL expressed in African green monkey COS7 cells assessed as reduction in triglyceride hydrolase activity at 200 uM using radio-labelled triolein substrate incubated for 1 hr by liquid scintillation counting

Source:: ChEMBL

Protein Target:: Patatin-like phospholipase domain-containing protein 2

Assay data:50 Tested

AID:: 1205483

Summary PubMed Citation Related BioAssays by Target

Select item 120548213.

Inhibition of mouse recombinant ATGL expressed in African green monkey COS7 cells assessed as reduction in triglyceride hydrolase activity using radio-labelled triolein substrate incubated for 1 hr by liquid scintillation counting

Source:: ChEMBL

Protein Target:: Patatin-like phospholipase domain-containing protein 2

Assay data:1 Active, 51 Tested

AID:: 1205482

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 105320814.

A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:788 Active, 16789 Tested

AID:: 1053208

Summary PubMed Citation

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BioActivity

Active Compounds (5)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 µM (1)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (2)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (4)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (1)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (11)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (3)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (2)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (11)
BioAssays extracted from the literature
Other (3)
BioAssays deposited by other experimentalists

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BioAssay by Target (List) for Gene (Select 66853) (14)
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